ISMARA results: HIF1A

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Illumina Body Map 2

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Results for HIF1A

Z-value: 0.61

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Transcription factors associated with HIF1A

Gene Symbol	Gene ID	Gene Info
HIF1A Ensembl NCBI GeneCards UniProt NextProt	ENSG00000100644.12	hypoxia inducible factor 1 subunit alpha

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HIF1A	hg19_v2_chr14_+_62162258_62162269	-0.40	2.3e-02	Click!

Activity profile of HIF1A motif

Sorted Z-values of HIF1A motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_220101944 Show fit	1.86	ENST00000366926.3 ENST00000536992.1	SLC30A10 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 30, member 10
chr11_-_35440579 Show fit	1.49	ENST00000606205.1	SLC1A2 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr11_-_35440796 Show fit	1.45	ENST00000278379.3	SLC1A2 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr3_+_11034403 Show fit	1.41	ENST00000287766.4 ENST00000425938.1	SLC6A1 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 6 (neurotransmitter transporter), member 1
chr7_+_100318423 Show fit	1.32	ENST00000252723.2	EPO Ensembl NCBI GeneCards UniProt NextProt Show fit	erythropoietin
chr7_+_26331541 Show fit	1.26	ENST00000416246.1 ENST00000338523.4 ENST00000412416.1	SNX10 Ensembl NCBI GeneCards UniProt NextProt Show fit	sorting nexin 10
chr12_+_6977323 Show fit	1.17	ENST00000462761.1	TPI1 Ensembl NCBI GeneCards UniProt NextProt Show fit	triosephosphate isomerase 1
chr11_+_75479763 Show fit	1.11	ENST00000228027.7	DGAT2 Ensembl NCBI GeneCards UniProt NextProt Show fit	diacylglycerol O-acyltransferase 2
chr7_+_26331678 Show fit	1.10	ENST00000446848.2	SNX10 Ensembl NCBI GeneCards UniProt NextProt Show fit	sorting nexin 10
chr11_+_75479850 Show fit	1.09	ENST00000376262.3 ENST00000604733.1	DGAT2 Ensembl NCBI GeneCards UniProt NextProt Show fit	diacylglycerol O-acyltransferase 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HIF1A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	3.9	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.3	2.6	GO:0006552	leucine catabolic process(GO:0006552)
0.5	2.2	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.5	2.2	GO:0046166	glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.4	2.2	GO:0071400	cellular response to oleic acid(GO:0071400)
0.1	2.2	GO:0071539	protein localization to centrosome(GO:0071539)
0.2	2.1	GO:0071421	manganese ion transmembrane transport(GO:0071421)
0.2	2.0	GO:0051790	short-chain fatty acid biosynthetic process(GO:0051790)
0.5	1.5	GO:0042450	arginine biosynthetic process via ornithine(GO:0042450)
0.3	1.5	GO:0006546	glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)

Showing 1 to 10 of 126 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.9	GO:0030673	axolemma(GO:0030673)
0.0	2.9	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
0.4	2.6	GO:1905202	3-methylcrotonyl-CoA carboxylase complex, mitochondrial(GO:0002169) methylcrotonoyl-CoA carboxylase complex(GO:1905202)
0.0	2.6	GO:0055037	recycling endosome(GO:0055037)
0.2	2.4	GO:0031313	extrinsic component of endosome membrane(GO:0031313)
0.0	2.1	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.0	1.9	GO:0042645	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1	1.7	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.5	1.5	GO:0005960	glycine cleavage complex(GO:0005960)
0.0	1.2	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)

Showing 1 to 10 of 50 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	3.9	GO:0015501	glutamate:sodium symporter activity(GO:0015501)
0.4	2.6	GO:0004485	methylcrotonoyl-CoA carboxylase activity(GO:0004485)
0.1	2.5	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.7	2.2	GO:0004807	triose-phosphate isomerase activity(GO:0004807)
0.4	2.2	GO:0050252	retinol O-fatty-acyltransferase activity(GO:0050252)
0.3	2.2	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.2	2.1	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.2	1.6	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.5	1.5	GO:0004618	phosphoglycerate kinase activity(GO:0004618)
0.4	1.5	GO:0004047	aminomethyltransferase activity(GO:0004047)

Showing 1 to 10 of 93 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.5	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	2.0	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	1.2	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	0.9	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.7	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.0	0.6	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.0	0.4	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	0.2	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events

Showing 1 to 8 of 8 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.0	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.0	4.3	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.1	2.9	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	2.3	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
0.1	1.7	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	1.7	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1	1.6	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	1.5	REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN	Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.1	1.2	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.0	1.2	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation

Showing 1 to 10 of 34 entries

Results for HIF1A

Z-value: 0.61

Motif logo

Transcription factors associated with HIF1A

Activity-expression correlation:

Activity profile of HIF1A motif

Sorted Z-values of HIF1A motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HIF1A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: