ISMARA results: HNF1A

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Illumina Body Map 2

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Results for HNF1A_HNF1B

Z-value: 9.13

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Transcription factors associated with HNF1A_HNF1B

Gene Symbol	Gene ID	Gene Info
HNF1A Ensembl NCBI GeneCards UniProt NextProt	ENSG00000135100.13	HNF1 homeobox A
HNF1B Ensembl NCBI GeneCards UniProt NextProt	ENSG00000108753.8	HNF1 homeobox B

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HNF1A	hg19_v2_chr12_+_121416489_121416552	0.84	1.4e-09	Click!
HNF1B	hg19_v2_chr17_-_36105009_36105060	0.68	1.8e-05	Click!

Activity profile of HNF1A_HNF1B motif

Sorted Z-values of HNF1A_HNF1B motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_-_72649763 Show fit	137.34	ENST00000513476.1	GC Ensembl NCBI GeneCards UniProt NextProt Show fit	group-specific component (vitamin D binding protein)
chr4_+_74347400 Show fit	115.09	ENST00000226355.3	AFM Ensembl NCBI GeneCards UniProt NextProt Show fit	afamin
chr17_-_64225508 Show fit	102.94	ENST00000205948.6	APOH Ensembl NCBI GeneCards UniProt NextProt Show fit	apolipoprotein H (beta-2-glycoprotein I)
chr4_+_155484103 Show fit	90.69	ENST00000302068.4	FGB Ensembl NCBI GeneCards UniProt NextProt Show fit	fibrinogen beta chain
chr4_-_155511887 Show fit	89.73	ENST00000302053.3 ENST00000403106.3	FGA Ensembl NCBI GeneCards UniProt NextProt Show fit	fibrinogen alpha chain
chr4_+_155484155 Show fit	88.97	ENST00000509493.1	FGB Ensembl NCBI GeneCards UniProt NextProt Show fit	fibrinogen beta chain
chr19_-_36304201 Show fit	87.29	ENST00000301175.3	PRODH2 Ensembl NCBI GeneCards UniProt NextProt Show fit	proline dehydrogenase (oxidase) 2
chr2_+_234601512 Show fit	73.28	ENST00000305139.6	UGT1A6 Ensembl NCBI GeneCards UniProt NextProt Show fit	UDP glucuronosyltransferase 1 family, polypeptide A6
chr2_+_234637754 Show fit	71.68	ENST00000482026.1 ENST00000609767.1	UGT1A3 Ensembl NCBI GeneCards UniProt NextProt Show fit UGT1A1 Ensembl NCBI GeneCards UniProt NextProt Show fit	UDP glucuronosyltransferase 1 family, polypeptide A3 UDP glucuronosyltransferase 1 family, polypeptide A8
chr20_+_43029911 Show fit	69.82	ENST00000443598.2 ENST00000316099.4 ENST00000415691.2	HNF4A Ensembl NCBI GeneCards UniProt NextProt Show fit	hepatocyte nuclear factor 4, alpha

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF1A_HNF1B

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
19.7	276.4	GO:0043152	induction of bacterial agglutination(GO:0043152)
4.2	266.5	GO:0051180	vitamin transport(GO:0051180)
39.7	198.5	GO:0070980	biphenyl catabolic process(GO:0070980)
14.3	185.5	GO:0051918	negative regulation of fibrinolysis(GO:0051918)
34.0	170.1	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
7.6	167.5	GO:0046415	urate metabolic process(GO:0046415)
16.3	162.7	GO:0045959	regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959)
18.1	126.5	GO:0008218	bioluminescence(GO:0008218)
12.2	122.2	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
3.7	118.5	GO:0035435	phosphate ion transmembrane transport(GO:0035435)

Showing 1 to 10 of 114 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	462.6	GO:0005615	extracellular space(GO:0005615)
1.8	461.1	GO:0072562	blood microparticle(GO:0072562)
23.7	332.1	GO:0005577	fibrinogen complex(GO:0005577)
0.5	260.1	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
8.3	198.5	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.0	172.3	GO:0005576	extracellular region(GO:0005576)
0.1	156.9	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.0	151.8	GO:0005654	nucleoplasm(GO:0005654)
0.3	150.7	GO:0030133	transport vesicle(GO:0030133)
0.2	150.0	GO:0005759	mitochondrial matrix(GO:0005759)

Showing 1 to 10 of 57 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
7.3	387.9	GO:0015020	glucuronosyltransferase activity(GO:0015020)
1.8	291.9	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
1.1	179.7	GO:0051087	chaperone binding(GO:0051087)
3.0	169.1	GO:0005504	fatty acid binding(GO:0005504)
7.4	147.6	GO:0005436	sodium:phosphate symporter activity(GO:0005436)
45.8	137.3	GO:1902271	D3 vitamins binding(GO:1902271)
9.8	127.1	GO:0004321	fatty-acyl-CoA synthase activity(GO:0004321)
0.4	121.6	GO:0004252	serine-type endopeptidase activity(GO:0004252)
1.3	116.9	GO:0005044	scavenger receptor activity(GO:0005044)
28.8	115.1	GO:0008431	vitamin E binding(GO:0008431)

Showing 1 to 10 of 101 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	541.8	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
3.2	294.2	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
3.9	269.7	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
1.8	110.6	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
1.7	108.5	PID CD40 PATHWAY	CD40/CD40L signaling
0.8	100.2	PID FGF PATHWAY	FGF signaling pathway
0.8	72.4	PID HNF3A PATHWAY	FOXA1 transcription factor network
1.2	68.6	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.2	54.0	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.4	42.8	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms

Showing 1 to 10 of 19 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
15.6	328.1	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
10.5	324.7	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
8.4	259.9	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
2.7	137.3	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
5.3	137.2	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
2.9	122.2	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
4.3	121.6	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
2.3	105.8	REACTOME LIPOPROTEIN METABOLISM	Genes involved in Lipoprotein metabolism
4.2	101.1	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.6	99.4	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+

Showing 1 to 10 of 46 entries

Results for HNF1A_HNF1B

Z-value: 9.13

Motif logo

Transcription factors associated with HNF1A_HNF1B

Activity-expression correlation:

Activity profile of HNF1A_HNF1B motif

Sorted Z-values of HNF1A_HNF1B motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF1A_HNF1B

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: