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Illumina Body Map 2
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Results for MNT_HEY1_HEY2
Z-value: 1.24
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Transcription factors associated with MNT_HEY1_HEY2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000070444.10 | MAX network transcriptional repressor | |
| ENSG00000164683.12 | hes related family bHLH transcription factor with YRPW motif 1 | |
| ENSG00000135547.4 | hes related family bHLH transcription factor with YRPW motif 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HEY1 | hg19_v2_chr8_-_80680078_80680101 | 0.19 | 3.1e-01 | Click! |
| MNT | hg19_v2_chr17_-_2304365_2304412 | 0.18 | 3.3e-01 | Click! |
| HEY2 | hg19_v2_chr6_+_126070726_126070768 | 0.05 | 8.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_241520525 Show fit | 6.99 |
ENST00000366565.1
|
regulator of G-protein signaling 7 |
|
| chr6_+_73331918 Show fit | 6.85 |
ENST00000402622.2
ENST00000355635.3 ENST00000403813.2 ENST00000414165.2 |
potassium voltage-gated channel, KQT-like subfamily, member 5 |
|
| chr15_+_75118888 Show fit | 5.13 |
ENST00000395018.4
|
complexin 3 |
|
| chr1_-_241520385 Show fit | 5.12 |
ENST00000366564.1
|
regulator of G-protein signaling 7 |
|
| chr1_+_150254936 Show fit | 4.65 |
ENST00000447007.1
ENST00000369095.1 ENST00000369094.1 |
chromosome 1 open reading frame 51 |
|
| chr1_-_26233423 Show fit | 4.10 |
ENST00000357865.2
|
stathmin 1 |
|
| chrX_+_152224766 Show fit | 4.00 |
ENST00000370265.4
ENST00000447306.1 |
paraneoplastic Ma antigen 3 |
|
| chr1_-_26232951 Show fit | 3.71 |
ENST00000426559.2
ENST00000455785.2 |
stathmin 1 |
|
| chrX_-_20134713 Show fit | 3.61 |
ENST00000452324.3
|
MAP7 domain containing 2 |
|
| chr1_-_26232522 Show fit | 3.55 |
ENST00000399728.1
|
stathmin 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MNT_HEY1_HEY2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.9 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 1.6 | 11.1 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 0.4 | 11.0 | GO:0034587 | piRNA metabolic process(GO:0034587) |
| 0.1 | 8.7 | GO:0046928 | regulation of neurotransmitter secretion(GO:0046928) |
| 0.8 | 8.3 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.4 | 6.6 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 2.2 | 6.5 | GO:0000921 | septin ring assembly(GO:0000921) septin ring organization(GO:0031106) |
| 0.3 | 6.2 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.1 | 5.6 | GO:0090383 | phagosome acidification(GO:0090383) |
| 1.8 | 5.5 | GO:2000854 | positive regulation of corticosterone secretion(GO:2000854) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.3 | GO:0005874 | microtubule(GO:0005874) |
| 0.2 | 12.5 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 11.6 | GO:0034705 | potassium channel complex(GO:0034705) |
| 0.1 | 8.8 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.4 | 8.1 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.0 | 7.7 | GO:0098793 | presynapse(GO:0098793) |
| 0.0 | 7.5 | GO:0030424 | axon(GO:0030424) |
| 0.0 | 7.2 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 7.1 | GO:0045121 | membrane raft(GO:0045121) |
| 0.8 | 6.5 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.6 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.8 | 12.1 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.1 | 10.3 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.2 | 6.7 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 6.2 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 6.0 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.2 | 5.8 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.1 | 5.6 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.1 | 5.6 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.2 | 5.1 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 10.1 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.2 | 7.0 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 5.9 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 4.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 4.1 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.1 | 4.0 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 3.8 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 3.3 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.1 | 2.4 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.0 | 2.4 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.1 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.2 | 13.1 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 10.4 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.2 | 9.9 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.1 | 4.8 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.1 | 4.6 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 0.0 | 4.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 3.9 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.1 | 3.8 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 3.7 | REACTOME RNA POL I TRANSCRIPTION INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |