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Illumina Body Map 2
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Results for ETV4_ETS2
Z-value: 1.22
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Transcription factors associated with ETV4_ETS2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ETS2 | hg19_v2_chr21_+_40177755_40177875 | 0.42 | 1.7e-02 | Click! |
| ETV4 | hg19_v2_chr17_-_41623716_41623800 | 0.34 | 5.6e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ETV4_ETS2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 14.0 | GO:0071801 | regulation of podosome assembly(GO:0071801) |
| 0.7 | 9.4 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.4 | 8.8 | GO:0033623 | regulation of integrin activation(GO:0033623) |
| 0.1 | 7.4 | GO:0001570 | vasculogenesis(GO:0001570) |
| 0.0 | 7.1 | GO:0045995 | regulation of embryonic development(GO:0045995) |
| 0.1 | 6.7 | GO:0050999 | regulation of nitric-oxide synthase activity(GO:0050999) |
| 0.6 | 6.2 | GO:1904379 | protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379) |
| 0.2 | 6.2 | GO:0036150 | phosphatidylserine acyl-chain remodeling(GO:0036150) |
| 0.0 | 5.8 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 0.1 | 5.4 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.2 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 11.2 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 9.4 | GO:0030016 | myofibril(GO:0030016) |
| 0.5 | 9.3 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.2 | 8.7 | GO:0005605 | basal lamina(GO:0005605) |
| 0.2 | 7.9 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.1 | 7.7 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 7.0 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.5 | 5.5 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
| 0.5 | 5.4 | GO:0005610 | laminin-5 complex(GO:0005610) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.6 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 13.1 | GO:0019787 | ubiquitin-like protein transferase activity(GO:0019787) |
| 0.1 | 11.9 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.2 | 8.6 | GO:0008329 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.2 | 7.7 | GO:0031005 | filamin binding(GO:0031005) |
| 0.0 | 6.5 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.3 | 6.2 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.0 | 5.6 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.8 | 5.3 | GO:0052739 | phosphatidylserine 1-acylhydrolase activity(GO:0052739) |
| 0.1 | 4.8 | GO:0030552 | cAMP binding(GO:0030552) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.7 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 18.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 6.3 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 4.2 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 4.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 4.1 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 3.8 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.1 | 3.8 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 3.5 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.0 | 3.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 17.0 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.3 | 12.5 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.2 | 8.0 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 0.1 | 7.4 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.2 | 6.5 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 5.7 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 4.4 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.2 | 4.3 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 3.8 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 3.6 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |