ISMARA results: FOSL1

Project

Illumina Body Map 2

Navigation

Downloads

Results for FOSL1

Z-value: 1.94

Motif logo

Transcription factors associated with FOSL1

Gene Symbol	Gene ID	Gene Info
FOSL1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000175592.4	FOS like 1, AP-1 transcription factor subunit

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOSL1	hg19_v2_chr11_-_65667884_65667895	0.56	8.8e-04	Click!

Activity profile of FOSL1 motif

Sorted Z-values of FOSL1 motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_+_394196 Show fit	9.28	ENST00000331563.2 ENST00000531857.1	PKP3 Ensembl NCBI GeneCards UniProt NextProt Show fit	plakophilin 3
chr19_-_56056888 Show fit	7.66	ENST00000592464.1 ENST00000420723.3	SBK3 Ensembl NCBI GeneCards UniProt NextProt Show fit	SH3 domain binding kinase family, member 3
chr17_-_39769005 Show fit	7.06	ENST00000301653.4 ENST00000593067.1	KRT16 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 16
chr1_-_95007193 Show fit	6.32	ENST00000370207.4 ENST00000334047.7	F3 Ensembl NCBI GeneCards UniProt NextProt Show fit	coagulation factor III (thromboplastin, tissue factor)
chr7_+_73245193 Show fit	6.12	ENST00000340958.2	CLDN4 Ensembl NCBI GeneCards UniProt NextProt Show fit	claudin 4
chr2_+_27505260 Show fit	5.91	ENST00000380075.2 ENST00000296098.4	TRIM54 Ensembl NCBI GeneCards UniProt NextProt Show fit	tripartite motif containing 54
chr10_-_76868931 Show fit	5.38	ENST00000372700.3 ENST00000473072.2 ENST00000491677.2 ENST00000607131.1 ENST00000372702.3	DUSP13 Ensembl NCBI GeneCards UniProt NextProt Show fit	dual specificity phosphatase 13
chr20_-_62129163 Show fit	5.37	ENST00000298049.7	EEF1A2 Ensembl NCBI GeneCards UniProt NextProt Show fit	eukaryotic translation elongation factor 1 alpha 2
chr2_+_170366203 Show fit	5.34	ENST00000284669.1	KLHL41 Ensembl NCBI GeneCards UniProt NextProt Show fit	kelch-like family member 41
chr17_+_4853442 Show fit	4.98	ENST00000522301.1	ENO3 Ensembl NCBI GeneCards UniProt NextProt Show fit	enolase 3 (beta, muscle)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of FOSL1

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.7	16.8	GO:0002159	desmosome assembly(GO:0002159)
0.5	16.8	GO:0061436	establishment of skin barrier(GO:0061436)
0.3	12.6	GO:0031581	hemidesmosome assembly(GO:0031581)
0.8	12.4	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.2	12.0	GO:0018149	peptide cross-linking(GO:0018149)
0.8	11.8	GO:0014722	regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.1	11.1	GO:0030239	myofibril assembly(GO:0030239)
0.4	11.0	GO:0051798	positive regulation of hair follicle development(GO:0051798)
0.4	10.7	GO:0007021	tubulin complex assembly(GO:0007021)
0.1	9.1	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)

Showing 1 to 10 of 230 entries

Gene overrepresentation in cellular_component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	33.1	GO:0031674	I band(GO:0031674)
0.5	18.1	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.2	17.6	GO:0001533	cornified envelope(GO:0001533)
0.4	15.0	GO:0031143	pseudopodium(GO:0031143)
0.3	13.0	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.1	12.9	GO:0005882	intermediate filament(GO:0005882)
0.3	10.9	GO:0032839	dendrite cytoplasm(GO:0032839)
0.7	10.7	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.6	10.7	GO:0097512	cardiac myofibril(GO:0097512)
1.9	7.6	GO:0005607	laminin-2 complex(GO:0005607)

Showing 1 to 10 of 111 entries

Gene overrepresentation in molecular_function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	49.8	GO:0005198	structural molecule activity(GO:0005198)
0.6	15.8	GO:0045294	alpha-catenin binding(GO:0045294)
0.1	12.0	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	11.9	GO:0003779	actin binding(GO:0003779)
0.1	10.5	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1	10.1	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	9.4	GO:0008017	microtubule binding(GO:0008017)
0.2	9.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
1.1	9.0	GO:0042289	MHC class II protein binding(GO:0042289)
0.5	8.8	GO:0030957	Tat protein binding(GO:0030957)

Showing 1 to 10 of 144 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	18.8	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2	18.1	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	13.9	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.5	13.8	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.1	10.0	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.1	9.6	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1	8.6	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.2	7.3	ST G ALPHA S PATHWAY	G alpha s Pathway
0.1	6.1	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.0	5.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Showing 1 to 10 of 48 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.9	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.3	10.7	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.1	10.5	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.1	9.6	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.1	8.4	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	8.4	REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM	Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.2	7.4	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.1	6.8	REACTOME SEMA4D IN SEMAPHORIN SIGNALING	Genes involved in Sema4D in semaphorin signaling
0.1	6.4	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1	6.3	REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE	Genes involved in Formation of Fibrin Clot (Clotting Cascade)

Showing 1 to 10 of 60 entries

Results for FOSL1

Z-value: 1.94

Motif logo

Transcription factors associated with FOSL1

Activity-expression correlation:

Activity profile of FOSL1 motif

Sorted Z-values of FOSL1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of FOSL1

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: