ISMARA results: FOXM1

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Illumina Body Map 2

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Results for FOXM1_TBL1XR1

Z-value: 3.02

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Transcription factors associated with FOXM1_TBL1XR1

Gene Symbol	Gene ID	Gene Info
FOXM1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000111206.8	forkhead box M1
TBL1XR1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000177565.11	TBL1X receptor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOXM1	hg19_v2_chr12_-_2986107_2986258	0.44	1.2e-02	Click!
TBL1XR1	hg19_v2_chr3_-_176914998_176915021	-0.11	5.6e-01	Click!

Activity profile of FOXM1_TBL1XR1 motif

Sorted Z-values of FOXM1_TBL1XR1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_+_22748980 Show fit	13.14	ENST00000390465.2	TRAV38-2DV8 Ensembl NCBI GeneCards UniProt NextProt Show fit	T cell receptor alpha variable 38-2/delta variable 8
chr1_+_117297007 Show fit	10.65	ENST00000369478.3 ENST00000369477.1	CD2 Ensembl NCBI GeneCards UniProt NextProt Show fit	CD2 molecule
chr2_+_102608306 Show fit	10.52	ENST00000332549.3	IL1R2 Ensembl NCBI GeneCards UniProt NextProt Show fit	interleukin 1 receptor, type II
chr1_-_169680745 Show fit	9.37	ENST00000236147.4	SELL Ensembl NCBI GeneCards UniProt NextProt Show fit	selectin L
chr7_+_37888199 Show fit	9.31	ENST00000199447.4 ENST00000455500.1	NME8 Ensembl NCBI GeneCards UniProt NextProt Show fit	NME/NM23 family member 8
chr7_+_142045246 Show fit	8.81	ENST00000390392.3	TRBV4-2 Ensembl NCBI GeneCards UniProt NextProt Show fit	T cell receptor beta variable 4-2
chr14_+_22771851 Show fit	8.74	ENST00000390466.1	TRAV39 Ensembl NCBI GeneCards UniProt NextProt Show fit	T cell receptor alpha variable 39
chr14_+_22520762 Show fit	8.57	ENST00000390449.3	TRAV21 Ensembl NCBI GeneCards UniProt NextProt Show fit	T cell receptor alpha variable 21
chr14_+_22739823 Show fit	8.43	ENST00000390464.2	TRAV38-1 Ensembl NCBI GeneCards UniProt NextProt Show fit	T cell receptor alpha variable 38-1
chr14_+_22689792 Show fit	8.42	ENST00000390462.1	TRAV35 Ensembl NCBI GeneCards UniProt NextProt Show fit	T cell receptor alpha variable 35

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXM1_TBL1XR1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	166.6	GO:0002377	immunoglobulin production(GO:0002377)
1.2	146.6	GO:0006958	complement activation, classical pathway(GO:0006958)
1.6	111.9	GO:0006910	phagocytosis, recognition(GO:0006910)
0.2	90.7	GO:0043312	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.5	50.1	GO:0031295	T cell costimulation(GO:0031295)
0.1	45.1	GO:0007283	spermatogenesis(GO:0007283)
0.3	45.0	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.2	39.0	GO:0002250	adaptive immune response(GO:0002250)
0.4	31.0	GO:0006968	cellular defense response(GO:0006968)
0.4	30.4	GO:0050853	B cell receptor signaling pathway(GO:0050853)

Showing 1 to 10 of 1,283 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	144.5	GO:0009897	external side of plasma membrane(GO:0009897)
0.1	112.8	GO:0005615	extracellular space(GO:0005615)
2.1	108.6	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.3	59.3	GO:0072562	blood microparticle(GO:0072562)
1.5	55.1	GO:0042101	T cell receptor complex(GO:0042101)
0.4	54.9	GO:0070821	tertiary granule membrane(GO:0070821)
0.1	38.7	GO:0034774	secretory granule lumen(GO:0034774)
0.3	35.6	GO:0035578	azurophil granule lumen(GO:0035578)
0.4	35.4	GO:0035580	specific granule lumen(GO:0035580)
0.7	31.5	GO:0031092	platelet alpha granule membrane(GO:0031092)

Showing 1 to 10 of 391 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	272.9	GO:0003823	antigen binding(GO:0003823)
1.8	119.2	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.1	50.2	GO:0030246	carbohydrate binding(GO:0030246)
0.4	38.5	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2	31.7	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.5	31.2	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.7	29.6	GO:0008009	chemokine activity(GO:0008009)
2.3	27.4	GO:0030369	ICAM-3 receptor activity(GO:0030369)
0.2	27.1	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.6	25.5	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)

Showing 1 to 10 of 731 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	84.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2	77.3	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.5	68.4	PID IL4 2PATHWAY	IL4-mediated signaling events
0.8	57.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.5	45.0	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.7	43.5	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.5	34.1	PID BCR 5PATHWAY	BCR signaling pathway
0.5	24.5	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.5	23.1	PID IL12 2PATHWAY	IL12-mediated signaling events
0.6	22.4	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Showing 1 to 10 of 118 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	139.3	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
1.0	70.6	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.3	46.8	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
1.3	39.9	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.4	35.8	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.3	32.3	REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	Genes involved in Antigen processing-Cross presentation
0.6	28.1	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.7	26.2	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.7	26.1	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.7	25.7	REACTOME BETA DEFENSINS	Genes involved in Beta defensins

Showing 1 to 10 of 168 entries

Results for FOXM1_TBL1XR1

Z-value: 3.02

Motif logo

Transcription factors associated with FOXM1_TBL1XR1

Activity-expression correlation:

Activity profile of FOXM1_TBL1XR1 motif

Sorted Z-values of FOXM1_TBL1XR1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXM1_TBL1XR1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: