ISMARA results: NFKB2

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Illumina Body Map 2

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Results for NFKB2

Z-value: 1.38

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Transcription factors associated with NFKB2

Gene Symbol	Gene ID	Gene Info
NFKB2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000077150.13	nuclear factor kappa B subunit 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFKB2	hg19_v2_chr10_+_104155450_104155479	0.47	6.9e-03	Click!

Activity profile of NFKB2 motif

Sorted Z-values of NFKB2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_+_30485267 Show fit	5.44	ENST00000569725.1	ITGAL Ensembl NCBI GeneCards UniProt NextProt Show fit	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr19_+_42381173 Show fit	5.16	ENST00000221972.3	CD79A Ensembl NCBI GeneCards UniProt NextProt Show fit	CD79a molecule, immunoglobulin-associated alpha
chr17_-_34207295 Show fit	5.02	ENST00000463941.1 ENST00000293272.3	CCL5 Ensembl NCBI GeneCards UniProt NextProt Show fit	chemokine (C-C motif) ligand 5
chr20_+_43803517 Show fit	4.95	ENST00000243924.3	PI3 Ensembl NCBI GeneCards UniProt NextProt Show fit	peptidase inhibitor 3, skin-derived
chr2_+_219745020 Show fit	4.77	ENST00000258411.3	WNT10A Ensembl NCBI GeneCards UniProt NextProt Show fit	wingless-type MMTV integration site family, member 10A
chr19_-_41859814 Show fit	4.44	ENST00000221930.5	TGFB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	transforming growth factor, beta 1
chr19_+_42381337 Show fit	4.40	ENST00000597454.1 ENST00000444740.2	CD79A Ensembl NCBI GeneCards UniProt NextProt Show fit	CD79a molecule, immunoglobulin-associated alpha
chr19_-_3786253 Show fit	4.28	ENST00000585778.1	MATK Ensembl NCBI GeneCards UniProt NextProt Show fit	megakaryocyte-associated tyrosine kinase
chr1_-_27961720 Show fit	4.27	ENST00000545953.1 ENST00000374005.3	FGR Ensembl NCBI GeneCards UniProt NextProt Show fit	feline Gardner-Rasheed sarcoma viral oncogene homolog
chr19_-_3786354 Show fit	4.13	ENST00000395040.2 ENST00000310132.6	MATK Ensembl NCBI GeneCards UniProt NextProt Show fit	megakaryocyte-associated tyrosine kinase

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NFKB2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	12.2	GO:0030449	regulation of complement activation(GO:0030449)
0.1	9.6	GO:0042100	B cell proliferation(GO:0042100)
0.3	7.9	GO:0090023	positive regulation of neutrophil chemotaxis(GO:0090023)
0.0	7.5	GO:0033209	tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.1	7.4	GO:0038128	ERBB2 signaling pathway(GO:0038128)
0.6	7.0	GO:0060753	regulation of mast cell chemotaxis(GO:0060753)
0.0	6.5	GO:0002377	immunoglobulin production(GO:0002377)
0.6	5.7	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.1	5.7	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.3	5.4	GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)

Showing 1 to 10 of 218 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	15.9	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0	9.8	GO:0009897	external side of plasma membrane(GO:0009897)
1.4	9.6	GO:0019815	B cell receptor complex(GO:0019815)
0.1	9.3	GO:0101003	ficolin-1-rich granule membrane(GO:0101003)
0.0	9.3	GO:0072562	blood microparticle(GO:0072562)
0.1	7.7	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.1	7.1	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.2	6.1	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.5	5.4	GO:0034687	integrin alphaL-beta2 complex(GO:0034687)
0.1	5.2	GO:0097542	ciliary tip(GO:0097542)

Showing 1 to 10 of 115 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	23.8	GO:0003823	antigen binding(GO:0003823)
0.0	9.4	GO:0005525	GTP binding(GO:0005525)
0.1	8.4	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.5	8.0	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.1	6.7	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	6.7	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.2	6.2	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.5	5.7	GO:0035005	lipid kinase activity(GO:0001727) 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1	5.7	GO:0005262	calcium channel activity(GO:0005262)
0.5	5.4	GO:0030369	ICAM-3 receptor activity(GO:0030369)

Showing 1 to 10 of 161 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	20.4	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2	16.4	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.1	10.8	PID BCR 5PATHWAY	BCR signaling pathway
0.1	7.4	PID RAC1 PATHWAY	RAC1 signaling pathway
0.0	6.0	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.1	5.7	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.2	5.6	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.1	5.5	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.1	5.4	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.2	4.9	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway

Showing 1 to 10 of 55 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	13.0	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2	12.5	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.1	9.1	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2	7.4	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.1	6.5	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.2	6.3	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.2	6.0	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.1	6.0	REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	Genes involved in Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
0.1	5.5	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.2	5.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling

Showing 1 to 10 of 69 entries

Results for NFKB2

Z-value: 1.38

Motif logo

Transcription factors associated with NFKB2

Activity-expression correlation:

Activity profile of NFKB2 motif

Sorted Z-values of NFKB2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NFKB2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: