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Illumina Body Map 2
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Results for RBPJ
Z-value: 1.30
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Transcription factors associated with RBPJ
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RBPJ | hg19_v2_chr4_+_26344754_26344772 | 0.49 | 4.2e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RBPJ
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.6 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 2.5 | 9.8 | GO:2000820 | negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820) |
| 0.5 | 7.4 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 0.3 | 6.4 | GO:0006828 | manganese ion transport(GO:0006828) |
| 0.0 | 6.3 | GO:0060333 | interferon-gamma-mediated signaling pathway(GO:0060333) |
| 0.3 | 5.4 | GO:0048755 | negative regulation of collateral sprouting(GO:0048671) branching morphogenesis of a nerve(GO:0048755) |
| 0.4 | 5.3 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.1 | 5.0 | GO:0010842 | retina layer formation(GO:0010842) |
| 1.4 | 4.2 | GO:0033058 | directional locomotion(GO:0033058) |
| 0.1 | 4.2 | GO:0071625 | vocalization behavior(GO:0071625) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 15.8 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 8.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 6.1 | GO:0030863 | cortical cytoskeleton(GO:0030863) |
| 0.3 | 5.3 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.0 | 4.8 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.7 | 4.2 | GO:0097513 | myosin II filament(GO:0097513) |
| 0.2 | 4.1 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.2 | 4.0 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.2 | 3.4 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.2 | 3.3 | GO:0045180 | basal cortex(GO:0045180) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 11.3 | GO:0035939 | microsatellite binding(GO:0035939) |
| 0.1 | 11.2 | GO:0005518 | collagen binding(GO:0005518) |
| 0.3 | 6.4 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.1 | 6.3 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.5 | 5.4 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.1 | 5.3 | GO:0038187 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.2 | 4.2 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 4.2 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.2 | 4.1 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.3 | 4.0 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 8.7 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 5.6 | ST ADRENERGIC | Adrenergic Pathway |
| 0.1 | 5.4 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.1 | 3.8 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 3.4 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 3.4 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 3.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 3.3 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.0 | 2.7 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.6 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 0.1 | 5.3 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 5.2 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 4.0 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.1 | 4.0 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 3.8 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.2 | 3.4 | REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.1 | 3.0 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.2 | 2.9 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 2.9 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |