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Illumina Body Map 2

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Results for ISL2

Z-value: 0.80

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Transcription factors associated with ISL2

Gene Symbol Gene ID Gene Info
ISL2
ENSG00000159556.5 ISL LIM homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ISL2hg19_v2_chr15_+_76629064_76629073-0.086.6e-01Click!

Activity profile of ISL2 motif

Sorted Z-values of ISL2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_163008903 2.55 ENST00000418842.2
ENST00000375497.3
GCG
glucagon
chr18_-_64271316 1.89 ENST00000540086.1
ENST00000580157.1
CDH19
cadherin 19, type 2
chr18_-_64271363 1.69 ENST00000262150.2
CDH19
cadherin 19, type 2
chr17_-_64225508 1.66 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr2_+_234580525 1.50 ENST00000609637.1
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A8
chr2_+_234580499 1.47 ENST00000354728.4
UGT1A9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr20_-_7238861 1.23 ENST00000428954.1
RP11-19D2.1
RP11-19D2.1
chr2_+_7865923 1.19 ENST00000417930.1
AC092580.4
AC092580.4
chr7_-_16844611 1.16 ENST00000401412.1
ENST00000419304.2
AGR2
anterior gradient 2
chr5_+_40909354 1.12 ENST00000313164.9
C7
complement component 7
chrX_-_84634708 1.10 ENST00000373145.3
POF1B
premature ovarian failure, 1B
chrX_-_84634737 1.02 ENST00000262753.4
POF1B
premature ovarian failure, 1B
chr11_-_13517565 0.94 ENST00000282091.1
ENST00000529816.1
PTH
parathyroid hormone
chr3_+_159943362 0.92 ENST00000326474.3
C3orf80
chromosome 3 open reading frame 80
chr2_+_234668894 0.88 ENST00000305208.5
ENST00000608383.1
ENST00000360418.3
UGT1A8
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
UDP glucuronosyltransferase 1 family, polypeptide A8
chr14_-_67878917 0.88 ENST00000216446.4
PLEK2
pleckstrin 2
chr4_+_169013666 0.86 ENST00000359299.3
ANXA10
annexin A10
chr21_+_39644395 0.82 ENST00000398934.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr21_+_39644305 0.81 ENST00000398930.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr11_-_327537 0.77 ENST00000602735.1
IFITM3
interferon induced transmembrane protein 3
chr1_+_63063152 0.77 ENST00000371129.3
ANGPTL3
angiopoietin-like 3
chr10_-_95242044 0.75 ENST00000371501.4
ENST00000371502.4
ENST00000371489.1
MYOF
myoferlin
chr4_+_113568207 0.75 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chr15_+_58702742 0.72 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr10_-_95241951 0.70 ENST00000358334.5
ENST00000359263.4
ENST00000371488.3
MYOF
myoferlin
chr10_-_29923893 0.68 ENST00000355867.4
SVIL
supervillin
chr20_+_30102231 0.68 ENST00000335574.5
ENST00000340852.5
ENST00000398174.3
ENST00000376127.3
ENST00000344042.5
HM13
histocompatibility (minor) 13
chr1_-_178840157 0.67 ENST00000367629.1
ENST00000234816.2
ANGPTL1
angiopoietin-like 1
chr12_+_2079939 0.65 ENST00000543114.1
CACNA1C
calcium channel, voltage-dependent, L type, alpha 1C subunit
chr4_+_95128748 0.63 ENST00000359052.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr2_-_40680578 0.60 ENST00000455476.1
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr12_+_104337515 0.60 ENST00000550595.1
HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr2_-_190446738 0.58 ENST00000427419.1
ENST00000455320.1
SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr8_-_124741451 0.55 ENST00000520519.1
ANXA13
annexin A13
chr2_+_234826016 0.53 ENST00000324695.4
ENST00000433712.2
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr10_-_13350447 0.51 ENST00000429930.1
AL138764.1
Uncharacterized protein
chr4_+_25162253 0.51 ENST00000512921.1
PI4K2B
phosphatidylinositol 4-kinase type 2 beta
chr4_+_86525299 0.50 ENST00000512201.1
ARHGAP24
Rho GTPase activating protein 24
chr12_+_131438443 0.50 ENST00000261654.5
GPR133
G protein-coupled receptor 133
chr5_+_32788945 0.50 ENST00000326958.1
AC026703.1
AC026703.1
chrX_-_32173579 0.49 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
DMD
dystrophin
chr6_+_26087509 0.49 ENST00000397022.3
ENST00000353147.5
ENST00000352392.4
ENST00000349999.4
ENST00000317896.7
ENST00000357618.5
ENST00000470149.1
ENST00000336625.8
ENST00000461397.1
ENST00000488199.1
HFE
hemochromatosis
chr7_-_111032971 0.48 ENST00000450877.1
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr2_-_169887827 0.47 ENST00000263817.6
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr4_+_169418195 0.47 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr4_+_169418255 0.46 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr2_+_108863651 0.45 ENST00000329106.2
ENST00000376700.1
SULT1C3
sulfotransferase family, cytosolic, 1C, member 3
chr11_+_28129795 0.45 ENST00000406787.3
ENST00000342303.5
ENST00000403099.1
ENST00000407364.3
METTL15
methyltransferase like 15
chr5_+_40841276 0.44 ENST00000254691.5
CARD6
caspase recruitment domain family, member 6
chr4_-_138453559 0.43 ENST00000511115.1
PCDH18
protocadherin 18
chr15_+_90735145 0.43 ENST00000559792.1
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chrM_+_9207 0.43 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr1_-_232651312 0.42 ENST00000262861.4
SIPA1L2
signal-induced proliferation-associated 1 like 2
chrX_-_55208866 0.42 ENST00000545075.1
MTRNR2L10
MT-RNR2-like 10
chr4_-_120243545 0.42 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr12_+_131438496 0.41 ENST00000543826.1
GPR133
G protein-coupled receptor 133
chr1_-_160924589 0.40 ENST00000368029.3
ITLN2
intelectin 2
chr1_-_223853348 0.39 ENST00000366872.5
CAPN8
calpain 8
chr4_-_138453606 0.39 ENST00000412923.2
ENST00000344876.4
ENST00000507846.1
ENST00000510305.1
PCDH18
protocadherin 18
chr1_-_238108575 0.39 ENST00000604646.1
MTRNR2L11
MT-RNR2-like 11 (pseudogene)
chr3_-_178103144 0.39 ENST00000417383.1
ENST00000418585.1
ENST00000411727.1
ENST00000439810.1
RP11-33A14.1
RP11-33A14.1
chr7_+_16700806 0.38 ENST00000446596.1
ENST00000438834.1
BZW2
basic leucine zipper and W2 domains 2
chr1_+_99127225 0.38 ENST00000370189.5
ENST00000529992.1
SNX7
sorting nexin 7
chr2_-_217559517 0.38 ENST00000449583.1
IGFBP5
insulin-like growth factor binding protein 5
chr7_-_151330218 0.38 ENST00000476632.1
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr12_-_95945246 0.38 ENST00000258499.3
USP44
ubiquitin specific peptidase 44
chr8_-_133772870 0.37 ENST00000522334.1
ENST00000519016.1
TMEM71
transmembrane protein 71
chr1_+_149871135 0.37 ENST00000369152.5
BOLA1
bolA family member 1
chr2_+_128177253 0.36 ENST00000427769.1
PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr6_-_138833630 0.36 ENST00000533765.1
NHSL1
NHS-like 1
chr11_-_5255861 0.36 ENST00000380299.3
HBD
hemoglobin, delta
chr6_+_130339710 0.35 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr1_-_152779104 0.35 ENST00000606576.1
ENST00000368768.1
LCE1C
late cornified envelope 1C
chr2_-_158295915 0.35 ENST00000418920.1
CYTIP
cytohesin 1 interacting protein
chr13_+_49551020 0.35 ENST00000541916.1
FNDC3A
fibronectin type III domain containing 3A
chr4_+_15471489 0.34 ENST00000424120.1
ENST00000413206.1
ENST00000438599.2
ENST00000511544.1
ENST00000512702.1
ENST00000507954.1
ENST00000515124.1
ENST00000503292.1
ENST00000503658.1
CC2D2A
coiled-coil and C2 domain containing 2A
chr3_+_43020773 0.34 ENST00000488863.1
FAM198A
family with sequence similarity 198, member A
chr10_+_35484793 0.33 ENST00000488741.1
ENST00000474931.1
ENST00000468236.1
ENST00000344351.5
ENST00000490511.1
CREM
cAMP responsive element modulator
chrX_-_77225135 0.33 ENST00000458128.1
PGAM4
phosphoglycerate mutase family member 4
chr12_-_110937351 0.32 ENST00000552130.2
VPS29
vacuolar protein sorting 29 homolog (S. cerevisiae)
chr8_+_133909919 0.31 ENST00000518505.1
TG
thyroglobulin
chr2_+_88047606 0.31 ENST00000359481.4
PLGLB2
plasminogen-like B2
chr20_-_33735070 0.31 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr6_+_161123270 0.30 ENST00000366924.2
ENST00000308192.9
ENST00000418964.1
PLG
plasminogen
chr14_-_23058063 0.30 ENST00000538631.1
ENST00000543337.1
ENST00000250498.4
DAD1
defender against cell death 1
chr1_+_149871171 0.30 ENST00000369150.1
BOLA1
bolA family member 1
chr11_-_92931098 0.30 ENST00000326402.4
SLC36A4
solute carrier family 36 (proton/amino acid symporter), member 4
chr1_-_223853425 0.30 ENST00000366873.2
ENST00000419193.2
CAPN8
calpain 8
chr5_-_173217931 0.29 ENST00000522731.1
CTB-43E15.4
CTB-43E15.4
chr6_-_32095968 0.29 ENST00000375203.3
ENST00000375201.4
ATF6B
activating transcription factor 6 beta
chr3_+_136649311 0.29 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1
chr12_+_4829507 0.28 ENST00000252318.2
GALNT8
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)
chr8_+_38662960 0.28 ENST00000524193.1
TACC1
transforming, acidic coiled-coil containing protein 1
chr8_-_121457608 0.28 ENST00000306185.3
MRPL13
mitochondrial ribosomal protein L13
chrM_+_10053 0.28 ENST00000361227.2
MT-ND3
mitochondrially encoded NADH dehydrogenase 3
chr2_-_85108363 0.28 ENST00000335459.5
TRABD2A
TraB domain containing 2A
chr9_-_95166976 0.27 ENST00000447356.1
OGN
osteoglycin
chr4_+_95128996 0.27 ENST00000457823.2
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chrX_+_65384182 0.27 ENST00000441993.2
ENST00000419594.1
HEPH
hephaestin
chr6_-_111804905 0.27 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr2_+_74685413 0.27 ENST00000233615.2
WBP1
WW domain binding protein 1
chr15_+_64680003 0.27 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chr12_+_64798826 0.27 ENST00000540203.1
XPOT
exportin, tRNA
chr3_-_141747950 0.26 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr17_+_1674982 0.26 ENST00000572048.1
ENST00000573763.1
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr7_-_84122033 0.25 ENST00000424555.1
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr5_+_102200948 0.25 ENST00000511477.1
ENST00000506006.1
ENST00000509832.1
PAM
peptidylglycine alpha-amidating monooxygenase
chr11_+_73498898 0.25 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48
mitochondrial ribosomal protein L48
chr14_+_22465771 0.25 ENST00000390445.2
TRAV17
T cell receptor alpha variable 17
chr5_+_40841410 0.25 ENST00000381677.3
CARD6
caspase recruitment domain family, member 6
chr3_-_164796269 0.24 ENST00000264382.3
SI
sucrase-isomaltase (alpha-glucosidase)
chr9_-_100854838 0.24 ENST00000538344.1
TRIM14
tripartite motif containing 14
chr5_-_130500922 0.24 ENST00000513012.1
ENST00000508488.1
ENST00000506908.1
ENST00000304043.5
HINT1
histidine triad nucleotide binding protein 1
chr11_-_8892900 0.23 ENST00000526155.1
ENST00000524757.1
ENST00000527392.1
ENST00000534665.1
ENST00000525169.1
ENST00000527516.1
ENST00000533471.1
ST5
suppression of tumorigenicity 5
chr4_+_156775910 0.23 ENST00000506072.1
ENST00000507590.1
TDO2
tryptophan 2,3-dioxygenase
chr17_-_7307358 0.23 ENST00000576017.1
ENST00000302422.3
ENST00000535512.1
TMEM256
TMEM256-PLSCR3
transmembrane protein 256
TMEM256-PLSCR3 readthrough (NMD candidate)
chrX_-_100872911 0.23 ENST00000361910.4
ENST00000539247.1
ENST00000538627.1
ARMCX6
armadillo repeat containing, X-linked 6
chr9_-_95166841 0.22 ENST00000262551.4
OGN
osteoglycin
chr14_+_57671888 0.21 ENST00000391612.1
AL391152.1
AL391152.1
chr4_+_128702969 0.21 ENST00000508776.1
ENST00000439123.2
HSPA4L
heat shock 70kDa protein 4-like
chr10_-_74283694 0.20 ENST00000398763.4
ENST00000418483.2
ENST00000489666.2
MICU1
mitochondrial calcium uptake 1
chr1_+_152730499 0.20 ENST00000368773.1
KPRP
keratinocyte proline-rich protein
chr12_-_118628350 0.19 ENST00000537952.1
ENST00000537822.1
TAOK3
TAO kinase 3
chr3_+_139063372 0.19 ENST00000478464.1
MRPS22
mitochondrial ribosomal protein S22
chr5_-_68339648 0.18 ENST00000479830.2
CTC-498J12.1
CTC-498J12.1
chr2_-_87248975 0.17 ENST00000409310.2
ENST00000355705.3
PLGLB1
plasminogen-like B1
chr2_-_217560248 0.17 ENST00000233813.4
IGFBP5
insulin-like growth factor binding protein 5
chr3_-_127455200 0.17 ENST00000398101.3
MGLL
monoglyceride lipase
chr12_-_118628315 0.17 ENST00000540561.1
TAOK3
TAO kinase 3
chr3_-_121740969 0.17 ENST00000393631.1
ENST00000273691.3
ENST00000344209.5
ILDR1
immunoglobulin-like domain containing receptor 1
chr13_-_46716969 0.16 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr15_+_48483736 0.16 ENST00000417307.2
ENST00000559641.1
CTXN2
SLC12A1
cortexin 2
solute carrier family 12 (sodium/potassium/chloride transporter), member 1
chr19_-_46234119 0.16 ENST00000317683.3
FBXO46
F-box protein 46
chr12_-_46121554 0.15 ENST00000609803.1
LINC00938
long intergenic non-protein coding RNA 938
chr4_-_68829144 0.14 ENST00000508048.1
TMPRSS11A
transmembrane protease, serine 11A
chr16_+_53133070 0.14 ENST00000565832.1
CHD9
chromodomain helicase DNA binding protein 9
chr1_-_95391315 0.14 ENST00000545882.1
ENST00000415017.1
CNN3
calponin 3, acidic
chr10_-_5046042 0.13 ENST00000421196.3
ENST00000455190.1
AKR1C2
aldo-keto reductase family 1, member C2
chr6_+_64345698 0.13 ENST00000506783.1
ENST00000481385.2
ENST00000515594.1
ENST00000494284.2
ENST00000262043.3
PHF3
PHD finger protein 3
chr17_-_33390667 0.13 ENST00000378516.2
ENST00000268850.7
ENST00000394597.2
RFFL
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr16_-_28937027 0.13 ENST00000358201.4
RABEP2
rabaptin, RAB GTPase binding effector protein 2
chr2_+_86669118 0.13 ENST00000427678.1
ENST00000542128.1
KDM3A
lysine (K)-specific demethylase 3A
chr4_-_48116540 0.12 ENST00000506073.1
TXK
TXK tyrosine kinase
chr22_-_29107919 0.12 ENST00000434810.1
ENST00000456369.1
CHEK2
checkpoint kinase 2
chrX_-_119077695 0.11 ENST00000371410.3
NKAP
NFKB activating protein
chr2_-_166060382 0.11 ENST00000409101.3
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr4_+_26324474 0.11 ENST00000514675.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr17_+_7155819 0.11 ENST00000570322.1
ENST00000576496.1
ENST00000574841.2
ELP5
elongator acetyltransferase complex subunit 5
chrX_+_102840408 0.11 ENST00000468024.1
ENST00000472484.1
ENST00000415568.2
ENST00000490644.1
ENST00000459722.1
ENST00000472745.1
ENST00000494801.1
ENST00000434216.2
ENST00000425011.1
TCEAL4
transcription elongation factor A (SII)-like 4
chr13_-_74993252 0.10 ENST00000325811.1
AL355390.1
Uncharacterized protein
chr3_-_178103080 0.10 ENST00000414475.1
RP11-33A14.1
RP11-33A14.1
chr5_+_68860949 0.10 ENST00000507595.1
GTF2H2C
general transcription factor IIH, polypeptide 2C
chr3_+_138327542 0.10 ENST00000360570.3
ENST00000393035.2
FAIM
Fas apoptotic inhibitory molecule
chr7_-_37488777 0.10 ENST00000445322.1
ENST00000448602.1
ELMO1
engulfment and cell motility 1
chr19_+_49199209 0.10 ENST00000522966.1
ENST00000425340.2
ENST00000391876.4
FUT2
fucosyltransferase 2 (secretor status included)
chr8_+_70404996 0.10 ENST00000402687.4
ENST00000419716.3
SULF1
sulfatase 1
chr1_-_93257951 0.10 ENST00000543509.1
ENST00000370331.1
ENST00000540033.1
EVI5
ecotropic viral integration site 5
chr1_-_202897724 0.09 ENST00000435533.3
ENST00000367258.1
KLHL12
kelch-like family member 12
chr9_-_99540328 0.09 ENST00000223428.4
ENST00000375231.1
ENST00000374641.3
ZNF510
zinc finger protein 510
chr6_+_151561085 0.09 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr12_-_12715266 0.09 ENST00000228862.2
DUSP16
dual specificity phosphatase 16
chr13_+_24144509 0.09 ENST00000248484.4
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr14_-_53258314 0.09 ENST00000216410.3
ENST00000557604.1
GNPNAT1
glucosamine-phosphate N-acetyltransferase 1
chr3_-_72150076 0.09 ENST00000488545.1
ENST00000608654.1
LINC00877
long intergenic non-protein coding RNA 877
chr16_+_28565230 0.09 ENST00000317058.3
CCDC101
coiled-coil domain containing 101
chr12_+_26164645 0.08 ENST00000542004.1
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr14_+_38677123 0.08 ENST00000267377.2
SSTR1
somatostatin receptor 1
chr8_-_125577940 0.08 ENST00000519168.1
ENST00000395508.2
MTSS1
metastasis suppressor 1
chr5_-_54988448 0.07 ENST00000503817.1
ENST00000512595.1
SLC38A9
solute carrier family 38, member 9
chr4_-_185275104 0.07 ENST00000317596.3
RP11-290F5.2
RP11-290F5.2
chr7_+_13141097 0.07 ENST00000411542.1
AC011288.2
AC011288.2
chrX_+_108779004 0.07 ENST00000218004.1
NXT2
nuclear transport factor 2-like export factor 2
chr14_+_102276132 0.07 ENST00000350249.3
ENST00000557621.1
ENST00000556946.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr7_-_37488834 0.07 ENST00000310758.4
ELMO1
engulfment and cell motility 1
chr2_-_10587897 0.07 ENST00000405333.1
ENST00000443218.1
ODC1
ornithine decarboxylase 1
chr1_-_12946025 0.06 ENST00000235349.5
PRAMEF4
PRAME family member 4
chr10_-_115904361 0.06 ENST00000428953.1
ENST00000543782.1
C10orf118
chromosome 10 open reading frame 118
chr11_+_101983176 0.06 ENST00000524575.1
YAP1
Yes-associated protein 1
chr1_+_152178320 0.06 ENST00000429352.1
RP11-107M16.2
RP11-107M16.2
chr11_-_62609281 0.06 ENST00000525239.1
ENST00000538098.2
WDR74
WD repeat domain 74
chrX_+_65382433 0.05 ENST00000374727.3
HEPH
hephaestin
chr7_-_45151272 0.05 ENST00000461363.1
ENST00000495078.1
ENST00000494076.1
ENST00000478532.1
ENST00000258770.3
ENST00000361278.3
TBRG4
transforming growth factor beta regulator 4
chr3_+_134514093 0.05 ENST00000398015.3
EPHB1
EPH receptor B1
chr21_-_30445886 0.05 ENST00000431234.1
ENST00000540844.1
ENST00000286788.4
CCT8
chaperonin containing TCP1, subunit 8 (theta)
chr11_-_58378759 0.05 ENST00000601906.1
AP001350.1
Uncharacterized protein
chr1_+_13421176 0.05 ENST00000376152.1
PRAMEF9
PRAME family member 9
chr6_-_47445214 0.04 ENST00000604014.1
RP11-385F7.1
RP11-385F7.1
chrX_+_65382381 0.04 ENST00000519389.1
HEPH
hephaestin
chr13_-_45768841 0.04 ENST00000379108.1
KCTD4
potassium channel tetramerization domain containing 4
chr17_-_47786375 0.04 ENST00000511657.1
SLC35B1
solute carrier family 35, member B1
chr15_-_75748115 0.04 ENST00000360439.4
SIN3A
SIN3 transcription regulator family member A
chr13_+_24144796 0.04 ENST00000403372.2
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr6_-_152639479 0.04 ENST00000356820.4
SYNE1
spectrin repeat containing, nuclear envelope 1
chr5_+_57787254 0.04 ENST00000502276.1
ENST00000396776.2
ENST00000511930.1
GAPT
GRB2-binding adaptor protein, transmembrane
chr4_-_16675930 0.04 ENST00000503178.2
LDB2
LIM domain binding 2
chr12_-_87232771 0.04 ENST00000550014.1
RP11-202H2.1
RP11-202H2.1
chr4_-_68829226 0.03 ENST00000396188.2
TMPRSS11A
transmembrane protease, serine 11A
chr15_+_79166065 0.03 ENST00000559690.1
ENST00000559158.1
MORF4L1
mortality factor 4 like 1
chr5_-_173217916 0.03 ENST00000523617.1
CTB-43E15.4
CTB-43E15.4
chr3_+_138327417 0.03 ENST00000338446.4
FAIM
Fas apoptotic inhibitory molecule

Network of associatons between targets according to the STRING database.

First level regulatory network of ISL2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.5 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.5 2.4 GO:0070980 biphenyl catabolic process(GO:0070980)
0.3 0.9 GO:1900158 negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.2 1.5 GO:0051552 flavone metabolic process(GO:0051552)
0.2 0.7 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.2 0.6 GO:0031247 actin rod assembly(GO:0031247)
0.2 0.6 GO:1903414 spleen trabecula formation(GO:0060345) iron cation export(GO:1903414) ferrous iron export(GO:1903988)
0.2 0.6 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.2 1.2 GO:1903899 lung goblet cell differentiation(GO:0060480) positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.2 0.5 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) response to iron ion starvation(GO:1990641)
0.2 0.5 GO:0061300 cerebellum vasculature development(GO:0061300)
0.1 2.0 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.1 0.3 GO:1903676 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.1 0.4 GO:0044537 regulation of circulating fibrinogen levels(GO:0044537)
0.1 1.4 GO:0001778 plasma membrane repair(GO:0001778)
0.1 0.3 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 0.5 GO:0015722 canalicular bile acid transport(GO:0015722)
0.1 0.5 GO:0050955 thermoception(GO:0050955)
0.1 0.8 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.1 0.6 GO:0098912 membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912)
0.1 0.3 GO:1904806 regulation of protein oxidation(GO:1904806) positive regulation of protein oxidation(GO:1904808)
0.1 0.3 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.1 0.3 GO:0036511 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.1 0.2 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.1 0.4 GO:0070475 rRNA base methylation(GO:0070475)
0.1 0.7 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 0.6 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.3 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 1.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.3 GO:0018032 protein amidation(GO:0018032)
0.0 0.1 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.0 0.5 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.3 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.0 0.2 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.9 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.9 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.3 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.1 GO:0046292 formaldehyde metabolic process(GO:0046292)
0.0 1.6 GO:0010107 potassium ion import(GO:0010107)
0.0 0.2 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 2.1 GO:0003382 epithelial cell morphogenesis(GO:0003382)
0.0 1.0 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.0 0.1 GO:0045208 MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209)
0.0 0.3 GO:0015705 iodide transport(GO:0015705)
0.0 0.4 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.1 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.5 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.4 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.2 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.3 GO:0036500 ATF6-mediated unfolded protein response(GO:0036500)
0.0 4.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.1 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.0 0.1 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.0 0.0 GO:0051389 positive regulation of long-term neuronal synaptic plasticity(GO:0048170) inactivation of MAPKK activity(GO:0051389)
0.0 0.1 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 0.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:0038170 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.0 0.4 GO:0006853 carnitine shuttle(GO:0006853)
0.0 0.4 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.4 GO:0015671 oxygen transport(GO:0015671)
0.0 0.1 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.0 0.3 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.1 GO:0006041 glucosamine metabolic process(GO:0006041)
0.0 0.1 GO:1901189 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.4 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.1 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.0 0.1 GO:0030035 microspike assembly(GO:0030035)
0.0 0.0 GO:0015785 UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.7 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.1 3.0 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 1.1 GO:0005579 membrane attack complex(GO:0005579)
0.1 1.7 GO:0031089 platelet dense granule lumen(GO:0031089)
0.1 0.3 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.1 0.5 GO:1990357 terminal web(GO:1990357)
0.1 0.6 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 2.1 GO:0030057 desmosome(GO:0030057)
0.0 0.3 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.1 GO:0002947 tumor necrosis factor receptor superfamily complex(GO:0002947)
0.0 0.5 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.7 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.5 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.3 GO:0044279 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.0 0.2 GO:1990246 uniplex complex(GO:1990246)
0.0 0.5 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.4 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.4 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.9 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)
0.0 0.9 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.4 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.2 GO:0061689 tricellular tight junction(GO:0061689)
0.0 1.1 GO:0002102 podosome(GO:0002102)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.1 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.3 GO:0043203 axon hillock(GO:0043203)
0.0 0.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.2 0.6 GO:0097689 iron channel activity(GO:0097689)
0.2 0.5 GO:0015432 bile acid-exporting ATPase activity(GO:0015432)
0.1 0.7 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 0.3 GO:1904854 proteasome core complex binding(GO:1904854)
0.1 0.6 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.1 0.3 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1 3.9 GO:0001972 retinoic acid binding(GO:0001972)
0.1 0.3 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 0.4 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.1 0.6 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.1 1.6 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.2 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.1 0.3 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.1 0.5 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 0.2 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.1 0.6 GO:0046790 virion binding(GO:0046790)
0.1 0.2 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.1 1.7 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.6 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.3 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.0 0.2 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.4 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.4 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.9 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.7 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.5 GO:1990459 beta-2-microglobulin binding(GO:0030881) transferrin receptor binding(GO:1990459)
0.0 0.9 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.9 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.3 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.1 GO:0018636 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086)
0.0 0.3 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 2.8 GO:0005179 hormone activity(GO:0005179)
0.0 0.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.3 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.4 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.7 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.5 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 0.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.7 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.0 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 2.5 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.7 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.9 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 2.5 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.6 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 1.6 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.9 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.5 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.7 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.5 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.5 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.4 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 1.1 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.9 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.6 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.4 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.2 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.3 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle