ISMARA results: RFX7_RFX4

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Illumina Body Map 2

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Results for RFX7_RFX4_RFX1

Z-value: 5.65

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Transcription factors associated with RFX7_RFX4_RFX1

Gene Symbol	Gene ID	Gene Info
RFX7 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000181827.10	regulatory factor X7
RFX4 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000111783.8	regulatory factor X4
RFX1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000132005.4	regulatory factor X1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
RFX4	hg19_v2_chr12_+_106994905_106994954	0.72	3.2e-06	Click!
RFX1	hg19_v2_chr19_-_14117074_14117141	0.32	7.6e-02	Click!
RFX7	hg19_v2_chr15_-_56535464_56535521	0.26	1.5e-01	Click!

Activity profile of RFX7_RFX4_RFX1 motif

Sorted Z-values of RFX7_RFX4_RFX1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_+_55888186 Show fit	33.78	ENST00000291934.3	TMEM190 Ensembl NCBI GeneCards UniProt NextProt Show fit	transmembrane protein 190
chr1_-_109655377 Show fit	31.80	ENST00000369948.3	C1orf194 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 1 open reading frame 194
chr1_-_109655355 Show fit	30.33	ENST00000369945.3	C1orf194 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 1 open reading frame 194
chr10_+_23216944 Show fit	27.70	ENST00000298032.5 ENST00000409983.3 ENST00000409049.3	ARMC3 Ensembl NCBI GeneCards UniProt NextProt Show fit	armadillo repeat containing 3
chr1_+_36549676 Show fit	27.67	ENST00000207457.3	TEKT2 Ensembl NCBI GeneCards UniProt NextProt Show fit	tektin 2 (testicular)
chr5_-_7851260 Show fit	24.92	ENST00000509627.1	C5orf49 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 5 open reading frame 49
chr22_-_23484246 Show fit	23.94	ENST00000216036.4	RTDR1 Ensembl NCBI GeneCards UniProt NextProt Show fit	rhabdoid tumor deletion region gene 1
chr2_+_54558004 Show fit	23.55	ENST00000405749.1 ENST00000398634.2 ENST00000447328.1	C2orf73 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 2 open reading frame 73
chr2_-_170550877 Show fit	23.23	ENST00000447353.1	CCDC173 Ensembl NCBI GeneCards UniProt NextProt Show fit	coiled-coil domain containing 173
chr10_+_23217006 Show fit	22.76	ENST00000376528.4 ENST00000447081.1	ARMC3 Ensembl NCBI GeneCards UniProt NextProt Show fit	armadillo repeat containing 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX7_RFX4_RFX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.2	76.4	GO:0036159	inner dynein arm assembly(GO:0036159)
1.0	72.0	GO:0042073	intraciliary transport(GO:0042073) protein transport along microtubule(GO:0098840)
4.5	67.4	GO:0036158	outer dynein arm assembly(GO:0036158)
1.6	38.3	GO:0003341	cilium movement(GO:0003341)
1.8	34.4	GO:0003351	epithelial cilium movement(GO:0003351)
0.2	32.4	GO:1903955	positive regulation of protein targeting to mitochondrion(GO:1903955)
0.2	30.2	GO:0007286	spermatid development(GO:0007286)
1.4	23.6	GO:0006348	chromatin silencing at telomere(GO:0006348)
1.1	21.7	GO:0035082	axoneme assembly(GO:0035082)
0.0	19.2	GO:0002244	hematopoietic progenitor cell differentiation(GO:0002244)

Showing 1 to 10 of 203 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	140.1	GO:0031514	motile cilium(GO:0031514)
5.7	73.8	GO:0036157	outer dynein arm(GO:0036157)
0.5	52.9	GO:0036064	ciliary basal body(GO:0036064)
6.1	48.8	GO:0002177	manchette(GO:0002177)
1.0	43.9	GO:0097228	sperm principal piece(GO:0097228)
0.1	35.9	GO:0005929	cilium(GO:0005929)
6.8	33.8	GO:0002079	inner acrosomal membrane(GO:0002079)
1.0	28.3	GO:0048188	Set1C/COMPASS complex(GO:0048188)
1.7	23.9	GO:0072687	meiotic spindle(GO:0072687)
1.0	17.2	GO:0097225	sperm midpiece(GO:0097225)

Showing 1 to 10 of 90 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.2	74.2	GO:0045504	dynein heavy chain binding(GO:0045504)
2.2	71.7	GO:0045505	dynein intermediate chain binding(GO:0045505)
0.3	32.3	GO:0043621	protein self-association(GO:0043621)
0.4	31.4	GO:0048487	beta-tubulin binding(GO:0048487)
0.1	30.1	GO:0017124	SH3 domain binding(GO:0017124)
0.9	28.3	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.6	17.2	GO:0004550	nucleoside diphosphate kinase activity(GO:0004550)
0.0	15.4	GO:0005096	GTPase activator activity(GO:0005096)
0.4	15.2	GO:0070840	dynein complex binding(GO:0070840)
0.0	15.2	GO:0000287	magnesium ion binding(GO:0000287)

Showing 1 to 10 of 135 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	15.1	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	13.7	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.2	9.0	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.1	6.9	PID RAC1 PATHWAY	RAC1 signaling pathway
0.5	6.2	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.1	5.9	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.1	3.8	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	3.6	PID BMP PATHWAY	BMP receptor signaling
0.0	3.6	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.2	3.5	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Showing 1 to 10 of 24 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	13.2	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.2	12.0	REACTOME KINESINS	Genes involved in Kinesins
0.1	11.1	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.1	9.0	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.2	7.6	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.1	6.9	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2	5.9	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2	4.5	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0	4.0	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.1	3.6	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta

Showing 1 to 10 of 42 entries

Results for RFX7_RFX4_RFX1

Z-value: 5.65

Motif logo

Transcription factors associated with RFX7_RFX4_RFX1

Activity-expression correlation:

Activity profile of RFX7_RFX4_RFX1 motif

Sorted Z-values of RFX7_RFX4_RFX1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX7_RFX4_RFX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: