ISMARA results: RFX5

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Illumina Body Map 2

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Results for RFX5

Z-value: 1.04

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Transcription factors associated with RFX5

Gene Symbol	Gene ID	Gene Info
RFX5 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000143390.13	regulatory factor X5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
RFX5	hg19_v2_chr1_-_151319283_151319314	0.41	1.8e-02	Click!

Activity profile of RFX5 motif

Sorted Z-values of RFX5 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_+_142020496 Show fit	4.98	ENST00000390381.3	TRBV5-1 Ensembl NCBI GeneCards UniProt NextProt Show fit	T cell receptor beta variable 5-1
chr6_-_32784687 Show fit	4.59	ENST00000447394.1 ENST00000438763.2	HLA-DOB Ensembl NCBI GeneCards UniProt NextProt Show fit	major histocompatibility complex, class II, DO beta
chr22_+_44576770 Show fit	4.56	ENST00000444313.3 ENST00000416291.1	PARVG Ensembl NCBI GeneCards UniProt NextProt Show fit	parvin, gamma
chr6_-_32731243 Show fit	4.10	ENST00000427449.1 ENST00000411527.1	HLA-DQB2 Ensembl NCBI GeneCards UniProt NextProt Show fit	major histocompatibility complex, class II, DQ beta 2
chr6_-_32498046 Show fit	3.89	ENST00000374975.3	HLA-DRB5 Ensembl NCBI GeneCards UniProt NextProt Show fit	major histocompatibility complex, class II, DR beta 5
chr22_+_44577237 Show fit	3.59	ENST00000415224.1 ENST00000417767.1	PARVG Ensembl NCBI GeneCards UniProt NextProt Show fit	parvin, gamma
chr6_-_32634425 Show fit	3.58	ENST00000399082.3 ENST00000399079.3 ENST00000374943.4 ENST00000434651.2	HLA-DQB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	major histocompatibility complex, class II, DQ beta 1
chr6_-_32731299 Show fit	3.56	ENST00000435145.2 ENST00000437316.2	HLA-DQB2 Ensembl NCBI GeneCards UniProt NextProt Show fit	major histocompatibility complex, class II, DQ beta 2
chr6_-_32908765 Show fit	2.86	ENST00000416244.2	HLA-DMB Ensembl NCBI GeneCards UniProt NextProt Show fit	major histocompatibility complex, class II, DM beta
chr6_-_32908792 Show fit	2.76	ENST00000418107.2	HLA-DMB Ensembl NCBI GeneCards UniProt NextProt Show fit	major histocompatibility complex, class II, DM beta

Showing 1 to 10 of 69 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	17.8	GO:0031295	T cell costimulation(GO:0031295)
2.2	10.8	GO:0002399	MHC class II protein complex assembly(GO:0002399)
0.0	7.3	GO:0031532	actin cytoskeleton reorganization(GO:0031532)
0.1	5.8	GO:0006521	regulation of cellular amino acid metabolic process(GO:0006521)
1.5	4.6	GO:0002581	negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.2	4.4	GO:0046007	negative regulation of activated T cell proliferation(GO:0046007)
0.0	2.9	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.5	2.6	GO:0002906	mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.0	2.4	GO:0006305	DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.1	2.3	GO:0015939	pantothenate metabolic process(GO:0015939)

Showing 1 to 10 of 26 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	35.8	GO:0042613	MHC class II protein complex(GO:0042613)
0.7	6.0	GO:1990111	spermatoproteasome complex(GO:1990111)
0.0	2.6	GO:0005637	nuclear inner membrane(GO:0005637)
0.1	2.4	GO:0090545	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.3	2.2	GO:0042825	TAP complex(GO:0042825)
0.3	1.6	GO:0031905	early endosome lumen(GO:0031905)
0.1	1.3	GO:0042611	MHC protein complex(GO:0042611)
0.1	0.9	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.2	0.5	GO:0097543	ciliary inversin compartment(GO:0097543)
0.0	0.4	GO:0070652	HAUS complex(GO:0070652)

Showing 1 to 10 of 11 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	15.8	GO:0032395	MHC class II receptor activity(GO:0032395)
0.3	11.6	GO:0042605	peptide antigen binding(GO:0042605)
0.3	8.1	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.2	6.0	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.5	2.9	GO:0016316	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.5	2.6	GO:0042289	MHC class II protein binding(GO:0042289)
0.4	2.3	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.1	1.3	GO:0032393	MHC class I receptor activity(GO:0032393)
0.0	1.1	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)
0.1	1.0	GO:0008240	tripeptidyl-peptidase activity(GO:0008240)

Showing 1 to 10 of 15 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.2	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	2.7	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	2.4	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.0	1.6	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.0	1.1	PID MYC PATHWAY	C-MYC pathway

Showing 1 to 5 of 5 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	15.3	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.4	9.3	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1	8.1	REACTOME ER PHAGOSOME PATHWAY	Genes involved in ER-Phagosome pathway
0.1	2.9	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.2	1.6	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.1	1.1	REACTOME REGULATION OF APOPTOSIS	Genes involved in Regulation of Apoptosis
0.0	1.0	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0	0.9	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0	0.8	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.0	0.3	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

Showing 1 to 10 of 10 entries

Results for RFX5

Z-value: 1.04

Motif logo

Transcription factors associated with RFX5

Activity-expression correlation:

Activity profile of RFX5 motif

Sorted Z-values of RFX5 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: