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Illumina Body Map 2

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Results for NKX2-4

Z-value: 1.00

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Transcription factors associated with NKX2-4

Gene Symbol Gene ID Gene Info
NKX2-4
ENSG00000125816.4 NK2 homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-4hg19_v2_chr20_-_21378666_213786660.163.9e-01Click!

Activity profile of NKX2-4 motif

Sorted Z-values of NKX2-4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_55669093 4.07 ENST00000344887.5
TNNI3
troponin I type 3 (cardiac)
chr11_-_19223523 3.99 ENST00000265968.3
CSRP3
cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr10_+_99332529 1.91 ENST00000455090.1
ANKRD2
ankyrin repeat domain 2 (stretch responsive muscle)
chr1_-_76398077 1.72 ENST00000284142.6
ASB17
ankyrin repeat and SOCS box containing 17
chr1_+_228395755 1.63 ENST00000284548.11
ENST00000570156.2
ENST00000422127.1
ENST00000366707.4
ENST00000366709.4
OBSCN
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
chr1_+_152850787 1.53 ENST00000368765.3
SMCP
sperm mitochondria-associated cysteine-rich protein
chr20_+_44350968 1.47 ENST00000279058.3
SPINT4
serine peptidase inhibitor, Kunitz type 4
chr11_+_73675873 1.39 ENST00000537753.1
ENST00000542350.1
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr2_+_36923830 1.29 ENST00000379242.3
ENST00000389975.3
VIT
vitrin
chrX_+_49593888 1.24 ENST00000218068.6
PAGE4
P antigen family, member 4 (prostate associated)
chrX_+_73524020 1.19 ENST00000339534.2
ZCCHC13
zinc finger, CCHC domain containing 13
chr10_-_28571015 1.19 ENST00000375719.3
ENST00000375732.1
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr3_-_71834207 1.18 ENST00000295619.3
PROK2
prokineticin 2
chr16_+_58010339 1.13 ENST00000290871.5
ENST00000441824.2
TEPP
testis, prostate and placenta expressed
chr6_+_31674639 1.13 ENST00000556581.1
ENST00000375832.4
ENST00000503322.1
LY6G6F
MEGT1
lymphocyte antigen 6 complex, locus G6F
HCG43720, isoform CRA_a; Lymphocyte antigen 6 complex locus protein G6f; Megakaryocyte-enhanced gene transcript 1 protein; Uncharacterized protein
chr5_+_150040403 1.11 ENST00000517768.1
ENST00000297130.4
MYOZ3
myozenin 3
chrX_-_133792480 1.11 ENST00000359237.4
PLAC1
placenta-specific 1
chrX_+_49593853 1.11 ENST00000376141.1
PAGE4
P antigen family, member 4 (prostate associated)
chr19_-_42348692 1.08 ENST00000330743.3
ENST00000601246.1
LYPD4
LY6/PLAUR domain containing 4
chr9_+_103340354 1.07 ENST00000307584.5
MURC
muscle-related coiled-coil protein
chr2_+_36923933 1.06 ENST00000497382.1
ENST00000404084.1
ENST00000379241.3
ENST00000401530.1
VIT
vitrin
chr1_-_205419053 1.05 ENST00000367154.1
LEMD1
LEM domain containing 1
chr19_+_41117770 1.05 ENST00000601032.1
LTBP4
latent transforming growth factor beta binding protein 4
chr11_+_61976137 1.04 ENST00000244930.4
SCGB2A1
secretoglobin, family 2A, member 1
chr2_+_149974684 0.99 ENST00000450639.1
LYPD6B
LY6/PLAUR domain containing 6B
chr1_-_197744763 0.96 ENST00000422998.1
DENND1B
DENN/MADD domain containing 1B
chr11_-_111383064 0.96 ENST00000525791.1
ENST00000456861.2
ENST00000356018.2
BTG4
B-cell translocation gene 4
chr15_+_45248880 0.95 ENST00000340827.3
C15orf43
chromosome 15 open reading frame 43
chr8_-_33455268 0.93 ENST00000522982.1
DUSP26
dual specificity phosphatase 26 (putative)
chr4_-_175041663 0.93 ENST00000503140.1
RP11-148L24.1
RP11-148L24.1
chr2_-_225434538 0.90 ENST00000409096.1
CUL3
cullin 3
chr16_+_50727479 0.89 ENST00000531674.1
NOD2
nucleotide-binding oligomerization domain containing 2
chr14_+_22356029 0.88 ENST00000390437.2
TRAV12-2
T cell receptor alpha variable 12-2
chr1_+_202431859 0.85 ENST00000391959.3
ENST00000367270.4
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chrX_-_125686784 0.84 ENST00000371126.1
DCAF12L1
DDB1 and CUL4 associated factor 12-like 1
chr10_-_115423792 0.83 ENST00000369360.3
ENST00000360478.3
ENST00000359988.3
ENST00000369358.4
NRAP
nebulin-related anchoring protein
chr5_-_131879205 0.83 ENST00000231454.1
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr3_-_6847096 0.82 ENST00000454410.2
ENST00000424366.1
ENST00000417482.1
ENST00000412629.1
GRM7-AS3
GRM7 antisense RNA 3
chr2_+_204571375 0.82 ENST00000374478.4
CD28
CD28 molecule
chr14_+_22309368 0.82 ENST00000390433.1
TRAV12-1
T cell receptor alpha variable 12-1
chr7_-_29235063 0.81 ENST00000437527.1
ENST00000455544.1
CPVL
carboxypeptidase, vitellogenic-like
chrX_+_78200913 0.81 ENST00000171757.2
P2RY10
purinergic receptor P2Y, G-protein coupled, 10
chr11_+_103907308 0.81 ENST00000302259.3
DDI1
DNA-damage inducible 1 homolog 1 (S. cerevisiae)
chr1_+_147374915 0.79 ENST00000240986.4
GJA8
gap junction protein, alpha 8, 50kDa
chr9_-_86432547 0.79 ENST00000376365.3
ENST00000376371.2
GKAP1
G kinase anchoring protein 1
chr3_+_156807663 0.78 ENST00000467995.1
ENST00000474477.1
ENST00000471719.1
LINC00881
long intergenic non-protein coding RNA 881
chr22_-_29457832 0.77 ENST00000216071.4
C22orf31
chromosome 22 open reading frame 31
chr11_+_125658006 0.77 ENST00000445202.1
PATE3
prostate and testis expressed 3
chr12_-_113658892 0.77 ENST00000299732.2
ENST00000416617.2
IQCD
IQ motif containing D
chr20_+_23471727 0.76 ENST00000449810.1
ENST00000246012.1
CST8
cystatin 8 (cystatin-related epididymal specific)
chr2_-_37899323 0.75 ENST00000295324.3
ENST00000457889.1
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr15_+_36887069 0.75 ENST00000566807.1
ENST00000567389.1
ENST00000562877.1
C15orf41
chromosome 15 open reading frame 41
chr7_-_142232071 0.74 ENST00000390364.3
TRBV10-1
T cell receptor beta variable 10-1(gene/pseudogene)
chr21_+_38792602 0.74 ENST00000398960.2
ENST00000398956.2
DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chrX_+_49178536 0.73 ENST00000442437.2
GAGE12J
G antigen 12J
chr1_-_57285038 0.72 ENST00000343433.6
C1orf168
chromosome 1 open reading frame 168
chr10_+_90521163 0.70 ENST00000404459.1
LIPN
lipase, family member N
chr9_-_118506518 0.69 ENST00000433546.2
RP11-284G10.1
RP11-284G10.1
chr12_-_58329819 0.69 ENST00000551421.1
RP11-620J15.3
RP11-620J15.3
chr10_-_69455873 0.69 ENST00000433211.2
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr10_+_69869237 0.69 ENST00000373675.3
MYPN
myopalladin
chr19_+_31658405 0.68 ENST00000589511.1
CTC-439O9.3
CTC-439O9.3
chr8_+_22844995 0.68 ENST00000524077.1
RHOBTB2
Rho-related BTB domain containing 2
chr9_+_128510454 0.68 ENST00000491787.3
ENST00000447726.2
PBX3
pre-B-cell leukemia homeobox 3
chr3_+_189349162 0.68 ENST00000264731.3
ENST00000382063.4
ENST00000418709.2
ENST00000320472.5
ENST00000392460.3
ENST00000440651.2
TP63
tumor protein p63
chr15_+_81391740 0.67 ENST00000561216.1
C15orf26
chromosome 15 open reading frame 26
chr17_+_46918925 0.67 ENST00000502761.1
CALCOCO2
calcium binding and coiled-coil domain 2
chr5_+_137203557 0.66 ENST00000515645.1
MYOT
myotilin
chr2_-_202483867 0.65 ENST00000439802.1
ENST00000286195.3
ENST00000439140.1
ENST00000450242.1
ALS2CR11
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11
chr2_-_220025263 0.65 ENST00000457600.1
NHEJ1
nonhomologous end-joining factor 1
chr19_+_42349009 0.65 ENST00000600017.1
DMRTC2
DMRT-like family C2
chr13_-_52026730 0.65 ENST00000420668.2
INTS6
integrator complex subunit 6
chr5_-_101834712 0.65 ENST00000506729.1
ENST00000389019.3
ENST00000379810.1
SLCO6A1
solute carrier organic anion transporter family, member 6A1
chr19_-_6057282 0.65 ENST00000592281.1
RFX2
regulatory factor X, 2 (influences HLA class II expression)
chr2_+_219110149 0.65 ENST00000456575.1
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr12_-_49488573 0.64 ENST00000266991.2
DHH
desert hedgehog
chr7_+_120629085 0.64 ENST00000428526.1
CPED1
cadherin-like and PC-esterase domain containing 1
chr2_+_220299547 0.64 ENST00000312358.7
SPEG
SPEG complex locus
chr12_-_122884553 0.62 ENST00000535290.1
CLIP1
CAP-GLY domain containing linker protein 1
chr5_-_78808617 0.62 ENST00000282260.6
ENST00000508576.1
ENST00000535690.1
HOMER1
homer homolog 1 (Drosophila)
chr2_-_220025548 0.62 ENST00000356853.5
NHEJ1
nonhomologous end-joining factor 1
chr17_+_7905912 0.62 ENST00000254854.4
GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chr6_-_30899924 0.62 ENST00000359086.3
SFTA2
surfactant associated 2
chr5_-_59481406 0.62 ENST00000546160.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr21_-_46534873 0.62 ENST00000596207.1
PRED58
PRED58
chr8_+_66955648 0.61 ENST00000522619.1
DNAJC5B
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr15_-_82338460 0.61 ENST00000558133.1
ENST00000329713.4
MEX3B
mex-3 RNA binding family member B
chr10_+_60094735 0.61 ENST00000373910.4
UBE2D1
ubiquitin-conjugating enzyme E2D 1
chr11_+_57105991 0.60 ENST00000263314.2
P2RX3
purinergic receptor P2X, ligand-gated ion channel, 3
chr19_+_42349092 0.60 ENST00000269945.3
ENST00000596258.1
DMRTC2
DMRT-like family C2
chr9_+_134065506 0.59 ENST00000483497.2
NUP214
nucleoporin 214kDa
chr6_+_42123141 0.59 ENST00000418175.1
ENST00000541991.1
ENST00000053469.4
ENST00000394237.1
ENST00000372963.1
GUCA1A
RP1-139D8.6
guanylate cyclase activator 1A (retina)
RP1-139D8.6
chr7_-_142149390 0.59 ENST00000390372.3
TRBV5-5
T cell receptor beta variable 5-5
chr1_-_223308098 0.59 ENST00000342210.6
TLR5
toll-like receptor 5
chr1_+_241815577 0.58 ENST00000366552.2
ENST00000437684.2
WDR64
WD repeat domain 64
chr12_-_18890940 0.58 ENST00000543242.1
ENST00000539072.1
ENST00000541966.1
ENST00000266505.7
ENST00000447925.2
ENST00000435379.1
PLCZ1
phospholipase C, zeta 1
chr17_+_9479971 0.58 ENST00000576499.1
WDR16
WD repeat domain 16
chr12_+_48516357 0.58 ENST00000549022.1
ENST00000547587.1
ENST00000312352.7
PFKM
phosphofructokinase, muscle
chr17_-_3595042 0.58 ENST00000552723.1
P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chrX_+_105445717 0.58 ENST00000372552.1
MUM1L1
melanoma associated antigen (mutated) 1-like 1
chr7_-_38331679 0.58 ENST00000390340.2
TRGV11
T cell receptor gamma variable 11 (non-functional)
chr14_+_22217447 0.58 ENST00000390427.3
TRAV5
T cell receptor alpha variable 5
chr14_+_39703084 0.58 ENST00000553728.1
RP11-407N17.3
cTAGE family member 5 isoform 4
chr20_+_4702548 0.57 ENST00000305817.2
PRND
prion protein 2 (dublet)
chr1_-_11024258 0.57 ENST00000418570.2
C1orf127
chromosome 1 open reading frame 127
chr7_+_80817106 0.57 ENST00000447776.1
AC005008.2
Uncharacterized protein
chr9_+_134065519 0.57 ENST00000531600.1
NUP214
nucleoporin 214kDa
chr7_+_129847688 0.57 ENST00000297819.3
SSMEM1
serine-rich single-pass membrane protein 1
chr6_+_159071015 0.56 ENST00000360448.3
SYTL3
synaptotagmin-like 3
chr12_+_113416340 0.56 ENST00000552756.1
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr11_-_64856497 0.56 ENST00000524632.1
ENST00000530719.1
AP003068.6
transmembrane protein 262
chr6_-_9933500 0.55 ENST00000492169.1
OFCC1
orofacial cleft 1 candidate 1
chr2_+_228736321 0.54 ENST00000309931.2
DAW1
dynein assembly factor with WDR repeat domains 1
chr1_+_64239657 0.54 ENST00000371080.1
ENST00000371079.1
ROR1
receptor tyrosine kinase-like orphan receptor 1
chr3_+_32737027 0.54 ENST00000454516.2
CNOT10
CCR4-NOT transcription complex, subunit 10
chr11_+_60524426 0.54 ENST00000528170.1
ENST00000337911.4
ENST00000405633.3
MS4A15
membrane-spanning 4-domains, subfamily A, member 15
chr14_+_22675388 0.54 ENST00000390461.2
TRAV34
T cell receptor alpha variable 34
chr5_+_155753745 0.54 ENST00000435422.3
ENST00000337851.4
ENST00000447401.1
SGCD
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
chrX_+_135730297 0.53 ENST00000370629.2
CD40LG
CD40 ligand
chr5_-_101834617 0.53 ENST00000513675.1
ENST00000379807.3
SLCO6A1
solute carrier organic anion transporter family, member 6A1
chr10_-_104001231 0.53 ENST00000370002.3
PITX3
paired-like homeodomain 3
chr1_+_117297007 0.52 ENST00000369478.3
ENST00000369477.1
CD2
CD2 molecule
chrX_+_78200829 0.52 ENST00000544091.1
P2RY10
purinergic receptor P2Y, G-protein coupled, 10
chr1_+_205225319 0.52 ENST00000329800.7
TMCC2
transmembrane and coiled-coil domain family 2
chr3_-_49229255 0.52 ENST00000432035.2
ENST00000545770.2
C3orf84
chromosome 3 open reading frame 84
chr3_-_18486354 0.52 ENST00000493952.2
ENST00000440737.1
SATB1
SATB homeobox 1
chr3_+_15045419 0.51 ENST00000406272.2
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr6_-_39282221 0.51 ENST00000453413.2
KCNK17
potassium channel, subfamily K, member 17
chr1_+_110036674 0.50 ENST00000393709.3
CYB561D1
cytochrome b561 family, member D1
chr12_-_113658826 0.50 ENST00000546692.1
IQCD
IQ motif containing D
chr7_+_106810165 0.50 ENST00000468401.1
ENST00000497535.1
ENST00000485846.1
HBP1
HMG-box transcription factor 1
chr19_+_10765614 0.49 ENST00000589283.1
ILF3
interleukin enhancer binding factor 3, 90kDa
chr4_-_157563459 0.49 ENST00000504237.1
ENST00000511399.1
RP11-171N4.2
Uncharacterized protein
chr20_-_35890211 0.49 ENST00000373614.2
GHRH
growth hormone releasing hormone
chr12_-_48500085 0.49 ENST00000549518.1
SENP1
SUMO1/sentrin specific peptidase 1
chr2_-_166650700 0.49 ENST00000422973.1
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr16_+_8736232 0.49 ENST00000562973.1
METTL22
methyltransferase like 22
chr10_-_32667660 0.49 ENST00000375110.2
EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr7_-_80551671 0.49 ENST00000419255.2
ENST00000544525.1
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr5_-_88120151 0.49 ENST00000506716.1
MEF2C
myocyte enhancer factor 2C
chr3_+_118905564 0.49 ENST00000460625.1
UPK1B
uroplakin 1B
chr7_-_38370536 0.49 ENST00000390343.2
TRGV8
T cell receptor gamma variable 8
chr3_-_18480173 0.48 ENST00000414509.1
SATB1
SATB homeobox 1
chr18_-_44500101 0.48 ENST00000589917.1
ENST00000587810.1
PIAS2
protein inhibitor of activated STAT, 2
chr3_-_49066811 0.48 ENST00000442157.1
ENST00000326739.4
IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr6_+_35265586 0.47 ENST00000542066.1
ENST00000316637.5
DEF6
differentially expressed in FDCP 6 homolog (mouse)
chr14_-_81408093 0.47 ENST00000555265.1
CEP128
centrosomal protein 128kDa
chr14_+_22919081 0.47 ENST00000390473.1
TRDJ1
T cell receptor delta joining 1
chr20_+_42523336 0.47 ENST00000428529.1
RP5-1030M6.3
RP5-1030M6.3
chr2_-_49381646 0.47 ENST00000346173.3
ENST00000406846.2
FSHR
follicle stimulating hormone receptor
chr12_+_2079939 0.46 ENST00000543114.1
CACNA1C
calcium channel, voltage-dependent, L type, alpha 1C subunit
chr11_-_10715287 0.46 ENST00000423302.2
MRVI1
murine retrovirus integration site 1 homolog
chr7_-_142139783 0.46 ENST00000390374.3
TRBV7-6
T cell receptor beta variable 7-6
chr16_+_78056412 0.46 ENST00000299642.4
ENST00000575655.1
CLEC3A
C-type lectin domain family 3, member A
chr6_-_49937338 0.46 ENST00000398718.1
DEFB113
defensin, beta 113
chr7_-_142207004 0.45 ENST00000426318.2
TRBV10-2
T cell receptor beta variable 10-2
chrX_+_135730373 0.45 ENST00000370628.2
CD40LG
CD40 ligand
chr14_+_22962389 0.45 ENST00000390491.1
TRAJ46
T cell receptor alpha joining 46
chr16_+_4606347 0.45 ENST00000444310.4
C16orf96
chromosome 16 open reading frame 96
chr15_-_83474806 0.44 ENST00000541889.1
ENST00000334574.8
ENST00000561368.1
FSD2
fibronectin type III and SPRY domain containing 2
chr1_-_144866711 0.44 ENST00000530130.1
PDE4DIP
phosphodiesterase 4D interacting protein
chr8_+_22844913 0.44 ENST00000519685.1
RHOBTB2
Rho-related BTB domain containing 2
chr2_+_30670209 0.44 ENST00000497423.1
ENST00000476535.1
LCLAT1
lysocardiolipin acyltransferase 1
chr1_-_115301235 0.44 ENST00000525878.1
CSDE1
cold shock domain containing E1, RNA-binding
chr6_+_27925019 0.44 ENST00000244623.1
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr15_+_63334831 0.44 ENST00000288398.6
ENST00000358278.3
ENST00000560445.1
ENST00000403994.3
ENST00000357980.4
ENST00000559556.1
ENST00000559397.1
ENST00000267996.7
ENST00000560970.1
TPM1
tropomyosin 1 (alpha)
chr1_-_100643765 0.44 ENST00000370137.1
ENST00000370138.1
ENST00000342895.3
LRRC39
leucine rich repeat containing 39
chr10_+_21823079 0.43 ENST00000377100.3
ENST00000377072.3
ENST00000446906.2
MLLT10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr12_+_93115281 0.43 ENST00000549856.1
PLEKHG7
pleckstrin homology domain containing, family G (with RhoGef domain) member 7
chr19_+_42349075 0.43 ENST00000596827.1
DMRTC2
DMRT-like family C2
chr2_+_28615669 0.43 ENST00000379619.1
ENST00000264716.4
FOSL2
FOS-like antigen 2
chr5_-_88120083 0.43 ENST00000509373.1
MEF2C
myocyte enhancer factor 2C
chr3_+_159706537 0.42 ENST00000305579.2
ENST00000480787.1
ENST00000466512.1
IL12A
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
chr11_-_10715502 0.42 ENST00000547195.1
MRVI1
murine retrovirus integration site 1 homolog
chr19_-_55767125 0.42 ENST00000592242.1
PPP6R1
protein phosphatase 6, regulatory subunit 1
chr14_+_23002427 0.42 ENST00000390527.1
TRAJ10
T cell receptor alpha joining 10
chr4_+_110834033 0.42 ENST00000509793.1
ENST00000265171.5
EGF
epidermal growth factor
chr5_-_88119580 0.42 ENST00000539796.1
MEF2C
myocyte enhancer factor 2C
chr11_-_19263145 0.42 ENST00000532666.1
ENST00000527884.1
E2F8
E2F transcription factor 8
chr11_+_19138670 0.42 ENST00000446113.2
ENST00000399351.3
ZDHHC13
zinc finger, DHHC-type containing 13
chr7_-_108524644 0.42 ENST00000379007.2
C7orf66
chromosome 7 open reading frame 66
chr8_+_145159846 0.41 ENST00000532522.1
ENST00000527572.1
ENST00000527058.1
MAF1
MAF1 homolog (S. cerevisiae)
chr9_-_28670283 0.41 ENST00000379992.2
LINGO2
leucine rich repeat and Ig domain containing 2
chr8_+_31496809 0.41 ENST00000518104.1
ENST00000519301.1
NRG1
neuregulin 1
chr1_+_158323755 0.41 ENST00000368157.1
ENST00000368156.1
ENST00000368155.3
ENST00000368154.1
ENST00000368160.3
ENST00000368161.3
CD1E
CD1e molecule
chr14_-_59932044 0.41 ENST00000395116.1
GPR135
G protein-coupled receptor 135
chr4_+_130692778 0.41 ENST00000513875.1
ENST00000508724.1
RP11-422J15.1
RP11-422J15.1
chr4_-_168155169 0.40 ENST00000534949.1
ENST00000535728.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr2_+_103353367 0.40 ENST00000454536.1
ENST00000409528.1
ENST00000409173.1
TMEM182
transmembrane protein 182
chr19_+_16830815 0.40 ENST00000549814.1
NWD1
NACHT and WD repeat domain containing 1
chr17_-_38574169 0.40 ENST00000423485.1
TOP2A
topoisomerase (DNA) II alpha 170kDa
chr6_-_149969871 0.40 ENST00000335643.8
ENST00000444282.1
KATNA1
katanin p60 (ATPase containing) subunit A 1
chr17_+_42977062 0.40 ENST00000410006.2
ENST00000357776.2
ENST00000410027.1
CCDC103
coiled-coil domain containing 103
chr3_-_72150076 0.40 ENST00000488545.1
ENST00000608654.1
LINC00877
long intergenic non-protein coding RNA 877
chr7_+_120629653 0.40 ENST00000450913.2
ENST00000340646.5
CPED1
cadherin-like and PC-esterase domain containing 1
chrX_+_23928500 0.40 ENST00000435707.1
CXorf58
chromosome X open reading frame 58
chr10_-_94301107 0.39 ENST00000436178.1
IDE
insulin-degrading enzyme
chr2_+_1417228 0.39 ENST00000382269.3
ENST00000337415.3
ENST00000345913.4
ENST00000346956.3
ENST00000349624.3
ENST00000539820.1
ENST00000329066.4
ENST00000382201.3
TPO
thyroid peroxidase
chr13_+_49280951 0.39 ENST00000282018.3
CYSLTR2
cysteinyl leukotriene receptor 2
chr2_-_166651191 0.39 ENST00000392701.3
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.0 GO:0035995 detection of muscle stretch(GO:0035995)
0.4 1.7 GO:1900111 positive regulation of histone H3-K9 dimethylation(GO:1900111)
0.3 1.4 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.3 0.8 GO:0045645 regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645)
0.3 1.6 GO:0036309 protein localization to M-band(GO:0036309)
0.2 0.9 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.2 0.7 GO:0007387 anterior compartment pattern formation(GO:0007387) posterior compartment specification(GO:0007388)
0.2 0.9 GO:0060584 detection of peptidoglycan(GO:0032499) activation of MAPK activity involved in innate immune response(GO:0035419) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585) positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.2 1.1 GO:0090214 spongiotrophoblast layer developmental growth(GO:0090214)
0.2 1.5 GO:0007341 penetration of zona pellucida(GO:0007341)
0.2 1.3 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.2 0.9 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.2 0.7 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.2 0.5 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.2 1.3 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.2 0.6 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.1 0.4 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.1 4.1 GO:0001976 neurological system process involved in regulation of systemic arterial blood pressure(GO:0001976)
0.1 0.4 GO:1901143 insulin catabolic process(GO:1901143)
0.1 0.4 GO:0002605 negative regulation of dendritic cell antigen processing and presentation(GO:0002605) regulation of cytotoxic T cell degranulation(GO:0043317) negative regulation of cytotoxic T cell degranulation(GO:0043318)
0.1 0.4 GO:1990426 homologous recombination-dependent replication fork processing(GO:1990426)
0.1 1.2 GO:0071896 protein localization to adherens junction(GO:0071896)
0.1 0.5 GO:0001545 primary ovarian follicle growth(GO:0001545)
0.1 0.6 GO:0007343 egg activation(GO:0007343)
0.1 0.5 GO:1904933 regulation of cell proliferation in midbrain(GO:1904933)
0.1 1.9 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.1 0.6 GO:0034146 toll-like receptor 5 signaling pathway(GO:0034146)
0.1 0.6 GO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
0.1 0.3 GO:0001543 ovarian follicle rupture(GO:0001543)
0.1 0.6 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.1 0.4 GO:0035574 histone H4-K20 demethylation(GO:0035574)
0.1 0.6 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.1 0.4 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.1 0.3 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.1 0.5 GO:0003350 pulmonary myocardium development(GO:0003350)
0.1 0.4 GO:1904640 response to methionine(GO:1904640)
0.1 0.3 GO:0099640 axo-dendritic protein transport(GO:0099640)
0.1 0.6 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.1 0.7 GO:0051013 microtubule severing(GO:0051013)
0.1 0.4 GO:1901536 negative regulation of DNA demethylation(GO:1901536)
0.1 0.3 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.1 0.3 GO:0051598 meiotic recombination checkpoint(GO:0051598)
0.1 0.4 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.1 0.5 GO:0006177 GMP biosynthetic process(GO:0006177)
0.1 1.0 GO:0002863 positive regulation of inflammatory response to antigenic stimulus(GO:0002863)
0.1 0.5 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885)
0.1 0.2 GO:2000870 positive regulation of female gonad development(GO:2000196) regulation of progesterone secretion(GO:2000870)
0.1 0.5 GO:1902617 response to fluoride(GO:1902617)
0.1 0.4 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.1 0.7 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.1 0.6 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 0.2 GO:0046103 adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103)
0.1 0.7 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.1 0.2 GO:0051796 regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910)
0.1 0.4 GO:0072660 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.2 GO:2000439 monocyte extravasation(GO:0035696) regulation of monocyte extravasation(GO:2000437) positive regulation of monocyte extravasation(GO:2000439)
0.1 1.3 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 0.4 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.1 0.4 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.1 0.6 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.1 0.2 GO:1902943 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161) regulation of voltage-gated chloride channel activity(GO:1902941) positive regulation of voltage-gated chloride channel activity(GO:1902943)
0.1 1.3 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1 0.2 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.1 0.2 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
0.1 0.6 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.6 GO:0071907 determination of digestive tract left/right asymmetry(GO:0071907)
0.1 0.1 GO:0071047 nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047)
0.1 0.2 GO:1903280 negative regulation of calcium:sodium antiporter activity(GO:1903280)
0.1 0.6 GO:0018377 protein myristoylation(GO:0018377)
0.0 0.4 GO:0098912 membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912)
0.0 0.5 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.8 GO:0031274 regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.6 GO:1902916 positive regulation of protein polyubiquitination(GO:1902916)
0.0 0.4 GO:2000510 positive regulation of dendritic cell chemotaxis(GO:2000510)
0.0 0.4 GO:0051931 regulation of sensory perception of pain(GO:0051930) regulation of sensory perception(GO:0051931)
0.0 1.0 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.4 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
0.0 0.2 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
0.0 0.4 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.6 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.0 0.2 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.0 0.4 GO:0038129 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129)
0.0 1.0 GO:0035745 T-helper 2 cell cytokine production(GO:0035745)
0.0 0.2 GO:0001923 B-1 B cell differentiation(GO:0001923)
0.0 0.6 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.3 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.4 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.1 GO:0034499 late endosome to Golgi transport(GO:0034499)
0.0 0.2 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.2 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.7 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.4 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.2 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.0 0.6 GO:0030238 male sex determination(GO:0030238) Leydig cell differentiation(GO:0033327)
0.0 1.2 GO:0045987 positive regulation of smooth muscle contraction(GO:0045987)
0.0 0.2 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.6 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.0 0.6 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.5 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.0 0.5 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.8 GO:0016180 snRNA processing(GO:0016180)
0.0 0.2 GO:0044211 CTP salvage(GO:0044211)
0.0 0.6 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.5 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.5 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.0 0.1 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.0 0.7 GO:0090312 positive regulation of protein deacetylation(GO:0090312)
0.0 0.6 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.0 0.3 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.5 GO:0035886 vascular smooth muscle cell differentiation(GO:0035886)
0.0 0.5 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 1.4 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.5 GO:0060766 negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0 0.4 GO:0001701 in utero embryonic development(GO:0001701)
0.0 0.1 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 0.1 GO:2000979 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.0 0.4 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.0 0.2 GO:1902659 regulation of glucose mediated signaling pathway(GO:1902659)
0.0 0.1 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0 0.7 GO:0030252 growth hormone secretion(GO:0030252)
0.0 0.1 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.0 0.5 GO:0001501 skeletal system development(GO:0001501)
0.0 0.3 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.0 0.3 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.0 0.4 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.0 0.1 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.0 0.1 GO:0072752 cellular response to rapamycin(GO:0072752)
0.0 0.1 GO:0060751 epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750) branch elongation involved in mammary gland duct branching(GO:0060751)
0.0 2.1 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.2 GO:0015705 iodide transport(GO:0015705)
0.0 0.2 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.1 GO:0031269 modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration(GO:0021815) pseudopodium assembly(GO:0031269)
0.0 0.2 GO:0045636 positive regulation of melanocyte differentiation(GO:0045636)
0.0 0.3 GO:0070129 regulation of mitochondrial translation(GO:0070129)
0.0 0.4 GO:0008228 opsonization(GO:0008228)
0.0 0.5 GO:0006590 thyroid hormone generation(GO:0006590)
0.0 0.2 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.5 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.1 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.2 GO:0015074 DNA integration(GO:0015074)
0.0 0.1 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.4 GO:0070233 negative regulation of T cell apoptotic process(GO:0070233)
0.0 0.3 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.0 0.2 GO:0060484 lung-associated mesenchyme development(GO:0060484)
0.0 0.0 GO:1904172 septin ring assembly(GO:0000921) septin ring organization(GO:0031106) regulation of bleb assembly(GO:1904170) positive regulation of bleb assembly(GO:1904172)
0.0 0.1 GO:0042640 anagen(GO:0042640)
0.0 0.3 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.0 0.1 GO:0043316 cytotoxic T cell degranulation(GO:0043316) positive regulation of constitutive secretory pathway(GO:1903435)
0.0 0.0 GO:1903288 positive regulation of potassium ion import(GO:1903288)
0.0 0.6 GO:0014002 astrocyte development(GO:0014002)
0.0 0.2 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)
0.0 0.2 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.7 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 1.2 GO:0030239 myofibril assembly(GO:0030239)
0.0 1.0 GO:0030521 androgen receptor signaling pathway(GO:0030521)
0.0 0.7 GO:1901998 toxin transport(GO:1901998)
0.0 0.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.1 GO:1990584 cardiac Troponin complex(GO:1990584)
0.2 1.2 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.2 0.6 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1 0.8 GO:0005927 muscle tendon junction(GO:0005927)
0.1 0.4 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.1 0.9 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 0.9 GO:0005827 polar microtubule(GO:0005827)
0.1 0.3 GO:1990923 PET complex(GO:1990923)
0.1 0.5 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.1 1.2 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 0.6 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.1 1.7 GO:0001741 XY body(GO:0001741)
0.1 0.6 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 0.5 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.8 GO:0032039 integrator complex(GO:0032039)
0.0 0.3 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.0 0.1 GO:0000229 cytoplasmic chromosome(GO:0000229)
0.0 0.5 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 12.8 GO:0031674 I band(GO:0031674)
0.0 0.9 GO:0005916 fascia adherens(GO:0005916)
0.0 0.2 GO:0032449 CBM complex(GO:0032449)
0.0 1.2 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.2 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.7 GO:0032059 bleb(GO:0032059)
0.0 0.2 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.0 0.9 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.3 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 0.4 GO:0031906 late endosome lumen(GO:0031906)
0.0 0.2 GO:0002177 manchette(GO:0002177)
0.0 0.4 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 1.7 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.4 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 1.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.8 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.9 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.2 GO:0070847 core mediator complex(GO:0070847)
0.0 0.4 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.1 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.5 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.2 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.3 GO:0070578 RISC-loading complex(GO:0070578)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.4 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 0.3 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.6 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0 0.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.2 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.3 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.4 GO:0000800 lateral element(GO:0000800)
0.0 1.0 GO:0098636 protein complex involved in cell adhesion(GO:0098636)
0.0 0.2 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.1 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.0 0.7 GO:0000421 autophagosome membrane(GO:0000421)
0.0 2.4 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 0.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.1 GO:0097550 transcriptional preinitiation complex(GO:0097550)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.5 4.1 GO:0030172 troponin C binding(GO:0030172)
0.4 5.3 GO:0031433 telethonin binding(GO:0031433)
0.3 1.0 GO:0005174 CD40 receptor binding(GO:0005174)
0.3 0.8 GO:0005137 interleukin-5 receptor binding(GO:0005137)
0.2 0.9 GO:0031208 POZ domain binding(GO:0031208)
0.1 0.4 GO:0000994 RNA polymerase III core binding(GO:0000994)
0.1 0.9 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 0.4 GO:0031626 beta-endorphin binding(GO:0031626)
0.1 0.5 GO:0016608 growth hormone-releasing hormone activity(GO:0016608)
0.1 0.5 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.1 0.4 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.1 0.7 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 1.2 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.5 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 0.4 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.1 0.6 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.1 0.3 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.1 0.4 GO:0019770 IgG receptor activity(GO:0019770)
0.1 1.7 GO:0031432 titin binding(GO:0031432)
0.1 1.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 0.8 GO:0005243 gap junction channel activity(GO:0005243)
0.1 0.7 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 0.3 GO:0034584 piRNA binding(GO:0034584)
0.1 0.4 GO:0004974 leukotriene receptor activity(GO:0004974)
0.1 0.5 GO:0004447 iodide peroxidase activity(GO:0004447)
0.1 0.6 GO:0030884 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.1 0.5 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 1.3 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.5 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.1 0.6 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.1 1.0 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.1 1.6 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.2 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.1 0.5 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 0.7 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.1 0.2 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.1 0.8 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1 0.2 GO:0019779 Atg12 activating enzyme activity(GO:0019778) Atg8 activating enzyme activity(GO:0019779)
0.0 0.4 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 1.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.4 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.6 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 0.3 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.8 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.7 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.5 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.0 0.4 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.6 GO:0005113 patched binding(GO:0005113)
0.0 0.3 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.4 GO:0022858 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.0 0.8 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.6 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.0 0.7 GO:0048156 tau protein binding(GO:0048156)
0.0 0.2 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.0 0.2 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 1.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.3 GO:0070883 pre-miRNA binding(GO:0070883)
0.0 0.1 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.0 0.6 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.9 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 0.8 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.0 0.6 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.8 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.6 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.4 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.2 GO:0070728 leucine binding(GO:0070728)
0.0 0.6 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.8 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 0.5 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.1 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.0 0.1 GO:0098770 FBXO family protein binding(GO:0098770)
0.0 0.4 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0 1.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.0 0.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.2 GO:0004849 uridine kinase activity(GO:0004849)
0.0 1.0 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.1 GO:0015333 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0 0.2 GO:0089720 caspase binding(GO:0089720)
0.0 0.1 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.1 GO:0019158 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.6 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.1 GO:0034603 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 0.3 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 0.4 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.1 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.7 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 1.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.4 GO:0005521 lamin binding(GO:0005521)
0.0 0.2 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 1.1 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.8 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.9 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.5 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.8 PID IL5 PATHWAY IL5-mediated signaling events
0.0 1.1 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 2.6 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.9 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 1.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.6 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 1.8 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 2.7 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.0 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.4 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.8 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.2 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.5 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.0 0.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.3 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 4.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 1.1 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.6 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.5 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.3 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 1.3 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 1.4 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 1.5 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.9 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.2 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.5 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.7 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.4 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.4 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 0.4 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.5 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 1.6 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.8 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 1.8 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.5 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.2 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 1.1 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.5 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.4 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.2 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.2 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus