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Illumina Body Map 2
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Results for RXRA_NR2F6_NR2C2
Z-value: 1.40
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Transcription factors associated with RXRA_NR2F6_NR2C2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000186350.8 | retinoid X receptor alpha | |
| ENSG00000160113.5 | nuclear receptor subfamily 2 group F member 6 | |
| ENSG00000177463.11 | nuclear receptor subfamily 2 group C member 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR2C2 | hg19_v2_chr3_+_14989076_14989113 | -0.71 | 4.8e-06 | Click! |
| RXRA | hg19_v2_chr9_+_137218362_137218426 | 0.41 | 1.9e-02 | Click! |
| NR2F6 | hg19_v2_chr19_-_17356697_17356762 | 0.40 | 2.4e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RXRA_NR2F6_NR2C2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 12.1 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 3.7 | 11.1 | GO:2000910 | negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910) |
| 0.1 | 10.4 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
| 0.7 | 6.7 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
| 0.3 | 6.3 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 1.0 | 6.1 | GO:0032571 | response to vitamin K(GO:0032571) |
| 0.3 | 5.9 | GO:0046951 | ketone body biosynthetic process(GO:0046951) |
| 0.1 | 5.7 | GO:0009250 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
| 0.3 | 5.5 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
| 0.8 | 5.4 | GO:0007598 | blood coagulation, extrinsic pathway(GO:0007598) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 40.1 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 24.0 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 19.6 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 14.5 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 12.3 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.5 | 9.9 | GO:0042627 | chylomicron(GO:0042627) |
| 0.8 | 7.6 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.1 | 5.2 | GO:0031304 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
| 0.1 | 5.1 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 5.1 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 3.2 | 13.0 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 0.0 | 10.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.3 | 8.0 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 1.1 | 6.7 | GO:0046899 | nucleoside triphosphate adenylate kinase activity(GO:0046899) |
| 0.2 | 6.5 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.2 | 6.3 | GO:0001848 | complement binding(GO:0001848) |
| 0.6 | 5.9 | GO:0005497 | androgen binding(GO:0005497) |
| 0.4 | 5.7 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
| 0.2 | 5.5 | GO:0035497 | cAMP response element binding(GO:0035497) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 18.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 7.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 7.2 | ST ADRENERGIC | Adrenergic Pathway |
| 0.0 | 5.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 4.8 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 4.7 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.2 | 4.4 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 3.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 3.1 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 15.2 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.2 | 14.5 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.5 | 13.8 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.1 | 12.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.5 | 11.4 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.1 | 10.5 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.5 | 9.6 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.1 | 9.2 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 8.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.4 | 7.5 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |