ISMARA results: NHLH1

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Illumina Body Map 2

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Results for NHLH1

Z-value: 1.50

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Transcription factors associated with NHLH1

Gene Symbol	Gene ID	Gene Info
NHLH1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000171786.5	nescient helix-loop-helix 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NHLH1	hg19_v2_chr1_+_160336851_160336868	0.37	3.7e-02	Click!

Activity profile of NHLH1 motif

Sorted Z-values of NHLH1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_+_105036909 Show fit	4.93	ENST00000369849.4	INA Ensembl NCBI GeneCards UniProt NextProt Show fit	internexin neuronal intermediate filament protein, alpha
chr11_+_17756279 Show fit	4.87	ENST00000265969.6	KCNC1 Ensembl NCBI GeneCards UniProt NextProt Show fit	potassium voltage-gated channel, Shaw-related subfamily, member 1
chr11_-_35441597 Show fit	4.54	ENST00000395753.1	SLC1A2 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr11_-_35441524 Show fit	4.47	ENST00000395750.1 ENST00000449068.1	SLC1A2 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr21_+_34442439 Show fit	3.89	ENST00000382348.1 ENST00000333063.5	OLIG1 Ensembl NCBI GeneCards UniProt NextProt Show fit	oligodendrocyte transcription factor 1
chr16_+_23847339 Show fit	3.78	ENST00000303531.7	PRKCB Ensembl NCBI GeneCards UniProt NextProt Show fit	protein kinase C, beta
chr8_+_24771265 Show fit	3.76	ENST00000518131.1 ENST00000437366.2	NEFM Ensembl NCBI GeneCards UniProt NextProt Show fit	neurofilament, medium polypeptide
chr16_+_23847267 Show fit	3.73	ENST00000321728.7	PRKCB Ensembl NCBI GeneCards UniProt NextProt Show fit	protein kinase C, beta
chr8_+_24772455 Show fit	3.73	ENST00000433454.2	NEFM Ensembl NCBI GeneCards UniProt NextProt Show fit	neurofilament, medium polypeptide
chr2_-_11810284 Show fit	3.69	ENST00000306928.5	NTSR2 Ensembl NCBI GeneCards UniProt NextProt Show fit	neurotensin receptor 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NHLH1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	13.2	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
2.4	9.6	GO:0035408	histone H3-T6 phosphorylation(GO:0035408)
0.8	9.0	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.2	9.0	GO:0048268	clathrin coat assembly(GO:0048268)
0.2	8.9	GO:0003298	physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
2.5	7.5	GO:0033693	neurofilament bundle assembly(GO:0033693)
0.3	6.5	GO:0035020	regulation of Rac protein signal transduction(GO:0035020)
0.0	6.4	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1	6.0	GO:0006891	intra-Golgi vesicle-mediated transport(GO:0006891)
0.5	4.9	GO:0060052	neurofilament cytoskeleton organization(GO:0060052)

Showing 1 to 10 of 229 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	14.6	GO:0030018	Z disc(GO:0030018)
0.2	12.9	GO:0030673	axolemma(GO:0030673)
0.8	12.4	GO:0005883	neurofilament(GO:0005883)
0.0	9.7	GO:0000139	Golgi membrane(GO:0000139)
0.1	8.1	GO:0005778	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1	8.0	GO:0005905	clathrin-coated pit(GO:0005905)
0.0	7.9	GO:0043197	dendritic spine(GO:0043197)
0.2	6.5	GO:0034451	centriolar satellite(GO:0034451)
0.0	6.1	GO:0030133	transport vesicle(GO:0030133)
0.0	5.8	GO:0043204	perikaryon(GO:0043204)

Showing 1 to 10 of 96 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	13.2	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	10.0	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
2.4	9.6	GO:0035403	histone kinase activity (H3-T6 specific)(GO:0035403)
0.2	9.4	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.2	9.2	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.9	9.0	GO:0015501	glutamate:sodium symporter activity(GO:0015501)
0.0	6.4	GO:0003924	GTPase activity(GO:0003924)
0.2	6.2	GO:0031489	myosin V binding(GO:0031489)
0.6	5.0	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1	5.0	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)

Showing 1 to 10 of 140 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	9.6	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.1	9.0	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	5.0	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.1	4.9	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.0	3.3	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	3.2	PID EPHA FWDPATHWAY	EPHA forward signaling
0.0	2.9	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.0	2.4	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	1.9	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	1.9	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly

Showing 1 to 10 of 21 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.9	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.2	9.6	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1	6.6	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.1	5.0	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.1	4.9	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.2	4.7	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1	4.3	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.1	4.1	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1	3.6	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.1	3.4	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions

Showing 1 to 10 of 53 entries

Results for NHLH1

Z-value: 1.50

Motif logo

Transcription factors associated with NHLH1

Activity-expression correlation:

Activity profile of NHLH1 motif

Sorted Z-values of NHLH1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NHLH1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: