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Illumina Body Map 2

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Results for HOXA4

Z-value: 1.62

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Transcription factors associated with HOXA4

Gene Symbol Gene ID Gene Info
ENSG00000197576.9 homeobox A4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXA4hg19_v2_chr7_-_27170352_271704180.019.5e-01Click!

Activity profile of HOXA4 motif

Sorted Z-values of HOXA4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_92681033 12.28 ENST00000371697.3
ankyrin repeat domain 1 (cardiac muscle)
chr1_+_160160346 6.78 ENST00000368078.3
calsequestrin 1 (fast-twitch, skeletal muscle)
chr1_+_160160283 6.67 ENST00000368079.3
calsequestrin 1 (fast-twitch, skeletal muscle)
chr3_+_121311966 6.24 ENST00000338040.4
F-box protein 40
chr17_-_10452929 6.22 ENST00000532183.2
ENST00000397183.2
ENST00000420805.1
myosin, heavy chain 2, skeletal muscle, adult
chr17_-_10421853 5.75 ENST00000226207.5
myosin, heavy chain 1, skeletal muscle, adult
chr22_+_26138108 5.69 ENST00000536101.1
ENST00000335473.7
ENST00000407587.2
myosin XVIIIB
chr1_-_100643765 5.50 ENST00000370137.1
ENST00000370138.1
ENST00000342895.3
leucine rich repeat containing 39
chr21_+_17442799 4.97 ENST00000602580.1
ENST00000458468.1
ENST00000602935.1
long intergenic non-protein coding RNA 478
chr16_+_7382745 4.41 ENST00000436368.2
ENST00000311745.5
ENST00000355637.4
ENST00000340209.4
RNA binding protein, fox-1 homolog (C. elegans) 1
chr3_-_42744270 4.24 ENST00000457462.1
hedgehog acyltransferase-like
chr5_-_38557561 4.14 ENST00000511561.1
leukemia inhibitory factor receptor alpha
chr11_+_112046190 4.05 ENST00000357685.5
ENST00000393032.2
ENST00000361053.4
beta-carotene oxygenase 2
chr10_-_75415825 4.02 ENST00000394810.2
synaptopodin 2-like
chr4_-_152147579 4.00 ENST00000304527.4
ENST00000455740.1
ENST00000424281.1
ENST00000409598.4
SH3 domain containing 19
chr10_-_69455873 3.94 ENST00000433211.2
catenin (cadherin-associated protein), alpha 3
chr3_-_42744130 3.87 ENST00000417472.1
ENST00000442469.1
hedgehog acyltransferase-like
chr3_-_52486841 3.75 ENST00000496590.1
troponin C type 1 (slow)
chr11_+_12766583 3.66 ENST00000361985.2
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr11_+_27062860 3.64 ENST00000528583.1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr11_-_13517565 3.53 ENST00000282091.1
ENST00000529816.1
parathyroid hormone
chr3_+_159557637 3.42 ENST00000445224.2
schwannomin interacting protein 1
chr12_+_12938541 3.34 ENST00000356591.4
apolipoprotein L domain containing 1
chr8_-_42358742 3.34 ENST00000517366.1
solute carrier family 20 (phosphate transporter), member 2
chr1_+_81771806 3.33 ENST00000370721.1
ENST00000370727.1
ENST00000370725.1
ENST00000370723.1
ENST00000370728.1
ENST00000370730.1
latrophilin 2
chr1_+_170632250 3.18 ENST00000367760.3
paired related homeobox 1
chr14_-_80697396 2.96 ENST00000557010.1
deiodinase, iodothyronine, type II
chr17_-_67138015 2.84 ENST00000284425.2
ENST00000590645.1
ATP-binding cassette, sub-family A (ABC1), member 6
chr8_+_79503458 2.72 ENST00000518467.1
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr16_+_6533380 2.72 ENST00000552089.1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr1_+_214161272 2.72 ENST00000498508.2
ENST00000366958.4
prospero homeobox 1
chr20_+_53092232 2.66 ENST00000395939.1
docking protein 5
chr5_+_150406527 2.65 ENST00000520059.1
glutathione peroxidase 3 (plasma)
chr11_-_27494309 2.64 ENST00000389858.4
leucine-rich repeat containing G protein-coupled receptor 4
chr5_-_1882858 2.61 ENST00000511126.1
ENST00000231357.2
iroquois homeobox 4
chr11_-_27494279 2.58 ENST00000379214.4
leucine-rich repeat containing G protein-coupled receptor 4
chr6_-_55740352 2.57 ENST00000370830.3
bone morphogenetic protein 5
chr2_-_180427304 2.45 ENST00000336917.5
zinc finger protein 385B
chr15_+_51669444 2.35 ENST00000396399.2
gliomedin
chr9_+_87284622 2.35 ENST00000395882.1
neurotrophic tyrosine kinase, receptor, type 2
chr1_-_216978709 2.27 ENST00000360012.3
estrogen-related receptor gamma
chr20_+_53092123 2.26 ENST00000262593.5
docking protein 5
chr21_+_17443521 2.24 ENST00000456342.1
long intergenic non-protein coding RNA 478
chr12_-_86650045 2.23 ENST00000604798.1
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr2_-_69098566 2.19 ENST00000295379.1
bone morphogenetic protein 10
chr7_-_14029283 2.13 ENST00000433547.1
ENST00000405192.2
ets variant 1
chr10_-_33623310 2.13 ENST00000395995.1
ENST00000374823.5
ENST00000374821.5
ENST00000374816.3
neuropilin 1
chr17_-_10372875 2.12 ENST00000255381.2
myosin, heavy chain 4, skeletal muscle
chr12_-_86650077 2.11 ENST00000552808.2
ENST00000547225.1
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr21_+_17961006 1.97 ENST00000602323.1
long intergenic non-protein coding RNA 478
chrX_-_55024967 1.96 ENST00000545676.1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr9_+_87284675 1.92 ENST00000376208.1
ENST00000304053.6
ENST00000277120.3
neurotrophic tyrosine kinase, receptor, type 2
chr12_-_86650154 1.91 ENST00000552435.2
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr2_-_190927447 1.85 ENST00000260950.4
myostatin
chr2_+_101437487 1.84 ENST00000427413.1
ENST00000542504.1
neuronal PAS domain protein 2
chr14_-_36988882 1.83 ENST00000498187.2
NK2 homeobox 1
chr8_-_28347737 1.79 ENST00000517673.1
ENST00000518734.1
ENST00000346498.2
ENST00000380254.2
F-box protein 16
chr7_-_14028488 1.78 ENST00000405358.4
ets variant 1
chr7_+_95115210 1.72 ENST00000428113.1
ENST00000325885.5
ankyrin repeat and SOCS box containing 4
chrM_+_5824 1.72 ENST00000361624.2
mitochondrially encoded cytochrome c oxidase I
chr7_-_14026123 1.65 ENST00000420159.2
ENST00000399357.3
ENST00000403527.1
ets variant 1
chr7_+_107110488 1.62 ENST00000304402.4
G protein-coupled receptor 22
chr11_+_22688150 1.62 ENST00000454584.2
growth arrest-specific 2
chr19_+_45409011 1.61 ENST00000252486.4
ENST00000446996.1
ENST00000434152.1
apolipoprotein E
chr14_-_36989336 1.59 ENST00000522719.2
NK2 homeobox 1
chr2_+_128403720 1.54 ENST00000272644.3
G protein-coupled receptor 17
chr7_-_143892748 1.48 ENST00000378115.2
Rho guanine nucleotide exchange factor (GEF) 35
chr7_-_143991230 1.47 ENST00000543357.1
Rho guanine nucleotide exchange factor (GEF) 35
chr21_+_17443434 1.47 ENST00000400178.2
long intergenic non-protein coding RNA 478
chr14_-_54423529 1.47 ENST00000245451.4
ENST00000559087.1
bone morphogenetic protein 4
chr5_-_56778635 1.46 ENST00000423391.1
actin, beta-like 2
chr20_+_57464200 1.45 ENST00000604005.1
GNAS complex locus
chr5_+_140810132 1.36 ENST00000252085.3
protocadherin gamma subfamily A, 12
chr12_-_11091862 1.36 ENST00000537503.1
taste receptor, type 2, member 14
chr12_+_111537227 1.33 ENST00000397643.3
cut-like homeobox 2
chr7_+_32996997 1.31 ENST00000242209.4
ENST00000538336.1
ENST00000538443.1
FK506 binding protein 9, 63 kDa
chr2_-_105030466 1.30 ENST00000449772.1
AC068535.3
chr16_-_85617170 1.29 ENST00000602862.1
RP11-118F19.1
chr3_-_120400960 1.24 ENST00000476082.2
homogentisate 1,2-dioxygenase
chr2_-_163099885 1.23 ENST00000443424.1
fibroblast activation protein, alpha
chr10_-_62332357 1.16 ENST00000503366.1
ankyrin 3, node of Ranvier (ankyrin G)
chr2_-_163100045 1.15 ENST00000188790.4
fibroblast activation protein, alpha
chr7_-_14026063 1.13 ENST00000443608.1
ENST00000438956.1
ets variant 1
chr12_+_27677085 1.12 ENST00000545334.1
ENST00000540114.1
ENST00000537927.1
ENST00000318304.8
ENST00000535047.1
ENST00000542629.1
ENST00000228425.6
PTPRF interacting protein, binding protein 1 (liprin beta 1)
chr14_-_23395623 1.10 ENST00000556043.1
protein arginine methyltransferase 5
chr8_+_39792474 1.09 ENST00000502986.2
indoleamine 2,3-dioxygenase 2
chrX_-_84634737 1.04 ENST00000262753.4
premature ovarian failure, 1B
chr8_+_77593474 1.04 ENST00000455469.2
ENST00000050961.6
zinc finger homeobox 4
chr12_-_16762971 1.02 ENST00000540590.1
LIM domain only 3 (rhombotin-like 2)
chr2_+_128403439 1.02 ENST00000544369.1
G protein-coupled receptor 17
chr5_+_159343688 0.96 ENST00000306675.3
adrenoceptor alpha 1B
chr17_-_77924627 0.96 ENST00000572862.1
ENST00000573782.1
ENST00000574427.1
ENST00000570373.1
ENST00000340848.7
ENST00000576768.1
TBC1 domain family, member 16
chr4_+_66536248 0.94 ENST00000514260.1
ENST00000507117.1
RP11-807H7.1
chr10_-_105845536 0.94 ENST00000393211.3
collagen, type XVII, alpha 1
chr12_-_57037284 0.90 ENST00000551570.1
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr15_+_36994210 0.89 ENST00000562489.1
chromosome 15 open reading frame 41
chr4_+_84457250 0.89 ENST00000395226.2
1-acylglycerol-3-phosphate O-acyltransferase 9
chr15_+_51669513 0.88 ENST00000558426.1
gliomedin
chr11_-_40315640 0.84 ENST00000278198.2
leucine rich repeat containing 4C
chr8_-_10512569 0.83 ENST00000382483.3
retinitis pigmentosa 1-like 1
chr9_-_113341985 0.83 ENST00000374469.1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr4_+_84457529 0.81 ENST00000264409.4
1-acylglycerol-3-phosphate O-acyltransferase 9
chr17_-_10325261 0.80 ENST00000403437.2
myosin, heavy chain 8, skeletal muscle, perinatal
chr12_-_24103841 0.79 ENST00000541847.1
SRY (sex determining region Y)-box 5
chr2_-_171571077 0.79 ENST00000409786.1
long intergenic non-protein coding RNA 1124
chr10_-_101825151 0.78 ENST00000441382.1
carboxypeptidase N, polypeptide 1
chr3_+_2553281 0.74 ENST00000434053.1
contactin 4
chr5_+_152870106 0.74 ENST00000285900.5
glutamate receptor, ionotropic, AMPA 1
chr3_-_64253655 0.74 ENST00000498162.1
prickle homolog 2 (Drosophila)
chr9_-_113342160 0.74 ENST00000401783.2
ENST00000374461.1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr21_+_17909594 0.70 ENST00000441820.1
ENST00000602280.1
long intergenic non-protein coding RNA 478
chr6_+_31514622 0.69 ENST00000376146.4
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr7_-_140714430 0.68 ENST00000393008.3
mitochondrial ribosomal protein S33
chr8_-_141774467 0.67 ENST00000520151.1
ENST00000519024.1
ENST00000519465.1
protein tyrosine kinase 2
chr1_-_12677714 0.66 ENST00000376223.2
dehydrogenase/reductase (SDR family) member 3
chr3_-_129513259 0.66 ENST00000329333.5
transmembrane and coiled-coil domain family 1
chr5_+_40909354 0.66 ENST00000313164.9
complement component 7
chr8_+_22424551 0.64 ENST00000523348.1
sorbin and SH3 domain containing 3
chr8_+_77593448 0.64 ENST00000521891.2
zinc finger homeobox 4
chr3_+_122103014 0.63 ENST00000232125.5
ENST00000477892.1
ENST00000469967.1
family with sequence similarity 162, member A
chr12_+_72058130 0.62 ENST00000547843.1
THAP domain containing, apoptosis associated protein 2
chr9_-_16253112 0.62 ENST00000380683.1
chromosome 9 open reading frame 92
chr5_+_133562095 0.61 ENST00000602919.1
CTD-2410N18.3
chr9_-_16276311 0.61 ENST00000380685.1
chromosome 9 open reading frame 92
chr10_-_105845674 0.60 ENST00000353479.5
ENST00000369733.3
collagen, type XVII, alpha 1
chr2_-_163099546 0.59 ENST00000447386.1
fibroblast activation protein, alpha
chr14_+_37131058 0.59 ENST00000361487.6
paired box 9
chr15_+_89631647 0.54 ENST00000569550.1
ENST00000565066.1
ENST00000565973.1
abhydrolase domain containing 2
chr19_-_10047219 0.49 ENST00000264833.4
olfactomedin 2
chr8_-_99955042 0.49 ENST00000519420.1
serine/threonine kinase 3
chr12_+_53848549 0.47 ENST00000439930.3
ENST00000548933.1
ENST00000562264.1
poly(rC) binding protein 2
chr5_+_60933634 0.44 ENST00000505642.1
chromosome 5 open reading frame 64
chr11_+_112832133 0.44 ENST00000524665.1
neural cell adhesion molecule 1
chr6_-_31514516 0.43 ENST00000303892.5
ENST00000483251.1
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr1_+_167298281 0.42 ENST00000367862.5
POU class 2 homeobox 1
chr6_+_152011628 0.42 ENST00000404742.1
ENST00000440973.1
estrogen receptor 1
chr1_+_155658849 0.41 ENST00000368336.5
ENST00000343043.3
ENST00000421487.2
ENST00000535183.1
ENST00000465375.1
ENST00000470830.1
death associated protein 3
chr15_-_61945400 0.40 ENST00000560686.1
RP11-507B12.1
chr15_+_89631381 0.38 ENST00000352732.5
abhydrolase domain containing 2
chr1_+_245318279 0.37 ENST00000407071.2
kinesin family member 26B
chr2_+_87135076 0.35 ENST00000409776.2
RANBP2-like and GRIP domain containing 1
chr11_+_120971882 0.33 ENST00000392793.1
tectorin alpha
chr5_+_66300446 0.32 ENST00000261569.7
microtubule associated serine/threonine kinase family member 4
chr5_+_66254698 0.32 ENST00000405643.1
ENST00000407621.1
ENST00000432426.1
microtubule associated serine/threonine kinase family member 4
chr5_+_69321074 0.31 ENST00000380751.5
ENST00000380750.3
ENST00000503931.1
ENST00000506542.1
small EDRK-rich factor 1B (centromeric)
chr5_+_67586465 0.30 ENST00000336483.5
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr7_+_129015671 0.28 ENST00000466993.1
adenosylhomocysteinase-like 2
chr18_+_13612613 0.28 ENST00000586765.1
low density lipoprotein receptor class A domain containing 4
chr2_-_187367356 0.27 ENST00000595956.1
AC018867.2
chr1_-_204329013 0.26 ENST00000272203.3
ENST00000414478.1
pleckstrin homology domain containing, family A member 6
chr14_+_101359265 0.26 ENST00000599197.1
Esophagus cancer-related gene-2 interaction susceptibility protein; Uncharacterized protein
chr14_+_39734482 0.25 ENST00000554392.1
ENST00000555716.1
ENST00000341749.3
ENST00000557038.1
CTAGE family, member 5
chr3_-_178984759 0.24 ENST00000349697.2
ENST00000497599.1
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr11_-_5080857 0.24 ENST00000321522.2
olfactory receptor, family 52, subfamily E, member 2
chr17_+_37894570 0.23 ENST00000394211.3
growth factor receptor-bound protein 7
chr2_+_53994927 0.23 ENST00000295304.4
ChaC, cation transport regulator homolog 2 (E. coli)
chr7_+_100273736 0.23 ENST00000412215.1
ENST00000393924.1
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr18_-_28742813 0.23 ENST00000257197.3
ENST00000257198.5
desmocollin 1
chr9_+_26746951 0.23 ENST00000523363.1
RP11-18A15.1
chr5_+_140535577 0.22 ENST00000539533.1
Protocadherin-psi1; Uncharacterized protein
chr9_+_75263565 0.21 ENST00000396237.3
transmembrane channel-like 1
chr16_+_67280799 0.21 ENST00000566345.2
solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
chr3_+_9774164 0.21 ENST00000426583.1
bromodomain and PHD finger containing, 1
chr10_-_101690650 0.19 ENST00000543621.1
dynamin binding protein
chrX_-_84634708 0.18 ENST00000373145.3
premature ovarian failure, 1B
chr2_+_54683419 0.17 ENST00000356805.4
spectrin, beta, non-erythrocytic 1
chr12_-_10959892 0.17 ENST00000240615.2
taste receptor, type 2, member 8
chr3_-_188665428 0.17 ENST00000444488.1
TPRG1 antisense RNA 1
chr7_+_8474817 0.16 ENST00000429542.1
neurexophilin 1
chrX_+_129473859 0.16 ENST00000424447.1
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr7_+_144052381 0.13 ENST00000498580.1
ENST00000056217.5
Rho guanine nucleotide exchange factor (GEF) 5
chr21_+_22370717 0.13 ENST00000284894.7
neural cell adhesion molecule 2
chr13_-_28545276 0.11 ENST00000381020.7
caudal type homeobox 2
chr12_+_53818855 0.11 ENST00000550839.1
anti-Mullerian hormone receptor, type II
chr12_-_24097236 0.10 ENST00000538083.1
SRY (sex determining region Y)-box 5
chr3_+_108855558 0.10 ENST00000467240.1
ENST00000477643.1
ENST00000479039.1
ENST00000593799.1
RP11-59E19.1
chr5_-_13944652 0.10 ENST00000265104.4
dynein, axonemal, heavy chain 5
chr15_+_80351977 0.09 ENST00000559157.1
ENST00000561012.1
ENST00000564367.1
ENST00000558494.1
zinc finger, AN1-type domain 6
chr18_-_658244 0.08 ENST00000585033.1
ENST00000323813.3
chromosome 18 open reading frame 56
chr8_-_95449155 0.08 ENST00000481490.2
fibrinogen silencer binding protein
chr7_-_27170352 0.08 ENST00000428284.2
ENST00000360046.5
homeobox A4
chr5_+_152870287 0.07 ENST00000340592.5
glutamate receptor, ionotropic, AMPA 1
chr19_-_893200 0.07 ENST00000269814.4
ENST00000395808.3
ENST00000312090.6
ENST00000325464.1
mediator complex subunit 16
chr15_-_33447055 0.05 ENST00000559047.1
ENST00000561249.1
formin 1
chr1_-_159832438 0.04 ENST00000368100.1
V-set and immunoglobulin domain containing 8
chr7_-_130598059 0.04 ENST00000432045.2
microRNA 29a
chr5_+_152870215 0.02 ENST00000518142.1
glutamate receptor, ionotropic, AMPA 1
chr2_+_171571827 0.02 ENST00000375281.3
Sp5 transcription factor
chr12_-_120241187 0.00 ENST00000392520.2
citron (rho-interacting, serine/threonine kinase 21)

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 8.1 GO:0060262 regulation of N-terminal protein palmitoylation(GO:0060254) negative regulation of N-terminal protein palmitoylation(GO:0060262) negative regulation of protein lipidation(GO:1903060)
1.4 4.1 GO:0042214 terpene metabolic process(GO:0042214)
1.3 5.2 GO:0061289 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
1.2 3.5 GO:1900158 negative regulation of bone mineralization involved in bone maturation(GO:1900158)
1.0 13.5 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
1.0 3.0 GO:1902362 melanocyte apoptotic process(GO:1902362)
0.9 3.8 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.9 2.7 GO:0043049 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.7 4.3 GO:0099540 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
0.6 4.1 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.6 1.7 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
0.5 2.2 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.5 1.6 GO:2000646 lipid transport involved in lipid storage(GO:0010877) positive regulation of receptor catabolic process(GO:2000646)
0.5 1.8 GO:1902725 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723) negative regulation of satellite cell differentiation(GO:1902725)
0.4 12.3 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.4 2.1 GO:0061552 vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.4 6.2 GO:0001778 plasma membrane repair(GO:0001778)
0.4 2.7 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.3 3.9 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.3 1.5 GO:0072200 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.3 3.4 GO:0021759 globus pallidus development(GO:0021759)
0.3 2.0 GO:0033133 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.3 3.6 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.3 6.7 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.3 3.2 GO:0048664 neuron fate determination(GO:0048664)
0.2 1.0 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.2 4.9 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.2 4.4 GO:0042118 endothelial cell activation(GO:0042118)
0.2 4.0 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.2 1.2 GO:0072660 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 3.3 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.2 3.0 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.2 3.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.2 1.4 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.2 0.8 GO:0030070 insulin processing(GO:0030070)
0.1 2.6 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.1 1.2 GO:0006572 tyrosine catabolic process(GO:0006572)
0.1 2.7 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 1.7 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.1 7.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 0.8 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 0.9 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.1 1.8 GO:0051775 response to redox state(GO:0051775)
0.1 1.0 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 1.1 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.1 3.7 GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.1 1.7 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.3 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.1 0.7 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.1 1.3 GO:0007614 short-term memory(GO:0007614)
0.1 0.4 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 0.7 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 1.5 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 2.9 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 3.6 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.0 1.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 2.9 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 0.4 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.0 0.2 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.5 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.2 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.0 0.7 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.7 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.9 GO:0007413 axonal fasciculation(GO:0007413)
0.0 0.2 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.1 GO:0001880 Mullerian duct regression(GO:0001880)
0.0 0.4 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 2.7 GO:0009798 axis specification(GO:0009798)
0.0 0.6 GO:0042481 regulation of odontogenesis(GO:0042481)
0.0 1.2 GO:0003382 epithelial cell morphogenesis(GO:0003382)
0.0 0.7 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.3 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 2.4 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 0.8 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 1.0 GO:0001919 regulation of receptor recycling(GO:0001919)
0.0 0.6 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 0.3 GO:0051531 NFAT protein import into nucleus(GO:0051531) positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.0 0.2 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.2 GO:0006751 glutathione catabolic process(GO:0006751)
0.0 6.2 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 0.3 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 0.2 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 5.6 GO:0006936 muscle contraction(GO:0006936)
0.0 5.2 GO:0006486 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 13.5 GO:0014802 terminal cisterna(GO:0014802)
0.8 6.2 GO:0005826 actomyosin contractile ring(GO:0005826)
0.6 3.8 GO:1990584 cardiac Troponin complex(GO:1990584)
0.6 3.7 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.5 1.6 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.3 8.7 GO:0032982 myosin filament(GO:0032982)
0.3 5.7 GO:0016461 unconventional myosin complex(GO:0016461)
0.2 2.1 GO:0097443 sorting endosome(GO:0097443)
0.2 1.7 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.2 3.9 GO:0005916 fascia adherens(GO:0005916)
0.2 3.0 GO:0071438 invadopodium membrane(GO:0071438)
0.1 0.8 GO:0044308 axonal spine(GO:0044308)
0.1 1.7 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.1 0.9 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.1 1.5 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.9 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 19.7 GO:0031674 I band(GO:0031674)
0.1 0.7 GO:0005579 membrane attack complex(GO:0005579)
0.1 1.1 GO:0034709 methylosome(GO:0034709)
0.0 0.3 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 4.3 GO:0043195 terminal bouton(GO:0043195)
0.0 1.1 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.4 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.7 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 1.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 7.1 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.7 GO:0030057 desmosome(GO:0030057)
0.0 0.8 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.2 GO:0032437 cuticular plate(GO:0032437)
0.0 0.2 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.2 GO:0032426 stereocilium tip(GO:0032426)
0.0 1.1 GO:0005884 actin filament(GO:0005884)
0.0 0.3 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 12.3 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
1.0 4.1 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923)
0.9 3.6 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.7 4.3 GO:0060175 brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.7 6.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.4 1.6 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.4 2.0 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.4 3.3 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.4 3.0 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.3 3.8 GO:0031013 troponin I binding(GO:0031013)
0.3 1.0 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.3 3.9 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.3 2.7 GO:0050692 DBD domain binding(GO:0050692)
0.3 2.3 GO:0050682 AF-2 domain binding(GO:0050682)
0.3 1.1 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.2 3.2 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.2 3.2 GO:0070700 BMP receptor binding(GO:0070700)
0.2 2.2 GO:0033612 receptor serine/threonine kinase binding(GO:0033612)
0.2 9.2 GO:0000146 microfilament motor activity(GO:0000146)
0.2 2.7 GO:0008430 selenium binding(GO:0008430)
0.2 1.1 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.2 3.4 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.2 2.1 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.1 5.3 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 3.7 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.1 0.9 GO:0043532 angiostatin binding(GO:0043532)
0.1 3.5 GO:0048018 receptor agonist activity(GO:0048018)
0.1 2.7 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 3.0 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 0.8 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 1.4 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 5.2 GO:0005158 insulin receptor binding(GO:0005158)
0.1 1.5 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 0.2 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 11.3 GO:0003774 motor activity(GO:0003774)
0.1 0.1 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.1 0.9 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 2.6 GO:0004950 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 1.7 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.4 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 0.7 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.4 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.2 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.0 0.7 GO:0008432 JUN kinase binding(GO:0008432)
0.0 1.8 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 1.8 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 2.1 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.1 GO:0010861 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
0.0 1.2 GO:0030507 spectrin binding(GO:0030507)
0.0 8.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 2.4 GO:0002039 p53 binding(GO:0002039)
0.0 0.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.6 GO:0017166 vinculin binding(GO:0017166)
0.0 6.2 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 2.9 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820)
0.0 0.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.2 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.7 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 2.1 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 6.2 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 6.1 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 1.8 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 4.3 PID SHP2 PATHWAY SHP2 signaling
0.0 2.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.8 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 1.5 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.4 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 1.5 PID BMP PATHWAY BMP receptor signaling
0.0 0.7 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 1.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.1 PID ALK2 PATHWAY ALK2 signaling events
0.0 5.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.2 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 2.6 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 3.0 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 2.8 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 2.1 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 17.9 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 1.6 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 4.6 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.1 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 1.7 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 1.6 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 4.0 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.7 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.9 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 2.0 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 2.7 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.8 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.3 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.3 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.8 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 1.0 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 3.5 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.7 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 4.3 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane
0.0 0.6 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.0 0.2 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.4 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 1.1 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 3.7 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.7 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.4 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter