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Illumina Body Map 2
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Results for PITX3
Z-value: 1.32
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Transcription factors associated with PITX3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PITX3 | hg19_v2_chr10_-_104001231_104001274 | 0.14 | 4.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_+_16500037 Show fit | 3.28 |
ENST00000536371.1
ENST00000010404.2 |
microsomal glutathione S-transferase 1 |
|
| chrX_-_55020511 Show fit | 2.52 |
ENST00000375006.3
ENST00000374992.2 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 |
|
| chr1_+_169079823 Show fit | 2.37 |
ENST00000367813.3
|
ATPase, Na+/K+ transporting, beta 1 polypeptide |
|
| chr18_+_29171689 Show fit | 2.15 |
ENST00000237014.3
|
transthyretin |
|
| chr7_+_73868439 Show fit | 2.04 |
ENST00000424337.2
|
GTF2I repeat domain containing 1 |
|
| chr19_-_3479086 Show fit | 2.02 |
ENST00000587847.1
|
chromosome 19 open reading frame 77 |
|
| chr16_+_30387141 Show fit | 1.78 |
ENST00000566955.1
|
myosin light chain, phosphorylatable, fast skeletal muscle |
|
| chr1_+_145413268 Show fit | 1.77 |
ENST00000421822.2
ENST00000336751.5 ENST00000497365.1 ENST00000475797.1 |
hemochromatosis type 2 (juvenile) |
|
| chr8_-_42360015 Show fit | 1.75 |
ENST00000522707.1
|
solute carrier family 20 (phosphate transporter), member 2 |
|
| chr12_-_54982420 Show fit | 1.56 |
ENST00000257905.8
|
protein phosphatase 1, regulatory (inhibitor) subunit 1A |
Network of associatons between targets according to the STRING database.
First level regulatory network of PITX3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.0 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 1.9 | 5.6 | GO:0071449 | cellular response to lipid hydroperoxide(GO:0071449) |
| 0.2 | 5.3 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.2 | 4.8 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.9 | 4.6 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.1 | 4.6 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.0 | 4.6 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.1 | 4.3 | GO:0072378 | blood coagulation, fibrin clot formation(GO:0072378) |
| 0.1 | 4.1 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.0 | 4.1 | GO:0005977 | glycogen metabolic process(GO:0005977) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.3 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 16.2 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 13.3 | GO:0031674 | I band(GO:0031674) |
| 0.1 | 11.0 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 7.5 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 6.7 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.0 | 6.5 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.1 | 5.7 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.0 | 5.7 | GO:0005903 | brush border(GO:0005903) |
| 0.1 | 4.6 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.5 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.3 | 6.4 | GO:0043295 | glutathione binding(GO:0043295) |
| 0.1 | 6.4 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 5.6 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 5.2 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.1 | 4.1 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.2 | 3.7 | GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857) |
| 0.0 | 3.7 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.1 | 3.6 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 3.4 | GO:0044325 | ion channel binding(GO:0044325) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 4.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 3.9 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 3.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 3.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 3.4 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 2.7 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 2.4 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 2.3 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 2.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.6 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 6.8 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 5.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 5.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 5.7 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 4.3 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 4.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 3.8 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.1 | 3.6 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 3.4 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |