ISMARA results: IRF7

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Illumina Body Map 2

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Results for IRF7

Z-value: 1.94

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Transcription factors associated with IRF7

Gene Symbol	Gene ID	Gene Info
IRF7 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000185507.15	interferon regulatory factor 7

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
IRF7	hg19_v2_chr11_-_615570_615728	-0.54	1.6e-03	Click!

Activity profile of IRF7 motif

Sorted Z-values of IRF7 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_91574142 Show fit	9.56	ENST00000547937.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr2_-_151344172 Show fit	6.87	ENST00000375734.2 ENST00000263895.4 ENST00000454202.1	RND3 Ensembl NCBI GeneCards UniProt NextProt Show fit	Rho family GTPase 3
chr6_-_46889694 Show fit	6.47	ENST00000283296.7 ENST00000362015.4 ENST00000456426.2	GPR116 Ensembl NCBI GeneCards UniProt NextProt Show fit	G protein-coupled receptor 116
chr4_+_41614909 Show fit	6.02	ENST00000509454.1 ENST00000396595.3 ENST00000381753.4	LIMCH1 Ensembl NCBI GeneCards UniProt NextProt Show fit	LIM and calponin homology domains 1
chr11_-_2160180 Show fit	5.85	ENST00000381406.4	IGF2 Ensembl NCBI GeneCards UniProt NextProt Show fit	insulin-like growth factor 2 (somatomedin A)
chr12_+_19358228 Show fit	5.68	ENST00000424268.1 ENST00000543806.1	PLEKHA5 Ensembl NCBI GeneCards UniProt NextProt Show fit	pleckstrin homology domain containing, family A member 5
chr1_-_85870177 Show fit	5.64	ENST00000542148.1	DDAH1 Ensembl NCBI GeneCards UniProt NextProt Show fit	dimethylarginine dimethylaminohydrolase 1
chr11_-_111794446 Show fit	5.44	ENST00000527950.1	CRYAB Ensembl NCBI GeneCards UniProt NextProt Show fit	crystallin, alpha B
chr2_-_216240386 Show fit	5.42	ENST00000438981.1	FN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	fibronectin 1
chr3_+_119316721 Show fit	5.40	ENST00000488919.1 ENST00000495992.1	PLA1A Ensembl NCBI GeneCards UniProt NextProt Show fit	phospholipase A1 member A

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF7

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	28.5	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1	17.3	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0	11.2	GO:0031032	actomyosin structure organization(GO:0031032)
0.5	10.4	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
1.0	10.2	GO:1990504	dense core granule exocytosis(GO:1990504)
0.4	10.1	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0	9.1	GO:0045727	positive regulation of translation(GO:0045727)
0.0	9.0	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.6	8.7	GO:0007258	JUN phosphorylation(GO:0007258)
0.2	8.6	GO:0036150	phosphatidylserine acyl-chain remodeling(GO:0036150)

Showing 1 to 10 of 341 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	28.5	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.7	22.6	GO:0005614	interstitial matrix(GO:0005614)
0.1	17.3	GO:0030018	Z disc(GO:0030018)
0.1	10.4	GO:0005923	bicellular tight junction(GO:0005923)
0.3	10.1	GO:0002080	acrosomal membrane(GO:0002080)
0.1	9.7	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.1	8.2	GO:0042734	presynaptic membrane(GO:0042734)
0.1	8.0	GO:0005796	Golgi lumen(GO:0005796)
0.1	7.0	GO:0032420	stereocilium(GO:0032420)
0.2	6.7	GO:0016327	apicolateral plasma membrane(GO:0016327)

Showing 1 to 10 of 130 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	26.1	GO:0050840	extracellular matrix binding(GO:0050840)
0.1	25.6	GO:0008201	heparin binding(GO:0008201)
0.0	20.9	GO:0005509	calcium ion binding(GO:0005509)
0.4	18.8	GO:0001972	retinoic acid binding(GO:0001972)
0.4	14.2	GO:0002162	dystroglycan binding(GO:0002162)
0.1	14.2	GO:0030165	PDZ domain binding(GO:0030165)
0.2	12.8	GO:0005158	insulin receptor binding(GO:0005158)
0.0	11.3	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.4	10.1	GO:0052739	phosphatidylserine 1-acylhydrolase activity(GO:0052739)
0.7	9.9	GO:0005132	type I interferon receptor binding(GO:0005132)

Showing 1 to 10 of 216 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	32.0	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	23.0	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	16.5	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.2	9.8	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.1	9.8	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.2	8.6	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1	7.5	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	7.1	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.1	6.4	PID SHP2 PATHWAY	SHP2 signaling
0.1	6.2	PID LKB1 PATHWAY	LKB1 signaling events

Showing 1 to 10 of 54 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	28.3	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.4	12.9	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.4	10.9	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	8.6	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.3	8.3	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.3	8.2	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.2	6.9	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.1	6.5	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.3	6.1	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.2	6.0	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway

Showing 1 to 10 of 78 entries

Results for IRF7

Z-value: 1.94

Motif logo

Transcription factors associated with IRF7

Activity-expression correlation:

Activity profile of IRF7 motif

Sorted Z-values of IRF7 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF7

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: