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Illumina Body Map 2
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Results for ESRRB_ESRRG
Z-value: 3.23
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Transcription factors associated with ESRRB_ESRRG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ESRRG | hg19_v2_chr1_-_216896780_216896800 | 0.81 | 1.9e-08 | Click! |
| ESRRB | hg19_v2_chr14_+_76776957_76777061 | 0.59 | 3.9e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ESRRB_ESRRG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.4 | 45.6 | GO:1903060 | regulation of N-terminal protein palmitoylation(GO:0060254) negative regulation of N-terminal protein palmitoylation(GO:0060262) negative regulation of protein lipidation(GO:1903060) |
| 2.6 | 44.9 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.5 | 40.3 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 1.1 | 37.0 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.3 | 26.8 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 1.5 | 26.4 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 3.5 | 24.6 | GO:0044861 | protein transport into plasma membrane raft(GO:0044861) positive regulation of calcium:sodium antiporter activity(GO:1903281) |
| 1.0 | 21.5 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 0.4 | 18.9 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
| 0.6 | 13.4 | GO:2001135 | regulation of endocytic recycling(GO:2001135) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 84.4 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 46.0 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.1 | 41.2 | GO:0030016 | myofibril(GO:0030016) |
| 1.1 | 39.4 | GO:0005753 | mitochondrial proton-transporting ATP synthase complex(GO:0005753) |
| 0.1 | 30.1 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.1 | 29.2 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.4 | 28.7 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.9 | 26.0 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.1 | 20.8 | GO:0030426 | growth cone(GO:0030426) |
| 1.3 | 16.8 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 44.9 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.5 | 29.9 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 1.0 | 24.6 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.8 | 24.2 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.6 | 20.0 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.5 | 18.9 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 17.9 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 2.4 | 16.7 | GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591) |
| 0.4 | 16.2 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 15.7 | GO:0051082 | unfolded protein binding(GO:0051082) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 22.3 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 20.7 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 9.9 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 9.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 7.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 7.7 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.2 | 7.1 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.3 | 6.6 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 5.6 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 5.5 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 63.2 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.7 | 63.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.5 | 34.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 31.5 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.5 | 31.4 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 1.1 | 26.2 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.3 | 16.6 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 12.7 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.4 | 11.9 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.4 | 10.7 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |