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Illumina Body Map 2
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Results for KLF8
Z-value: 1.90
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Transcription factors associated with KLF8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF8 | hg19_v2_chrX_+_56258844_56258882 | 0.12 | 5.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_+_22712087 Show fit | 8.11 |
ENST00000390294.2
|
immunoglobulin lambda variable 1-47 |
|
| chr22_+_22735135 Show fit | 6.98 |
ENST00000390297.2
|
immunoglobulin lambda variable 1-44 |
|
| chr14_-_106114739 Show fit | 5.31 |
ENST00000460164.1
|
RP11-731F5.2 |
|
| chr22_+_22764088 Show fit | 5.16 |
ENST00000390299.2
|
immunoglobulin lambda variable 1-40 |
|
| chr22_+_22676808 Show fit | 4.84 |
ENST00000390290.2
|
immunoglobulin lambda variable 1-51 |
|
| chr22_+_22385332 Show fit | 4.42 |
ENST00000390282.2
|
immunoglobulin lambda variable 4-69 |
|
| chr22_+_22681656 Show fit | 4.04 |
ENST00000390291.2
|
immunoglobulin lambda variable 1-50 (non-functional) |
|
| chr22_+_22786288 Show fit | 3.71 |
ENST00000390301.2
|
immunoglobulin lambda variable 1-36 |
|
| chr14_-_106209368 Show fit | 3.49 |
ENST00000390548.2
ENST00000390549.2 ENST00000390542.2 |
immunoglobulin heavy constant gamma 1 (G1m marker) |
|
| chr22_+_23089870 Show fit | 3.45 |
ENST00000390311.2
|
immunoglobulin lambda variable 3-16 |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF8
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 125.7 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.2 | 45.5 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.2 | 7.2 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.1 | 7.0 | GO:0031295 | T cell costimulation(GO:0031295) |
| 0.1 | 6.7 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.3 | 5.7 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.3 | 5.6 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 0.2 | 4.9 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.0 | 4.3 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 1.4 | 4.2 | GO:0002522 | leukocyte migration involved in immune response(GO:0002522) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 51.0 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 42.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 25.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 19.7 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 11.4 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 10.3 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 9.1 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 7.6 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.3 | 7.4 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.0 | 6.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 120.7 | GO:0003823 | antigen binding(GO:0003823) |
| 0.9 | 56.2 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.2 | 12.0 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.3 | 9.1 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.0 | 8.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 8.0 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.1 | 7.8 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.2 | 7.6 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.6 | 6.5 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
| 0.0 | 6.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.0 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.2 | 16.3 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 13.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 11.0 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 9.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 8.3 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.2 | 7.1 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.2 | 6.9 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 5.2 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 4.8 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.9 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 10.7 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 8.8 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 8.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 7.3 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.3 | 6.0 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 5.6 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.0 | 5.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.3 | 5.4 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.1 | 5.3 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |