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Illumina Body Map 2
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Results for GLIS2
Z-value: 1.26
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Transcription factors associated with GLIS2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GLIS2 | hg19_v2_chr16_+_4364762_4364762 | 0.29 | 1.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GLIS2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 5.8 | GO:0010900 | negative regulation of phosphatidylcholine catabolic process(GO:0010900) |
| 0.1 | 5.7 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.5 | 5.5 | GO:0043129 | surfactant homeostasis(GO:0043129) |
| 0.0 | 5.5 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.3 | 4.5 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 0.0 | 4.0 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.0 | 3.9 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.3 | 3.3 | GO:0010459 | negative regulation of heart rate(GO:0010459) protein maturation by protein folding(GO:0022417) |
| 0.1 | 3.3 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.1 | 3.0 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.1 | GO:0042627 | chylomicron(GO:0042627) |
| 0.1 | 5.7 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.4 | 4.5 | GO:0097486 | alveolar lamellar body(GO:0097208) multivesicular body lumen(GO:0097486) |
| 0.0 | 4.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 3.4 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 3.1 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 3.0 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 2.8 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.0 | 2.7 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 2.6 | GO:0005901 | caveola(GO:0005901) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.4 | GO:0003823 | antigen binding(GO:0003823) |
| 0.7 | 7.3 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.1 | 5.6 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 4.4 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) |
| 0.2 | 4.2 | GO:0016918 | retinal binding(GO:0016918) |
| 0.0 | 3.8 | GO:0020037 | heme binding(GO:0020037) |
| 0.7 | 3.3 | GO:0005219 | ryanodine-sensitive calcium-release channel activity(GO:0005219) |
| 0.2 | 3.3 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.2 | 3.0 | GO:0005280 | hydrogen:amino acid symporter activity(GO:0005280) |
| 0.1 | 2.9 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.8 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 3.1 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 3.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.0 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 2.7 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 2.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 2.2 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 2.1 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.1 | 1.6 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 1.5 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.4 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 3.0 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 2.8 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 2.7 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.1 | 2.6 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 2.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 1.8 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 1.8 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.0 | 1.8 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.0 | 1.7 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |