ISMARA results: HAND1

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Illumina Body Map 2

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Results for HAND1

Z-value: 0.89

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Transcription factors associated with HAND1

Gene Symbol	Gene ID	Gene Info
HAND1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000113196.2	heart and neural crest derivatives expressed 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HAND1	hg19_v2_chr5_-_153857819_153857824	-0.17	3.5e-01	Click!

Activity profile of HAND1 motif

Sorted Z-values of HAND1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_-_65409502 Show fit	3.18	ENST00000389614.5	GPX2 Ensembl NCBI GeneCards UniProt NextProt Show fit	glutathione peroxidase 2 (gastrointestinal)
chr14_-_65409438 Show fit	3.01	ENST00000557049.1	GPX2 Ensembl NCBI GeneCards UniProt NextProt Show fit	glutathione peroxidase 2 (gastrointestinal)
chr14_-_106642049 Show fit	2.89	ENST00000390605.2	IGHV1-18 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin heavy variable 1-18
chr17_-_64216748 Show fit	2.68	ENST00000585162.1	APOH Ensembl NCBI GeneCards UniProt NextProt Show fit	apolipoprotein H (beta-2-glycoprotein I)
chr2_+_90153696 Show fit	2.56	ENST00000417279.2	IGKV3D-15 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 3D-15 (gene/pseudogene)
chr2_+_228678550 Show fit	2.51	ENST00000409189.3 ENST00000358813.4	CCL20 Ensembl NCBI GeneCards UniProt NextProt Show fit	chemokine (C-C motif) ligand 20
chr16_-_31147020 Show fit	1.93	ENST00000568261.1 ENST00000567797.1 ENST00000317508.6	PRSS8 Ensembl NCBI GeneCards UniProt NextProt Show fit	protease, serine, 8
chr6_+_134210243 Show fit	1.90	ENST00000367882.4	TCF21 Ensembl NCBI GeneCards UniProt NextProt Show fit	transcription factor 21
chr7_-_116963334 Show fit	1.88	ENST00000265441.3	WNT2 Ensembl NCBI GeneCards UniProt NextProt Show fit	wingless-type MMTV integration site family member 2
chr6_-_39282329 Show fit	1.63	ENST00000373231.4	KCNK17 Ensembl NCBI GeneCards UniProt NextProt Show fit	potassium channel, subfamily K, member 17

Showing 1 to 10 of 171 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HAND1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	7.6	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	6.1	GO:0098869	cellular oxidant detoxification(GO:0098869)
0.5	5.2	GO:0030450	regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959)
0.2	4.3	GO:0006068	ethanol catabolic process(GO:0006068)
0.4	3.4	GO:1904954	canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904954)
0.1	2.9	GO:0030322	stabilization of membrane potential(GO:0030322)
0.0	2.9	GO:0006910	phagocytosis, recognition(GO:0006910)
0.5	2.7	GO:0045590	negative regulation of regulatory T cell differentiation(GO:0045590)
0.2	2.7	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0	2.7	GO:0010765	positive regulation of sodium ion transport(GO:0010765)

Showing 1 to 10 of 46 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.6	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.0	4.9	GO:0044216	other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0	3.6	GO:0098636	protein complex involved in cell adhesion(GO:0098636)
0.2	3.4	GO:1990909	Wnt signalosome(GO:1990909)
0.1	3.4	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.1	2.9	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.1	2.7	GO:0031089	platelet dense granule lumen(GO:0031089)
0.2	1.8	GO:0097442	CA3 pyramidal cell dendrite(GO:0097442)
0.0	1.3	GO:0031527	filopodium membrane(GO:0031527)
0.0	0.6	GO:0031265	CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)

Showing 1 to 10 of 14 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.6	GO:0042056	chemoattractant activity(GO:0042056)
0.2	6.1	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.6	4.3	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894)
0.0	3.7	GO:0017080	sodium channel regulator activity(GO:0017080)
0.1	3.4	GO:0048018	receptor agonist activity(GO:0048018)
0.1	2.9	GO:0022841	potassium ion leak channel activity(GO:0022841)
0.0	2.9	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.4	2.7	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	2.6	GO:0003823	antigen binding(GO:0003823)
0.8	2.5	GO:0031731	CCR6 chemokine receptor binding(GO:0031731)

Showing 1 to 10 of 32 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.6	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.1	6.0	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	5.2	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	3.4	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	2.7	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	2.1	PID LKB1 PATHWAY	LKB1 signaling events
0.0	0.8	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.8	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.0	0.7	PID IL23 PATHWAY	IL23-mediated signaling events
0.0	0.6	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Showing 1 to 10 of 12 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	7.6	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.2	5.2	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.1	4.3	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.0	3.9	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.2	2.9	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	2.7	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	2.5	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	2.1	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.8	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.0	0.8	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling

Showing 1 to 10 of 12 entries

Results for HAND1

Z-value: 0.89

Motif logo

Transcription factors associated with HAND1

Activity-expression correlation:

Activity profile of HAND1 motif

Sorted Z-values of HAND1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HAND1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: