ISMARA results: GATA5

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Illumina Body Map 2

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Results for GATA5

Z-value: 1.38

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Transcription factors associated with GATA5

Gene Symbol	Gene ID	Gene Info
GATA5 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000130700.6	GATA binding protein 5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GATA5	hg19_v2_chr20_-_61051026_61051057	-0.28	1.2e-01	Click!

Activity profile of GATA5 motif

Sorted Z-values of GATA5 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_+_155484155 Show fit	8.73	ENST00000509493.1	FGB Ensembl NCBI GeneCards UniProt NextProt Show fit	fibrinogen beta chain
chr4_+_155484103 Show fit	7.54	ENST00000302068.4	FGB Ensembl NCBI GeneCards UniProt NextProt Show fit	fibrinogen beta chain
chr4_-_72649763 Show fit	5.77	ENST00000513476.1	GC Ensembl NCBI GeneCards UniProt NextProt Show fit	group-specific component (vitamin D binding protein)
chr1_+_57320437 Show fit	5.62	ENST00000361249.3	C8A Ensembl NCBI GeneCards UniProt NextProt Show fit	complement component 8, alpha polypeptide
chr15_-_54025300 Show fit	4.13	ENST00000559418.1	WDR72 Ensembl NCBI GeneCards UniProt NextProt Show fit	WD repeat domain 72
chr21_+_39668478 Show fit	4.01	ENST00000398927.1	KCNJ15 Ensembl NCBI GeneCards UniProt NextProt Show fit	potassium inwardly-rectifying channel, subfamily J, member 15
chr5_+_75904918 Show fit	3.91	ENST00000514001.1 ENST00000396234.3 ENST00000509074.1	IQGAP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	IQ motif containing GTPase activating protein 2
chr5_+_75904950 Show fit	3.58	ENST00000502745.1	IQGAP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	IQ motif containing GTPase activating protein 2
chr2_+_102615416 Show fit	3.08	ENST00000393414.2	IL1R2 Ensembl NCBI GeneCards UniProt NextProt Show fit	interleukin 1 receptor, type II
chr10_+_7745303 Show fit	3.05	ENST00000429820.1 ENST00000379587.4	ITIH2 Ensembl NCBI GeneCards UniProt NextProt Show fit	inter-alpha-trypsin inhibitor heavy chain 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	16.3	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.3	7.4	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.3	6.5	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.1	6.1	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2	5.8	GO:0042359	vitamin D metabolic process(GO:0042359)
0.1	5.8	GO:0030212	hyaluronan metabolic process(GO:0030212)
0.4	4.8	GO:0042904	9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.2	4.1	GO:0070166	enamel mineralization(GO:0070166)
0.1	4.0	GO:0010107	potassium ion import(GO:0010107)
0.8	3.1	GO:0050712	negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)

Showing 1 to 10 of 113 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	16.3	GO:0005577	fibrinogen complex(GO:0005577)
0.0	12.1	GO:0072562	blood microparticle(GO:0072562)
0.1	8.4	GO:0031941	filamentous actin(GO:0031941)
0.1	6.1	GO:0045271	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.6	5.6	GO:0005579	membrane attack complex(GO:0005579)
0.9	2.7	GO:0005960	glycine cleavage complex(GO:0005960)
0.0	2.3	GO:0035578	azurophil granule lumen(GO:0035578)
0.0	2.2	GO:0090665	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.2	2.1	GO:0031314	extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1	2.0	GO:0000800	lateral element(GO:0000800)

Showing 1 to 10 of 51 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	16.4	GO:0051087	chaperone binding(GO:0051087)
0.5	7.5	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.2	6.5	GO:0001848	complement binding(GO:0001848)
0.1	6.1	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.9	5.8	GO:1902271	D3 vitamins binding(GO:1902271)
0.4	4.8	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	4.1	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.2	4.0	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.6	3.1	GO:0004910	interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.5	2.8	GO:0017159	pantetheine hydrolase activity(GO:0017159)

Showing 1 to 10 of 80 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	16.4	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	4.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	4.0	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	3.1	PID IL1 PATHWAY	IL1-mediated signaling events
0.0	1.9	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	1.9	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	1.7	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	1.7	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	1.3	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	1.3	PID CASPASE PATHWAY	Caspase cascade in apoptosis

Showing 1 to 10 of 21 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	16.3	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.1	6.1	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.1	5.8	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.1	4.0	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	3.1	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.0	2.5	REACTOME G ALPHA S SIGNALLING EVENTS	Genes involved in G alpha (s) signalling events
0.0	2.4	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.0	2.3	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	2.2	REACTOME DEFENSINS	Genes involved in Defensins
0.1	1.7	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts

Showing 1 to 10 of 36 entries

Results for GATA5

Z-value: 1.38

Motif logo

Transcription factors associated with GATA5

Activity-expression correlation:

Activity profile of GATA5 motif

Sorted Z-values of GATA5 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: