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Illumina Body Map 2
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Results for HIC2
Z-value: 1.84
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Transcription factors associated with HIC2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HIC2 | hg19_v2_chr22_+_21771656_21771693 | -0.44 | 1.3e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HIC2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 12.6 | GO:0046951 | ketone body biosynthetic process(GO:0046951) |
| 2.1 | 12.3 | GO:0099540 | synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551) |
| 0.2 | 9.8 | GO:0032958 | inositol phosphate biosynthetic process(GO:0032958) |
| 0.7 | 8.0 | GO:2000467 | positive regulation of glycogen (starch) synthase activity(GO:2000467) |
| 0.8 | 7.5 | GO:0038033 | positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033) |
| 0.6 | 7.3 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.4 | 7.1 | GO:0009313 | oligosaccharide catabolic process(GO:0009313) |
| 0.2 | 7.0 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.6 | 6.9 | GO:0070120 | ciliary neurotrophic factor-mediated signaling pathway(GO:0070120) |
| 0.4 | 6.7 | GO:0060681 | branch elongation involved in ureteric bud branching(GO:0060681) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 39.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 23.2 | GO:0031674 | I band(GO:0031674) |
| 0.0 | 22.7 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.1 | 17.0 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 15.7 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.4 | 10.1 | GO:0005922 | connexon complex(GO:0005922) |
| 0.3 | 8.6 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 8.4 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 7.1 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.1 | 6.8 | GO:0031526 | brush border membrane(GO:0031526) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 46.6 | GO:0005509 | calcium ion binding(GO:0005509) |
| 2.1 | 12.3 | GO:0060175 | brain-derived neurotrophic factor-activated receptor activity(GO:0060175) |
| 0.3 | 10.8 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.2 | 10.2 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 9.7 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.2 | 9.5 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.3 | 9.2 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 1.8 | 9.1 | GO:0052836 | inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839) |
| 0.2 | 8.6 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.9 | 8.2 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 25.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 18.5 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.2 | 12.8 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.3 | 9.8 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 9.2 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 7.0 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 6.9 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.1 | 6.9 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 6.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 6.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.5 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.4 | 12.8 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 12.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 10.7 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.6 | 9.6 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.4 | 9.4 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 8.8 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.2 | 8.2 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.3 | 7.8 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 7.6 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |