ISMARA results: PROX1

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Illumina Body Map 2

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Results for PROX1

Z-value: 1.24

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Transcription factors associated with PROX1

Gene Symbol	Gene ID	Gene Info
PROX1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000117707.11	prospero homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PROX1	hg19_v2_chr1_+_214161272_214161322	-0.17	3.6e-01	Click!

Activity profile of PROX1 motif

Sorted Z-values of PROX1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_+_22180536 Show fit	4.91	ENST00000390424.2	TRAV2 Ensembl NCBI GeneCards UniProt NextProt Show fit	T cell receptor alpha variable 2
chr14_+_22409308 Show fit	4.89	ENST00000390441.2	TRAV9-2 Ensembl NCBI GeneCards UniProt NextProt Show fit	T cell receptor alpha variable 9-2
chr5_+_156569944 Show fit	4.81	ENST00000521769.1	ITK Ensembl NCBI GeneCards UniProt NextProt Show fit	IL2-inducible T-cell kinase
chr14_+_22320634 Show fit	4.21	ENST00000390435.1	TRAV8-3 Ensembl NCBI GeneCards UniProt NextProt Show fit	T cell receptor alpha variable 8-3
chr12_+_113229737 Show fit	3.75	ENST00000551052.1 ENST00000415485.3	RPH3A Ensembl NCBI GeneCards UniProt NextProt Show fit	rabphilin 3A homolog (mouse)
chr12_+_113229543 Show fit	3.23	ENST00000447659.2	RPH3A Ensembl NCBI GeneCards UniProt NextProt Show fit	rabphilin 3A homolog (mouse)
chr14_+_22788560 Show fit	3.18	ENST00000390468.1	TRAV41 Ensembl NCBI GeneCards UniProt NextProt Show fit	T cell receptor alpha variable 41
chr1_-_160832490 Show fit	2.97	ENST00000322302.7 ENST00000368033.3	CD244 Ensembl NCBI GeneCards UniProt NextProt Show fit	CD244 molecule, natural killer cell receptor 2B4
chr1_-_160832642 Show fit	2.92	ENST00000368034.4	CD244 Ensembl NCBI GeneCards UniProt NextProt Show fit	CD244 molecule, natural killer cell receptor 2B4
chr12_+_113229452 Show fit	2.87	ENST00000389385.4	RPH3A Ensembl NCBI GeneCards UniProt NextProt Show fit	rabphilin 3A homolog (mouse)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of PROX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	12.8	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1	12.2	GO:0002377	immunoglobulin production(GO:0002377)
2.1	8.5	GO:0071613	granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663)
0.0	4.9	GO:0031295	T cell costimulation(GO:0031295)
0.3	4.8	GO:0001865	NK T cell differentiation(GO:0001865)
0.1	3.6	GO:0006509	membrane protein ectodomain proteolysis(GO:0006509)
0.0	3.2	GO:0007602	phototransduction(GO:0007602)
0.9	2.8	GO:0002519	natural killer cell tolerance induction(GO:0002519) regulation of tolerance induction dependent upon immune response(GO:0002652) negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838) negative regulation of natural killer cell mediated immune response to tumor cell(GO:0002856) negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002859)
0.7	2.6	GO:0051413	response to cortisone(GO:0051413)
0.0	2.6	GO:0034260	negative regulation of GTPase activity(GO:0034260)

Showing 1 to 10 of 113 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.9	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0	10.1	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	3.8	GO:0035578	azurophil granule lumen(GO:0035578)
0.0	3.8	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0	3.2	GO:0101003	ficolin-1-rich granule membrane(GO:0101003)
0.0	2.8	GO:0034707	chloride channel complex(GO:0034707)
0.4	2.5	GO:0019815	B cell receptor complex(GO:0019815)
0.0	2.5	GO:0001750	photoreceptor outer segment(GO:0001750)
0.2	2.2	GO:0097169	AIM2 inflammasome complex(GO:0097169)
0.1	2.2	GO:0043186	P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)

Showing 1 to 10 of 58 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	12.8	GO:0008430	selenium binding(GO:0008430)
0.2	8.5	GO:0042288	MHC class I protein binding(GO:0042288)
0.0	5.1	GO:0004518	nuclease activity(GO:0004518)
0.0	4.8	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	4.4	GO:0017124	SH3 domain binding(GO:0017124)
0.4	2.6	GO:0016936	galactoside binding(GO:0016936)
0.1	2.5	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.5	2.4	GO:0004666	prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1	2.2	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.1	2.2	GO:0008171	O-methyltransferase activity(GO:0008171)

Showing 1 to 10 of 98 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.4	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	2.7	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.1	2.5	PID EPHA FWDPATHWAY	EPHA forward signaling
0.0	1.6	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0	1.5	PID FANCONI PATHWAY	Fanconi anemia pathway
0.1	1.4	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.0	1.4	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	1.3	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	0.9	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.9	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events

Showing 1 to 10 of 19 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.9	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.1	4.8	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	4.5	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
0.1	2.6	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.1	2.5	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.1	2.2	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.1	2.2	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.1	2.1	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.0	1.9	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.1	1.6	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism

Showing 1 to 10 of 30 entries

Results for PROX1

Z-value: 1.24

Motif logo

Transcription factors associated with PROX1

Activity-expression correlation:

Activity profile of PROX1 motif

Sorted Z-values of PROX1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of PROX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: