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Illumina Body Map 2
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Results for HMBOX1
Z-value: 0.90
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Transcription factors associated with HMBOX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HMBOX1 | hg19_v2_chr8_+_28747884_28747938 | -0.29 | 1.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_-_71610985 Show fit | 5.19 |
ENST00000355962.4
|
tyrosine aminotransferase |
|
| chr20_-_7238861 Show fit | 4.39 |
ENST00000428954.1
|
RP11-19D2.1 |
|
| chr20_+_42187682 Show fit | 4.37 |
ENST00000373092.3
ENST00000373077.1 |
serum/glucocorticoid regulated kinase 2 |
|
| chr20_+_42187608 Show fit | 3.73 |
ENST00000373100.1
|
serum/glucocorticoid regulated kinase 2 |
|
| chr6_-_107235331 Show fit | 3.56 |
ENST00000433965.1
ENST00000430094.1 |
RP1-60O19.1 |
|
| chr6_-_52668605 Show fit | 2.97 |
ENST00000334575.5
|
glutathione S-transferase alpha 1 |
|
| chr6_-_107235287 Show fit | 2.77 |
ENST00000436659.1
ENST00000428750.1 ENST00000427903.1 |
RP1-60O19.1 |
|
| chr7_-_120498357 Show fit | 2.75 |
ENST00000415871.1
ENST00000222747.3 ENST00000430985.1 |
tetraspanin 12 |
|
| chr10_+_115312766 Show fit | 2.50 |
ENST00000351270.3
|
hyaluronan binding protein 2 |
|
| chr8_-_63951730 Show fit | 2.41 |
ENST00000260118.6
|
gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) |
Network of associatons between targets according to the STRING database.
First level regulatory network of HMBOX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.9 | GO:0032411 | positive regulation of transporter activity(GO:0032411) |
| 0.6 | 5.2 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
| 0.1 | 4.8 | GO:1901687 | glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687) |
| 0.8 | 3.8 | GO:0051919 | positive regulation of fibrinolysis(GO:0051919) |
| 0.0 | 3.7 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 0.1 | 2.8 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.1 | 2.6 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.6 | 2.4 | GO:0046900 | tetrahydrofolylpolyglutamate metabolic process(GO:0046900) |
| 0.2 | 2.3 | GO:0051873 | killing by host of symbiont cells(GO:0051873) |
| 0.3 | 2.2 | GO:0044375 | regulation of peroxisome size(GO:0044375) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.4 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 3.0 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 2.4 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.4 | 2.2 | GO:0031205 | endoplasmic reticulum Sec complex(GO:0031205) |
| 0.1 | 1.9 | GO:0005685 | U1 snRNP(GO:0005685) |
| 0.0 | 1.8 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 1.7 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.0 | 1.7 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 1.5 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.2 | 1.2 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.0 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
| 0.1 | 5.8 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 1.7 | 5.2 | GO:0070546 | L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130) |
| 0.1 | 3.9 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.0 | 3.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 3.1 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 2.8 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 2.5 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 2.4 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.1 | 2.3 | GO:0005537 | mannose binding(GO:0005537) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.3 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.5 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.0 | 1.5 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 1.1 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 0.8 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.6 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 0.5 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.4 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 5.8 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 5.3 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.0 | 4.7 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 3.9 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.2 | 2.3 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.0 | 2.1 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.1 | 2.0 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.1 | 1.8 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.1 | 1.8 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |