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Illumina Body Map 2
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Results for MLXIPL
Z-value: 1.93
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Transcription factors associated with MLXIPL
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MLXIPL | hg19_v2_chr7_-_73038822_73038862 | -0.28 | 1.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_64511789 Show fit | 3.98 |
ENST00000419843.1
ENST00000394430.1 |
RAS guanyl releasing protein 2 (calcium and DAG-regulated) |
|
| chrX_-_153881842 Show fit | 3.83 |
ENST00000369585.3
ENST00000247306.4 |
cancer/testis antigen 2 |
|
| chr14_+_22337014 Show fit | 3.62 |
ENST00000390436.2
|
T cell receptor alpha variable 13-1 |
|
| chr14_-_106758101 Show fit | 3.56 |
ENST00000390611.2
|
immunoglobulin heavy variable 2-26 |
|
| chr7_-_142181009 Show fit | 3.26 |
ENST00000390368.2
|
T cell receptor beta variable 6-5 |
|
| chr14_-_106312010 Show fit | 3.12 |
ENST00000390556.2
|
immunoglobulin heavy constant delta |
|
| chr17_-_14140166 Show fit | 3.01 |
ENST00000420162.2
ENST00000431716.2 |
CMT1A duplicated region transcript 15 |
|
| chr16_+_28943260 Show fit | 3.01 |
ENST00000538922.1
ENST00000324662.3 ENST00000567541.1 |
CD19 molecule |
|
| chr8_+_11351494 Show fit | 2.96 |
ENST00000259089.4
|
B lymphoid tyrosine kinase |
|
| chr8_+_11351876 Show fit | 2.94 |
ENST00000529894.1
|
B lymphoid tyrosine kinase |
Network of associatons between targets according to the STRING database.
First level regulatory network of MLXIPL
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 32.5 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.1 | 21.1 | GO:0002433 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
| 0.2 | 14.1 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.0 | 14.1 | GO:0043312 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 0.1 | 10.0 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.2 | 7.6 | GO:0050855 | regulation of B cell receptor signaling pathway(GO:0050855) |
| 0.2 | 7.3 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.1 | 7.1 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.0 | 6.5 | GO:0050852 | T cell receptor signaling pathway(GO:0050852) |
| 0.8 | 6.3 | GO:0002774 | Fc receptor mediated inhibitory signaling pathway(GO:0002774) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 33.2 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.2 | 20.2 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.1 | 16.4 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 10.5 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 7.4 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.5 | 6.6 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.6 | 6.4 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.0 | 5.9 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 4.9 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.3 | 4.8 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 35.4 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.2 | 31.6 | GO:0003823 | antigen binding(GO:0003823) |
| 0.2 | 16.6 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.9 | 6.9 | GO:0032396 | inhibitory MHC class I receptor activity(GO:0032396) |
| 0.5 | 6.5 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
| 0.2 | 5.9 | GO:0042288 | MHC class I protein binding(GO:0042288) |
| 0.1 | 5.9 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.0 | 5.8 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 1.9 | 5.7 | GO:0004877 | complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877) |
| 0.0 | 5.6 | GO:0003714 | transcription corepressor activity(GO:0003714) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.7 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.2 | 9.6 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.1 | 8.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 7.9 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.1 | 6.4 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 5.1 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 5.1 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 4.7 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 4.4 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 3.5 | PID ATR PATHWAY | ATR signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 29.8 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 11.9 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.2 | 8.8 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 7.5 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 6.5 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.0 | 4.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 4.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 4.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 4.0 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.1 | 3.9 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |