ISMARA results: MAFA

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Illumina Body Map 2

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Results for MAFA

Z-value: 0.95

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Transcription factors associated with MAFA

Gene Symbol	Gene ID	Gene Info
MAFA Ensembl NCBI GeneCards UniProt NextProt	ENSG00000182759.3	MAF bZIP transcription factor A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MAFA	hg19_v2_chr8_-_144512576_144512576	-0.28	1.1e-01	Click!

Activity profile of MAFA motif

Sorted Z-values of MAFA motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr22_+_22730353 Show fit	2.80	ENST00000390296.2	IGLV5-45 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda variable 5-45
chr22_+_22697537 Show fit	2.57	ENST00000427632.2	IGLV9-49 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda variable 9-49
chr22_+_22764088 Show fit	2.47	ENST00000390299.2	IGLV1-40 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda variable 1-40
chr22_+_23063100 Show fit	2.16	ENST00000390309.2	IGLV3-19 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda variable 3-19
chr22_-_30662828 Show fit	1.90	ENST00000403463.1 ENST00000215781.2	OSM Ensembl NCBI GeneCards UniProt NextProt Show fit	oncostatin M
chr12_-_22487588 Show fit	1.74	ENST00000381424.3	ST8SIA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr16_+_28996572 Show fit	1.71	ENST00000360872.5 ENST00000566177.1 ENST00000354453.4	LAT Ensembl NCBI GeneCards UniProt NextProt Show fit	linker for activation of T cells
chr16_+_28996364 Show fit	1.61	ENST00000564277.1	LAT Ensembl NCBI GeneCards UniProt NextProt Show fit	linker for activation of T cells
chr9_-_130712995 Show fit	1.57	ENST00000373084.4	FAM102A Ensembl NCBI GeneCards UniProt NextProt Show fit	family with sequence similarity 102, member A
chr1_+_200842083 Show fit	1.56	ENST00000304244.2	GPR25 Ensembl NCBI GeneCards UniProt NextProt Show fit	G protein-coupled receptor 25

Showing 1 to 10 of 199 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of MAFA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.1	GO:0002377	immunoglobulin production(GO:0002377)
0.0	5.9	GO:0030449	regulation of complement activation(GO:0030449)
0.0	3.3	GO:0043303	mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303)
0.1	3.1	GO:0006688	glycosphingolipid biosynthetic process(GO:0006688)
0.0	3.0	GO:0050919	negative chemotaxis(GO:0050919)
0.6	2.6	GO:1905229	cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)
0.0	2.3	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.3	2.0	GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.2	2.0	GO:0031914	negative regulation of synaptic plasticity(GO:0031914)
0.0	2.0	GO:0031338	regulation of vesicle fusion(GO:0031338)

Showing 1 to 10 of 53 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.3	GO:0016323	basolateral plasma membrane(GO:0016323)
0.1	3.3	GO:0042629	mast cell granule(GO:0042629)
0.2	2.0	GO:0060200	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0	1.8	GO:0044295	axonal growth cone(GO:0044295)
0.1	1.6	GO:0042599	lamellar body(GO:0042599)
0.3	1.3	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	1.3	GO:0000930	gamma-tubulin complex(GO:0000930)
0.0	1.3	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1	0.9	GO:0005744	mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0	0.9	GO:0034451	centriolar satellite(GO:0034451)

Showing 1 to 10 of 22 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	11.3	GO:0003823	antigen binding(GO:0003823)
0.1	3.9	GO:0005452	inorganic anion exchanger activity(GO:0005452)
0.0	3.3	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.3	3.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1	3.1	GO:0038191	neuropilin binding(GO:0038191)
0.1	2.8	GO:0016805	dipeptidase activity(GO:0016805)
0.4	2.6	GO:0004996	thyroid-stimulating hormone receptor activity(GO:0004996)
0.2	2.0	GO:0030348	syntaxin-3 binding(GO:0030348)
0.2	1.3	GO:0004359	glutaminase activity(GO:0004359)
0.1	1.3	GO:0005176	ErbB-2 class receptor binding(GO:0005176)

Showing 1 to 10 of 50 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	3.3	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	2.6	PID ARF6 PATHWAY	Arf6 signaling events
0.0	2.0	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.0	1.9	PID IL3 PATHWAY	IL3-mediated signaling events
0.0	1.8	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	1.3	PID EPHA FWDPATHWAY	EPHA forward signaling
0.0	1.0	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	0.9	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	0.7	PID RAS PATHWAY	Regulation of Ras family activation

Showing 1 to 10 of 12 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.2	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.2	2.6	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors
0.0	2.6	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.1	2.5	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.1	2.3	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.0	1.8	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	1.6	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.1	1.3	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.1	1.1	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.0	1.0	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)

Showing 1 to 10 of 19 entries

Results for MAFA

Z-value: 0.95

Motif logo

Transcription factors associated with MAFA

Activity-expression correlation:

Activity profile of MAFA motif

Sorted Z-values of MAFA motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of MAFA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: