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Illumina Body Map 2

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Results for IRX2

Z-value: 1.29

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Transcription factors associated with IRX2

Gene Symbol Gene ID Gene Info
IRX2
ENSG00000170561.8 iroquois homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX2hg19_v2_chr5_-_2751762_27517840.144.5e-01Click!

Activity profile of IRX2 motif

Sorted Z-values of IRX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_61122220 6.39 ENST00000422313.2
ENST00000435852.2
ENST00000442566.3
ENST00000373868.2
ENST00000277705.6
ENST00000373867.3
ENST00000419214.2
FAM13C
family with sequence similarity 13, member C
chr2_+_168675182 3.63 ENST00000305861.1
B3GALT1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr4_+_88896819 3.62 ENST00000237623.7
ENST00000395080.3
ENST00000508233.1
ENST00000360804.4
SPP1
secreted phosphoprotein 1
chr5_+_36608422 3.59 ENST00000381918.3
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_+_166958346 3.50 ENST00000367872.4
MAEL
maelstrom spermatogenic transposon silencer
chr1_+_166958497 3.48 ENST00000367870.2
MAEL
maelstrom spermatogenic transposon silencer
chr21_-_22175341 2.95 ENST00000416768.1
ENST00000452561.1
ENST00000419299.1
ENST00000437238.1
LINC00320
long intergenic non-protein coding RNA 320
chr1_+_166958504 2.87 ENST00000447624.1
MAEL
maelstrom spermatogenic transposon silencer
chr19_-_51466681 2.82 ENST00000456750.2
KLK6
kallikrein-related peptidase 6
chr16_+_58537737 2.80 ENST00000561738.1
NDRG4
NDRG family member 4
chr21_-_22175450 2.77 ENST00000435279.2
LINC00320
long intergenic non-protein coding RNA 320
chrX_-_132095419 2.70 ENST00000370836.2
ENST00000521489.1
HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr15_-_44486632 2.66 ENST00000484674.1
FRMD5
FERM domain containing 5
chr4_-_168155417 2.65 ENST00000511269.1
ENST00000506697.1
ENST00000512042.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr4_+_169575875 2.60 ENST00000503457.1
PALLD
palladin, cytoskeletal associated protein
chr10_-_23528745 2.58 ENST00000376501.5
C10orf115
chromosome 10 open reading frame 115
chr2_+_171640291 2.56 ENST00000409885.1
ERICH2
glutamate-rich 2
chr4_+_158141843 2.47 ENST00000509417.1
ENST00000296526.7
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr4_+_158142750 2.30 ENST00000505888.1
ENST00000449365.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr14_+_29236269 2.20 ENST00000313071.4
FOXG1
forkhead box G1
chr10_-_61122625 2.19 ENST00000468840.2
FAM13C
family with sequence similarity 13, member C
chr8_-_82359662 2.19 ENST00000519260.1
ENST00000256103.2
PMP2
peripheral myelin protein 2
chr18_+_50278430 2.18 ENST00000578080.1
ENST00000582875.1
ENST00000412726.1
DCC
deleted in colorectal carcinoma
chrX_-_138790348 2.17 ENST00000414978.1
ENST00000519895.1
MCF2
MCF.2 cell line derived transforming sequence
chr18_+_55018044 2.15 ENST00000324000.3
ST8SIA3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr15_+_38226827 2.09 ENST00000559502.1
ENST00000558148.1
ENST00000558158.1
TMCO5A
transmembrane and coiled-coil domains 5A
chr4_+_114214125 2.06 ENST00000509550.1
ANK2
ankyrin 2, neuronal
chr1_-_190446759 2.03 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr14_+_62462541 2.00 ENST00000430451.2
SYT16
synaptotagmin XVI
chr11_+_98891797 2.00 ENST00000527185.1
ENST00000528682.1
ENST00000524871.1
CNTN5
contactin 5
chr9_-_79267432 1.97 ENST00000424866.1
PRUNE2
prune homolog 2 (Drosophila)
chr9_-_73736511 1.94 ENST00000377110.3
ENST00000377111.2
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr2_+_48844937 1.93 ENST00000448460.1
ENST00000437125.1
ENST00000430487.2
GTF2A1L
general transcription factor IIA, 1-like
chr3_+_169539710 1.89 ENST00000340806.6
LRRIQ4
leucine-rich repeats and IQ motif containing 4
chr18_+_32455201 1.86 ENST00000590831.2
DTNA
dystrobrevin, alpha
chr9_-_23779367 1.84 ENST00000440102.1
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr19_-_55953704 1.83 ENST00000416792.1
SHISA7
shisa family member 7
chr9_+_34957477 1.80 ENST00000544237.1
KIAA1045
KIAA1045
chrX_+_150869023 1.79 ENST00000448324.1
PRRG3
proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)
chr4_+_158141899 1.79 ENST00000264426.9
ENST00000506284.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr6_+_88117683 1.78 ENST00000369562.4
C6ORF165
UPF0704 protein C6orf165
chr16_-_20367584 1.77 ENST00000570689.1
UMOD
uromodulin
chr17_-_26127525 1.70 ENST00000313735.6
NOS2
nitric oxide synthase 2, inducible
chr14_+_75536280 1.69 ENST00000238686.8
ZC2HC1C
zinc finger, C2HC-type containing 1C
chr19_-_38720294 1.68 ENST00000412732.1
ENST00000456296.1
DPF1
D4, zinc and double PHD fingers family 1
chr10_-_61122582 1.67 ENST00000503444.1
FAM13C
family with sequence similarity 13, member C
chr5_+_161277603 1.65 ENST00000519621.1
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr19_-_35719609 1.64 ENST00000324675.3
FAM187B
family with sequence similarity 187, member B
chr14_+_50999744 1.63 ENST00000441560.2
ATL1
atlastin GTPase 1
chr7_-_123673471 1.62 ENST00000455783.1
TMEM229A
transmembrane protein 229A
chr5_-_138210977 1.60 ENST00000274711.6
ENST00000521094.2
LRRTM2
leucine rich repeat transmembrane neuronal 2
chrX_-_100129128 1.60 ENST00000372960.4
ENST00000372964.1
ENST00000217885.5
NOX1
NADPH oxidase 1
chr14_+_32964258 1.59 ENST00000556638.1
AKAP6
A kinase (PRKA) anchor protein 6
chr11_+_33037652 1.58 ENST00000311388.3
DEPDC7
DEP domain containing 7
chr2_-_233877912 1.57 ENST00000264051.3
NGEF
neuronal guanine nucleotide exchange factor
chr9_+_12695702 1.56 ENST00000381136.2
TYRP1
tyrosinase-related protein 1
chr1_-_238649319 1.53 ENST00000400946.2
RP11-371I1.2
long intergenic non-protein coding RNA 1139
chrX_-_117119243 1.51 ENST00000539496.1
ENST00000469946.1
KLHL13
kelch-like family member 13
chr11_-_62477313 1.50 ENST00000464544.1
ENST00000530009.1
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr4_+_57371509 1.49 ENST00000360096.2
ARL9
ADP-ribosylation factor-like 9
chr12_-_16758059 1.49 ENST00000261169.6
LMO3
LIM domain only 3 (rhombotin-like 2)
chr1_+_10292308 1.48 ENST00000377081.1
KIF1B
kinesin family member 1B
chrX_+_148855726 1.47 ENST00000370416.4
HSFX1
heat shock transcription factor family, X linked 1
chr3_+_94657016 1.41 ENST00000462219.1
LINC00879
long intergenic non-protein coding RNA 879
chr2_+_48844973 1.40 ENST00000403751.3
GTF2A1L
general transcription factor IIA, 1-like
chr8_-_124665190 1.40 ENST00000325995.7
KLHL38
kelch-like family member 38
chrX_+_30261847 1.39 ENST00000378981.3
ENST00000397550.1
MAGEB1
melanoma antigen family B, 1
chr4_+_159131596 1.39 ENST00000512481.1
TMEM144
transmembrane protein 144
chr7_-_14880892 1.36 ENST00000406247.3
ENST00000399322.3
ENST00000258767.5
DGKB
diacylglycerol kinase, beta 90kDa
chr12_-_16758304 1.35 ENST00000320122.6
LMO3
LIM domain only 3 (rhombotin-like 2)
chr1_-_173572181 1.35 ENST00000536496.1
ENST00000367714.3
SLC9C2
solute carrier family 9, member C2 (putative)
chr8_+_67405794 1.34 ENST00000522977.1
ENST00000480005.1
C8orf46
chromosome 8 open reading frame 46
chrX_-_148676974 1.34 ENST00000524178.1
HSFX2
heat shock transcription factor family, X linked 2
chr10_+_127661942 1.33 ENST00000417114.1
ENST00000445510.1
ENST00000368691.1
FANK1
fibronectin type III and ankyrin repeat domains 1
chr1_+_204839959 1.30 ENST00000404076.1
NFASC
neurofascin
chr6_-_50016364 1.28 ENST00000322246.4
DEFB112
defensin, beta 112
chr1_+_108918421 1.27 ENST00000444143.2
ENST00000294652.8
NBPF6
neuroblastoma breakpoint family, member 6
chr19_-_38720354 1.25 ENST00000416611.1
DPF1
D4, zinc and double PHD fingers family 1
chrX_+_107020963 1.25 ENST00000509000.2
NCBP2L
nuclear cap binding protein subunit 2-like
chr4_-_80247162 1.24 ENST00000286794.4
NAA11
N(alpha)-acetyltransferase 11, NatA catalytic subunit
chr22_-_36013368 1.23 ENST00000442617.1
ENST00000397326.2
ENST00000397328.1
ENST00000451685.1
MB
myoglobin
chr1_+_113009163 1.23 ENST00000256640.5
WNT2B
wingless-type MMTV integration site family, member 2B
chr9_+_35792151 1.22 ENST00000342694.2
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr4_+_83821835 1.22 ENST00000302236.5
THAP9
THAP domain containing 9
chr7_-_7603957 1.21 ENST00000608807.1
RP5-1159O4.1
RP5-1159O4.1
chr5_-_138211051 1.20 ENST00000518785.1
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr6_+_46661575 1.19 ENST00000450697.1
TDRD6
tudor domain containing 6
chr9_-_113100088 1.18 ENST00000374510.4
ENST00000423740.2
ENST00000374511.3
ENST00000374507.4
TXNDC8
thioredoxin domain containing 8 (spermatozoa)
chr14_+_75536335 1.17 ENST00000554763.1
ENST00000439583.2
ENST00000526130.1
ENST00000525046.1
ZC2HC1C
zinc finger, C2HC-type containing 1C
chr14_-_65289812 1.17 ENST00000389720.3
ENST00000389721.5
ENST00000389722.3
SPTB
spectrin, beta, erythrocytic
chr16_+_81272287 1.17 ENST00000425577.2
ENST00000564552.1
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr12_-_91572278 1.13 ENST00000425043.1
ENST00000420120.2
ENST00000441303.2
ENST00000456569.2
DCN
decorin
chr19_+_13134772 1.12 ENST00000587760.1
ENST00000585575.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr18_+_5748793 1.11 ENST00000566533.1
ENST00000562452.2
RP11-945C19.1
RP11-945C19.1
chr16_-_32687431 1.10 ENST00000398680.3
ENST00000569420.1
TP53TG3
TP53 target 3
chr11_+_103907308 1.10 ENST00000302259.3
DDI1
DNA-damage inducible 1 homolog 1 (S. cerevisiae)
chr4_+_159131630 1.10 ENST00000504569.1
ENST00000509278.1
ENST00000514558.1
ENST00000503200.1
TMEM144
transmembrane protein 144
chr3_+_132843652 1.07 ENST00000508711.1
TMEM108
transmembrane protein 108
chr1_+_29138654 1.05 ENST00000234961.2
OPRD1
opioid receptor, delta 1
chrX_-_73061339 1.03 ENST00000602863.1
XIST
X inactive specific transcript (non-protein coding)
chr11_+_124789146 1.03 ENST00000408930.5
HEPN1
hepatocellular carcinoma, down-regulated 1
chr3_+_259218 1.03 ENST00000449294.2
CHL1
cell adhesion molecule L1-like
chr11_+_111126707 1.02 ENST00000280325.4
C11orf53
chromosome 11 open reading frame 53
chrX_-_74742846 1.01 ENST00000373361.3
ZDHHC15
zinc finger, DHHC-type containing 15
chr13_+_35516390 1.00 ENST00000540320.1
ENST00000400445.3
ENST00000310336.4
NBEA
neurobeachin
chr14_+_101295638 1.00 ENST00000523671.2
MEG3
maternally expressed 3 (non-protein coding)
chr20_-_31592113 0.99 ENST00000420875.1
ENST00000375519.2
ENST00000375523.3
ENST00000356173.3
SUN5
Sad1 and UNC84 domain containing 5
chr1_-_151148442 0.97 ENST00000441701.1
ENST00000416280.2
TMOD4
tropomodulin 4 (muscle)
chr15_-_45670924 0.94 ENST00000396659.3
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr10_-_28270795 0.94 ENST00000545014.1
ARMC4
armadillo repeat containing 4
chr12_+_112856690 0.93 ENST00000392597.1
ENST00000351677.2
PTPN11
protein tyrosine phosphatase, non-receptor type 11
chr14_+_101295948 0.93 ENST00000452514.2
MEG3
maternally expressed 3 (non-protein coding)
chr12_+_80730292 0.92 ENST00000298820.3
OTOGL
otogelin-like
chr1_+_16083154 0.92 ENST00000375771.1
FBLIM1
filamin binding LIM protein 1
chr16_+_33205585 0.92 ENST00000360260.2
ENST00000398666.3
TP53TG3C
TP53 target 3C
chr16_+_33262120 0.92 ENST00000569741.1
ENST00000380147.3
TP53TG3B
TP53 target 3B
chr1_-_151148492 0.91 ENST00000295314.4
TMOD4
tropomodulin 4 (muscle)
chr10_+_134150835 0.90 ENST00000432555.2
LRRC27
leucine rich repeat containing 27
chr20_-_29978286 0.90 ENST00000376315.2
DEFB119
defensin, beta 119
chr16_-_12062333 0.89 ENST00000597717.1
AC007216.2
Uncharacterized protein
chrX_-_100129320 0.89 ENST00000372966.3
NOX1
NADPH oxidase 1
chr3_+_183815318 0.88 ENST00000425359.2
HTR3E
5-hydroxytryptamine (serotonin) receptor 3E, ionotropic
chr1_-_109399682 0.87 ENST00000369995.3
ENST00000370001.3
AKNAD1
AKNA domain containing 1
chr22_+_45714672 0.86 ENST00000424557.1
FAM118A
family with sequence similarity 118, member A
chr19_-_51334769 0.85 ENST00000596931.1
ENST00000416184.1
ENST00000301421.2
ENST00000598239.1
KLK15
kallikrein-related peptidase 15
chr5_+_158690089 0.85 ENST00000296786.6
UBLCP1
ubiquitin-like domain containing CTD phosphatase 1
chr14_-_75536182 0.84 ENST00000555463.1
ACYP1
acylphosphatase 1, erythrocyte (common) type
chr9_-_35812140 0.84 ENST00000497810.1
ENST00000396638.2
ENST00000484764.1
SPAG8
sperm associated antigen 8
chr6_+_24775153 0.83 ENST00000356509.3
ENST00000230056.3
GMNN
geminin, DNA replication inhibitor
chr16_+_68678892 0.81 ENST00000429102.2
CDH3
cadherin 3, type 1, P-cadherin (placental)
chr8_-_11996586 0.80 ENST00000333796.3
USP17L2
ubiquitin specific peptidase 17-like family member 2
chr15_-_102463298 0.80 ENST00000326183.3
OR4F4
olfactory receptor, family 4, subfamily F, member 4
chr1_+_113010056 0.79 ENST00000369686.5
WNT2B
wingless-type MMTV integration site family, member 2B
chr2_+_27371866 0.79 ENST00000296096.5
TCF23
transcription factor 23
chr10_-_100027943 0.78 ENST00000260702.3
LOXL4
lysyl oxidase-like 4
chr21_-_31864275 0.77 ENST00000334063.4
KRTAP19-3
keratin associated protein 19-3
chr18_+_32402321 0.76 ENST00000587723.1
DTNA
dystrobrevin, alpha
chr2_+_46844290 0.75 ENST00000238892.3
CRIPT
cysteine-rich PDZ-binding protein
chr11_-_110561721 0.74 ENST00000357139.3
ARHGAP20
Rho GTPase activating protein 20
chr19_+_110679 0.69 ENST00000318050.3
OR4F17
olfactory receptor, family 4, subfamily F, member 17
chr6_+_46714654 0.68 ENST00000565422.1
ANKRD66
ankyrin repeat domain 66
chr2_+_159651821 0.68 ENST00000309950.3
ENST00000409042.1
DAPL1
death associated protein-like 1
chr4_+_48807155 0.67 ENST00000504654.1
OCIAD1
OCIA domain containing 1
chr12_+_80750652 0.67 ENST00000550182.1
OTOGL
otogelin-like
chr4_-_153332886 0.65 ENST00000603841.1
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr4_+_189060573 0.65 ENST00000332517.3
TRIML1
tripartite motif family-like 1
chrX_-_24045303 0.63 ENST00000328046.8
KLHL15
kelch-like family member 15
chr2_+_78143006 0.63 ENST00000443419.1
AC073628.1
AC073628.1
chr9_-_13175823 0.62 ENST00000545857.1
MPDZ
multiple PDZ domain protein
chr9_-_35812236 0.61 ENST00000340291.2
SPAG8
sperm associated antigen 8
chr1_-_149783914 0.61 ENST00000369167.1
ENST00000427880.2
ENST00000545683.1
HIST2H2BF
histone cluster 2, H2bf
chrX_+_135618258 0.61 ENST00000440515.1
ENST00000456412.1
VGLL1
vestigial like 1 (Drosophila)
chr8_+_26240666 0.57 ENST00000523949.1
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr11_+_56467864 0.56 ENST00000312153.1
OR9G1
olfactory receptor, family 9, subfamily G, member 1
chr20_-_35329063 0.56 ENST00000422536.1
NDRG3
NDRG family member 3
chr5_+_36608280 0.55 ENST00000513646.1
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_+_81391740 0.54 ENST00000561216.1
C15orf26
chromosome 15 open reading frame 26
chr5_-_150138061 0.54 ENST00000521533.1
ENST00000424236.1
DCTN4
dynactin 4 (p62)
chr3_+_46616017 0.53 ENST00000542931.1
TDGF1
teratocarcinoma-derived growth factor 1
chr1_+_244227632 0.52 ENST00000598000.1
AL590483.1
Uncharacterized protein; cDNA FLJ42623 fis, clone BRACE3015894
chr6_+_13272904 0.52 ENST00000379335.3
ENST00000379329.1
PHACTR1
phosphatase and actin regulator 1
chr2_-_166060552 0.51 ENST00000283254.7
ENST00000453007.1
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr11_-_59383617 0.50 ENST00000263847.1
OSBP
oxysterol binding protein
chr2_+_113479063 0.50 ENST00000327581.4
NT5DC4
5'-nucleotidase domain containing 4
chr1_+_248097071 0.50 ENST00000318244.3
OR2AJ1
olfactory receptor, family 2, subfamily AJ, member 1
chr13_+_112240638 0.50 ENST00000375713.1
RP11-65D24.2
HCG2045795; Uncharacterized protein
chr12_+_78359999 0.50 ENST00000550503.1
NAV3
neuron navigator 3
chr6_+_138266498 0.49 ENST00000434437.1
ENST00000417800.1
RP11-240M16.1
RP11-240M16.1
chr4_+_22999152 0.48 ENST00000511453.1
RP11-412P11.1
RP11-412P11.1
chr3_+_183814852 0.48 ENST00000415389.2
HTR3E
5-hydroxytryptamine (serotonin) receptor 3E, ionotropic
chr14_-_50999190 0.47 ENST00000557390.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr8_+_30244580 0.47 ENST00000523115.1
ENST00000519647.1
RBPMS
RNA binding protein with multiple splicing
chr5_-_150138246 0.45 ENST00000518015.1
DCTN4
dynactin 4 (p62)
chr6_-_31620403 0.44 ENST00000451898.1
ENST00000439687.2
ENST00000362049.6
ENST00000424480.1
BAG6
BCL2-associated athanogene 6
chr2_-_166060382 0.44 ENST00000409101.3
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr20_+_43835638 0.44 ENST00000372781.3
ENST00000244069.6
SEMG1
semenogelin I
chr12_+_65996599 0.43 ENST00000539116.1
ENST00000541391.1
RP11-221N13.3
RP11-221N13.3
chr6_-_31620455 0.43 ENST00000437771.1
ENST00000404765.2
ENST00000375964.6
ENST00000211379.5
BAG6
BCL2-associated athanogene 6
chr7_-_130598059 0.43 ENST00000432045.2
MIR29B1
microRNA 29a
chr1_-_111506562 0.43 ENST00000485275.2
ENST00000369763.4
LRIF1
ligand dependent nuclear receptor interacting factor 1
chr5_-_83016632 0.42 ENST00000515590.1
HAPLN1
hyaluronan and proteoglycan link protein 1
chr19_-_53770972 0.40 ENST00000311170.4
VN1R4
vomeronasal 1 receptor 4
chr8_+_40018977 0.40 ENST00000520487.1
RP11-470M17.2
RP11-470M17.2
chr10_-_4285835 0.40 ENST00000454470.1
LINC00702
long intergenic non-protein coding RNA 702
chr20_+_43849941 0.39 ENST00000372769.3
SEMG2
semenogelin II
chr11_+_62648357 0.38 ENST00000541372.1
ENST00000539458.1
SLC3A2
solute carrier family 3 (amino acid transporter heavy chain), member 2
chr6_+_46714680 0.38 ENST00000536046.1
ANKRD66
ankyrin repeat domain 66
chr6_-_49931818 0.37 ENST00000322066.3
DEFB114
defensin, beta 114
chr11_+_6866883 0.37 ENST00000299454.4
ENST00000379831.2
OR10A5
olfactory receptor, family 10, subfamily A, member 5
chr12_-_112450915 0.36 ENST00000437003.2
ENST00000552374.2
ENST00000550831.3
ENST00000354825.3
ENST00000549537.2
ENST00000355445.3
TMEM116
transmembrane protein 116
chr1_-_108786689 0.33 ENST00000415641.3
NBPF4
neuroblastoma breakpoint family, member 4
chr11_-_33795893 0.32 ENST00000526785.1
ENST00000534136.1
ENST00000265651.3
ENST00000530401.1
ENST00000448981.2
FBXO3
F-box protein 3
chr6_+_37897735 0.32 ENST00000373389.5
ZFAND3
zinc finger, AN1-type domain 3
chr16_+_76668895 0.31 ENST00000512279.1
RP11-96P7.1
RP11-96P7.1
chr2_-_166060571 0.31 ENST00000360093.3
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr7_-_33140498 0.31 ENST00000448915.1
RP9
retinitis pigmentosa 9 (autosomal dominant)
chr3_-_126327398 0.30 ENST00000383572.2
TXNRD3NB
thioredoxin reductase 3 neighbor
chr4_+_26165074 0.28 ENST00000512351.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr8_+_94767072 0.27 ENST00000452276.1
ENST00000453321.3
ENST00000498673.1
ENST00000518319.1
TMEM67
transmembrane protein 67
chr3_-_15140629 0.27 ENST00000507357.1
ENST00000449050.1
ENST00000253699.3
ENST00000435849.3
ENST00000476527.2
ZFYVE20
zinc finger, FYVE domain containing 20

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.6 GO:2000863 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.6 2.5 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.5 2.2 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.5 1.6 GO:0043438 acetoacetic acid metabolic process(GO:0043438)
0.5 2.7 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.4 2.1 GO:0036371 protein localization to T-tubule(GO:0036371)
0.4 4.1 GO:0070779 gamma-aminobutyric acid biosynthetic process(GO:0009449) D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.4 1.5 GO:1904647 response to rotenone(GO:1904647)
0.4 9.9 GO:0034587 piRNA metabolic process(GO:0034587)
0.4 1.8 GO:0072023 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.3 1.2 GO:0017198 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.3 3.6 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.3 0.8 GO:0080120 CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.2 0.9 GO:0006601 creatine biosynthetic process(GO:0006601)
0.2 0.9 GO:0061582 intestinal epithelial cell migration(GO:0061582)
0.2 1.6 GO:0046373 arabinose metabolic process(GO:0019566) L-arabinose metabolic process(GO:0046373)
0.2 2.0 GO:0060424 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492)
0.2 2.8 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.2 0.8 GO:0060901 regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910)
0.2 1.6 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.2 1.2 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.2 1.9 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.2 0.8 GO:1900005 positive regulation of serine-type endopeptidase activity(GO:1900005) positive regulation of serine-type peptidase activity(GO:1902573)
0.2 2.8 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.2 3.8 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 1.2 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.1 0.6 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 2.8 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.1 0.8 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
0.1 1.3 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 1.7 GO:0051712 positive regulation of killing of cells of other organism(GO:0051712)
0.1 1.6 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.1 1.0 GO:0016188 synaptic vesicle maturation(GO:0016188)
0.1 2.1 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 2.6 GO:0003334 keratinocyte development(GO:0003334)
0.1 6.6 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 0.6 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.1 1.1 GO:0097106 postsynaptic density organization(GO:0097106)
0.1 2.1 GO:0016540 protein autoprocessing(GO:0016540)
0.1 0.9 GO:1904379 protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.1 1.8 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 1.2 GO:0015074 DNA integration(GO:0015074)
0.1 0.8 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.1 1.7 GO:0071420 cellular response to histamine(GO:0071420)
0.1 1.1 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.1 1.0 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.1 1.2 GO:0006662 glycerol ether metabolic process(GO:0006662)
0.1 1.4 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 0.4 GO:0061760 antifungal innate immune response(GO:0061760)
0.1 0.9 GO:0003356 regulation of cilium beat frequency(GO:0003356)
0.1 0.4 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.1 1.9 GO:0016048 detection of temperature stimulus(GO:0016048)
0.1 2.6 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.1 0.4 GO:0019236 response to pheromone(GO:0019236)
0.0 1.2 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 1.0 GO:0007097 nuclear migration(GO:0007097)
0.0 1.5 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.9 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 0.3 GO:0060356 leucine import(GO:0060356)
0.0 2.3 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.1 GO:0051685 maintenance of ER location(GO:0051685)
0.0 0.3 GO:1905068 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 1.0 GO:0035640 exploration behavior(GO:0035640)
0.0 0.1 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.0 0.2 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 1.4 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.1 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0 0.5 GO:0008595 tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.0 2.0 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 1.3 GO:0019228 neuronal action potential(GO:0019228)
0.0 1.6 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 0.5 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0 1.2 GO:0051693 actin filament capping(GO:0051693)
0.0 0.1 GO:0070980 biphenyl catabolic process(GO:0070980)
0.0 0.1 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 1.1 GO:0050434 positive regulation of viral transcription(GO:0050434)
0.0 0.3 GO:0010826 negative regulation of centrosome duplication(GO:0010826)
0.0 0.5 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 2.2 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 0.2 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 1.7 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.3 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.2 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.7 GO:0034198 cellular response to amino acid starvation(GO:0034198)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 9.9 GO:0030849 autosome(GO:0030849)
0.9 6.6 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.3 1.3 GO:0097454 Schwann cell microvillus(GO:0097454)
0.3 3.3 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.2 1.2 GO:0005846 nuclear cap binding complex(GO:0005846)
0.2 1.6 GO:0042025 host cell nucleus(GO:0042025)
0.2 1.2 GO:0031415 NatA complex(GO:0031415)
0.1 2.5 GO:0071438 invadopodium membrane(GO:0071438)
0.1 1.6 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 2.9 GO:0071565 nBAF complex(GO:0071565)
0.1 0.6 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 1.6 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 1.1 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.9 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 1.2 GO:0033391 chromatoid body(GO:0033391)
0.1 1.6 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 1.2 GO:0008091 spectrin(GO:0008091)
0.0 1.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 1.7 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.7 GO:0005869 dynactin complex(GO:0005869)
0.0 1.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 2.5 GO:1904115 axon cytoplasm(GO:1904115)
0.0 1.9 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 1.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 2.6 GO:0002102 podosome(GO:0002102)
0.0 2.1 GO:0043034 costamere(GO:0043034)
0.0 0.2 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.3 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.3 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 3.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.0 1.1 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.6 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 4.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)
0.0 0.9 GO:0097546 ciliary base(GO:0097546)
0.0 0.1 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.2 GO:0033263 CORVET complex(GO:0033263)
0.0 0.2 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)
0.0 2.6 GO:0042383 sarcolemma(GO:0042383)
0.0 0.8 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.5 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 2.3 GO:0043209 myelin sheath(GO:0043209)
0.0 1.6 GO:0030426 growth cone(GO:0030426)
0.0 1.7 GO:0030863 cortical cytoskeleton(GO:0030863)
0.0 1.6 GO:0001669 acrosomal vesicle(GO:0001669)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.7 2.7 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.5 2.2 GO:0005042 netrin receptor activity(GO:0005042)
0.4 2.5 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.4 4.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.4 1.6 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.3 6.6 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.3 0.9 GO:0015067 amidinotransferase activity(GO:0015067) glycine amidinotransferase activity(GO:0015068)
0.3 1.2 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.3 1.2 GO:0004803 transposase activity(GO:0004803)
0.3 1.7 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.3 1.7 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.2 1.6 GO:0046556 alpha-L-arabinofuranosidase activity(GO:0046556)
0.2 2.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.2 1.2 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 0.8 GO:0003998 acylphosphatase activity(GO:0003998)
0.1 0.4 GO:0016503 pheromone receptor activity(GO:0016503)
0.1 2.8 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 1.8 GO:0019864 IgG binding(GO:0019864)
0.1 1.4 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 1.9 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 2.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.2 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.1 0.6 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 2.6 GO:0043495 protein anchor(GO:0043495)
0.1 1.1 GO:0004985 opioid receptor activity(GO:0004985)
0.1 2.7 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.3 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
0.1 0.5 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.1 0.9 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 1.2 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 1.9 GO:0005523 tropomyosin binding(GO:0005523)
0.1 1.2 GO:0031005 filamin binding(GO:0031005)
0.1 1.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 4.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 1.3 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.5 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.5 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 2.0 GO:0005109 frizzled binding(GO:0005109)
0.0 1.3 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.9 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.7 GO:0070513 death domain binding(GO:0070513)
0.0 1.2 GO:0000339 RNA cap binding(GO:0000339)
0.0 1.2 GO:0030506 ankyrin binding(GO:0030506)
0.0 1.9 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 2.1 GO:0030507 spectrin binding(GO:0030507)
0.0 1.7 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.8 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 2.3 GO:1901476 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.0 1.1 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.1 GO:0042019 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.0 2.2 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.2 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.3 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.5 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.8 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 1.9 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.3 GO:0000150 recombinase activity(GO:0000150)
0.0 0.4 GO:0005521 lamin binding(GO:0005521)
0.0 2.0 GO:0030276 clathrin binding(GO:0030276)
0.0 0.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 2.7 GO:0005178 integrin binding(GO:0005178)
0.0 0.4 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 1.8 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.1 GO:0001042 RNA polymerase I core binding(GO:0001042) receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.7 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 5.3 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 3.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.6 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 2.2 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 2.8 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 2.5 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 1.5 PID AURORA B PATHWAY Aurora B signaling
0.0 2.2 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.5 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.6 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.6 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 2.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 2.1 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 2.7 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.7 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 4.4 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.8 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 1.1 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 1.7 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 1.4 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.9 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.2 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 3.6 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 2.0 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.9 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 1.2 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.5 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway