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Results for OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Z-value: 0.98

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Transcription factors associated with OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Gene Symbol Gene ID Gene Info
OTP
ENSG00000171540.6 orthopedia homeobox
PHOX2B
ENSG00000109132.5 paired like homeobox 2B
LHX1
ENSG00000132130.7 LIM homeobox 1
LMX1A
ENSG00000162761.10 LIM homeobox transcription factor 1 alpha
LHX5
ENSG00000089116.3 LIM homeobox 5
HOXC4
ENSG00000198353.6 homeobox C4
HOXC4
ENSG00000273266.1 homeobox C4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX1hg19_v2_chr17_+_35294075_35294102-0.441.1e-02Click!
LHX5hg19_v2_chr12_-_113909877_113909877-0.144.5e-01Click!
PHOX2Bhg19_v2_chr4_-_41750922_417509870.134.8e-01Click!
OTPhg19_v2_chr5_-_76935513_76935513-0.115.4e-01Click!
HOXC4hg19_v2_chr12_+_54410664_544107150.105.8e-01Click!
LMX1Ahg19_v2_chr1_-_165324983_165325012-0.038.7e-01Click!

Activity profile of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Sorted Z-values of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_191000172 5.32 ENST00000427544.2
UTS2B
urotensin 2B
chr1_-_92952433 4.64 ENST00000294702.5
GFI1
growth factor independent 1 transcription repressor
chr19_+_50016610 3.58 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr5_+_66300464 3.47 ENST00000436277.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr20_-_29978383 3.31 ENST00000339144.3
ENST00000376321.3
DEFB119
defensin, beta 119
chr6_-_49931818 2.81 ENST00000322066.3
DEFB114
defensin, beta 114
chr6_+_130339710 2.77 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr6_-_9933500 2.63 ENST00000492169.1
OFCC1
orofacial cleft 1 candidate 1
chr19_+_50016411 2.61 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chrX_+_153533275 2.48 ENST00000426989.1
ENST00000426203.1
ENST00000369912.2
TKTL1
transketolase-like 1
chr6_+_114178512 2.40 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr16_-_14109841 2.23 ENST00000576797.1
ENST00000575424.1
CTD-2135D7.5
CTD-2135D7.5
chr3_-_164796269 2.17 ENST00000264382.3
SI
sucrase-isomaltase (alpha-glucosidase)
chr14_+_22465771 2.12 ENST00000390445.2
TRAV17
T cell receptor alpha variable 17
chr20_-_29978286 2.08 ENST00000376315.2
DEFB119
defensin, beta 119
chr5_+_66300446 1.99 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr2_-_40680578 1.92 ENST00000455476.1
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr2_+_182850743 1.83 ENST00000409702.1
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr2_-_89385283 1.82 ENST00000390252.2
IGKV3-15
immunoglobulin kappa variable 3-15
chr12_+_4385230 1.82 ENST00000536537.1
CCND2
cyclin D2
chr17_+_12569472 1.75 ENST00000343344.4
MYOCD
myocardin
chr17_+_12569306 1.66 ENST00000425538.1
MYOCD
myocardin
chr16_-_52061283 1.64 ENST00000566314.1
C16orf97
chromosome 16 open reading frame 97
chr15_+_96904487 1.64 ENST00000600790.1
AC087477.1
Uncharacterized protein
chr2_+_152214098 1.57 ENST00000243347.3
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr2_-_89327228 1.57 ENST00000483158.1
IGKV3-11
immunoglobulin kappa variable 3-11
chr1_+_152178320 1.54 ENST00000429352.1
RP11-107M16.2
RP11-107M16.2
chr6_-_32157947 1.54 ENST00000375050.4
PBX2
pre-B-cell leukemia homeobox 2
chr3_+_45927994 1.49 ENST00000357632.2
ENST00000395963.2
CCR9
chemokine (C-C motif) receptor 9
chr2_+_90211643 1.45 ENST00000390277.2
IGKV3D-11
immunoglobulin kappa variable 3D-11
chr9_+_125133315 1.44 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr2_+_90273679 1.42 ENST00000423080.2
IGKV3D-7
immunoglobulin kappa variable 3D-7
chr4_+_169418195 1.40 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr9_+_125133467 1.39 ENST00000426608.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr22_+_40297079 1.37 ENST00000344138.4
ENST00000543252.1
GRAP2
GRB2-related adaptor protein 2
chr2_+_90077680 1.33 ENST00000390270.2
IGKV3D-20
immunoglobulin kappa variable 3D-20
chr13_-_99910673 1.32 ENST00000397473.2
ENST00000397470.2
GPR18
G protein-coupled receptor 18
chr9_+_125132803 1.31 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr2_+_78143006 1.30 ENST00000443419.1
AC073628.1
AC073628.1
chr3_-_141747950 1.28 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr14_+_22670455 1.25 ENST00000390460.1
TRAV26-2
T cell receptor alpha variable 26-2
chr4_-_120243545 1.24 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr14_+_20187174 1.23 ENST00000557414.1
OR4N2
olfactory receptor, family 4, subfamily N, member 2
chr7_+_115862858 1.21 ENST00000393481.2
TES
testis derived transcript (3 LIM domains)
chr8_-_86253888 1.19 ENST00000522389.1
ENST00000432364.2
ENST00000517618.1
CA1
carbonic anhydrase I
chr6_+_26402465 1.18 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
BTN3A1
butyrophilin, subfamily 3, member A1
chr3_+_186692745 1.17 ENST00000438590.1
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr4_+_169418255 1.09 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr2_-_25391507 1.09 ENST00000380794.1
POMC
proopiomelanocortin
chr14_+_31046959 1.08 ENST00000547532.1
ENST00000555429.1
G2E3
G2/M-phase specific E3 ubiquitin protein ligase
chr4_-_68829144 1.08 ENST00000508048.1
TMPRSS11A
transmembrane protease, serine 11A
chr3_-_185538849 1.07 ENST00000421047.2
IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr13_-_99910620 1.06 ENST00000416594.1
GPR18
G protein-coupled receptor 18
chr10_-_4285835 1.05 ENST00000454470.1
LINC00702
long intergenic non-protein coding RNA 702
chr12_+_59989918 1.05 ENST00000547379.1
ENST00000549465.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr12_+_8666126 1.04 ENST00000299665.2
CLEC4D
C-type lectin domain family 4, member D
chr7_-_84122033 1.04 ENST00000424555.1
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr6_+_26402517 1.04 ENST00000414912.2
BTN3A1
butyrophilin, subfamily 3, member A1
chr2_-_25391425 1.04 ENST00000264708.3
ENST00000449220.1
POMC
proopiomelanocortin
chr6_+_26440700 1.03 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr3_+_157154578 1.02 ENST00000295927.3
PTX3
pentraxin 3, long
chr22_+_40297105 1.01 ENST00000540310.1
GRAP2
GRB2-related adaptor protein 2
chr4_-_68829226 1.01 ENST00000396188.2
TMPRSS11A
transmembrane protease, serine 11A
chr18_-_47018869 1.00 ENST00000583036.1
ENST00000580261.1
RPL17
ribosomal protein L17
chr16_-_1538765 1.00 ENST00000447419.2
ENST00000440447.2
PTX4
pentraxin 4, long
chr2_-_25391468 1.00 ENST00000395826.2
POMC
proopiomelanocortin
chrX_-_52827141 0.99 ENST00000375511.3
SPANXN5
SPANX family, member N5
chr12_-_10022735 0.99 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr11_+_59824060 0.99 ENST00000395032.2
ENST00000358152.2
MS4A3
membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chr2_-_25391772 0.97 ENST00000405623.1
POMC
proopiomelanocortin
chr16_+_28565230 0.96 ENST00000317058.3
CCDC101
coiled-coil domain containing 101
chr20_-_33735070 0.96 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chrX_-_21676442 0.95 ENST00000379499.2
KLHL34
kelch-like family member 34
chr10_-_4285923 0.92 ENST00000418372.1
ENST00000608792.1
LINC00702
long intergenic non-protein coding RNA 702
chr11_+_59824127 0.92 ENST00000278865.3
MS4A3
membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chrX_+_107288280 0.91 ENST00000458383.1
VSIG1
V-set and immunoglobulin domain containing 1
chr11_-_327537 0.91 ENST00000602735.1
IFITM3
interferon induced transmembrane protein 3
chr1_+_117544366 0.91 ENST00000256652.4
ENST00000369470.1
CD101
CD101 molecule
chr10_-_50396357 0.90 ENST00000453436.1
ENST00000474718.1
C10orf128
chromosome 10 open reading frame 128
chr5_+_40841276 0.90 ENST00000254691.5
CARD6
caspase recruitment domain family, member 6
chr12_+_131438443 0.89 ENST00000261654.5
GPR133
G protein-coupled receptor 133
chr5_+_40841410 0.89 ENST00000381677.3
CARD6
caspase recruitment domain family, member 6
chr20_+_57594309 0.89 ENST00000217133.1
TUBB1
tubulin, beta 1 class VI
chr13_+_46276441 0.88 ENST00000310521.1
ENST00000533564.1
SPERT
spermatid associated
chr11_-_74800799 0.87 ENST00000305159.3
OR2AT4
olfactory receptor, family 2, subfamily AT, member 4
chrX_-_139047669 0.85 ENST00000370540.1
CXorf66
chromosome X open reading frame 66
chr15_-_20193370 0.84 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr13_-_81801115 0.82 ENST00000567258.1
LINC00564
long intergenic non-protein coding RNA 564
chr10_+_94451574 0.81 ENST00000492654.2
HHEX
hematopoietically expressed homeobox
chr4_+_113568207 0.78 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chr17_-_9694614 0.78 ENST00000330255.5
ENST00000571134.1
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr16_-_28634874 0.77 ENST00000395609.1
ENST00000350842.4
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr12_+_10124001 0.77 ENST00000396507.3
ENST00000304361.4
ENST00000434319.2
CLEC12A
C-type lectin domain family 12, member A
chr4_+_119809984 0.77 ENST00000307142.4
ENST00000448416.2
ENST00000429713.2
SYNPO2
synaptopodin 2
chr10_-_50396407 0.76 ENST00000374153.2
ENST00000374151.3
C10orf128
chromosome 10 open reading frame 128
chr4_+_119810134 0.74 ENST00000434046.2
SYNPO2
synaptopodin 2
chr2_+_3800169 0.73 ENST00000399143.3
DCDC2C
doublecortin domain containing 2C
chr12_+_10124110 0.73 ENST00000350667.4
CLEC12A
C-type lectin domain family 12, member A
chr15_+_94899183 0.73 ENST00000557742.1
MCTP2
multiple C2 domains, transmembrane 2
chr18_-_47018897 0.73 ENST00000418495.1
RPL17
ribosomal protein L17
chr6_+_42749759 0.72 ENST00000314073.5
GLTSCR1L
GLTSCR1-like
chr10_-_75415825 0.72 ENST00000394810.2
SYNPO2L
synaptopodin 2-like
chr7_+_134528635 0.69 ENST00000445569.2
CALD1
caldesmon 1
chr8_+_7353368 0.69 ENST00000355602.2
DEFB107B
defensin, beta 107B
chr15_+_64680003 0.68 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chr6_+_42584847 0.68 ENST00000372883.3
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chrX_+_107288239 0.68 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr18_-_47018769 0.67 ENST00000583637.1
ENST00000578528.1
ENST00000578532.1
ENST00000580387.1
ENST00000579248.1
ENST00000581373.1
RPL17
ribosomal protein L17
chr10_-_99030395 0.66 ENST00000355366.5
ENST00000371027.1
ARHGAP19
Rho GTPase activating protein 19
chr14_-_54425475 0.66 ENST00000559642.1
BMP4
bone morphogenetic protein 4
chr9_-_26947220 0.65 ENST00000520884.1
PLAA
phospholipase A2-activating protein
chr3_-_141719195 0.65 ENST00000397991.4
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr17_+_68164752 0.64 ENST00000535240.1
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr2_+_218994002 0.63 ENST00000428565.1
CXCR2
chemokine (C-X-C motif) receptor 2
chr12_+_131438496 0.63 ENST00000543826.1
GPR133
G protein-coupled receptor 133
chr4_+_26324474 0.62 ENST00000514675.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr17_+_18086392 0.61 ENST00000541285.1
ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr19_+_48112371 0.60 ENST00000594866.1
GLTSCR1
glioma tumor suppressor candidate region gene 1
chr4_+_71091786 0.60 ENST00000317987.5
FDCSP
follicular dendritic cell secreted protein
chr6_+_155334780 0.60 ENST00000538270.1
ENST00000535231.1
TIAM2
T-cell lymphoma invasion and metastasis 2
chr12_+_10163231 0.60 ENST00000396502.1
ENST00000338896.5
CLEC12B
C-type lectin domain family 12, member B
chr14_+_22947861 0.59 ENST00000390482.1
TRAJ57
T cell receptor alpha joining 57
chr2_-_231860596 0.59 ENST00000441063.1
ENST00000434094.1
ENST00000418330.1
ENST00000457803.1
ENST00000414876.1
ENST00000446741.1
ENST00000426904.1
AC105344.2
SPATA3 antisense RNA 1 (head to head)
chr1_+_62439037 0.58 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr12_+_8662057 0.58 ENST00000382064.2
CLEC4D
C-type lectin domain family 4, member D
chr1_-_153518270 0.57 ENST00000354332.4
ENST00000368716.4
S100A4
S100 calcium binding protein A4
chr8_-_7673238 0.57 ENST00000335021.2
DEFB107A
defensin, beta 107A
chr2_+_68962014 0.57 ENST00000467265.1
ARHGAP25
Rho GTPase activating protein 25
chr2_+_68961934 0.57 ENST00000409202.3
ARHGAP25
Rho GTPase activating protein 25
chr11_-_107729287 0.56 ENST00000375682.4
SLC35F2
solute carrier family 35, member F2
chr1_-_160924589 0.55 ENST00000368029.3
ITLN2
intelectin 2
chr6_+_3259122 0.55 ENST00000438998.2
ENST00000380305.4
PSMG4
proteasome (prosome, macropain) assembly chaperone 4
chr11_+_5710919 0.54 ENST00000379965.3
ENST00000425490.1
TRIM22
tripartite motif containing 22
chr12_+_72061563 0.54 ENST00000551238.1
THAP2
THAP domain containing, apoptosis associated protein 2
chr18_-_44181442 0.54 ENST00000398722.4
LOXHD1
lipoxygenase homology domains 1
chr7_-_144435985 0.54 ENST00000549981.1
TPK1
thiamin pyrophosphokinase 1
chr17_+_57233087 0.53 ENST00000578777.1
ENST00000577457.1
ENST00000582995.1
PRR11
proline rich 11
chr3_+_44840679 0.53 ENST00000425755.1
KIF15
kinesin family member 15
chr12_-_112123524 0.53 ENST00000327551.6
BRAP
BRCA1 associated protein
chr5_+_179135246 0.53 ENST00000508787.1
CANX
calnexin
chr2_+_68961905 0.52 ENST00000295381.3
ARHGAP25
Rho GTPase activating protein 25
chr1_+_78383813 0.52 ENST00000342754.5
NEXN
nexilin (F actin binding protein)
chr18_-_51750948 0.52 ENST00000583046.1
ENST00000398398.2
MBD2
methyl-CpG binding domain protein 2
chr4_+_86525299 0.51 ENST00000512201.1
ARHGAP24
Rho GTPase activating protein 24
chr17_+_74463650 0.51 ENST00000392492.3
AANAT
aralkylamine N-acetyltransferase
chr2_-_163008903 0.50 ENST00000418842.2
ENST00000375497.3
GCG
glucagon
chr11_+_71934962 0.50 ENST00000543234.1
INPPL1
inositol polyphosphate phosphatase-like 1
chr1_-_92371839 0.50 ENST00000370399.2
TGFBR3
transforming growth factor, beta receptor III
chr7_-_22862406 0.49 ENST00000372879.4
TOMM7
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr4_+_95128748 0.49 ENST00000359052.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr11_+_59856130 0.49 ENST00000278888.3
MS4A2
membrane-spanning 4-domains, subfamily A, member 2
chr10_-_95242044 0.48 ENST00000371501.4
ENST00000371502.4
ENST00000371489.1
MYOF
myoferlin
chr7_-_22862448 0.46 ENST00000358435.4
TOMM7
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr10_-_95241951 0.46 ENST00000358334.5
ENST00000359263.4
ENST00000371488.3
MYOF
myoferlin
chr2_+_102615416 0.46 ENST00000393414.2
IL1R2
interleukin 1 receptor, type II
chr10_-_28571015 0.45 ENST00000375719.3
ENST00000375732.1
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr5_-_53115506 0.45 ENST00000511953.1
ENST00000504552.1
CTD-2081C10.1
CTD-2081C10.1
chr7_-_44580861 0.44 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
NPC1L1
NPC1-like 1
chr16_+_31271274 0.43 ENST00000287497.8
ENST00000544665.3
ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr12_+_12510352 0.43 ENST00000298571.6
LOH12CR1
loss of heterozygosity, 12, chromosomal region 1
chr10_-_50396425 0.43 ENST00000374148.1
C10orf128
chromosome 10 open reading frame 128
chr11_-_107729504 0.43 ENST00000265836.7
SLC35F2
solute carrier family 35, member F2
chr7_-_38305279 0.42 ENST00000443402.2
TRGC1
T cell receptor gamma constant 1
chr4_-_39979576 0.42 ENST00000303538.8
ENST00000503396.1
PDS5A
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr17_-_46688334 0.42 ENST00000239165.7
HOXB7
homeobox B7
chr16_-_30122717 0.42 ENST00000566613.1
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chrX_+_134975753 0.41 ENST00000535938.1
SAGE1
sarcoma antigen 1
chr7_+_142000747 0.41 ENST00000455382.2
TRBV2
T cell receptor beta variable 2
chr14_-_106668095 0.40 ENST00000390606.2
IGHV3-20
immunoglobulin heavy variable 3-20
chr19_+_48949087 0.40 ENST00000598711.1
GRWD1
glutamate-rich WD repeat containing 1
chr4_+_108745711 0.39 ENST00000394684.4
SGMS2
sphingomyelin synthase 2
chr2_-_207583120 0.39 ENST00000452335.2
DYTN
dystrotelin
chr4_+_71108300 0.39 ENST00000304954.3
CSN3
casein kappa
chrY_-_6740649 0.39 ENST00000383036.1
ENST00000383037.4
AMELY
amelogenin, Y-linked
chr15_-_34635314 0.38 ENST00000557912.1
ENST00000328848.4
NOP10
NOP10 ribonucleoprotein
chr14_+_22782867 0.38 ENST00000390467.3
TRAV40
T cell receptor alpha variable 40
chr19_+_48949030 0.38 ENST00000253237.5
GRWD1
glutamate-rich WD repeat containing 1
chr2_+_182850551 0.38 ENST00000452904.1
ENST00000409137.3
ENST00000280295.3
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr20_+_31805131 0.37 ENST00000375454.3
ENST00000375452.3
BPIFA3
BPI fold containing family A, member 3
chr7_-_5465045 0.37 ENST00000399434.2
TNRC18
trinucleotide repeat containing 18
chr20_+_30697298 0.37 ENST00000398022.2
TM9SF4
transmembrane 9 superfamily protein member 4
chr17_-_72527605 0.36 ENST00000392621.1
ENST00000314401.3
CD300LB
CD300 molecule-like family member b
chr17_-_39093672 0.35 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
KRT23
keratin 23 (histone deacetylase inducible)
chr12_-_10282836 0.35 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A
chr14_+_22951993 0.35 ENST00000390485.1
TRAJ53
T cell receptor alpha joining 53
chr1_-_114414316 0.35 ENST00000528414.1
ENST00000538253.1
ENST00000460620.1
ENST00000420377.2
ENST00000525799.1
ENST00000359785.5
PTPN22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
chr3_-_112564797 0.35 ENST00000398214.1
ENST00000448932.1
CD200R1L
CD200 receptor 1-like
chr4_+_71019903 0.35 ENST00000344526.5
C4orf40
chromosome 4 open reading frame 40
chr14_-_106552755 0.34 ENST00000390600.2
IGHV3-9
immunoglobulin heavy variable 3-9
chr9_+_111624577 0.33 ENST00000333999.3
ACTL7A
actin-like 7A
chrX_+_134975858 0.33 ENST00000537770.1
SAGE1
sarcoma antigen 1
chr11_-_559377 0.33 ENST00000486629.1
C11orf35
chromosome 11 open reading frame 35
chr20_+_55904815 0.33 ENST00000371263.3
ENST00000345868.4
ENST00000371260.4
ENST00000418127.1
SPO11
SPO11 meiotic protein covalently bound to DSB
chr6_-_50016364 0.33 ENST00000322246.4
DEFB112
defensin, beta 112
chr20_-_21086975 0.32 ENST00000420705.1
ENST00000593272.1
LINC00237
long intergenic non-protein coding RNA 237
chr21_-_15583165 0.32 ENST00000536861.1
LIPI
lipase, member I
chr12_-_10151773 0.32 ENST00000298527.6
ENST00000348658.4
CLEC1B
C-type lectin domain family 1, member B
chr20_+_31870927 0.32 ENST00000253354.1
BPIFB1
BPI fold containing family B, member 1
chr3_+_140396881 0.31 ENST00000286349.3
TRIM42
tripartite motif containing 42
chr4_-_48116540 0.31 ENST00000506073.1
TXK
TXK tyrosine kinase

Network of associatons between targets according to the STRING database.

First level regulatory network of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.2 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
1.5 4.6 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
1.0 3.9 GO:0002304 gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305)
0.9 3.4 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.5 4.1 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.5 2.8 GO:0061760 antifungal innate immune response(GO:0061760)
0.3 3.0 GO:0006772 thiamine metabolic process(GO:0006772)
0.3 2.2 GO:0044245 polysaccharide digestion(GO:0044245)
0.3 0.3 GO:0035690 cellular response to drug(GO:0035690)
0.3 0.8 GO:0061010 negative regulation of transcription by transcription factor localization(GO:0010621) gall bladder development(GO:0061010)
0.3 1.0 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.2 0.8 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.2 1.0 GO:0036512 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.2 4.1 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.2 1.9 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.2 2.8 GO:0043249 erythrocyte maturation(GO:0043249)
0.2 0.5 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.1 1.0 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.1 0.7 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.7 GO:0071893 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.1 1.0 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.1 0.4 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.1 0.6 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.1 0.9 GO:0071461 cellular response to redox state(GO:0071461)
0.1 0.6 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.1 0.5 GO:0032690 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.1 0.6 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.1 0.6 GO:0038112 interleukin-8-mediated signaling pathway(GO:0038112)
0.1 0.3 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 0.5 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.1 0.3 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.1 2.5 GO:0003334 keratinocyte development(GO:0003334)
0.1 3.0 GO:0072643 interferon-gamma secretion(GO:0072643)
0.1 1.0 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.1 0.6 GO:0002767 immune response-inhibiting cell surface receptor signaling pathway(GO:0002767)
0.1 0.3 GO:0000706 meiotic DNA double-strand break processing(GO:0000706) double-strand break repair involved in meiotic recombination(GO:1990918)
0.1 0.7 GO:1901189 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.1 4.0 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.1 0.4 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.1 1.9 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 0.5 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.1 0.2 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 0.2 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.1 0.4 GO:0003185 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.1 2.4 GO:0051764 actin crosslink formation(GO:0051764)
0.1 0.9 GO:0001778 plasma membrane repair(GO:0001778)
0.1 0.2 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 0.5 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.2 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.0 0.5 GO:0071896 protein localization to adherens junction(GO:0071896)
0.0 0.2 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.0 0.2 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.0 1.2 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.2 GO:0072709 cellular response to sorbitol(GO:0072709)
0.0 1.9 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.2 GO:0071284 cellular response to lead ion(GO:0071284)
0.0 0.2 GO:2000521 negative regulation of immunological synapse formation(GO:2000521) negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001189)
0.0 6.2 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 1.3 GO:0030728 ovulation(GO:0030728)
0.0 0.4 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.7 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.1 GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476)
0.0 0.8 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.0 1.5 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.4 GO:0030299 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.0 0.9 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 0.3 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.4 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.0 0.1 GO:0045209 MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209)
0.0 0.7 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.8 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.3 GO:0018406 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 0.5 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.6 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.3 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.2 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.2 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.0 0.4 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.0 7.2 GO:0042742 defense response to bacterium(GO:0042742)
0.0 0.1 GO:0042278 purine nucleoside metabolic process(GO:0042278)
0.0 0.5 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.2 GO:1902856 negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.0 0.2 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.5 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 1.2 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 2.4 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.4 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.3 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.0 0.4 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.2 GO:0051775 response to redox state(GO:0051775)
0.0 5.4 GO:0008217 regulation of blood pressure(GO:0008217)
0.0 0.4 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.3 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.2 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.4 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 2.5 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 3.2 GO:0002377 immunoglobulin production(GO:0002377)
0.0 0.2 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.3 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.1 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
0.0 0.7 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880)
0.0 0.1 GO:0043126 regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043126) positive regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043128)
0.0 0.1 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.0 0.3 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 1.1 GO:0042035 regulation of cytokine biosynthetic process(GO:0042035)
0.0 0.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.2 GO:0060252 positive regulation of glial cell proliferation(GO:0060252)
0.0 0.5 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.3 GO:0030220 platelet formation(GO:0030220)
0.0 0.2 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0 0.9 GO:0002763 positive regulation of myeloid leukocyte differentiation(GO:0002763)
0.0 1.5 GO:0000045 autophagosome assembly(GO:0000045)
0.0 5.3 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.5 GO:0046839 phospholipid dephosphorylation(GO:0046839) phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.1 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.0 0.1 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.0 0.5 GO:0050982 detection of mechanical stimulus(GO:0050982)
0.0 0.2 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.7 GO:1901998 toxin transport(GO:1901998)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.4 GO:0042585 germinal vesicle(GO:0042585)
0.2 1.8 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.2 0.5 GO:0032998 Fc receptor complex(GO:0032997) Fc-epsilon receptor I complex(GO:0032998)
0.1 0.5 GO:0005873 plus-end kinesin complex(GO:0005873)
0.1 0.5 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.1 1.0 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 0.1 GO:0030008 TRAPP complex(GO:0030008)
0.1 0.2 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.1 0.7 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 0.2 GO:0043614 multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993) glial limiting end-foot(GO:0097451)
0.1 0.4 GO:0072589 box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.1 0.4 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.0 0.7 GO:0030478 actin cap(GO:0030478)
0.0 4.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 2.5 GO:0002102 podosome(GO:0002102)
0.0 0.2 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.5 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.5 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 4.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 2.6 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.4 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 4.7 GO:0035579 specific granule membrane(GO:0035579)
0.0 1.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.1 GO:0000125 PCAF complex(GO:0000125)
0.0 0.2 GO:0036128 CatSper complex(GO:0036128)
0.0 0.3 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 1.0 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.2 GO:0072687 meiotic spindle(GO:0072687)
0.0 1.7 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.1 GO:0043257 laminin-8 complex(GO:0043257)
0.0 1.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)
0.0 2.7 GO:0005903 brush border(GO:0005903)
0.0 2.7 GO:0072562 blood microparticle(GO:0072562)
0.0 0.6 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.6 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.5 GO:0032420 stereocilium(GO:0032420)
0.0 0.1 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 2.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.3 GO:0043194 axon initial segment(GO:0043194)
0.0 0.2 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 2.6 GO:0030018 Z disc(GO:0030018)
0.0 4.3 GO:0034774 secretory granule lumen(GO:0034774)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 6.2 GO:0019770 IgG receptor activity(GO:0019770)
0.8 4.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.6 2.5 GO:0004802 transketolase activity(GO:0004802)
0.5 2.2 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.5 3.7 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.3 1.9 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.3 1.0 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.2 0.8 GO:0016005 phospholipase A2 activator activity(GO:0016005)
0.2 0.5 GO:0070123 transforming growth factor beta receptor activity, type III(GO:0070123)
0.1 1.2 GO:0004064 arylesterase activity(GO:0004064)
0.1 2.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 0.5 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.1 0.6 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.1 1.2 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 0.8 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.1 4.0 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.6 GO:0004918 interleukin-8 receptor activity(GO:0004918)
0.1 1.0 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.9 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.1 0.7 GO:0070728 leucine binding(GO:0070728)
0.1 0.5 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.1 0.3 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.1 0.3 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.1 4.1 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 0.9 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 1.0 GO:0015266 protein channel activity(GO:0015266)
0.1 0.7 GO:0019863 IgE binding(GO:0019863)
0.1 1.5 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.1 1.0 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 0.6 GO:0003696 satellite DNA binding(GO:0003696)
0.1 0.4 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 2.8 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.1 0.2 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1 0.2 GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.0 0.5 GO:0016778 diphosphotransferase activity(GO:0016778)
0.0 0.4 GO:0030345 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.1 GO:0046978 peptide antigen-transporting ATPase activity(GO:0015433) TAP binding(GO:0046977) TAP1 binding(GO:0046978)
0.0 1.5 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.7 GO:0070700 BMP receptor binding(GO:0070700)
0.0 2.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.2 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532) copper-dependent protein binding(GO:0032767)
0.0 1.0 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.2 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.4 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 1.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.3 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 7.9 GO:0003823 antigen binding(GO:0003823)
0.0 0.8 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.3 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.1 GO:0036033 mediator complex binding(GO:0036033)
0.0 5.3 GO:0005179 hormone activity(GO:0005179)
0.0 0.4 GO:0001851 complement component C3b binding(GO:0001851)
0.0 0.7 GO:0000150 recombinase activity(GO:0000150)
0.0 0.5 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.0 0.6 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.6 GO:0030547 receptor inhibitor activity(GO:0030547)
0.0 0.2 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.6 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.0 0.7 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 2.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 2.1 GO:0005080 protein kinase C binding(GO:0005080)
0.0 1.4 GO:0005504 fatty acid binding(GO:0005504)
0.0 1.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.7 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.1 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.0 0.7 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.2 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.4 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 4.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.1 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.0 0.1 GO:0030760 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.0 0.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 5.0 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.1 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 0.1 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.5 GO:0070888 E-box binding(GO:0070888)
0.0 0.1 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.5 GO:0008139 nuclear localization sequence binding(GO:0008139)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 2.1 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 4.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.8 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 1.0 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 4.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.9 PID E2F PATHWAY E2F transcription factor network
0.0 1.5 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.1 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.5 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.5 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.7 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.9 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.7 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.1 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.2 9.9 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.2 2.4 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 2.2 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 1.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 1.5 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 1.4 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 1.0 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 2.4 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.7 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.2 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.3 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 2.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.8 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.7 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.8 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.3 REACTOME OPSINS Genes involved in Opsins
0.0 1.9 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 2.5 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.5 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 3.8 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.3 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 1.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.6 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.6 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.0 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.4 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.3 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.5 REACTOME KINESINS Genes involved in Kinesins