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Illumina Body Map 2
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Results for HOXB7
Z-value: 1.42
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Transcription factors associated with HOXB7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXB7 | hg19_v2_chr17_-_46688334_46688385 | -0.01 | 9.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB7
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 16.5 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 2.0 | 10.1 | GO:0070980 | biphenyl catabolic process(GO:0070980) |
| 0.5 | 9.7 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 1.0 | 9.3 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 1.0 | 7.1 | GO:0052697 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 0.0 | 6.9 | GO:0034605 | cellular response to heat(GO:0034605) |
| 1.4 | 5.6 | GO:0007499 | ectoderm and mesoderm interaction(GO:0007499) |
| 0.5 | 5.6 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.3 | 5.3 | GO:0048681 | negative regulation of axon regeneration(GO:0048681) |
| 0.1 | 4.8 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.4 | GO:0030018 | Z disc(GO:0030018) |
| 0.5 | 15.8 | GO:0032982 | myosin filament(GO:0032982) |
| 0.0 | 10.8 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.4 | 10.1 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.1 | 9.8 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 6.7 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 6.3 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.5 | 4.3 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.0 | 4.0 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.2 | 3.5 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 27.0 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.7 | 25.9 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.2 | 9.3 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.4 | 5.6 | GO:0097371 | MDM2/MDM4 family protein binding(GO:0097371) |
| 0.3 | 5.6 | GO:1990459 | transferrin receptor binding(GO:1990459) |
| 0.0 | 5.6 | GO:0005516 | calmodulin binding(GO:0005516) |
| 1.1 | 4.3 | GO:0008281 | sulfonylurea receptor activity(GO:0008281) |
| 0.0 | 4.3 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.5 | 3.7 | GO:0050682 | AF-2 domain binding(GO:0050682) |
| 0.3 | 3.7 | GO:0070324 | thyroid hormone binding(GO:0070324) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.2 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 6.2 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 4.7 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 3.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 3.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 3.3 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 3.0 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 2.6 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 2.3 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 2.3 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 25.0 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.2 | 16.1 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 5.6 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 5.3 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 4.9 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.1 | 4.8 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 4.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 4.1 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 3.5 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 3.5 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |