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Results for IRX6_IRX4

Z-value: 0.56

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Transcription factors associated with IRX6_IRX4

Gene Symbol Gene ID Gene Info
IRX6
ENSG00000159387.7 iroquois homeobox 6
IRX4
ENSG00000113430.5 iroquois homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX4hg19_v2_chr5_-_1882858_1883003-0.134.9e-01Click!
IRX6hg19_v2_chr16_+_55357672_55357672-0.057.7e-01Click!

Activity profile of IRX6_IRX4 motif

Sorted Z-values of IRX6_IRX4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_46716969 1.87 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr17_+_38673270 1.62 ENST00000578280.1
RP5-1028K7.2
RP5-1028K7.2
chr21_-_34185989 1.22 ENST00000487113.1
ENST00000382373.4
C21orf62
chromosome 21 open reading frame 62
chr5_+_54320078 1.15 ENST00000231009.2
GZMK
granzyme K (granzyme 3; tryptase II)
chr21_-_34185944 1.12 ENST00000479548.1
C21orf62
chromosome 21 open reading frame 62
chr21_-_34186006 1.11 ENST00000490358.1
C21orf62
chromosome 21 open reading frame 62
chr7_-_142232071 1.09 ENST00000390364.3
TRBV10-1
T cell receptor beta variable 10-1(gene/pseudogene)
chr3_-_27498235 1.00 ENST00000295736.5
ENST00000428386.1
ENST00000428179.1
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr16_+_777739 0.83 ENST00000563792.1
HAGHL
hydroxyacylglutathione hydrolase-like
chr6_+_140175987 0.75 ENST00000414038.1
ENST00000431609.1
RP5-899B16.1
RP5-899B16.1
chr8_-_101724989 0.71 ENST00000517403.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr1_+_26644441 0.70 ENST00000374213.2
CD52
CD52 molecule
chrX_+_49294472 0.70 ENST00000361446.5
GAGE12B
G antigen 12B
chr6_-_108145499 0.69 ENST00000369020.3
ENST00000369022.2
SCML4
sex comb on midleg-like 4 (Drosophila)
chr12_-_76462713 0.66 ENST00000552056.1
NAP1L1
nucleosome assembly protein 1-like 1
chr1_-_8763278 0.63 ENST00000468247.1
RERE
arginine-glutamic acid dipeptide (RE) repeats
chr15_-_51630772 0.62 ENST00000557858.1
ENST00000558328.1
ENST00000396404.4
ENST00000561075.1
ENST00000405011.2
ENST00000559980.1
ENST00000453807.2
ENST00000396402.1
CYP19A1
cytochrome P450, family 19, subfamily A, polypeptide 1
chr2_+_58655520 0.61 ENST00000455219.3
ENST00000449448.2
AC007092.1
long intergenic non-protein coding RNA 1122
chr16_+_776936 0.60 ENST00000549114.1
ENST00000341413.4
ENST00000562187.1
ENST00000564537.1
HAGHL
hydroxyacylglutathione hydrolase-like
chr18_+_616672 0.59 ENST00000338387.7
CLUL1
clusterin-like 1 (retinal)
chr4_+_40195262 0.57 ENST00000503941.1
RHOH
ras homolog family member H
chr4_+_40194570 0.57 ENST00000507851.1
RHOH
ras homolog family member H
chr12_-_10282742 0.56 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chr16_+_777246 0.54 ENST00000561546.1
ENST00000564545.1
ENST00000389703.3
ENST00000567414.1
ENST00000568141.1
HAGHL
hydroxyacylglutathione hydrolase-like
chr7_+_143826151 0.53 ENST00000408899.2
OR2A14
olfactory receptor, family 2, subfamily A, member 14
chr14_+_22992573 0.53 ENST00000390516.1
TRAJ21
T cell receptor alpha joining 21
chr12_-_10282681 0.51 ENST00000533022.1
CLEC7A
C-type lectin domain family 7, member A
chr4_-_143481822 0.51 ENST00000510812.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr3_-_9994021 0.51 ENST00000411976.2
ENST00000412055.1
PRRT3
proline-rich transmembrane protein 3
chr12_+_32655048 0.49 ENST00000427716.2
ENST00000266482.3
FGD4
FYVE, RhoGEF and PH domain containing 4
chr14_-_106845789 0.49 ENST00000390617.2
IGHV3-35
immunoglobulin heavy variable 3-35 (non-functional)
chr12_-_10282836 0.48 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A
chr7_-_16844611 0.48 ENST00000401412.1
ENST00000419304.2
AGR2
anterior gradient 2
chr9_-_5084580 0.48 ENST00000601793.1
AL161450.1
Uncharacterized protein
chr15_-_64665911 0.48 ENST00000606793.1
ENST00000561349.1
ENST00000560278.1
CTD-2116N17.1
Uncharacterized protein
chr2_-_207583120 0.47 ENST00000452335.2
DYTN
dystrotelin
chr14_+_22993296 0.44 ENST00000390517.1
TRAJ20
T cell receptor alpha joining 20
chr4_+_40194609 0.44 ENST00000508513.1
RHOH
ras homolog family member H
chr17_-_29641084 0.43 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chrX_+_15767971 0.42 ENST00000479740.1
ENST00000454127.2
CA5B
carbonic anhydrase VB, mitochondrial
chr17_-_29641104 0.42 ENST00000577894.1
ENST00000330927.4
EVI2B
ecotropic viral integration site 2B
chr10_+_90660832 0.42 ENST00000371924.1
STAMBPL1
STAM binding protein-like 1
chr5_+_59783540 0.41 ENST00000515734.2
PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr1_-_3566627 0.41 ENST00000419924.2
ENST00000270708.7
WRAP73
WD repeat containing, antisense to TP73
chr12_+_32655110 0.41 ENST00000546442.1
ENST00000583694.1
FGD4
FYVE, RhoGEF and PH domain containing 4
chr14_-_21737551 0.40 ENST00000554891.1
ENST00000555883.1
ENST00000553753.1
ENST00000555914.1
ENST00000557336.1
ENST00000555215.1
ENST00000556628.1
ENST00000555137.1
ENST00000556226.1
ENST00000555309.1
ENST00000556142.1
ENST00000554969.1
ENST00000554455.1
ENST00000556513.1
ENST00000557201.1
ENST00000420743.2
ENST00000557768.1
ENST00000553300.1
ENST00000554383.1
ENST00000554539.1
HNRNPC
heterogeneous nuclear ribonucleoprotein C (C1/C2)
chr22_-_24096562 0.39 ENST00000398465.3
VPREB3
pre-B lymphocyte 3
chr10_-_115904361 0.39 ENST00000428953.1
ENST00000543782.1
C10orf118
chromosome 10 open reading frame 118
chrX_+_47990039 0.38 ENST00000304270.5
SPACA5B
sperm acrosome associated 5B
chrX_+_47867194 0.36 ENST00000376940.3
SPACA5
sperm acrosome associated 5
chr7_-_55583740 0.35 ENST00000453256.1
VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr2_+_58655461 0.35 ENST00000429095.1
ENST00000429664.1
ENST00000452840.1
AC007092.1
long intergenic non-protein coding RNA 1122
chr4_+_158142750 0.34 ENST00000505888.1
ENST00000449365.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr16_+_777118 0.33 ENST00000562141.1
HAGHL
hydroxyacylglutathione hydrolase-like
chr17_-_42327236 0.32 ENST00000399246.2
AC003102.1
AC003102.1
chr1_-_3566590 0.31 ENST00000424367.1
ENST00000378322.3
WRAP73
WD repeat containing, antisense to TP73
chr7_-_92855762 0.31 ENST00000453812.2
ENST00000394468.2
HEPACAM2
HEPACAM family member 2
chr3_+_68053359 0.30 ENST00000478136.1
FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr15_+_81225699 0.30 ENST00000560027.1
KIAA1199
KIAA1199
chr5_+_169758393 0.28 ENST00000521471.1
ENST00000518357.1
ENST00000436248.3
CTB-114C7.3
CTB-114C7.3
chr17_-_6524159 0.25 ENST00000589033.1
KIAA0753
KIAA0753
chrX_-_19988382 0.25 ENST00000356980.3
ENST00000379687.3
ENST00000379682.4
CXorf23
chromosome X open reading frame 23
chr11_+_61891445 0.25 ENST00000394818.3
ENST00000533896.1
ENST00000278849.4
INCENP
inner centromere protein antigens 135/155kDa
chr7_-_80141328 0.25 ENST00000398291.3
GNAT3
guanine nucleotide binding protein, alpha transducing 3
chrY_-_21738068 0.24 ENST00000599485.1
AC009977.1
Uncharacterized protein
chr19_-_22379753 0.23 ENST00000397121.2
ZNF676
zinc finger protein 676
chr1_-_149859466 0.23 ENST00000331128.3
HIST2H2AB
histone cluster 2, H2ab
chr5_+_175490540 0.21 ENST00000515817.1
FAM153B
family with sequence similarity 153, member B
chr6_+_116691001 0.21 ENST00000537543.1
DSE
dermatan sulfate epimerase
chr5_-_177207634 0.21 ENST00000513554.1
ENST00000440605.3
FAM153A
family with sequence similarity 153, member A
chr8_+_84824920 0.20 ENST00000523678.1
RP11-120I21.2
RP11-120I21.2
chr6_-_117747015 0.17 ENST00000368508.3
ENST00000368507.3
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr20_+_11008408 0.17 ENST00000378252.1
C20orf187
chromosome 20 open reading frame 187
chr1_+_67673297 0.17 ENST00000425614.1
ENST00000395227.1
IL23R
interleukin 23 receptor
chr7_+_23210760 0.17 ENST00000366347.4
AC005082.1
Uncharacterized protein
chr7_+_6121296 0.16 ENST00000428901.1
AC004895.4
AC004895.4
chr18_-_28622774 0.16 ENST00000434452.1
DSC3
desmocollin 3
chr17_-_47723943 0.16 ENST00000510476.1
ENST00000503676.1
SPOP
speckle-type POZ protein
chr11_+_6897856 0.15 ENST00000379829.2
OR10A4
olfactory receptor, family 10, subfamily A, member 4
chrX_+_36254051 0.15 ENST00000378657.4
CXorf30
chromosome X open reading frame 30
chr20_+_10199566 0.14 ENST00000430336.1
SNAP25
synaptosomal-associated protein, 25kDa
chr2_+_160590469 0.14 ENST00000409591.1
MARCH7
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
chr14_+_56127989 0.14 ENST00000555573.1
KTN1
kinectin 1 (kinesin receptor)
chr1_+_170904612 0.13 ENST00000367759.4
ENST00000367758.3
MROH9
maestro heat-like repeat family member 9
chr20_+_44330651 0.13 ENST00000305479.2
WFDC13
WAP four-disulfide core domain 13
chrX_-_135962923 0.13 ENST00000565438.1
RBMX
RNA binding motif protein, X-linked
chr1_-_110284384 0.12 ENST00000540225.1
GSTM3
glutathione S-transferase mu 3 (brain)
chr4_+_158141899 0.11 ENST00000264426.9
ENST00000506284.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr18_-_56985776 0.11 ENST00000587244.1
CPLX4
complexin 4
chr14_+_56127960 0.11 ENST00000553624.1
KTN1
kinectin 1 (kinesin receptor)
chr19_-_20048639 0.11 ENST00000595282.1
AC007204.1
Uncharacterized protein
chr10_+_118350522 0.10 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
PNLIPRP1
pancreatic lipase-related protein 1
chrX_+_47863734 0.10 ENST00000304355.5
SPACA5
sperm acrosome associated 5
chr10_+_118350468 0.10 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
PNLIPRP1
pancreatic lipase-related protein 1
chr3_-_139199565 0.09 ENST00000511956.1
RBP2
retinol binding protein 2, cellular
chr3_-_139199589 0.09 ENST00000506825.1
RBP2
retinol binding protein 2, cellular
chr12_-_88423164 0.08 ENST00000298699.2
ENST00000550553.1
C12orf50
chromosome 12 open reading frame 50
chr4_+_130017268 0.08 ENST00000425929.1
ENST00000508673.1
ENST00000508622.1
C4orf33
chromosome 4 open reading frame 33
chr6_-_49834209 0.07 ENST00000507853.1
CRISP1
cysteine-rich secretory protein 1
chr9_-_37465396 0.07 ENST00000307750.4
ZBTB5
zinc finger and BTB domain containing 5
chr4_-_104119488 0.07 ENST00000514974.1
CENPE
centromere protein E, 312kDa
chr11_+_110225855 0.06 ENST00000526605.1
ENST00000526703.1
RP11-347E10.1
RP11-347E10.1
chr6_-_49834240 0.06 ENST00000335847.4
CRISP1
cysteine-rich secretory protein 1
chr6_-_39290744 0.06 ENST00000507712.1
KCNK16
potassium channel, subfamily K, member 16
chr12_-_124118151 0.06 ENST00000534960.1
EIF2B1
eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
chr4_-_104119528 0.05 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE
centromere protein E, 312kDa
chr8_-_74495065 0.05 ENST00000523533.1
STAU2
staufen double-stranded RNA binding protein 2
chr9_-_27573651 0.05 ENST00000379995.1
ENST00000379997.3
C9orf72
chromosome 9 open reading frame 72
chr3_-_168865522 0.05 ENST00000464456.1
MECOM
MDS1 and EVI1 complex locus
chr10_+_86184676 0.05 ENST00000543283.1
CCSER2
coiled-coil serine-rich protein 2
chr3_+_186158169 0.05 ENST00000435548.1
ENST00000421006.1
RP11-78H24.1
RP11-78H24.1
chr4_+_144312659 0.04 ENST00000509992.1
GAB1
GRB2-associated binding protein 1
chr2_-_238333919 0.04 ENST00000409162.1
AC112721.1
Uncharacterized protein
chr3_+_111758553 0.04 ENST00000419127.1
TMPRSS7
transmembrane protease, serine 7
chr20_+_10199468 0.04 ENST00000254976.2
ENST00000304886.2
SNAP25
synaptosomal-associated protein, 25kDa
chr14_-_23623577 0.04 ENST00000422941.2
ENST00000453702.1
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr13_-_41768654 0.03 ENST00000379483.3
KBTBD7
kelch repeat and BTB (POZ) domain containing 7
chr2_+_226264401 0.03 ENST00000431435.1
AC067961.1
AC067961.1
chr8_+_67976593 0.03 ENST00000262210.5
ENST00000412460.1
CSPP1
centrosome and spindle pole associated protein 1
chr21_-_48024986 0.02 ENST00000291700.4
ENST00000367071.4
S100B
S100 calcium binding protein B
chrY_-_6742068 0.02 ENST00000215479.5
AMELY
amelogenin, Y-linked
chr8_+_27631903 0.01 ENST00000305188.8
ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr3_+_111630451 0.01 ENST00000495180.1
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr4_+_71458012 0.00 ENST00000449493.2
AMBN
ameloblastin (enamel matrix protein)
chr15_+_66585555 0.00 ENST00000319194.5
ENST00000525134.2
ENST00000441424.2
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX6_IRX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.1 0.6 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.1 1.9 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 1.6 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.1 0.5 GO:1903899 lung goblet cell differentiation(GO:0060480) positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.1 0.7 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.2 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.0 0.2 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.0 0.2 GO:0010966 regulation of phosphate transport(GO:0010966)
0.0 0.2 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.0 1.0 GO:0060117 auditory receptor cell development(GO:0060117)
0.0 0.5 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.2 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.7 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.1 GO:0070458 establishment of blood-nerve barrier(GO:0008065) cellular detoxification of nitrogen compound(GO:0070458)
0.0 1.6 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.0 0.1 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.0 0.7 GO:0045730 respiratory burst(GO:0045730)
0.0 0.4 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.2 GO:0006776 vitamin A metabolic process(GO:0006776)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.1 1.9 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.2 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.0 0.2 GO:0000801 central element(GO:0000801)
0.0 0.2 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0 0.1 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 1.6 GO:0001772 immunological synapse(GO:0001772)
0.0 0.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.0 GO:0032420 stereocilium(GO:0032420)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0008267 poly-glutamine tract binding(GO:0008267)
0.1 0.5 GO:0017161 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.0 1.6 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.2 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 1.6 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 1.0 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.2 GO:0042020 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.0 1.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.5 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.4 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.6 GO:0070330 aromatase activity(GO:0070330)
0.0 0.4 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.5 GO:0002162 dystroglycan binding(GO:0002162)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.6 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.5 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.7 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.4 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation