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Illumina Body Map 2
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Results for IKZF2
Z-value: 1.52
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Transcription factors associated with IKZF2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IKZF2 | hg19_v2_chr2_-_214014959_214015058 | 0.36 | 4.4e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_71532207 Show fit | 6.36 |
ENST00000543780.1
ENST00000391614.3 |
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides |
|
| chr4_-_71532601 Show fit | 6.34 |
ENST00000510614.1
|
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides |
|
| chr4_-_71532339 Show fit | 5.68 |
ENST00000254801.4
|
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides |
|
| chr14_-_106552755 Show fit | 4.17 |
ENST00000390600.2
|
immunoglobulin heavy variable 3-9 |
|
| chr4_+_68424434 Show fit | 4.02 |
ENST00000265404.2
ENST00000396225.1 |
signal transducing adaptor family member 1 |
|
| chr5_+_35852797 Show fit | 3.51 |
ENST00000508941.1
|
interleukin 7 receptor |
|
| chr12_-_122240792 Show fit | 3.43 |
ENST00000545885.1
ENST00000542933.1 ENST00000428029.2 ENST00000541694.1 ENST00000536662.1 ENST00000535643.1 ENST00000541657.1 |
AC084018.1 ras homolog family member F (in filopodia) |
|
| chr14_-_106926724 Show fit | 3.35 |
ENST00000434710.1
|
immunoglobulin heavy variable 3-43 |
|
| chr14_-_106668095 Show fit | 3.25 |
ENST00000390606.2
|
immunoglobulin heavy variable 3-20 |
|
| chr14_-_107114267 Show fit | 3.18 |
ENST00000454421.2
|
immunoglobulin heavy variable 3-64 |
Network of associatons between targets according to the STRING database.
First level regulatory network of IKZF2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.9 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.0 | 5.2 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 0.5 | 4.9 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.0 | 4.8 | GO:0050852 | T cell receptor signaling pathway(GO:0050852) |
| 0.0 | 4.2 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 1.3 | 4.0 | GO:1903980 | negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973) positive regulation of microglial cell activation(GO:1903980) |
| 0.1 | 3.8 | GO:0051023 | regulation of immunoglobulin secretion(GO:0051023) |
| 0.2 | 3.5 | GO:0001915 | negative regulation of T cell mediated cytotoxicity(GO:0001915) |
| 1.1 | 3.3 | GO:2000458 | astrocyte chemotaxis(GO:0035700) regulation of astrocyte chemotaxis(GO:2000458) |
| 0.4 | 2.8 | GO:1904220 | regulation of serine C-palmitoyltransferase activity(GO:1904220) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 15.1 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 8.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 5.9 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 5.3 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.2 | 2.8 | GO:0017059 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 0.4 | 2.5 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
| 0.2 | 2.4 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.0 | 2.3 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 2.2 | GO:0043204 | perikaryon(GO:0043204) |
| 0.1 | 2.1 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.1 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 7.9 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.5 | 4.9 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.0 | 4.2 | GO:0003823 | antigen binding(GO:0003823) |
| 0.5 | 4.0 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 1.3 | 3.9 | GO:0005174 | CD40 receptor binding(GO:0005174) |
| 0.1 | 3.9 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.9 | 3.5 | GO:0004917 | interleukin-7 receptor activity(GO:0004917) |
| 0.4 | 3.1 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.4 | 2.8 | GO:0004758 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.6 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 6.5 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.1 | 4.6 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 4.4 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 4.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 3.7 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 3.7 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 3.7 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 3.5 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 3.3 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.4 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 6.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 4.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 3.8 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 3.8 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.1 | 3.8 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 3.8 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.1 | 3.5 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 3.4 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 3.0 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |