ISMARA results: MEIS2

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Illumina Body Map 2

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Results for MEIS2

Z-value: 2.10

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Transcription factors associated with MEIS2

Gene Symbol	Gene ID	Gene Info
MEIS2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000134138.15	Meis homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MEIS2	hg19_v2_chr15_-_37390482_37390572	-0.87	1.4e-10	Click!

Activity profile of MEIS2 motif

Sorted Z-values of MEIS2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_-_133084580 Show fit	5.57	ENST00000525270.1 ENST00000530536.1 ENST00000524919.1	VNN2 Ensembl NCBI GeneCards UniProt NextProt Show fit	vanin 2
chr7_+_37723450 Show fit	4.95	ENST00000447769.1	GPR141 Ensembl NCBI GeneCards UniProt NextProt Show fit	G protein-coupled receptor 141
chr17_-_29648761 Show fit	4.86	ENST00000247270.3 ENST00000462804.2	EVI2A Ensembl NCBI GeneCards UniProt NextProt Show fit	ecotropic viral integration site 2A
chr6_-_133084564 Show fit	4.79	ENST00000532012.1	VNN2 Ensembl NCBI GeneCards UniProt NextProt Show fit	vanin 2
chr1_-_167487758 Show fit	4.64	ENST00000362089.5	CD247 Ensembl NCBI GeneCards UniProt NextProt Show fit	CD247 molecule
chr8_-_126963387 Show fit	4.52	ENST00000522865.1 ENST00000517869.1	LINC00861 Ensembl NCBI GeneCards UniProt NextProt Show fit	long intergenic non-protein coding RNA 861
chr7_-_142162390 Show fit	4.37	ENST00000390371.3	TRBV6-6 Ensembl NCBI GeneCards UniProt NextProt Show fit	T cell receptor beta variable 6-6
chr7_-_142224280 Show fit	4.29	ENST00000390367.3	TRBV11-1 Ensembl NCBI GeneCards UniProt NextProt Show fit	T cell receptor beta variable 11-1
chr6_+_42883727 Show fit	4.24	ENST00000304672.1 ENST00000441198.1 ENST00000446507.1	PTCRA Ensembl NCBI GeneCards UniProt NextProt Show fit	pre T-cell antigen receptor alpha
chr2_+_204801471 Show fit	4.19	ENST00000316386.6 ENST00000435193.1	ICOS Ensembl NCBI GeneCards UniProt NextProt Show fit	inducible T-cell co-stimulator

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of MEIS2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	107.8	GO:0042119	neutrophil activation(GO:0042119)
0.5	70.9	GO:0031295	T cell costimulation(GO:0031295)
0.2	40.2	GO:0038094	Fc-gamma receptor signaling pathway(GO:0038094)
0.2	23.0	GO:0002377	immunoglobulin production(GO:0002377)
0.2	17.2	GO:0006910	phagocytosis, recognition(GO:0006910)
0.2	14.3	GO:0038083	peptidyl-tyrosine autophosphorylation(GO:0038083)
0.7	12.5	GO:0015939	pantothenate metabolic process(GO:0015939)
3.0	11.9	GO:0071613	granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663)
0.8	11.2	GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.2	10.2	GO:0002755	MyD88-dependent toll-like receptor signaling pathway(GO:0002755)

Showing 1 to 10 of 1,165 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	80.3	GO:0009897	external side of plasma membrane(GO:0009897)
0.2	52.1	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2	42.7	GO:0016605	PML body(GO:0016605)
0.3	31.4	GO:0101003	ficolin-1-rich granule membrane(GO:0101003)
0.2	22.1	GO:0035580	specific granule lumen(GO:0035580)
0.1	21.9	GO:1904813	ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0	20.4	GO:0016607	nuclear speck(GO:0016607)
0.8	19.4	GO:0042101	T cell receptor complex(GO:0042101)
0.2	19.2	GO:0035577	azurophil granule membrane(GO:0035577)
0.5	18.2	GO:0001891	phagocytic cup(GO:0001891)

Showing 1 to 10 of 417 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	54.8	GO:0003823	antigen binding(GO:0003823)
0.3	26.9	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	22.0	GO:0030695	GTPase regulator activity(GO:0030695)
0.4	21.0	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.6	20.4	GO:0042288	MHC class I protein binding(GO:0042288)
0.1	16.2	GO:0017137	Rab GTPase binding(GO:0017137)
1.3	15.5	GO:0030369	ICAM-3 receptor activity(GO:0030369)
0.0	13.1	GO:0003924	GTPase activity(GO:0003924)
0.0	13.0	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.7	12.9	GO:0019864	IgG binding(GO:0019864)

Showing 1 to 10 of 718 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	71.3	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.5	36.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.3	21.8	PID BCR 5PATHWAY	BCR signaling pathway
0.6	21.5	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3	18.2	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.4	16.0	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.3	16.0	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.1	14.7	PID CMYB PATHWAY	C-MYB transcription factor network
0.1	13.3	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.1	12.8	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II

Showing 1 to 10 of 108 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	82.9	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.3	31.8	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
1.0	26.7	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2	19.9	REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	Genes involved in Antigen processing-Cross presentation
0.4	18.0	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.5	16.7	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.2	15.0	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.1	14.3	REACTOME G ALPHA1213 SIGNALLING EVENTS	Genes involved in G alpha (12/13) signalling events
0.2	13.6	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.2	13.3	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction

Showing 1 to 10 of 194 entries

Results for MEIS2

Z-value: 2.10

Motif logo

Transcription factors associated with MEIS2

Activity-expression correlation:

Activity profile of MEIS2 motif

Sorted Z-values of MEIS2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of MEIS2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: