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Illumina Body Map 2
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Results for POU2F1
Z-value: 1.88
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Transcription factors associated with POU2F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU2F1 | hg19_v2_chr1_+_167298281_167298319 | -0.09 | 6.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_+_34391625 Show fit | 8.47 |
ENST00000004921.3
|
chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) |
|
| chr14_-_106453155 Show fit | 6.87 |
ENST00000390594.2
|
immunoglobulin heavy variable 1-2 |
|
| chr14_-_106733624 Show fit | 6.69 |
ENST00000390610.2
|
immunoglobulin heavy variable 1-24 |
|
| chr2_-_238305397 Show fit | 6.62 |
ENST00000409809.1
|
collagen, type VI, alpha 3 |
|
| chr14_-_106539557 Show fit | 6.09 |
ENST00000390599.2
|
immunoglobulin heavy variable 1-8 |
|
| chr14_-_106967788 Show fit | 6.00 |
ENST00000390622.2
|
immunoglobulin heavy variable 1-46 |
|
| chr21_+_10862622 Show fit | 5.87 |
ENST00000302092.5
ENST00000559480.1 |
immunoglobulin heavy variable 1/OR21-1 (non-functional) |
|
| chr2_-_89545079 Show fit | 5.81 |
ENST00000468494.1
|
immunoglobulin kappa variable 2-30 |
|
| chr2_+_89975669 Show fit | 5.61 |
ENST00000474213.1
|
immunoglobulin kappa variable 2D-30 |
|
| chr2_-_89521942 Show fit | 5.57 |
ENST00000482769.1
|
immunoglobulin kappa variable 2-28 |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU2F1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 113.7 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 14.6 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 1.8 | 9.2 | GO:1904075 | trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075) |
| 0.0 | 9.1 | GO:0002250 | adaptive immune response(GO:0002250) |
| 0.1 | 7.7 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
| 0.0 | 6.9 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.1 | 6.6 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.3 | 5.1 | GO:0042908 | xenobiotic transport(GO:0042908) |
| 0.4 | 4.9 | GO:0098735 | positive regulation of the force of heart contraction(GO:0098735) |
| 1.5 | 4.6 | GO:1990922 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 40.2 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.2 | 36.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 28.9 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 10.0 | GO:0016363 | nuclear matrix(GO:0016363) |
| 1.2 | 9.2 | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) |
| 0.6 | 8.5 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.3 | 8.2 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.3 | 4.9 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.1 | 4.4 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 3.9 | GO:0031225 | anchored component of membrane(GO:0031225) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 79.8 | GO:0003823 | antigen binding(GO:0003823) |
| 0.6 | 40.2 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 9.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 8.6 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.2 | 8.5 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.0 | 8.5 | GO:0005539 | glycosaminoglycan binding(GO:0005539) |
| 0.0 | 7.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 5.5 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 5.2 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.4 | 5.1 | GO:0008559 | xenobiotic-transporting ATPase activity(GO:0008559) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.6 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.0 | 7.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 6.6 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 6.0 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.2 | 4.9 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.1 | 4.9 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.1 | 3.4 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 2.4 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 2.3 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 2.1 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.1 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 6.4 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 5.1 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.0 | 5.1 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 4.3 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 3.2 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.0 | 3.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 2.5 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.1 | 2.3 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.0 | 2.3 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |