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Illumina Body Map 2
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Results for PBX2
Z-value: 0.65
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Transcription factors associated with PBX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PBX2 | hg19_v2_chr6_-_32157947_32157992 | -0.12 | 5.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_52864680 Show fit | 2.88 |
ENST00000406595.1
ENST00000485816.1 ENST00000434759.3 ENST00000346281.5 ENST00000266041.4 |
inter-alpha-trypsin inhibitor heavy chain family, member 4 |
|
| chr4_-_100065419 Show fit | 2.47 |
ENST00000504125.1
ENST00000505590.1 |
alcohol dehydrogenase 4 (class II), pi polypeptide |
|
| chr8_-_6420930 Show fit | 2.43 |
ENST00000325203.5
|
angiopoietin 2 |
|
| chr10_-_45474237 Show fit | 1.88 |
ENST00000448778.1
ENST00000298295.3 |
chromosome 10 open reading frame 10 |
|
| chr2_+_234601512 Show fit | 1.87 |
ENST00000305139.6
|
UDP glucuronosyltransferase 1 family, polypeptide A6 |
|
| chr2_+_234602305 Show fit | 1.78 |
ENST00000406651.1
|
UDP glucuronosyltransferase 1 family, polypeptide A6 |
|
| chr4_-_100065389 Show fit | 1.72 |
ENST00000512499.1
|
alcohol dehydrogenase 4 (class II), pi polypeptide |
|
| chr12_+_57390745 Show fit | 1.48 |
ENST00000600202.1
|
HBcAg-binding protein; Uncharacterized protein |
|
| chr4_-_100065440 Show fit | 1.43 |
ENST00000508393.1
ENST00000265512.7 |
alcohol dehydrogenase 4 (class II), pi polypeptide |
|
| chr2_+_204732487 Show fit | 1.37 |
ENST00000302823.3
|
cytotoxic T-lymphocyte-associated protein 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PBX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.6 | GO:0006069 | ethanol oxidation(GO:0006069) |
| 0.3 | 3.6 | GO:0052696 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 0.0 | 2.9 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 0.5 | 2.5 | GO:0045590 | negative regulation of regulatory T cell differentiation(GO:0045590) |
| 0.6 | 2.4 | GO:0050928 | negative regulation of positive chemotaxis(GO:0050928) |
| 0.2 | 1.3 | GO:0035026 | leading edge cell differentiation(GO:0035026) |
| 0.2 | 1.3 | GO:0030950 | establishment or maintenance of actin cytoskeleton polarity(GO:0030950) |
| 0.1 | 1.3 | GO:2000467 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) positive regulation of glycogen (starch) synthase activity(GO:2000467) |
| 0.4 | 1.1 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.1 | 0.9 | GO:0030241 | skeletal muscle myosin thick filament assembly(GO:0030241) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.9 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.0 | 2.5 | GO:0098636 | protein complex involved in cell adhesion(GO:0098636) |
| 0.1 | 1.3 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.0 | 1.3 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.4 | 1.1 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.0 | 0.9 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.1 | 0.8 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 0.4 | GO:0097169 | AIM2 inflammasome complex(GO:0097169) |
| 0.1 | 0.3 | GO:1990075 | periciliary membrane compartment(GO:1990075) |
| 0.0 | 0.3 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 5.6 | GO:0019115 | benzaldehyde dehydrogenase activity(GO:0019115) |
| 0.1 | 3.6 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 2.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 2.4 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.0 | 1.3 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.0 | 1.3 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 1.3 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.1 | 0.9 | GO:0031433 | telethonin binding(GO:0031433) |
| 0.0 | 0.8 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 0.8 | GO:0070064 | proline-rich region binding(GO:0070064) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 2.4 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 1.5 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 1.3 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.0 | 1.3 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 1.1 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.8 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.6 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 0.6 | PID S1P S1P1 PATHWAY | S1P1 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.6 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.1 | 3.6 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 2.5 | REACTOME CTLA4 INHIBITORY SIGNALING | Genes involved in CTLA4 inhibitory signaling |
| 0.1 | 2.4 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 1.3 | REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |
| 0.1 | 1.3 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 1.3 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 1.1 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.8 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.0 | 0.8 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |