ISMARA results: PITX1

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Illumina Body Map 2

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Results for PITX1

Z-value: 3.29

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Transcription factors associated with PITX1

Gene Symbol	Gene ID	Gene Info
PITX1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000069011.11	paired like homeodomain 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PITX1	hg19_v2_chr5_-_134369973_134369988	-0.04	8.2e-01	Click!

Activity profile of PITX1 motif

Sorted Z-values of PITX1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_161035655 Show fit	10.09	ENST00000600454.1	AL591806.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	Uncharacterized protein
chr5_-_55224569 Show fit	8.37	ENST00000595799.1	AC008914.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	Uncharacterized protein
chr12_-_66317967 Show fit	8.08	ENST00000601398.1	AC090673.2 Ensembl NCBI GeneCards UniProt NextProt Show fit	Uncharacterized protein
chr19_-_2256405 Show fit	6.80	ENST00000300961.6	JSRP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	junctional sarcoplasmic reticulum protein 1
chr22_-_24096562 Show fit	6.72	ENST00000398465.3	VPREB3 Ensembl NCBI GeneCards UniProt NextProt Show fit	pre-B lymphocyte 3
chr22_-_24096630 Show fit	6.60	ENST00000248948.3	VPREB3 Ensembl NCBI GeneCards UniProt NextProt Show fit	pre-B lymphocyte 3
chr11_-_118213455 Show fit	6.49	ENST00000300692.4	CD3D Ensembl NCBI GeneCards UniProt NextProt Show fit	CD3d molecule, delta (CD3-TCR complex)
chr7_+_73623717 Show fit	6.05	ENST00000344995.5 ENST00000460943.1	LAT2 Ensembl NCBI GeneCards UniProt NextProt Show fit	linker for activation of T cells family, member 2
chr16_+_30386098 Show fit	5.72	ENST00000322861.7	MYLPF Ensembl NCBI GeneCards UniProt NextProt Show fit	myosin light chain, phosphorylatable, fast skeletal muscle
chr11_-_118213331 Show fit	5.63	ENST00000392884.2	CD3D Ensembl NCBI GeneCards UniProt NextProt Show fit	CD3d molecule, delta (CD3-TCR complex)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	21.2	GO:0045576	mast cell activation(GO:0045576)
0.4	17.5	GO:0035590	purinergic nucleotide receptor signaling pathway(GO:0035590)
0.1	17.4	GO:0002377	immunoglobulin production(GO:0002377)
1.1	17.1	GO:0045059	positive thymic T cell selection(GO:0045059)
0.6	16.1	GO:0072540	T-helper 17 cell lineage commitment(GO:0072540)
0.1	15.9	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.6	11.0	GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.6	10.6	GO:0043383	negative T cell selection(GO:0043383)
0.3	9.1	GO:0006337	nucleosome disassembly(GO:0006337)
0.1	6.3	GO:0002260	lymphocyte homeostasis(GO:0002260)

Showing 1 to 10 of 590 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	27.8	GO:0101003	ficolin-1-rich granule membrane(GO:0101003)
1.4	18.8	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	18.0	GO:0009897	external side of plasma membrane(GO:0009897)
0.4	16.5	GO:0042629	mast cell granule(GO:0042629)
0.5	15.7	GO:0031229	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.2	15.5	GO:0001772	immunological synapse(GO:0001772)
1.1	12.0	GO:0034687	integrin alphaL-beta2 complex(GO:0034687)
0.1	10.8	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.1	10.1	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.2	8.5	GO:0005859	muscle myosin complex(GO:0005859)

Showing 1 to 10 of 253 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	17.0	GO:0046982	protein heterodimerization activity(GO:0046982)
0.0	16.8	GO:0005525	GTP binding(GO:0005525)
1.4	16.3	GO:0004931	extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.2	16.3	GO:0042169	SH2 domain binding(GO:0042169)
0.0	13.2	GO:0005096	GTPase activator activity(GO:0005096)
1.0	12.0	GO:0030369	ICAM-3 receptor activity(GO:0030369)
0.1	11.6	GO:0003735	structural constituent of ribosome(GO:0003735)
0.3	10.8	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.1	10.0	GO:0004004	ATP-dependent RNA helicase activity(GO:0004004)
0.1	7.7	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)

Showing 1 to 10 of 379 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	22.2	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.1	13.7	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.2	12.9	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.2	12.6	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1	11.7	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.2	10.0	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.2	8.1	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.1	8.1	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.0	7.4	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.1	7.2	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)

Showing 1 to 10 of 81 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	17.4	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1	16.5	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2	14.7	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.1	11.7	REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.2	11.5	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.1	10.6	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.3	8.4	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.0	7.4	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.4	6.5	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.1	6.5	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus

Showing 1 to 10 of 121 entries

Results for PITX1

Z-value: 3.29

Motif logo

Transcription factors associated with PITX1

Activity-expression correlation:

Activity profile of PITX1 motif

Sorted Z-values of PITX1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: