ISMARA results: LEF1

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Illumina Body Map 2

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Results for LEF1

Z-value: 1.92

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Transcription factors associated with LEF1

Gene Symbol	Gene ID	Gene Info
LEF1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000138795.5	lymphoid enhancer binding factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
LEF1	hg19_v2_chr4_-_109087906_109087953	-0.46	7.8e-03	Click!

Activity profile of LEF1 motif

Sorted Z-values of LEF1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_-_124553437 Show fit	7.25	ENST00000517956.1 ENST00000443022.2	FBXO32 Ensembl NCBI GeneCards UniProt NextProt Show fit	F-box protein 32
chr5_+_140480083 Show fit	7.06	ENST00000231130.2	PCDHB3 Ensembl NCBI GeneCards UniProt NextProt Show fit	protocadherin beta 3
chr10_+_123970670 Show fit	6.63	ENST00000496913.2	TACC2 Ensembl NCBI GeneCards UniProt NextProt Show fit	transforming, acidic coiled-coil containing protein 2
chr11_-_111794446 Show fit	6.09	ENST00000527950.1	CRYAB Ensembl NCBI GeneCards UniProt NextProt Show fit	crystallin, alpha B
chr7_-_27219849 Show fit	5.96	ENST00000396344.4	HOXA10 Ensembl NCBI GeneCards UniProt NextProt Show fit	homeobox A10
chr1_+_78383813 Show fit	5.56	ENST00000342754.5	NEXN Ensembl NCBI GeneCards UniProt NextProt Show fit	nexilin (F actin binding protein)
chr3_+_173302222 Show fit	5.04	ENST00000361589.4	NLGN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	neuroligin 1
chr10_+_54074033 Show fit	4.92	ENST00000373970.3	DKK1 Ensembl NCBI GeneCards UniProt NextProt Show fit	dickkopf WNT signaling pathway inhibitor 1
chr3_-_149375783 Show fit	4.68	ENST00000467467.1 ENST00000460517.1 ENST00000360632.3	WWTR1 Ensembl NCBI GeneCards UniProt NextProt Show fit	WW domain containing transcription regulator 1
chr21_+_40823753 Show fit	4.67	ENST00000333634.4	SH3BGR Ensembl NCBI GeneCards UniProt NextProt Show fit	SH3 domain binding glutamic acid-rich protein

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of LEF1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	21.1	GO:0009954	proximal/distal pattern formation(GO:0009954)
1.5	20.4	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1	15.6	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3	12.1	GO:0001573	ganglioside metabolic process(GO:0001573)
0.2	11.4	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
0.6	11.1	GO:0046069	cGMP catabolic process(GO:0046069)
0.1	8.9	GO:0035329	hippo signaling(GO:0035329)
0.4	8.4	GO:0071420	cellular response to histamine(GO:0071420)
0.1	8.4	GO:0021987	cerebral cortex development(GO:0021987)
0.0	8.2	GO:0045727	positive regulation of translation(GO:0045727)

Showing 1 to 10 of 267 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	39.3	GO:0030018	Z disc(GO:0030018)
0.0	28.3	GO:0043025	neuronal cell body(GO:0043025)
0.0	17.2	GO:0045211	postsynaptic membrane(GO:0045211)
0.0	11.2	GO:0031225	anchored component of membrane(GO:0031225)
0.2	10.7	GO:0031941	filamentous actin(GO:0031941)
0.1	9.7	GO:0043296	apical junction complex(GO:0043296)
0.1	9.3	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.0	9.3	GO:0016323	basolateral plasma membrane(GO:0016323)
0.1	9.2	GO:0016328	lateral plasma membrane(GO:0016328)
0.3	8.6	GO:0031045	dense core granule(GO:0031045)

Showing 1 to 10 of 103 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	25.9	GO:0008307	structural constituent of muscle(GO:0008307)
0.1	12.6	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.1	11.4	GO:0001618	virus receptor activity(GO:0001618)
1.6	11.1	GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0	10.0	GO:0003714	transcription corepressor activity(GO:0003714)
0.2	7.8	GO:0071837	HMG box domain binding(GO:0071837)
0.6	7.7	GO:0035374	chondroitin sulfate binding(GO:0035374)
0.1	7.2	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1	7.2	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.7	7.0	GO:0004111	creatine kinase activity(GO:0004111)

Showing 1 to 10 of 190 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	20.5	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	9.0	PID BMP PATHWAY	BMP receptor signaling
0.1	8.9	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.2	8.0	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.5	7.7	PID FGF PATHWAY	FGF signaling pathway
0.1	6.6	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.2	6.3	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.2	6.3	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	6.1	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.1	4.6	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events

Showing 1 to 10 of 42 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	18.3	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.3	15.0	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.2	12.1	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.2	11.9	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.2	11.9	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	8.7	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.2	8.4	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.0	7.0	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.2	6.3	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.3	5.7	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors

Showing 1 to 10 of 56 entries

Results for LEF1

Z-value: 1.92

Motif logo

Transcription factors associated with LEF1

Activity-expression correlation:

Activity profile of LEF1 motif

Sorted Z-values of LEF1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of LEF1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: