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Illumina Body Map 2

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Results for MEF2C

Z-value: 4.54

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Transcription factors associated with MEF2C

Gene Symbol Gene ID Gene Info
MEF2C
ENSG00000081189.9 myocyte enhancer factor 2C

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MEF2Chg19_v2_chr5_-_88120151_881201770.373.7e-02Click!

Activity profile of MEF2C motif

Sorted Z-values of MEF2C motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_19223523 55.51 ENST00000265968.3
CSRP3
cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr12_-_111358372 53.49 ENST00000548438.1
ENST00000228841.8
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr3_-_39234074 48.18 ENST00000340369.3
ENST00000421646.1
ENST00000396251.1
XIRP1
xin actin-binding repeat containing 1
chr1_-_201391149 47.32 ENST00000555948.1
ENST00000556362.1
TNNI1
troponin I type 1 (skeletal, slow)
chr5_+_191592 45.79 ENST00000328278.3
LRRC14B
leucine rich repeat containing 14B
chr17_+_37821593 45.79 ENST00000578283.1
TCAP
titin-cap
chr6_-_123958111 44.31 ENST00000542443.1
TRDN
triadin
chr6_-_123957942 42.66 ENST00000398178.3
TRDN
triadin
chr7_-_113559104 42.38 ENST00000284601.3
PPP1R3A
protein phosphatase 1, regulatory subunit 3A
chr22_-_36013368 41.06 ENST00000442617.1
ENST00000397326.2
ENST00000397328.1
ENST00000451685.1
MB
myoglobin
chr6_-_123958051 40.91 ENST00000546248.1
TRDN
triadin
chr2_+_168043793 37.22 ENST00000409273.1
ENST00000409605.1
XIRP2
xin actin-binding repeat containing 2
chr22_+_26138108 36.19 ENST00000536101.1
ENST00000335473.7
ENST00000407587.2
MYO18B
myosin XVIIIB
chr10_-_75410771 35.77 ENST00000372873.4
SYNPO2L
synaptopodin 2-like
chr6_-_123958141 34.79 ENST00000334268.4
TRDN
triadin
chr10_+_50507232 34.18 ENST00000374144.3
C10orf71
chromosome 10 open reading frame 71
chr16_-_31439735 32.75 ENST00000287490.4
COX6A2
cytochrome c oxidase subunit VIa polypeptide 2
chr10_+_50507181 31.93 ENST00000323868.4
C10orf71
chromosome 10 open reading frame 71
chr1_-_26394114 30.40 ENST00000374272.3
TRIM63
tripartite motif containing 63, E3 ubiquitin protein ligase
chr11_+_1942580 30.20 ENST00000381558.1
TNNT3
troponin T type 3 (skeletal, fast)
chr2_+_170366203 29.01 ENST00000284669.1
KLHL41
kelch-like family member 41
chr2_+_88367299 28.96 ENST00000419482.2
ENST00000444564.2
SMYD1
SET and MYND domain containing 1
chr3_-_52486841 28.90 ENST00000496590.1
TNNC1
troponin C type 1 (slow)
chr1_-_917497 28.64 ENST00000433179.2
C1orf170
chromosome 1 open reading frame 170
chr4_+_120056939 27.87 ENST00000307128.5
MYOZ2
myozenin 2
chr10_-_115423792 27.08 ENST00000369360.3
ENST00000360478.3
ENST00000359988.3
ENST00000369358.4
NRAP
nebulin-related anchoring protein
chr10_-_75415825 26.83 ENST00000394810.2
SYNPO2L
synaptopodin 2-like
chr1_+_145413268 26.46 ENST00000421822.2
ENST00000336751.5
ENST00000497365.1
ENST00000475797.1
HFE2
hemochromatosis type 2 (juvenile)
chr2_-_211168332 25.78 ENST00000341685.4
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr1_+_228395755 25.69 ENST00000284548.11
ENST00000570156.2
ENST00000422127.1
ENST00000366707.4
ENST00000366709.4
OBSCN
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
chr17_+_4855053 25.43 ENST00000518175.1
ENO3
enolase 3 (beta, muscle)
chr2_+_88367368 25.35 ENST00000438570.1
SMYD1
SET and MYND domain containing 1
chrX_-_15332665 25.03 ENST00000537676.1
ENST00000344384.4
ASB11
ankyrin repeat and SOCS box containing 11
chr1_-_917466 24.74 ENST00000341290.2
C1orf170
chromosome 1 open reading frame 170
chr14_-_23877474 24.47 ENST00000405093.3
MYH6
myosin, heavy chain 6, cardiac muscle, alpha
chr5_+_53751445 24.32 ENST00000302005.1
HSPB3
heat shock 27kDa protein 3
chr17_-_9694614 22.46 ENST00000330255.5
ENST00000571134.1
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr11_+_1940925 21.96 ENST00000453458.1
ENST00000381557.2
ENST00000381589.3
ENST00000381579.3
ENST00000381563.4
ENST00000344578.4
TNNT3
troponin T type 3 (skeletal, fast)
chr11_+_1860200 21.37 ENST00000381911.1
TNNI2
troponin I type 2 (skeletal, fast)
chr11_+_1940786 20.99 ENST00000278317.6
ENST00000381561.4
ENST00000381548.3
ENST00000360603.3
ENST00000381549.3
TNNT3
troponin T type 3 (skeletal, fast)
chr12_+_101962128 20.61 ENST00000550514.1
MYBPC1
myosin binding protein C, slow type
chr3_-_46904946 20.37 ENST00000292327.4
MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr10_+_88428370 20.34 ENST00000372066.3
ENST00000263066.6
ENST00000372056.4
ENST00000310944.6
ENST00000361373.4
ENST00000542786.1
LDB3
LIM domain binding 3
chr3_-_46904918 20.26 ENST00000395869.1
MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr8_+_1993152 19.97 ENST00000262113.4
MYOM2
myomesin 2
chr2_+_239047337 19.00 ENST00000409223.1
ENST00000305959.4
KLHL30
kelch-like family member 30
chr1_+_160160283 18.89 ENST00000368079.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr7_-_44105158 18.84 ENST00000297283.3
PGAM2
phosphoglycerate mutase 2 (muscle)
chr1_+_160160346 18.81 ENST00000368078.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr8_-_33457453 18.28 ENST00000523956.1
ENST00000256261.4
DUSP26
dual specificity phosphatase 26 (putative)
chr8_+_1993173 18.19 ENST00000523438.1
MYOM2
myomesin 2
chr7_-_150884332 18.00 ENST00000275838.1
ENST00000422024.1
ENST00000434669.1
ASB10
ankyrin repeat and SOCS box containing 10
chr1_-_201390846 17.77 ENST00000367312.1
ENST00000555340.2
ENST00000361379.4
TNNI1
troponin I type 1 (skeletal, slow)
chr1_-_116311402 17.41 ENST00000261448.5
CASQ2
calsequestrin 2 (cardiac muscle)
chr1_-_116311323 17.26 ENST00000456138.2
CASQ2
calsequestrin 2 (cardiac muscle)
chr11_+_1860832 17.00 ENST00000252898.7
TNNI2
troponin I type 2 (skeletal, fast)
chr10_+_88428206 16.08 ENST00000429277.2
ENST00000458213.2
ENST00000352360.5
LDB3
LIM domain binding 3
chr1_-_31845914 16.00 ENST00000373713.2
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr16_+_31225337 15.98 ENST00000322122.3
TRIM72
tripartite motif containing 72
chr20_+_61147651 15.76 ENST00000370527.3
ENST00000370524.2
C20orf166
chromosome 20 open reading frame 166
chr17_-_27949911 15.68 ENST00000492276.2
ENST00000345068.5
ENST00000584602.1
CORO6
coronin 6
chr18_-_3219847 15.55 ENST00000261606.7
MYOM1
myomesin 1
chr2_-_179537145 15.50 ENST00000448510.2
TTN
titin
chr3_+_135741576 15.37 ENST00000334546.2
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chrX_-_63450480 15.16 ENST00000362002.2
ASB12
ankyrin repeat and SOCS box containing 12
chr7_-_150884873 15.13 ENST00000377867.3
ASB10
ankyrin repeat and SOCS box containing 10
chr11_+_1860682 14.90 ENST00000381906.1
TNNI2
troponin I type 2 (skeletal, fast)
chr18_-_3220106 14.54 ENST00000356443.4
ENST00000400569.3
MYOM1
myomesin 1
chr1_-_24438664 14.48 ENST00000374434.3
ENST00000330966.7
ENST00000329601.7
MYOM3
myomesin 3
chrX_+_135279179 14.35 ENST00000370676.3
FHL1
four and a half LIM domains 1
chr16_+_7382745 14.31 ENST00000436368.2
ENST00000311745.5
ENST00000355637.4
ENST00000340209.4
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr3_+_42727011 14.07 ENST00000287777.4
KLHL40
kelch-like family member 40
chr12_-_49393092 13.91 ENST00000421952.2
DDN
dendrin
chr6_-_45983581 13.91 ENST00000339561.6
CLIC5
chloride intracellular channel 5
chrX_+_153046456 13.82 ENST00000393786.3
ENST00000370104.1
ENST00000370108.3
ENST00000370101.3
ENST00000430541.1
ENST00000370100.1
SRPK3
SRSF protein kinase 3
chr15_+_65369082 13.42 ENST00000432196.2
KBTBD13
kelch repeat and BTB (POZ) domain containing 13
chr14_-_94421923 13.38 ENST00000555507.1
ASB2
ankyrin repeat and SOCS box containing 2
chr1_-_100643765 13.24 ENST00000370137.1
ENST00000370138.1
ENST00000342895.3
LRRC39
leucine rich repeat containing 39
chr11_+_3666335 13.21 ENST00000250693.1
ART1
ADP-ribosyltransferase 1
chr6_-_45983549 13.20 ENST00000544153.1
CLIC5
chloride intracellular channel 5
chr8_-_70745575 12.43 ENST00000524945.1
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr3_+_179370517 12.35 ENST00000263966.3
USP13
ubiquitin specific peptidase 13 (isopeptidase T-3)
chr11_-_47374246 12.34 ENST00000545968.1
ENST00000399249.2
ENST00000256993.4
MYBPC3
myosin binding protein C, cardiac
chr4_+_114066764 12.32 ENST00000511380.1
ANK2
ankyrin 2, neuronal
chr14_-_94421605 11.94 ENST00000556062.1
ASB2
ankyrin repeat and SOCS box containing 2
chr12_+_109569155 11.93 ENST00000539864.1
ACACB
acetyl-CoA carboxylase beta
chr10_-_69455873 11.83 ENST00000433211.2
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr5_-_16509101 11.53 ENST00000399793.2
FAM134B
family with sequence similarity 134, member B
chr6_-_76203345 11.53 ENST00000393004.2
FILIP1
filamin A interacting protein 1
chr22_-_51017084 11.47 ENST00000360719.2
ENST00000457250.1
ENST00000440709.1
CPT1B
carnitine palmitoyltransferase 1B (muscle)
chrX_+_135278908 11.47 ENST00000539015.1
ENST00000370683.1
FHL1
four and a half LIM domains 1
chr17_+_7184986 11.45 ENST00000317370.8
ENST00000571308.1
SLC2A4
solute carrier family 2 (facilitated glucose transporter), member 4
chr6_-_76203454 11.25 ENST00000237172.7
FILIP1
filamin A interacting protein 1
chr7_+_80267949 11.22 ENST00000482059.2
CD36
CD36 molecule (thrombospondin receptor)
chr22_-_51016846 11.19 ENST00000312108.7
ENST00000395650.2
CPT1B
carnitine palmitoyltransferase 1B (muscle)
chr2_+_220299547 11.00 ENST00000312358.7
SPEG
SPEG complex locus
chr12_-_57644952 10.82 ENST00000554578.1
ENST00000546246.2
ENST00000553489.1
ENST00000332782.2
STAC3
SH3 and cysteine rich domain 3
chr17_+_65040678 10.62 ENST00000226021.3
CACNG1
calcium channel, voltage-dependent, gamma subunit 1
chr11_+_57308979 10.59 ENST00000457912.1
SMTNL1
smoothelin-like 1
chr7_+_80231466 10.55 ENST00000309881.7
ENST00000534394.1
CD36
CD36 molecule (thrombospondin receptor)
chr7_-_56160625 10.52 ENST00000446428.1
ENST00000432123.1
ENST00000452681.2
ENST00000537360.1
PHKG1
phosphorylase kinase, gamma 1 (muscle)
chr4_-_186697044 10.43 ENST00000437304.2
SORBS2
sorbin and SH3 domain containing 2
chr7_+_80267973 10.20 ENST00000394788.3
ENST00000447544.2
CD36
CD36 molecule (thrombospondin receptor)
chr9_-_33402506 10.02 ENST00000377425.4
ENST00000537089.1
ENST00000297988.1
ENST00000539936.1
ENST00000541274.1
AQP7
aquaporin 7
chr1_-_115238207 9.87 ENST00000520113.2
ENST00000369538.3
ENST00000353928.6
AMPD1
adenosine monophosphate deaminase 1
chr15_-_83474806 9.86 ENST00000541889.1
ENST00000334574.8
ENST00000561368.1
FSD2
fibronectin type III and SPRY domain containing 2
chr16_+_6069072 9.78 ENST00000547605.1
ENST00000550418.1
ENST00000553186.1
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr3_+_8543533 9.76 ENST00000454244.1
LMCD1
LIM and cysteine-rich domains 1
chr13_+_76378305 9.74 ENST00000526371.1
ENST00000526528.1
LMO7
LIM domain 7
chr3_+_8543393 9.52 ENST00000157600.3
ENST00000415597.1
ENST00000535732.1
LMCD1
LIM and cysteine-rich domains 1
chr2_+_103378472 9.47 ENST00000412401.2
TMEM182
transmembrane protein 182
chr7_-_56160666 9.45 ENST00000297373.2
PHKG1
phosphorylase kinase, gamma 1 (muscle)
chr4_+_110834033 9.19 ENST00000509793.1
ENST00000265171.5
EGF
epidermal growth factor
chr3_-_192445289 9.16 ENST00000430714.1
ENST00000418610.1
ENST00000448795.1
ENST00000445105.2
FGF12
fibroblast growth factor 12
chr1_-_201346761 8.94 ENST00000455702.1
ENST00000422165.1
ENST00000367318.5
ENST00000367320.2
ENST00000438742.1
ENST00000412633.1
ENST00000458432.2
ENST00000421663.2
ENST00000367322.1
ENST00000509001.1
TNNT2
troponin T type 2 (cardiac)
chr17_-_10276319 8.73 ENST00000252172.4
ENST00000418404.3
MYH13
myosin, heavy chain 13, skeletal muscle
chr19_-_49576198 8.59 ENST00000221444.1
KCNA7
potassium voltage-gated channel, shaker-related subfamily, member 7
chr10_-_29923893 8.57 ENST00000355867.4
SVIL
supervillin
chr4_+_169418255 8.53 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr21_+_35552978 8.35 ENST00000428914.2
ENST00000609062.1
ENST00000609947.1
LINC00310
long intergenic non-protein coding RNA 310
chr4_+_3465027 8.30 ENST00000389653.2
ENST00000507039.1
ENST00000340083.5
DOK7
docking protein 7
chr3_+_8543561 8.00 ENST00000397386.3
LMCD1
LIM and cysteine-rich domains 1
chr7_-_82073031 8.00 ENST00000356253.5
ENST00000423588.1
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr7_-_82073109 7.56 ENST00000356860.3
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr7_+_95115210 7.41 ENST00000428113.1
ENST00000325885.5
ASB4
ankyrin repeat and SOCS box containing 4
chr15_+_42651691 7.31 ENST00000357568.3
ENST00000349748.3
ENST00000318023.7
ENST00000397163.3
CAPN3
calpain 3, (p94)
chr2_-_237172988 7.14 ENST00000409749.3
ENST00000430053.1
ASB18
ankyrin repeat and SOCS box containing 18
chr19_+_35630344 7.01 ENST00000455515.2
FXYD1
FXYD domain containing ion transport regulator 1
chr3_+_127634069 6.82 ENST00000405109.1
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr10_-_61900762 6.80 ENST00000355288.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr7_+_143013198 6.63 ENST00000343257.2
CLCN1
chloride channel, voltage-sensitive 1
chr13_+_76378407 6.60 ENST00000447038.1
LMO7
LIM domain 7
chr3_+_127634312 6.52 ENST00000407609.3
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr5_+_96077888 6.51 ENST00000509259.1
ENST00000503828.1
CAST
calpastatin
chr2_-_179914760 6.47 ENST00000420890.2
ENST00000409284.1
ENST00000443758.1
ENST00000446116.1
CCDC141
coiled-coil domain containing 141
chr12_-_70004942 6.29 ENST00000361484.3
LRRC10
leucine rich repeat containing 10
chr12_+_52431016 6.29 ENST00000553200.1
NR4A1
nuclear receptor subfamily 4, group A, member 1
chr17_-_10372875 6.07 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chr4_+_95373037 5.98 ENST00000359265.4
ENST00000437932.1
ENST00000380180.3
ENST00000318007.5
ENST00000450793.1
ENST00000538141.1
ENST00000317968.4
ENST00000512274.1
ENST00000503974.1
ENST00000504489.1
ENST00000542407.1
PDLIM5
PDZ and LIM domain 5
chr4_-_186696561 5.90 ENST00000445115.1
ENST00000451701.1
ENST00000457247.1
ENST00000435480.1
ENST00000425679.1
ENST00000457934.1
SORBS2
sorbin and SH3 domain containing 2
chr3_+_159570722 5.89 ENST00000482804.1
SCHIP1
schwannomin interacting protein 1
chr13_+_76378357 5.68 ENST00000489941.2
ENST00000525373.1
LMO7
LIM domain 7
chr1_-_205782304 5.63 ENST00000367137.3
SLC41A1
solute carrier family 41 (magnesium transporter), member 1
chr3_+_69812877 5.50 ENST00000457080.1
ENST00000328528.6
MITF
microphthalmia-associated transcription factor
chr4_-_186696636 5.42 ENST00000444771.1
SORBS2
sorbin and SH3 domain containing 2
chr5_-_142065223 5.42 ENST00000378046.1
FGF1
fibroblast growth factor 1 (acidic)
chr5_-_142065612 5.42 ENST00000360966.5
ENST00000411960.1
FGF1
fibroblast growth factor 1 (acidic)
chr13_+_76334567 5.38 ENST00000321797.8
LMO7
LIM domain 7
chr4_-_186696425 5.37 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
SORBS2
sorbin and SH3 domain containing 2
chr5_-_145252531 5.37 ENST00000377976.1
GRXCR2
glutaredoxin, cysteine rich 2
chr1_-_154164534 5.32 ENST00000271850.7
ENST00000368530.2
TPM3
tropomyosin 3
chr8_-_72268721 5.30 ENST00000419131.1
ENST00000388743.2
EYA1
eyes absent homolog 1 (Drosophila)
chr16_+_30076052 5.30 ENST00000563987.1
ALDOA
aldolase A, fructose-bisphosphate
chr16_+_30075463 5.23 ENST00000562168.1
ENST00000569545.1
ALDOA
aldolase A, fructose-bisphosphate
chr2_+_30569506 5.15 ENST00000421976.2
AC109642.1
AC109642.1
chr1_-_178838404 5.14 ENST00000444255.1
ANGPTL1
angiopoietin-like 1
chr14_-_104408645 5.12 ENST00000557640.1
RD3L
retinal degeneration 3-like
chr4_+_41614720 5.09 ENST00000509277.1
LIMCH1
LIM and calponin homology domains 1
chr16_+_30075595 5.07 ENST00000563060.2
ALDOA
aldolase A, fructose-bisphosphate
chr12_-_22094336 5.05 ENST00000326684.4
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr8_-_72268889 5.01 ENST00000388742.4
EYA1
eyes absent homolog 1 (Drosophila)
chr4_+_41362796 4.97 ENST00000508501.1
ENST00000512946.1
ENST00000313860.7
ENST00000512632.1
ENST00000512820.1
LIMCH1
LIM and calponin homology domains 1
chr19_+_35630022 4.95 ENST00000589209.1
FXYD1
FXYD domain containing ion transport regulator 1
chr3_+_35683651 4.94 ENST00000187397.4
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr9_+_70971815 4.85 ENST00000396392.1
ENST00000396396.1
PGM5
phosphoglucomutase 5
chr4_+_41614909 4.81 ENST00000509454.1
ENST00000396595.3
ENST00000381753.4
LIMCH1
LIM and calponin homology domains 1
chr3_+_138067521 4.79 ENST00000494949.1
MRAS
muscle RAS oncogene homolog
chr1_+_170633047 4.78 ENST00000239461.6
ENST00000497230.2
PRRX1
paired related homeobox 1
chr5_+_113391696 4.78 ENST00000512927.1
RP11-371M22.1
RP11-371M22.1
chr4_+_41362615 4.74 ENST00000509638.1
LIMCH1
LIM and calponin homology domains 1
chr2_-_100925967 4.73 ENST00000409647.1
LONRF2
LON peptidase N-terminal domain and ring finger 2
chr3_+_69928256 4.71 ENST00000394355.2
MITF
microphthalmia-associated transcription factor
chr4_-_23891658 4.70 ENST00000507380.1
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr2_+_182850743 4.70 ENST00000409702.1
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr12_-_22094159 4.60 ENST00000538350.1
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr13_+_76334795 4.56 ENST00000526202.1
ENST00000465261.2
LMO7
LIM domain 7
chr16_+_30075783 4.53 ENST00000412304.2
ALDOA
aldolase A, fructose-bisphosphate
chr7_+_75931861 4.48 ENST00000248553.6
HSPB1
heat shock 27kDa protein 1
chr11_+_12766583 4.38 ENST00000361985.2
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr18_+_3252206 4.36 ENST00000578562.2
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr17_-_79900255 4.35 ENST00000330655.3
ENST00000582198.1
MYADML2
PYCR1
myeloid-associated differentiation marker-like 2
pyrroline-5-carboxylate reductase 1
chr17_-_42188598 4.33 ENST00000591714.1
HDAC5
histone deacetylase 5
chr14_+_76776957 4.32 ENST00000512784.1
ESRRB
estrogen-related receptor beta
chr9_+_100263912 4.28 ENST00000259365.4
TMOD1
tropomodulin 1
chr3_+_138067314 4.21 ENST00000423968.2
MRAS
muscle RAS oncogene homolog
chr10_+_52751010 4.14 ENST00000373985.1
PRKG1
protein kinase, cGMP-dependent, type I
chr4_-_186696515 4.13 ENST00000456596.1
ENST00000414724.1
SORBS2
sorbin and SH3 domain containing 2
chr14_-_23652849 4.05 ENST00000316902.7
ENST00000469263.1
ENST00000525062.1
ENST00000524758.1
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr15_-_70994612 4.04 ENST00000558758.1
ENST00000379983.2
ENST00000560441.1
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr8_-_72268968 3.99 ENST00000388740.3
EYA1
eyes absent homolog 1 (Drosophila)
chrM_+_5824 3.94 ENST00000361624.2
MT-CO1
mitochondrially encoded cytochrome c oxidase I
chr15_+_78558523 3.90 ENST00000446172.2
DNAJA4
DnaJ (Hsp40) homolog, subfamily A, member 4
chr3_+_138067666 3.78 ENST00000475711.1
ENST00000464896.1
MRAS
muscle RAS oncogene homolog
chr19_+_35629702 3.76 ENST00000351325.4
FXYD1
FXYD domain containing ion transport regulator 1
chr18_+_3252265 3.75 ENST00000580887.1
ENST00000536605.1
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr10_-_14880002 3.75 ENST00000465530.1
CDNF
cerebral dopamine neurotrophic factor
chr1_+_74701062 3.68 ENST00000326637.3
TNNI3K
TNNI3 interacting kinase
chr10_+_63661053 3.67 ENST00000279873.7
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr15_+_63889577 3.62 ENST00000534939.1
ENST00000539570.3
FBXL22
F-box and leucine-rich repeat protein 22
chrX_-_138304939 3.58 ENST00000448673.1
FGF13
fibroblast growth factor 13

Network of associatons between targets according to the STRING database.

First level regulatory network of MEF2C

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
40.7 162.7 GO:1901846 positive regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901846)
14.6 116.8 GO:0035995 detection of muscle stretch(GO:0035995)
9.5 37.8 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
9.4 37.7 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
7.3 36.5 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
7.2 115.7 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
6.9 41.4 GO:0036309 protein localization to M-band(GO:0036309)
5.8 34.7 GO:0071313 cellular response to caffeine(GO:0071313)
5.1 41.1 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
4.9 53.5 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
4.7 18.8 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
4.6 18.3 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
4.1 12.4 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
3.8 65.1 GO:0014883 transition between fast and slow fiber(GO:0014883)
3.3 233.0 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
3.2 16.0 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
2.7 32.0 GO:2000332 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
2.0 14.1 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
2.0 11.9 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
2.0 15.7 GO:0010734 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
1.9 15.6 GO:0086048 membrane depolarization during bundle of His cell action potential(GO:0086048)
1.8 9.2 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
1.6 29.0 GO:0031272 regulation of pseudopodium assembly(GO:0031272)
1.5 27.1 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
1.5 54.3 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
1.4 36.7 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
1.3 14.3 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
1.3 8.9 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
1.3 13.8 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
1.2 10.5 GO:0015793 glycerol transport(GO:0015793)
1.1 9.2 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
1.1 21.3 GO:0006853 carnitine shuttle(GO:0006853)
1.1 4.5 GO:0099640 axo-dendritic protein transport(GO:0099640)
1.1 26.5 GO:0016540 protein autoprocessing(GO:0016540)
1.1 20.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
1.0 7.3 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
1.0 6.2 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650)
1.0 39.5 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
1.0 10.8 GO:0060681 branch elongation involved in ureteric bud branching(GO:0060681)
0.9 25.9 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.9 11.8 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.9 9.9 GO:0032264 IMP salvage(GO:0032264)
0.9 4.3 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.8 36.2 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.7 36.4 GO:0045214 sarcomere organization(GO:0045214)
0.7 4.1 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.6 3.2 GO:0015862 uridine transport(GO:0015862)
0.6 3.7 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.6 4.4 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.6 64.2 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.6 37.2 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.6 1.7 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.6 2.9 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.6 1.7 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.5 25.4 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.5 66.5 GO:0005977 glycogen metabolic process(GO:0005977)
0.5 2.9 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.5 4.8 GO:0051013 microtubule severing(GO:0051013)
0.5 6.6 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.5 11.6 GO:0003334 keratinocyte development(GO:0003334)
0.5 3.7 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.5 1.8 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.4 7.2 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.4 2.4 GO:0015840 urea transport(GO:0015840)
0.4 1.6 GO:1903028 positive regulation of opsonization(GO:1903028)
0.4 15.4 GO:0030239 myofibril assembly(GO:0030239)
0.4 26.1 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.3 2.1 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.3 4.1 GO:0044557 relaxation of smooth muscle(GO:0044557) relaxation of vascular smooth muscle(GO:0060087)
0.3 6.5 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.3 25.8 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.3 10.8 GO:0003009 skeletal muscle contraction(GO:0003009)
0.3 2.4 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.3 11.6 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.3 5.2 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051)
0.3 0.9 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.3 10.6 GO:0045907 positive regulation of vasoconstriction(GO:0045907)
0.3 13.2 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.2 1.4 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.2 2.6 GO:0071492 cellular response to UV-A(GO:0071492)
0.2 12.4 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.2 4.8 GO:0042474 middle ear morphogenesis(GO:0042474)
0.2 3.9 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.2 31.4 GO:0032091 negative regulation of protein binding(GO:0032091)
0.2 2.5 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.2 137.5 GO:0043687 post-translational protein modification(GO:0043687)
0.2 1.4 GO:0021564 vagus nerve development(GO:0021564)
0.2 11.8 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.2 2.2 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.2 13.8 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.1 8.3 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)
0.1 0.5 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.1 2.0 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.1 4.0 GO:0055013 cardiac muscle cell development(GO:0055013)
0.1 2.7 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.1 4.1 GO:0015695 organic cation transport(GO:0015695)
0.1 5.4 GO:0007605 sensory perception of sound(GO:0007605)
0.1 16.3 GO:0031032 actomyosin structure organization(GO:0031032)
0.1 4.7 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.1 3.3 GO:0060644 mammary gland epithelial cell differentiation(GO:0060644)
0.1 1.1 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.1 0.7 GO:0015838 quaternary ammonium group transport(GO:0015697) amino-acid betaine transport(GO:0015838)
0.1 8.1 GO:0070527 platelet aggregation(GO:0070527)
0.1 0.2 GO:0033058 directional locomotion(GO:0033058)
0.1 21.2 GO:0006986 response to unfolded protein(GO:0006986)
0.1 3.4 GO:0031529 ruffle organization(GO:0031529)
0.1 3.7 GO:0016577 histone demethylation(GO:0016577)
0.1 0.9 GO:1904424 regulation of GTP binding(GO:1904424)
0.1 3.1 GO:0007405 neuroblast proliferation(GO:0007405)
0.1 1.8 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.1 4.4 GO:0035329 hippo signaling(GO:0035329)
0.1 10.2 GO:0016925 protein sumoylation(GO:0016925)
0.1 1.7 GO:2000178 negative regulation of neural precursor cell proliferation(GO:2000178)
0.1 7.5 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 1.3 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.0 0.4 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.0 4.7 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 3.2 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.7 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.1 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 2.3 GO:0006941 striated muscle contraction(GO:0006941)
0.0 0.9 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.2 GO:0015692 lead ion transport(GO:0015692)
0.0 3.4 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 20.9 GO:0016567 protein ubiquitination(GO:0016567)
0.0 1.8 GO:1901222 regulation of NIK/NF-kappaB signaling(GO:1901222)
0.0 1.2 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.0 0.5 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.0 1.7 GO:0007044 cell-substrate junction assembly(GO:0007044)
0.0 0.4 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 0.7 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 2.1 GO:0050821 protein stabilization(GO:0050821)
0.0 1.5 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.8 GO:0090002 establishment of protein localization to plasma membrane(GO:0090002)
0.0 0.8 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.0 1.3 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.1 GO:0015684 ferrous iron transport(GO:0015684) ferrous iron transmembrane transport(GO:1903874)
0.0 1.2 GO:0031100 organ regeneration(GO:0031100)
0.0 2.1 GO:0007586 digestion(GO:0007586)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
15.2 197.4 GO:0030314 junctional membrane complex(GO:0030314)
10.6 42.4 GO:0005863 striated muscle myosin thick filament(GO:0005863)
9.6 229.4 GO:0005861 troponin complex(GO:0005861)
5.4 37.7 GO:0014802 terminal cisterna(GO:0014802)
4.5 194.4 GO:0005859 muscle myosin complex(GO:0005859)
4.5 27.1 GO:0005927 muscle tendon junction(GO:0005927)
4.1 53.5 GO:0097512 cardiac myofibril(GO:0097512)
3.6 25.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
3.3 32.7 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
3.1 131.5 GO:0031430 M band(GO:0031430)
2.0 36.7 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
2.0 20.0 GO:0005964 phosphorylase kinase complex(GO:0005964)
2.0 37.6 GO:0016461 unconventional myosin complex(GO:0016461)
1.9 11.4 GO:0032593 insulin-responsive compartment(GO:0032593)
1.7 26.5 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
1.5 11.8 GO:0005916 fascia adherens(GO:0005916)
1.4 338.6 GO:0030018 Z disc(GO:0030018)
1.4 14.1 GO:0031672 A band(GO:0031672)
1.2 9.6 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
1.2 15.6 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
1.1 5.7 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.8 37.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.7 32.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.7 4.4 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.7 48.2 GO:0031941 filamentous actin(GO:0031941)
0.7 5.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.6 15.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.5 13.9 GO:0032591 dendritic spine membrane(GO:0032591)
0.5 8.6 GO:0036449 microtubule minus-end(GO:0036449)
0.5 4.3 GO:0036379 myofilament(GO:0036379)
0.4 45.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 15.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.3 33.7 GO:0034707 chloride channel complex(GO:0034707)
0.3 3.2 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.3 4.3 GO:0032039 integrator complex(GO:0032039)
0.2 13.2 GO:0016528 sarcoplasm(GO:0016528)
0.2 10.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 2.6 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.2 75.5 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.2 6.1 GO:0097440 apical dendrite(GO:0097440)
0.2 6.3 GO:0030017 sarcomere(GO:0030017)
0.2 3.1 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 0.4 GO:0020003 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005)
0.1 6.6 GO:0016459 myosin complex(GO:0016459)
0.1 1.2 GO:0098642 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.1 2.0 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 1.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 5.4 GO:0032420 stereocilium(GO:0032420)
0.1 2.7 GO:0098827 endoplasmic reticulum subcompartment(GO:0098827)
0.1 2.9 GO:0001891 phagocytic cup(GO:0001891)
0.1 2.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 0.8 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 0.9 GO:0000322 storage vacuole(GO:0000322)
0.1 0.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 1.6 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 5.1 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 35.4 GO:0015629 actin cytoskeleton(GO:0015629)
0.1 1.7 GO:0005614 interstitial matrix(GO:0005614)
0.0 5.6 GO:0042383 sarcolemma(GO:0042383)
0.0 2.9 GO:0005771 multivesicular body(GO:0005771)
0.0 7.2 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 10.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 3.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 9.3 GO:0005802 trans-Golgi network(GO:0005802)
0.0 27.3 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.9 GO:0071564 npBAF complex(GO:0071564)
0.0 14.3 GO:0005924 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925)
0.0 2.4 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.2 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.0 2.4 GO:0030027 lamellipodium(GO:0030027)
0.0 2.4 GO:0016605 PML body(GO:0016605)
0.0 0.3 GO:0048786 presynaptic active zone(GO:0048786)
0.0 2.1 GO:0010008 endosome membrane(GO:0010008)
0.0 3.5 GO:0005730 nucleolus(GO:0005730)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
18.3 73.2 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
12.3 73.7 GO:0051373 FATZ binding(GO:0051373)
8.1 40.6 GO:0032038 myosin II heavy chain binding(GO:0032038)
6.5 71.0 GO:0031433 telethonin binding(GO:0031433)
6.0 190.7 GO:0051371 muscle alpha-actinin binding(GO:0051371)
5.9 41.5 GO:0031013 troponin I binding(GO:0031013)
5.3 16.0 GO:0070538 oleic acid binding(GO:0070538)
5.2 15.6 GO:0086057 voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057)
4.7 18.8 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
4.5 63.4 GO:0032036 myosin heavy chain binding(GO:0032036)
4.4 53.3 GO:0031014 troponin T binding(GO:0031014)
3.3 26.5 GO:0098821 BMP receptor activity(GO:0098821)
3.2 63.4 GO:0031432 titin binding(GO:0031432)
2.9 32.0 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
2.8 22.7 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
2.8 25.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
2.7 24.5 GO:0017018 myosin phosphatase activity(GO:0017018)
2.6 18.3 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
2.4 9.6 GO:0008281 sulfonylurea receptor activity(GO:0008281)
2.0 10.0 GO:0015254 glycerol channel activity(GO:0015254)
2.0 20.0 GO:0004689 phosphorylase kinase activity(GO:0004689)
2.0 11.9 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
1.7 20.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
1.5 12.4 GO:1904288 BAT3 complex binding(GO:1904288)
1.4 46.6 GO:0051393 alpha-actinin binding(GO:0051393)
1.3 29.7 GO:0005344 oxygen transporter activity(GO:0005344)
1.3 13.2 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
1.1 4.5 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
1.0 36.7 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
1.0 3.0 GO:0017130 poly(C) RNA binding(GO:0017130)
0.9 11.8 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.8 4.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.7 31.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.7 4.4 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.7 5.7 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.7 4.8 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.7 184.5 GO:0044325 ion channel binding(GO:0044325)
0.7 21.0 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.6 54.2 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.6 10.7 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.6 6.5 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.6 5.2 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.6 1.7 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.5 11.4 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.5 7.9 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.5 27.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.5 3.2 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.4 4.8 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.4 31.1 GO:0008307 structural constituent of muscle(GO:0008307)
0.4 2.0 GO:0004556 alpha-amylase activity(GO:0004556)
0.4 10.8 GO:0044548 S100 protein binding(GO:0044548)
0.4 16.2 GO:0000146 microfilament motor activity(GO:0000146)
0.4 2.7 GO:0031849 olfactory receptor binding(GO:0031849)
0.4 20.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.4 6.0 GO:0042805 actinin binding(GO:0042805)
0.3 33.2 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.3 250.7 GO:0003779 actin binding(GO:0003779)
0.3 4.1 GO:0019534 toxin transporter activity(GO:0019534)
0.3 1.7 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.3 4.7 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.3 201.6 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.2 12.4 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.2 5.6 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.2 2.7 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.2 6.6 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 2.2 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.2 10.6 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 0.4 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.1 6.4 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.1 3.4 GO:0071837 HMG box domain binding(GO:0071837)
0.1 2.0 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 4.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 10.2 GO:0070888 E-box binding(GO:0070888)
0.1 15.7 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 4.3 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 1.5 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 6.4 GO:0005158 insulin receptor binding(GO:0005158)
0.1 2.2 GO:0031702 angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702)
0.1 3.2 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 1.1 GO:0015266 protein channel activity(GO:0015266)
0.1 0.3 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.1 5.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 14.2 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 0.9 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.5 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.9 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 5.8 GO:0051082 unfolded protein binding(GO:0051082)
0.0 2.5 GO:0043022 ribosome binding(GO:0043022)
0.0 0.1 GO:0015056 corticotrophin-releasing factor receptor activity(GO:0015056)
0.0 1.3 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.2 GO:0015094 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 2.5 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.9 GO:0035257 nuclear hormone receptor binding(GO:0035257)
0.0 0.2 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 1.4 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.3 GO:0001968 fibronectin binding(GO:0001968)
0.0 2.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.0 1.7 GO:0043130 ubiquitin binding(GO:0043130)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 53.5 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.6 32.9 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.3 26.5 PID BMP PATHWAY BMP receptor signaling
0.2 21.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 27.6 PID RHOA REG PATHWAY Regulation of RhoA activity
0.2 6.3 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 6.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 16.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 5.7 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.1 2.2 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 10.4 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 4.9 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.1 8.2 PID FGF PATHWAY FGF signaling pathway
0.1 2.5 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.1 1.7 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.1 8.3 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 1.7 PID EPO PATHWAY EPO signaling pathway
0.0 4.5 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 1.9 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 2.9 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 3.2 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 0.9 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.7 PID AP1 PATHWAY AP-1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 376.6 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.9 56.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.8 34.6 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.7 10.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.6 20.0 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.6 10.8 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.4 11.4 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.4 9.9 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.3 2.9 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.3 138.4 REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION Genes involved in Class I MHC mediated antigen processing & presentation
0.3 9.2 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.3 26.5 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.3 26.7 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.2 10.2 REACTOME DEFENSINS Genes involved in Defensins
0.2 4.5 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.2 1.7 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.1 4.4 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.6 REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.1 7.2 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 8.6 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.0 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 5.6 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 3.2 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 4.1 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 1.7 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 4.7 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 0.4 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 3.2 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.8 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 2.0 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.8 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 2.9 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.3 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 3.9 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.9 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 1.1 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.2 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.4 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation