ISMARA results: EZH2

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Illumina Body Map 2

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Results for EZH2

Z-value: 2.38

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Transcription factors associated with EZH2

Gene Symbol	Gene ID	Gene Info
EZH2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000106462.6	enhancer of zeste 2 polycomb repressive complex 2 subunit

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
EZH2	hg19_v2_chr7_-_148581251_148581347	-0.41	2.0e-02	Click!

Activity profile of EZH2 motif

Sorted Z-values of EZH2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_116164306 Show fit	12.59	ENST00000490035.2	LSAMP Ensembl NCBI GeneCards UniProt NextProt Show fit	limbic system-associated membrane protein
chr15_+_43885252 Show fit	11.31	ENST00000453782.1 ENST00000300283.6 ENST00000437924.1 ENST00000450086.2	CKMT1B Ensembl NCBI GeneCards UniProt NextProt Show fit	creatine kinase, mitochondrial 1B
chr3_+_115342159 Show fit	10.20	ENST00000305124.6	GAP43 Ensembl NCBI GeneCards UniProt NextProt Show fit	growth associated protein 43
chr11_+_27062272 Show fit	9.61	ENST00000529202.1 ENST00000533566.1	BBOX1 Ensembl NCBI GeneCards UniProt NextProt Show fit	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr5_+_175298487 Show fit	9.19	ENST00000393745.3	CPLX2 Ensembl NCBI GeneCards UniProt NextProt Show fit	complexin 2
chr4_+_24797085 Show fit	8.85	ENST00000382120.3	SOD3 Ensembl NCBI GeneCards UniProt NextProt Show fit	superoxide dismutase 3, extracellular
chr3_+_115342349 Show fit	8.83	ENST00000393780.3	GAP43 Ensembl NCBI GeneCards UniProt NextProt Show fit	growth associated protein 43
chr11_-_111781610 Show fit	8.66	ENST00000525823.1	CRYAB Ensembl NCBI GeneCards UniProt NextProt Show fit	crystallin, alpha B
chr15_+_43985084 Show fit	8.57	ENST00000434505.1 ENST00000411750.1	CKMT1A Ensembl NCBI GeneCards UniProt NextProt Show fit	creatine kinase, mitochondrial 1A
chr5_+_92919043 Show fit	8.39	ENST00000327111.3	NR2F1 Ensembl NCBI GeneCards UniProt NextProt Show fit	nuclear receptor subfamily 2, group F, member 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of EZH2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	42.3	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.0	25.2	GO:0007021	tubulin complex assembly(GO:0007021)
1.0	23.2	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.8	23.0	GO:0031915	positive regulation of synaptic plasticity(GO:0031915)
1.6	22.6	GO:0016198	axon choice point recognition(GO:0016198)
0.6	22.2	GO:0010669	epithelial structure maintenance(GO:0010669)
0.4	21.9	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
1.2	15.9	GO:0045329	carnitine biosynthetic process(GO:0045329)
0.9	15.9	GO:0090129	positive regulation of synapse maturation(GO:0090129)
0.9	15.9	GO:0006600	creatine metabolic process(GO:0006600)

Showing 1 to 10 of 424 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	40.6	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.1	31.7	GO:0031225	anchored component of membrane(GO:0031225)
1.6	29.6	GO:0097512	cardiac myofibril(GO:0097512)
0.5	27.2	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.2	27.2	GO:0042734	presynaptic membrane(GO:0042734)
0.2	26.7	GO:0005796	Golgi lumen(GO:0005796)
0.1	25.7	GO:0045211	postsynaptic membrane(GO:0045211)
0.1	25.1	GO:0032587	ruffle membrane(GO:0032587)
2.3	22.6	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.1	22.2	GO:0030426	growth cone(GO:0030426)

Showing 1 to 10 of 173 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	48.4	GO:0005509	calcium ion binding(GO:0005509)
0.8	24.5	GO:0005212	structural constituent of eye lens(GO:0005212)
1.2	23.4	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
0.1	22.8	GO:0051015	actin filament binding(GO:0051015)
0.1	20.8	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
1.2	19.8	GO:0097109	neuroligin family protein binding(GO:0097109)
1.7	18.3	GO:0035727	lysophosphatidic acid binding(GO:0035727)
0.1	17.0	GO:0001618	virus receptor activity(GO:0001618)
0.2	16.9	GO:0050840	extracellular matrix binding(GO:0050840)
0.4	16.2	GO:0017075	syntaxin-1 binding(GO:0017075)

Showing 1 to 10 of 278 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	27.3	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.3	24.4	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.2	14.7	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.0	14.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	14.1	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.1	12.7	PID FGF PATHWAY	FGF signaling pathway
0.1	12.7	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.2	11.4	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.0	10.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2	8.9	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family

Showing 1 to 10 of 54 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	55.5	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.6	27.2	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1	19.3	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.3	17.1	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.3	16.4	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.1	16.2	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
0.2	11.8	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.2	11.8	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.8	10.9	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.2	10.3	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions

Showing 1 to 10 of 94 entries

Results for EZH2

Z-value: 2.38

Motif logo

Transcription factors associated with EZH2

Activity-expression correlation:

Activity profile of EZH2 motif

Sorted Z-values of EZH2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of EZH2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: