ISMARA results: MECP2

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Illumina Body Map 2

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Results for MECP2

Z-value: 2.39

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Transcription factors associated with MECP2

Gene Symbol	Gene ID	Gene Info
MECP2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000169057.15	methyl-CpG binding protein 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MECP2	hg19_v2_chrX_-_153363188_153363212	-0.14	4.6e-01	Click!

Activity profile of MECP2 motif

Sorted Z-values of MECP2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_-_2050852 Show fit	4.20	ENST00000541165.1 ENST00000591601.1	MKNK2 Ensembl NCBI GeneCards UniProt NextProt Show fit	MAP kinase interacting serine/threonine kinase 2
chr7_-_139477500 Show fit	3.97	ENST00000406875.3 ENST00000428878.2	HIPK2 Ensembl NCBI GeneCards UniProt NextProt Show fit	homeodomain interacting protein kinase 2
chr10_+_6186847 Show fit	3.64	ENST00000536985.1 ENST00000379789.4	PFKFB3 Ensembl NCBI GeneCards UniProt NextProt Show fit	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr19_+_35521616 Show fit	3.24	ENST00000595652.1	SCN1B Ensembl NCBI GeneCards UniProt NextProt Show fit	sodium channel, voltage-gated, type I, beta subunit
chr20_+_48807351 Show fit	3.22	ENST00000303004.3	CEBPB Ensembl NCBI GeneCards UniProt NextProt Show fit	CCAAT/enhancer binding protein (C/EBP), beta
chr9_+_137218362 Show fit	3.14	ENST00000481739.1	RXRA Ensembl NCBI GeneCards UniProt NextProt Show fit	retinoid X receptor, alpha
chr19_-_33793430 Show fit	3.02	ENST00000498907.2	CEBPA Ensembl NCBI GeneCards UniProt NextProt Show fit	CCAAT/enhancer binding protein (C/EBP), alpha
chr9_-_134615326 Show fit	2.97	ENST00000438647.1	RAPGEF1 Ensembl NCBI GeneCards UniProt NextProt Show fit	Rap guanine nucleotide exchange factor (GEF) 1
chr16_+_21610879 Show fit	2.91	ENST00000396014.4	METTL9 Ensembl NCBI GeneCards UniProt NextProt Show fit	methyltransferase like 9
chr20_+_57466461 Show fit	2.82	ENST00000306090.10	GNAS Ensembl NCBI GeneCards UniProt NextProt Show fit	GNAS complex locus

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of MECP2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	73.8	GO:0042119	neutrophil activation(GO:0042119)
0.3	39.5	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.2	21.4	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.1	16.6	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.4	14.8	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.2	14.5	GO:0032481	positive regulation of type I interferon production(GO:0032481)
0.2	14.4	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
0.2	11.8	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1	10.6	GO:0038095	Fc-epsilon receptor signaling pathway(GO:0038095)
0.1	10.0	GO:0006413	translational initiation(GO:0006413)

Showing 1 to 10 of 1,516 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	100.2	GO:0005739	mitochondrion(GO:0005739)
0.0	87.2	GO:0005654	nucleoplasm(GO:0005654)
0.1	57.3	GO:0005759	mitochondrial matrix(GO:0005759)
0.1	42.6	GO:0005765	lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.2	36.0	GO:0016605	PML body(GO:0016605)
0.2	35.0	GO:1904813	ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.3	31.2	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.1	30.6	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.1	29.3	GO:0000790	nuclear chromatin(GO:0000790)
0.2	27.4	GO:0035579	specific granule membrane(GO:0035579)

Showing 1 to 10 of 487 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	49.1	GO:0003735	structural constituent of ribosome(GO:0003735)
0.1	31.0	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
0.0	29.3	GO:0003723	RNA binding(GO:0003723)
0.2	19.0	GO:0019843	rRNA binding(GO:0019843)
0.0	17.2	GO:0003924	GTPase activity(GO:0003924)
0.0	15.9	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.2	14.3	GO:0003743	translation initiation factor activity(GO:0003743)
0.1	14.3	GO:0003725	double-stranded RNA binding(GO:0003725)
0.6	13.9	GO:0009931	calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0	13.8	GO:0003714	transcription corepressor activity(GO:0003714)

Showing 1 to 10 of 927 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	28.3	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.2	25.3	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.3	21.4	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.3	19.9	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.2	19.8	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.3	19.7	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.3	16.9	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.3	16.7	PID EPO PATHWAY	EPO signaling pathway
0.2	16.0	PID P53 REGULATION PATHWAY	p53 pathway
0.2	13.2	PID CDC42 REG PATHWAY	Regulation of CDC42 activity

Showing 1 to 10 of 129 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	54.7	REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.2	21.2	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.5	19.7	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	19.3	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.2	18.4	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.2	17.2	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.3	16.5	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
0.4	16.2	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.3	14.5	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.3	14.4	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL

Showing 1 to 10 of 236 entries

Results for MECP2

Z-value: 2.39

Motif logo

Transcription factors associated with MECP2

Activity-expression correlation:

Activity profile of MECP2 motif

Sorted Z-values of MECP2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of MECP2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: