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Illumina Body Map 2
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Results for RUNX1_RUNX2
Z-value: 3.45
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Transcription factors associated with RUNX1_RUNX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RUNX1 | hg19_v2_chr21_-_36421401_36421462 | 0.54 | 1.6e-03 | Click! |
| RUNX2 | hg19_v2_chr6_+_45389893_45389914 | 0.53 | 1.8e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RUNX1_RUNX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 102.5 | GO:0038094 | Fc-gamma receptor signaling pathway(GO:0038094) |
| 0.6 | 90.7 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.1 | 83.3 | GO:0002283 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 2.6 | 47.3 | GO:1900017 | positive regulation of cytokine production involved in inflammatory response(GO:1900017) |
| 0.5 | 40.5 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.4 | 36.8 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 3.7 | 29.8 | GO:0002378 | immunoglobulin biosynthetic process(GO:0002378) |
| 1.5 | 29.3 | GO:0043383 | negative T cell selection(GO:0043383) |
| 0.7 | 29.1 | GO:0048305 | immunoglobulin secretion(GO:0048305) |
| 0.5 | 27.8 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 109.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 1.6 | 59.7 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.5 | 56.0 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.7 | 42.6 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.2 | 36.9 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 31.7 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.3 | 31.1 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.6 | 30.8 | GO:0042571 | immunoglobulin complex(GO:0019814) immunoglobulin complex, circulating(GO:0042571) |
| 1.0 | 27.4 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.2 | 25.5 | GO:0035578 | azurophil granule lumen(GO:0035578) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 177.5 | GO:0003823 | antigen binding(GO:0003823) |
| 0.4 | 45.4 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 4.8 | 43.3 | GO:0070891 | lipoteichoic acid binding(GO:0070891) |
| 0.1 | 29.9 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.6 | 29.6 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 4.2 | 25.2 | GO:0004698 | calcium-dependent protein kinase C activity(GO:0004698) |
| 0.5 | 20.0 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.5 | 19.9 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.1 | 19.8 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.2 | 19.6 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 103.2 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.5 | 42.5 | PID BCR 5PATHWAY | BCR signaling pathway |
| 1.0 | 38.5 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.8 | 31.8 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.2 | 30.9 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.4 | 26.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.8 | 24.1 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.3 | 24.0 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.4 | 22.8 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.5 | 19.3 | PID IL2 1PATHWAY | IL2-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 59.7 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 1.2 | 55.8 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.7 | 53.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.7 | 40.1 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 1.0 | 35.2 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 1.0 | 32.4 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.1 | 26.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.7 | 21.7 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.3 | 19.6 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.3 | 19.0 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |