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Illumina Body Map 2
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Results for MXI1_MYC_MYCN
Z-value: 2.33
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Transcription factors associated with MXI1_MYC_MYCN
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000119950.16 | MAX interactor 1, dimerization protein | |
| ENSG00000136997.10 | MYC proto-oncogene, bHLH transcription factor | |
| ENSG00000134323.10 | MYCN proto-oncogene, bHLH transcription factor |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MXI1 | hg19_v2_chr10_+_111967345_111967442 | -0.54 | 1.3e-03 | Click! |
| MYC | hg19_v2_chr8_+_128747757_128747800 | 0.50 | 3.6e-03 | Click! |
| MYCN | hg19_v2_chr2_+_16080659_16080686 | -0.42 | 1.8e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_64014379 Show fit | 6.62 |
ENST00000309318.3
|
protein phosphatase 1, regulatory (inhibitor) subunit 14B |
|
| chr17_+_72428218 Show fit | 5.84 |
ENST00000392628.2
|
G protein-coupled receptor, family C, group 5, member C |
|
| chr7_-_27169801 Show fit | 5.59 |
ENST00000511914.1
|
homeobox A4 |
|
| chr6_+_31865552 Show fit | 5.47 |
ENST00000469372.1
ENST00000497706.1 |
complement component 2 |
|
| chr1_-_27240455 Show fit | 5.15 |
ENST00000254227.3
|
nuclear receptor subfamily 0, group B, member 2 |
|
| chr11_-_57282349 Show fit | 5.15 |
ENST00000528450.1
|
solute carrier family 43 (amino acid system L transporter), member 1 |
|
| chr17_+_72428266 Show fit | 4.89 |
ENST00000582473.1
|
G protein-coupled receptor, family C, group 5, member C |
|
| chr1_+_43148625 Show fit | 4.88 |
ENST00000436427.1
|
Y box binding protein 1 |
|
| chr3_+_184032419 Show fit | 4.82 |
ENST00000352767.3
ENST00000427141.2 |
eukaryotic translation initiation factor 4 gamma, 1 |
|
| chr7_-_27170352 Show fit | 4.61 |
ENST00000428284.2
ENST00000360046.5 |
homeobox A4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MXI1_MYC_MYCN
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 52.0 | GO:0006364 | rRNA processing(GO:0006364) |
| 2.0 | 20.4 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
| 0.4 | 14.9 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.9 | 13.9 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
| 4.1 | 12.2 | GO:1900073 | regulation of neuromuscular synaptic transmission(GO:1900073) positive regulation of neuromuscular synaptic transmission(GO:1900075) |
| 0.1 | 11.2 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 1.1 | 9.8 | GO:1904636 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) |
| 0.4 | 9.8 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
| 0.3 | 9.5 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 0.5 | 9.3 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 52.9 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 38.4 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 36.2 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.1 | 33.6 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.3 | 31.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 22.2 | GO:0031966 | mitochondrial membrane(GO:0031966) |
| 0.0 | 20.7 | GO:0016604 | nuclear body(GO:0016604) |
| 0.1 | 20.4 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.4 | 19.2 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.7 | 18.5 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 61.3 | GO:0003723 | RNA binding(GO:0003723) |
| 0.2 | 49.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 2.0 | 20.4 | GO:0004793 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.7 | 18.6 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.5 | 16.0 | GO:0043495 | protein anchor(GO:0043495) |
| 0.0 | 15.6 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.0 | 15.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 12.8 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.2 | 11.2 | GO:0070888 | E-box binding(GO:0070888) |
| 0.5 | 9.8 | GO:0017070 | U6 snRNA binding(GO:0017070) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 66.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 15.6 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 9.2 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.1 | 8.8 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.4 | 8.7 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 8.4 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 8.3 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 7.9 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 7.9 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.4 | 7.5 | ST STAT3 PATHWAY | STAT3 Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 52.0 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.3 | 19.5 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.2 | 17.6 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.7 | 16.4 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.2 | 16.4 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.5 | 15.1 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 15.1 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.4 | 13.7 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.2 | 13.5 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.5 | 13.1 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |