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Illumina Body Map 2
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Results for HIVEP1
Z-value: 1.65
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Transcription factors associated with HIVEP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HIVEP1 | hg19_v2_chr6_+_12012536_12012571 | 0.32 | 7.5e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_106791536 Show fit | 6.52 |
ENST00000390613.2
|
immunoglobulin heavy variable 3-30 |
|
| chr14_-_107049312 Show fit | 5.70 |
ENST00000390627.2
|
immunoglobulin heavy variable 3-53 |
|
| chr12_-_9913489 Show fit | 5.54 |
ENST00000228434.3
ENST00000536709.1 |
CD69 molecule |
|
| chr14_-_106322288 Show fit | 5.07 |
ENST00000390559.2
|
immunoglobulin heavy constant mu |
|
| chr22_+_22930626 Show fit | 4.80 |
ENST00000390302.2
|
immunoglobulin lambda variable 2-33 (non-functional) |
|
| chr2_+_219745020 Show fit | 4.76 |
ENST00000258411.3
|
wingless-type MMTV integration site family, member 10A |
|
| chr14_-_106622419 Show fit | 4.55 |
ENST00000390604.2
|
immunoglobulin heavy variable 3-16 (non-functional) |
|
| chr14_-_106518922 Show fit | 4.36 |
ENST00000390598.2
|
immunoglobulin heavy variable 3-7 |
|
| chr14_-_106866934 Show fit | 4.06 |
ENST00000390618.2
|
immunoglobulin heavy variable 3-38 (non-functional) |
|
| chr14_-_106586656 Show fit | 3.73 |
ENST00000390602.2
|
immunoglobulin heavy variable 3-13 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HIVEP1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 37.6 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.2 | 27.0 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 10.5 | GO:0070664 | negative regulation of leukocyte proliferation(GO:0070664) |
| 0.5 | 7.6 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
| 0.3 | 7.3 | GO:0045063 | T-helper 1 cell differentiation(GO:0045063) |
| 0.7 | 7.2 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.3 | 6.9 | GO:0010623 | programmed cell death involved in cell development(GO:0010623) |
| 0.3 | 6.1 | GO:0042832 | defense response to protozoan(GO:0042832) |
| 0.4 | 5.1 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.3 | 4.8 | GO:0048733 | sebaceous gland development(GO:0048733) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 37.6 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 13.2 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 9.9 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.3 | 7.5 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.7 | 7.2 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 7.1 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 6.6 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.1 | 5.7 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.3 | 4.7 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.5 | 4.6 | GO:0070552 | BRISC complex(GO:0070552) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 39.9 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.2 | 34.6 | GO:0003823 | antigen binding(GO:0003823) |
| 0.2 | 6.6 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.3 | 5.2 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.1 | 4.8 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 4.7 | GO:0004520 | endodeoxyribonuclease activity(GO:0004520) |
| 0.5 | 4.6 | GO:0004793 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.1 | 4.6 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.2 | 4.5 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.0 | 4.5 | GO:0019887 | protein kinase regulator activity(GO:0019887) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.4 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.1 | 8.2 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 8.1 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.0 | 7.3 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 6.9 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 6.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 4.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.4 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 3.1 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 2.9 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.1 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.7 | 7.2 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 7.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 6.9 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 5.6 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.2 | 5.1 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.1 | 4.6 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.2 | 4.0 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.2 | 4.0 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.1 | 4.0 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |