ISMARA results: NFIX

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Illumina Body Map 2

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Results for NFIX_NFIB

Z-value: 3.35

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Transcription factors associated with NFIX_NFIB

Gene Symbol	Gene ID	Gene Info
NFIX Ensembl NCBI GeneCards UniProt NextProt	ENSG00000008441.12	nuclear factor I X
NFIB Ensembl NCBI GeneCards UniProt NextProt	ENSG00000147862.10	nuclear factor I B

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFIB	hg19_v2_chr9_-_14313893_14313984	0.68	1.7e-05	Click!
NFIX	hg19_v2_chr19_+_13135790_13135811	0.46	7.9e-03	Click!

Activity profile of NFIX_NFIB motif

Sorted Z-values of NFIX_NFIB motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_-_95360983 Show fit	14.32	ENST00000371464.3	RBP4 Ensembl NCBI GeneCards UniProt NextProt Show fit	retinol binding protein 4, plasma
chr4_+_111397216 Show fit	11.72	ENST00000265162.5	ENPEP Ensembl NCBI GeneCards UniProt NextProt Show fit	glutamyl aminopeptidase (aminopeptidase A)
chr1_+_171154347 Show fit	10.93	ENST00000209929.7 ENST00000441535.1	FMO2 Ensembl NCBI GeneCards UniProt NextProt Show fit	flavin containing monooxygenase 2 (non-functional)
chr22_-_36018569 Show fit	10.85	ENST00000419229.1 ENST00000406324.1	MB Ensembl NCBI GeneCards UniProt NextProt Show fit	myoglobin
chr20_+_43343886 Show fit	10.71	ENST00000190983.4	WISP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	WNT1 inducible signaling pathway protein 2
chr16_-_31439735 Show fit	8.71	ENST00000287490.4	COX6A2 Ensembl NCBI GeneCards UniProt NextProt Show fit	cytochrome c oxidase subunit VIa polypeptide 2
chr11_+_77774897 Show fit	7.97	ENST00000281030.2	THRSP Ensembl NCBI GeneCards UniProt NextProt Show fit	thyroid hormone responsive
chr21_-_31588365 Show fit	7.76	ENST00000399899.1	CLDN8 Ensembl NCBI GeneCards UniProt NextProt Show fit	claudin 8
chr20_+_43343476 Show fit	7.55	ENST00000372868.2	WISP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	WNT1 inducible signaling pathway protein 2
chr21_-_31588338 Show fit	7.54	ENST00000286809.1	CLDN8 Ensembl NCBI GeneCards UniProt NextProt Show fit	claudin 8

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NFIX_NFIB

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	39.3	GO:0033275	muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.8	26.1	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.5	23.9	GO:0060216	definitive hemopoiesis(GO:0060216)
0.5	20.1	GO:0031581	hemidesmosome assembly(GO:0031581)
2.2	20.0	GO:0051552	flavone metabolic process(GO:0051552)
0.5	20.0	GO:0003298	physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.6	19.2	GO:0006590	thyroid hormone generation(GO:0006590)
0.2	18.9	GO:0030574	collagen catabolic process(GO:0030574)
0.1	16.0	GO:0070126	mitochondrial translational termination(GO:0070126)
1.6	15.8	GO:0072592	oxygen metabolic process(GO:0072592)

Showing 1 to 10 of 1,192 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	166.2	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.4	112.8	GO:0031674	I band(GO:0031674)
0.1	82.2	GO:0005759	mitochondrial matrix(GO:0005759)
0.0	64.7	GO:0070062	extracellular exosome(GO:0070062)
0.9	38.4	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.8	38.0	GO:0034364	high-density lipoprotein particle(GO:0034364)
1.4	35.4	GO:0043205	microfibril(GO:0001527) fibril(GO:0043205)
0.1	33.9	GO:0005743	mitochondrial inner membrane(GO:0005743)
1.8	29.9	GO:0031089	platelet dense granule lumen(GO:0031089)
0.9	29.7	GO:0032982	myosin filament(GO:0032982)

Showing 1 to 10 of 328 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	74.6	GO:0005198	structural molecule activity(GO:0005198)
0.4	59.8	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.5	53.7	GO:0008307	structural constituent of muscle(GO:0008307)
0.3	49.7	GO:0008201	heparin binding(GO:0008201)
0.3	45.0	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
1.3	39.7	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.8	30.8	GO:0001972	retinoic acid binding(GO:0001972)
0.8	28.2	GO:0051371	muscle alpha-actinin binding(GO:0051371)
1.7	24.0	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.3	23.9	GO:0050840	extracellular matrix binding(GO:0050840)

Showing 1 to 10 of 755 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	202.7	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.3	132.9	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	29.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	23.1	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.3	22.1	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.8	21.9	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.2	19.2	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.4	17.3	NABA COLLAGENS	Genes encoding collagen proteins
0.2	17.3	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	16.7	NABA MATRISOME	Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins

Showing 1 to 10 of 79 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	49.0	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.3	38.9	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.2	36.2	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
1.2	35.7	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.4	35.1	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.6	28.4	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
1.5	26.5	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.5	26.0	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.5	22.8	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.2	19.9	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization

Showing 1 to 10 of 146 entries

Results for NFIX_NFIB

Z-value: 3.35

Motif logo

Transcription factors associated with NFIX_NFIB

Activity-expression correlation:

Activity profile of NFIX_NFIB motif

Sorted Z-values of NFIX_NFIB motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NFIX_NFIB

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: