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Illumina Body Map 2
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Results for GATA6
Z-value: 1.04
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Transcription factors associated with GATA6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GATA6 | hg19_v2_chr18_+_19750894_19750980 | 0.09 | 6.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GATA6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 6.4 | GO:0038172 | interleukin-33-mediated signaling pathway(GO:0038172) |
| 1.6 | 4.9 | GO:0010949 | negative regulation of intestinal phytosterol absorption(GO:0010949) negative regulation of intestinal cholesterol absorption(GO:0045796) intestinal phytosterol absorption(GO:0060752) negative regulation of intestinal lipid absorption(GO:1904730) |
| 0.7 | 4.4 | GO:0098707 | ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707) |
| 0.1 | 4.3 | GO:0070207 | protein homotrimerization(GO:0070207) |
| 1.0 | 4.1 | GO:0010903 | negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903) |
| 0.3 | 3.5 | GO:0000821 | regulation of arginine metabolic process(GO:0000821) |
| 0.1 | 3.5 | GO:0006337 | nucleosome disassembly(GO:0006337) |
| 0.1 | 3.3 | GO:0030220 | platelet formation(GO:0030220) |
| 0.0 | 3.0 | GO:0032024 | positive regulation of insulin secretion(GO:0032024) |
| 0.1 | 2.8 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.3 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.3 | 4.9 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
| 0.3 | 4.4 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.3 | 4.3 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 1.4 | 4.1 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 0.0 | 3.2 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 2.8 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 1.9 | GO:0031228 | intrinsic component of Golgi membrane(GO:0031228) |
| 0.0 | 1.9 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 1.6 | GO:0042629 | mast cell granule(GO:0042629) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 6.4 | GO:0002113 | interleukin-33 binding(GO:0002113) |
| 1.1 | 4.4 | GO:0004998 | transferrin receptor activity(GO:0004998) |
| 0.0 | 4.3 | GO:1990782 | protein tyrosine kinase binding(GO:1990782) |
| 1.0 | 4.1 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 0.2 | 3.5 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 0.1 | 3.5 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.1 | 3.3 | GO:0017127 | cholesterol transporter activity(GO:0017127) |
| 0.2 | 3.0 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.1 | 2.7 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 2.5 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.9 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 5.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 3.1 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 3.0 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 3.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 2.7 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 2.1 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 1.8 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.6 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 1.5 | PID CMYB PATHWAY | C-MYB transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.0 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 5.3 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.2 | 4.3 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 4.1 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 4.0 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 2.7 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.1 | 2.5 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 1.9 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 1.9 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 1.9 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |