ISMARA results: PDX1

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Illumina Body Map 2

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Results for PDX1

Z-value: 1.36

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Transcription factors associated with PDX1

Gene Symbol	Gene ID	Gene Info
PDX1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000139515.5	pancreatic and duodenal homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PDX1	hg19_v2_chr13_+_28494130_28494168	-0.10	6.0e-01	Click!

Activity profile of PDX1 motif

Sorted Z-values of PDX1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_-_32157947 Show fit	7.57	ENST00000375050.4	PBX2 Ensembl NCBI GeneCards UniProt NextProt Show fit	pre-B-cell leukemia homeobox 2
chr13_-_46716969 Show fit	6.56	ENST00000435666.2	LCP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	lymphocyte cytosolic protein 1 (L-plastin)
chr4_-_36245561 Show fit	5.85	ENST00000506189.1	ARAP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr15_+_75080883 Show fit	5.30	ENST00000567571.1	CSK Ensembl NCBI GeneCards UniProt NextProt Show fit	c-src tyrosine kinase
chr7_+_50348268 Show fit	4.87	ENST00000438033.1 ENST00000439701.1	IKZF1 Ensembl NCBI GeneCards UniProt NextProt Show fit	IKAROS family zinc finger 1 (Ikaros)
chr1_+_198607801 Show fit	4.76	ENST00000367379.1	PTPRC Ensembl NCBI GeneCards UniProt NextProt Show fit	protein tyrosine phosphatase, receptor type, C
chr12_-_45269251 Show fit	4.36	ENST00000553120.1	NELL2 Ensembl NCBI GeneCards UniProt NextProt Show fit	NEL-like 2 (chicken)
chr3_+_108541608 Show fit	4.35	ENST00000426646.1	TRAT1 Ensembl NCBI GeneCards UniProt NextProt Show fit	T cell receptor associated transmembrane adaptor 1
chr3_-_39321512 Show fit	4.27	ENST00000399220.2	CX3CR1 Ensembl NCBI GeneCards UniProt NextProt Show fit	chemokine (C-X3-C motif) receptor 1
chr3_+_108541545 Show fit	4.26	ENST00000295756.6	TRAT1 Ensembl NCBI GeneCards UniProt NextProt Show fit	T cell receptor associated transmembrane adaptor 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of PDX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	13.2	GO:1903435	positive regulation of constitutive secretory pathway(GO:1903435)
2.5	12.7	GO:2000473	regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473)
1.0	10.2	GO:0038129	directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129)
1.0	8.6	GO:0001920	negative regulation of receptor recycling(GO:0001920)
0.6	7.6	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.2	7.6	GO:0009954	proximal/distal pattern formation(GO:0009954)
1.2	6.9	GO:0015722	canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.3	6.7	GO:0071803	positive regulation of podosome assembly(GO:0071803)
0.4	6.5	GO:0070257	positive regulation of mucus secretion(GO:0070257)
0.7	5.3	GO:0010989	negative regulation of low-density lipoprotein particle clearance(GO:0010989)

Showing 1 to 10 of 131 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	13.4	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	12.0	GO:0019897	extrinsic component of plasma membrane(GO:0019897)
0.2	10.2	GO:0030673	axolemma(GO:0030673)
0.5	10.0	GO:0033093	Weibel-Palade body(GO:0033093)
0.2	8.6	GO:0042101	T cell receptor complex(GO:0042101)
0.1	7.7	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1	7.6	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.2	6.6	GO:0001891	phagocytic cup(GO:0001891)
0.2	6.5	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.3	4.9	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)

Showing 1 to 10 of 58 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	13.5	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.4	13.2	GO:0031489	myosin V binding(GO:0031489)
0.8	10.2	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	8.7	GO:0003682	chromatin binding(GO:0003682)
0.3	8.6	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
1.4	6.9	GO:0015254	glycerol channel activity(GO:0015254)
0.1	6.8	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.2	6.5	GO:0042043	neurexin family protein binding(GO:0042043)
0.1	6.5	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1	5.4	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)

Showing 1 to 10 of 90 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	18.6	PID ARF6 PATHWAY	Arf6 signaling events
0.2	15.4	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.1	11.6	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2	10.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	5.7	PID AP1 PATHWAY	AP-1 transcription factor network
0.1	5.3	ST B CELL ANTIGEN RECEPTOR	B Cell Antigen Receptor
0.0	4.4	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.1	3.6	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	3.6	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.0	3.3	PID PLK1 PATHWAY	PLK1 signaling events

Showing 1 to 10 of 29 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	17.9	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.3	13.2	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.3	10.2	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.2	8.6	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.1	7.8	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.2	7.6	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.5	6.9	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	5.3	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	4.9	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.1	4.3	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines

Showing 1 to 10 of 40 entries

Results for PDX1

Z-value: 1.36

Motif logo

Transcription factors associated with PDX1

Activity-expression correlation:

Activity profile of PDX1 motif

Sorted Z-values of PDX1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of PDX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: