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Illumina Body Map 2
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Results for IRX2
Z-value: 1.29
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Transcription factors associated with IRX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRX2 | hg19_v2_chr5_-_2751762_2751784 | 0.14 | 4.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.9 | GO:0034587 | piRNA metabolic process(GO:0034587) |
| 0.1 | 6.6 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.4 | 4.1 | GO:0070779 | gamma-aminobutyric acid biosynthetic process(GO:0009449) D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.2 | 3.8 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.9 | 3.6 | GO:2000863 | positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866) |
| 0.3 | 3.6 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.2 | 2.8 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 0.2 | 2.8 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
| 0.1 | 2.8 | GO:2001135 | regulation of endocytic recycling(GO:2001135) |
| 0.5 | 2.7 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 9.9 | GO:0030849 | autosome(GO:0030849) |
| 0.9 | 6.6 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
| 0.0 | 4.3 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.3 | 3.3 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.0 | 3.2 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 2.9 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.0 | 2.6 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 2.6 | GO:0042383 | sarcolemma(GO:0042383) |
| 0.1 | 2.5 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.0 | 2.5 | GO:1904115 | axon cytoplasm(GO:1904115) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.6 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.0 | 4.7 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.4 | 4.1 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 1.2 | 3.6 | GO:0047275 | glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275) |
| 0.1 | 2.8 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.7 | 2.7 | GO:0017095 | heparan sulfate 6-O-sulfotransferase activity(GO:0017095) |
| 0.1 | 2.7 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 2.7 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.0 | 2.7 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 2.6 | GO:0043495 | protein anchor(GO:0043495) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.7 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 5.3 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 3.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 2.8 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 2.5 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 2.2 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 2.2 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 1.6 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 1.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 0.6 | PID MYC PATHWAY | C-MYC pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.6 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.0 | 4.4 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 3.6 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 2.7 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 2.2 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.1 | 2.1 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 2.0 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.7 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 1.7 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.0 | 1.4 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |