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Illumina Body Map 2

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Results for SIX1_SIX3_SIX2

Z-value: 1.12

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Transcription factors associated with SIX1_SIX3_SIX2

Gene Symbol Gene ID Gene Info
SIX1
ENSG00000126778.7 SIX homeobox 1
SIX3
ENSG00000138083.3 SIX homeobox 3
SIX2
ENSG00000170577.7 SIX homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIX2hg19_v2_chr2_-_45236540_45236577-0.576.4e-04Click!
SIX1hg19_v2_chr14_-_61116168_61116180-0.412.1e-02Click!
SIX3hg19_v2_chr2_+_45168875_451689160.048.1e-01Click!

Activity profile of SIX1_SIX3_SIX2 motif

Sorted Z-values of SIX1_SIX3_SIX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_46679144 6.70 ENST00000181383.4
CPB2
carboxypeptidase B2 (plasma)
chr11_-_58499434 6.69 ENST00000344743.3
ENST00000278400.3
GLYAT
glycine-N-acyltransferase
chr13_-_46679185 6.39 ENST00000439329.3
CPB2
carboxypeptidase B2 (plasma)
chr1_+_196946680 5.33 ENST00000256785.4
CFHR5
complement factor H-related 5
chr1_+_196946664 5.32 ENST00000367414.5
CFHR5
complement factor H-related 5
chr6_-_136847099 4.21 ENST00000438100.2
MAP7
microtubule-associated protein 7
chr2_+_234826016 3.86 ENST00000324695.4
ENST00000433712.2
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr6_-_136847610 3.48 ENST00000454590.1
ENST00000432797.2
MAP7
microtubule-associated protein 7
chr3_-_42917363 2.72 ENST00000437102.1
CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr10_-_33405600 2.59 ENST00000414308.1
RP11-342D11.3
RP11-342D11.3
chr10_+_5238793 2.55 ENST00000263126.1
AKR1C4
aldo-keto reductase family 1, member C4
chr8_+_30496078 2.36 ENST00000517349.1
SMIM18
small integral membrane protein 18
chr1_+_241695424 2.31 ENST00000366558.3
ENST00000366559.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr2_+_211421262 2.30 ENST00000233072.5
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chrX_+_138612889 2.26 ENST00000218099.2
ENST00000394090.2
F9
coagulation factor IX
chr14_+_62462541 2.13 ENST00000430451.2
SYT16
synaptotagmin XVI
chr19_+_45445491 2.12 ENST00000592954.1
ENST00000419266.2
ENST00000589057.1
APOC4
APOC4-APOC2
apolipoprotein C-IV
APOC4-APOC2 readthrough (NMD candidate)
chr1_+_207277590 2.08 ENST00000367070.3
C4BPA
complement component 4 binding protein, alpha
chr14_-_74296806 2.01 ENST00000555539.1
RP5-1021I20.2
RP5-1021I20.2
chr3_+_52448539 1.97 ENST00000461861.1
PHF7
PHD finger protein 7
chr1_+_241695670 1.91 ENST00000366557.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr19_-_50836762 1.91 ENST00000474951.1
ENST00000391818.2
KCNC3
potassium voltage-gated channel, Shaw-related subfamily, member 3
chr4_+_155484155 1.90 ENST00000509493.1
FGB
fibrinogen beta chain
chr6_+_131894284 1.89 ENST00000368087.3
ENST00000356962.2
ARG1
arginase 1
chr10_+_7745303 1.81 ENST00000429820.1
ENST00000379587.4
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr8_+_76452097 1.81 ENST00000396423.2
HNF4G
hepatocyte nuclear factor 4, gamma
chr17_+_4675175 1.77 ENST00000270560.3
TM4SF5
transmembrane 4 L six family member 5
chr10_+_7745232 1.76 ENST00000358415.4
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr11_-_128712362 1.74 ENST00000392664.2
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr7_-_121944491 1.73 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZF1
FEZ family zinc finger 1
chr3_-_10452359 1.69 ENST00000452124.1
ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr1_+_207277632 1.69 ENST00000421786.1
C4BPA
complement component 4 binding protein, alpha
chr9_-_6645628 1.64 ENST00000321612.6
GLDC
glycine dehydrogenase (decarboxylating)
chr7_-_48068699 1.63 ENST00000412142.1
ENST00000395572.2
SUN3
Sad1 and UNC84 domain containing 3
chr16_+_56666563 1.54 ENST00000570233.1
MT1M
metallothionein 1M
chr1_-_12958101 1.41 ENST00000235347.4
PRAMEF10
PRAME family member 10
chr12_-_55378452 1.40 ENST00000449076.1
TESPA1
thymocyte expressed, positive selection associated 1
chr5_+_56910048 1.36 ENST00000509844.1
CTD-2023N9.3
CTD-2023N9.3
chr1_+_26737253 1.36 ENST00000326279.6
LIN28A
lin-28 homolog A (C. elegans)
chr17_-_7080883 1.34 ENST00000570576.1
ASGR1
asialoglycoprotein receptor 1
chr2_+_211342432 1.29 ENST00000430249.2
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr3_+_149192475 1.28 ENST00000465758.1
TM4SF4
transmembrane 4 L six family member 4
chr1_-_240906911 1.27 ENST00000431139.2
RP11-80B9.4
RP11-80B9.4
chr14_+_22739823 1.23 ENST00000390464.2
TRAV38-1
T cell receptor alpha variable 38-1
chr11_-_2924720 1.20 ENST00000455942.2
SLC22A18AS
solute carrier family 22 (organic cation transporter), member 18 antisense
chr19_-_48389651 1.18 ENST00000222002.3
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr14_-_27291313 1.18 ENST00000549330.1
RP11-626P14.1
RP11-626P14.1
chr7_-_141541221 1.17 ENST00000350549.3
ENST00000438520.1
PRSS37
protease, serine, 37
chr19_+_41594377 1.17 ENST00000330436.3
CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
chr7_-_48068643 1.16 ENST00000453192.2
SUN3
Sad1 and UNC84 domain containing 3
chr3_+_149191723 1.15 ENST00000305354.4
TM4SF4
transmembrane 4 L six family member 4
chr3_+_42850959 1.15 ENST00000442925.1
ENST00000422265.1
ENST00000497921.1
ENST00000426937.1
ACKR2
KRBOX1
atypical chemokine receptor 2
KRAB box domain containing 1
chr14_-_94759361 1.13 ENST00000393096.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr7_-_48068671 1.11 ENST00000297325.4
SUN3
Sad1 and UNC84 domain containing 3
chr8_+_18248755 1.09 ENST00000286479.3
NAT2
N-acetyltransferase 2 (arylamine N-acetyltransferase)
chr14_+_95047725 1.08 ENST00000554760.1
ENST00000554866.1
ENST00000329597.7
ENST00000556775.1
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr5_-_35089722 1.06 ENST00000511486.1
ENST00000310101.5
ENST00000231423.3
ENST00000513753.1
ENST00000348262.3
ENST00000397391.3
ENST00000542609.1
PRLR
prolactin receptor
chr11_+_27062502 1.04 ENST00000263182.3
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr8_-_29120580 1.04 ENST00000524189.1
KIF13B
kinesin family member 13B
chr9_+_6645887 1.03 ENST00000413145.1
RP11-390F4.6
RP11-390F4.6
chr10_-_134331695 1.02 ENST00000455414.1
RP11-432J24.5
RP11-432J24.5
chr10_+_106937525 0.99 ENST00000369699.4
SORCS3
sortilin-related VPS10 domain containing receptor 3
chr8_+_18248786 0.99 ENST00000520116.1
NAT2
N-acetyltransferase 2 (arylamine N-acetyltransferase)
chr11_+_64323428 0.98 ENST00000377581.3
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr12_-_323689 0.96 ENST00000428720.1
SLC6A12
solute carrier family 6 (neurotransmitter transporter), member 12
chr6_+_147830362 0.95 ENST00000566741.1
SAMD5
sterile alpha motif domain containing 5
chr6_+_147981838 0.91 ENST00000427015.1
ENST00000432506.1
RP11-307P5.1
RP11-307P5.1
chr3_+_113609472 0.90 ENST00000472026.1
ENST00000462838.1
GRAMD1C
GRAM domain containing 1C
chr1_-_207119738 0.89 ENST00000356495.4
PIGR
polymeric immunoglobulin receptor
chr11_+_34654011 0.88 ENST00000531794.1
EHF
ets homologous factor
chr7_-_71912046 0.86 ENST00000395276.2
ENST00000431984.1
CALN1
calneuron 1
chr19_+_45445524 0.85 ENST00000591600.1
APOC4
apolipoprotein C-IV
chr14_+_75761099 0.82 ENST00000561000.1
ENST00000558575.1
RP11-293M10.5
RP11-293M10.5
chr21_-_34185944 0.81 ENST00000479548.1
C21orf62
chromosome 21 open reading frame 62
chr11_-_49230144 0.80 ENST00000343844.4
FOLH1
folate hydrolase (prostate-specific membrane antigen) 1
chr15_+_58430368 0.79 ENST00000558772.1
ENST00000219919.4
AQP9
aquaporin 9
chr3_+_111718036 0.78 ENST00000455401.2
TAGLN3
transgelin 3
chr3_-_157251383 0.77 ENST00000487753.1
ENST00000489602.1
ENST00000461299.1
ENST00000479987.1
VEPH1
ventricular zone expressed PH domain-containing 1
chr1_+_26737292 0.77 ENST00000254231.4
LIN28A
lin-28 homolog A (C. elegans)
chr11_+_61520075 0.77 ENST00000278836.5
MYRF
myelin regulatory factor
chr1_+_196743912 0.77 ENST00000367425.4
CFHR3
complement factor H-related 3
chr14_-_94759595 0.77 ENST00000261994.4
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr2_+_171640291 0.76 ENST00000409885.1
ERICH2
glutamate-rich 2
chrX_+_152907913 0.75 ENST00000370167.4
DUSP9
dual specificity phosphatase 9
chr6_+_28048753 0.74 ENST00000377325.1
ZNF165
zinc finger protein 165
chr15_+_58430567 0.74 ENST00000536493.1
AQP9
aquaporin 9
chr3_-_125900369 0.73 ENST00000490367.1
ALDH1L1
aldehyde dehydrogenase 1 family, member L1
chr1_+_186265399 0.73 ENST00000367486.3
ENST00000367484.3
ENST00000533951.1
ENST00000367482.4
ENST00000367483.4
ENST00000367485.4
ENST00000445192.2
PRG4
proteoglycan 4
chr1_+_50571949 0.72 ENST00000357083.4
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr9_+_140032842 0.72 ENST00000371561.3
ENST00000315048.3
GRIN1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
chr2_+_128177253 0.71 ENST00000427769.1
PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr11_+_71900572 0.70 ENST00000312293.4
FOLR1
folate receptor 1 (adult)
chr1_+_12916941 0.70 ENST00000240189.2
PRAMEF2
PRAME family member 2
chr12_-_11036844 0.69 ENST00000428168.2
PRH1
proline-rich protein HaeIII subfamily 1
chr16_-_68014732 0.69 ENST00000268793.4
DPEP3
dipeptidase 3
chr19_-_56249740 0.69 ENST00000590200.1
ENST00000332836.2
NLRP9
NLR family, pyrin domain containing 9
chr7_+_29519486 0.68 ENST00000409041.4
CHN2
chimerin 2
chr3_-_129147432 0.68 ENST00000503957.1
ENST00000505956.1
ENST00000326085.3
EFCAB12
EF-hand calcium binding domain 12
chrX_+_144908928 0.67 ENST00000408967.2
TMEM257
transmembrane protein 257
chr8_-_29120604 0.66 ENST00000521515.1
KIF13B
kinesin family member 13B
chr3_+_111718173 0.65 ENST00000494932.1
TAGLN3
transgelin 3
chr1_+_215740709 0.65 ENST00000259154.4
KCTD3
potassium channel tetramerization domain containing 3
chr3_+_111717600 0.64 ENST00000273368.4
TAGLN3
transgelin 3
chr10_+_48359344 0.62 ENST00000412534.1
ENST00000444585.1
ZNF488
zinc finger protein 488
chr12_+_16500037 0.61 ENST00000536371.1
ENST00000010404.2
MGST1
microsomal glutathione S-transferase 1
chr14_+_51026844 0.61 ENST00000554886.1
ATL1
atlastin GTPase 1
chr2_-_18770802 0.60 ENST00000416783.1
NT5C1B
5'-nucleotidase, cytosolic IB
chr11_+_64323156 0.59 ENST00000377585.3
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr9_+_6716478 0.59 ENST00000452643.1
RP11-390F4.3
RP11-390F4.3
chr12_-_109458820 0.59 ENST00000550490.1
SVOP
SV2 related protein homolog (rat)
chr16_+_27214802 0.58 ENST00000380948.2
ENST00000286096.4
KDM8
lysine (K)-specific demethylase 8
chr19_+_42055879 0.56 ENST00000407170.2
ENST00000601116.1
ENST00000595395.1
CEACAM21
AC006129.2
carcinoembryonic antigen-related cell adhesion molecule 21
AC006129.2
chr6_+_31554456 0.55 ENST00000339530.4
LST1
leukocyte specific transcript 1
chr19_+_11457232 0.55 ENST00000587531.1
CCDC159
coiled-coil domain containing 159
chr6_+_31554779 0.55 ENST00000376090.2
LST1
leukocyte specific transcript 1
chr21_+_37442239 0.54 ENST00000530908.1
ENST00000290349.6
ENST00000439427.2
ENST00000399191.3
CBR1
carbonyl reductase 1
chr22_+_36113919 0.53 ENST00000249044.2
APOL5
apolipoprotein L, 5
chr4_-_99064387 0.53 ENST00000295268.3
STPG2
sperm-tail PG-rich repeat containing 2
chr16_+_451826 0.52 ENST00000219481.5
ENST00000397710.1
ENST00000424398.2
DECR2
2,4-dienoyl CoA reductase 2, peroxisomal
chr19_+_11457175 0.52 ENST00000458408.1
ENST00000586451.1
ENST00000588592.1
CCDC159
coiled-coil domain containing 159
chr15_+_75550940 0.52 ENST00000300576.5
GOLGA6C
golgin A6 family, member C
chr22_+_41074754 0.51 ENST00000249016.4
MCHR1
melanin-concentrating hormone receptor 1
chr1_-_169337176 0.51 ENST00000472647.1
ENST00000367811.3
NME7
NME/NM23 family member 7
chr14_+_58711539 0.51 ENST00000216455.4
ENST00000412908.2
ENST00000557508.1
PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr6_-_159466042 0.51 ENST00000338313.5
TAGAP
T-cell activation RhoGTPase activating protein
chr6_+_88757507 0.49 ENST00000237201.1
SPACA1
sperm acrosome associated 1
chr16_+_29690358 0.49 ENST00000395384.4
ENST00000562473.1
QPRT
quinolinate phosphoribosyltransferase
chr6_+_31554962 0.49 ENST00000376092.3
ENST00000376086.3
ENST00000303757.8
ENST00000376093.2
ENST00000376102.3
LST1
leukocyte specific transcript 1
chr18_-_11148587 0.49 ENST00000302079.6
ENST00000580640.1
ENST00000503781.3
PIEZO2
piezo-type mechanosensitive ion channel component 2
chr8_-_18666360 0.49 ENST00000286485.8
PSD3
pleckstrin and Sec7 domain containing 3
chr5_+_20616500 0.49 ENST00000512688.1
RP11-774D14.1
RP11-774D14.1
chr16_+_56642041 0.48 ENST00000245185.5
MT2A
metallothionein 2A
chr17_-_45056606 0.47 ENST00000322329.3
RPRML
reprimo-like
chr21_-_33957805 0.47 ENST00000300258.3
ENST00000472557.1
TCP10L
t-complex 10-like
chr7_-_155326532 0.47 ENST00000406197.1
ENST00000321736.5
CNPY1
canopy FGF signaling regulator 1
chr19_+_47523058 0.47 ENST00000602212.1
ENST00000602189.1
NPAS1
neuronal PAS domain protein 1
chr7_-_44198874 0.46 ENST00000395796.3
ENST00000345378.2
GCK
glucokinase (hexokinase 4)
chr16_+_85936295 0.46 ENST00000563180.1
ENST00000564617.1
ENST00000564803.1
IRF8
interferon regulatory factor 8
chr17_-_56769382 0.46 ENST00000240361.8
ENST00000349033.5
ENST00000389934.3
TEX14
testis expressed 14
chr15_-_55562582 0.46 ENST00000396307.2
RAB27A
RAB27A, member RAS oncogene family
chr22_-_44258280 0.45 ENST00000540422.1
SULT4A1
sulfotransferase family 4A, member 1
chr10_+_5090940 0.44 ENST00000602997.1
AKR1C3
aldo-keto reductase family 1, member C3
chr21_-_35883613 0.44 ENST00000337385.3
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr11_-_34533257 0.44 ENST00000312319.2
ELF5
E74-like factor 5 (ets domain transcription factor)
chr19_+_17862274 0.44 ENST00000596536.1
ENST00000593870.1
ENST00000598086.1
ENST00000598932.1
ENST00000595023.1
ENST00000594068.1
ENST00000596507.1
ENST00000595033.1
ENST00000597718.1
FCHO1
FCH domain only 1
chr16_+_777739 0.43 ENST00000563792.1
HAGHL
hydroxyacylglutathione hydrolase-like
chr12_+_56862301 0.43 ENST00000338146.5
SPRYD4
SPRY domain containing 4
chr20_+_18488137 0.43 ENST00000450074.1
ENST00000262544.2
ENST00000336714.3
ENST00000377475.3
SEC23B
Sec23 homolog B (S. cerevisiae)
chr10_-_43762329 0.43 ENST00000395810.1
RASGEF1A
RasGEF domain family, member 1A
chr22_+_32455111 0.42 ENST00000543737.1
SLC5A1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr17_-_34524157 0.42 ENST00000378354.4
ENST00000394484.1
CCL3L3
chemokine (C-C motif) ligand 3-like 3
chr7_-_142630820 0.42 ENST00000442623.1
ENST00000265310.1
TRPV5
transient receptor potential cation channel, subfamily V, member 5
chr9_-_113018746 0.41 ENST00000374515.5
TXN
thioredoxin
chr15_+_40650408 0.41 ENST00000267889.3
DISP2
dispatched homolog 2 (Drosophila)
chr7_-_14880892 0.41 ENST00000406247.3
ENST00000399322.3
ENST00000258767.5
DGKB
diacylglycerol kinase, beta 90kDa
chr12_-_9913489 0.41 ENST00000228434.3
ENST00000536709.1
CD69
CD69 molecule
chr8_+_35649365 0.41 ENST00000437887.1
AC012215.1
Uncharacterized protein
chr11_+_102552041 0.41 ENST00000537079.1
RP11-817J15.3
Uncharacterized protein
chr14_+_21214039 0.41 ENST00000326842.2
EDDM3A
epididymal protein 3A
chr11_+_64323098 0.40 ENST00000301891.4
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr12_+_51236703 0.40 ENST00000551456.1
ENST00000398458.3
TMPRSS12
transmembrane (C-terminal) protease, serine 12
chr1_+_53793885 0.40 ENST00000445039.2
RP4-784A16.5
RP4-784A16.5
chr1_-_157670528 0.39 ENST00000368186.5
ENST00000496769.1
FCRL3
Fc receptor-like 3
chr15_+_75041184 0.39 ENST00000343932.4
CYP1A2
cytochrome P450, family 1, subfamily A, polypeptide 2
chr22_-_30814469 0.39 ENST00000598426.1
KIAA1658
KIAA1658
chr1_-_8000872 0.38 ENST00000377507.3
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr4_+_105828492 0.38 ENST00000506148.1
RP11-556I14.1
RP11-556I14.1
chr4_-_140477910 0.38 ENST00000404104.3
SETD7
SET domain containing (lysine methyltransferase) 7
chr13_-_60737898 0.38 ENST00000377908.2
ENST00000400319.1
ENST00000400320.1
ENST00000267215.4
DIAPH3
diaphanous-related formin 3
chr1_-_179457805 0.37 ENST00000600581.1
AL160286.1
Uncharacterized protein
chr1_+_182419261 0.37 ENST00000294854.8
ENST00000542961.1
RGSL1
regulator of G-protein signaling like 1
chr19_+_16222439 0.37 ENST00000300935.3
RAB8A
RAB8A, member RAS oncogene family
chr3_-_9595480 0.36 ENST00000287585.6
LHFPL4
lipoma HMGIC fusion partner-like 4
chr1_+_40942887 0.36 ENST00000372706.1
ZFP69
ZFP69 zinc finger protein
chr12_-_10320256 0.36 ENST00000538745.1
OLR1
oxidized low density lipoprotein (lectin-like) receptor 1
chr4_-_48136217 0.36 ENST00000264316.4
TXK
TXK tyrosine kinase
chr6_-_167797887 0.36 ENST00000476779.2
ENST00000460930.2
ENST00000397829.4
ENST00000366827.2
TCP10
t-complex 10
chr17_+_73997796 0.36 ENST00000586261.1
CDK3
cyclin-dependent kinase 3
chr1_-_57285038 0.35 ENST00000343433.6
C1orf168
chromosome 1 open reading frame 168
chr20_-_1538319 0.35 ENST00000381621.1
SIRPD
signal-regulatory protein delta
chr3_+_101818088 0.35 ENST00000491959.1
ZPLD1
zona pellucida-like domain containing 1
chr7_-_34978980 0.35 ENST00000428054.1
DPY19L1
dpy-19-like 1 (C. elegans)
chr5_+_140201183 0.34 ENST00000529619.1
ENST00000529859.1
ENST00000378126.3
PCDHA5
protocadherin alpha 5
chr11_-_108438847 0.34 ENST00000531386.1
EXPH5
exophilin 5
chr11_-_15643937 0.34 ENST00000533082.1
RP11-531H8.2
RP11-531H8.2
chr12_-_10321754 0.33 ENST00000539518.1
OLR1
oxidized low density lipoprotein (lectin-like) receptor 1
chr1_+_38022572 0.33 ENST00000541606.1
DNALI1
dynein, axonemal, light intermediate chain 1
chr19_-_4902877 0.33 ENST00000381781.2
ARRDC5
arrestin domain containing 5
chr22_-_32767017 0.33 ENST00000400234.1
RFPL3S
RFPL3 antisense
chr3_+_38323785 0.33 ENST00000466887.1
ENST00000448498.1
SLC22A14
solute carrier family 22, member 14
chr12_+_110011571 0.33 ENST00000539696.1
ENST00000228510.3
ENST00000392727.3
MVK
mevalonate kinase
chr14_+_91709103 0.33 ENST00000553725.1
CTD-2547L24.3
HCG1816139; Uncharacterized protein
chr13_-_25754077 0.32 ENST00000413501.1
AMER2-AS1
AMER2 antisense RNA 1 (head to head)
chr7_+_150759634 0.32 ENST00000392826.2
ENST00000461735.1
SLC4A2
solute carrier family 4 (anion exchanger), member 2
chr5_+_125758865 0.32 ENST00000542322.1
ENST00000544396.1
GRAMD3
GRAM domain containing 3
chr3_-_19975665 0.32 ENST00000295824.9
ENST00000389256.4
EFHB
EF-hand domain family, member B
chrX_+_114524275 0.32 ENST00000371921.1
ENST00000451986.2
ENST00000371920.3
LUZP4
leucine zipper protein 4
chr6_-_52710893 0.32 ENST00000284562.2
GSTA5
glutathione S-transferase alpha 5
chr10_+_135207598 0.32 ENST00000477902.2
MTG1
mitochondrial ribosome-associated GTPase 1
chr2_+_217498105 0.32 ENST00000233809.4
IGFBP2
insulin-like growth factor binding protein 2, 36kDa

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX1_SIX3_SIX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 13.1 GO:0003330 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
1.2 3.6 GO:1903717 carbamoyl phosphate metabolic process(GO:0070408) carbamoyl phosphate biosynthetic process(GO:0070409) response to ammonia(GO:1903717) cellular response to ammonia(GO:1903718)
0.7 10.6 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.6 4.2 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.6 3.9 GO:0050955 thermoception(GO:0050955)
0.4 3.4 GO:0071395 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.4 1.9 GO:0043091 L-arginine import(GO:0043091) arginine import(GO:0090467)
0.4 3.8 GO:0030450 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959)
0.3 3.0 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.3 1.6 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.3 1.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 2.3 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.3 1.9 GO:0008218 bioluminescence(GO:0008218)
0.3 1.5 GO:0015722 canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.2 0.5 GO:0046874 quinolinate metabolic process(GO:0046874)
0.2 6.1 GO:0006544 glycine metabolic process(GO:0006544)
0.2 0.7 GO:0043449 cellular alkene metabolic process(GO:0043449)
0.2 1.2 GO:0030573 bile acid catabolic process(GO:0030573)
0.2 0.7 GO:0061713 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.2 2.1 GO:0010587 miRNA catabolic process(GO:0010587)
0.2 0.6 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.2 1.2 GO:0009804 coumarin metabolic process(GO:0009804)
0.2 0.4 GO:2001183 negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
0.2 1.1 GO:0061107 seminal vesicle development(GO:0061107)
0.2 0.9 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.2 0.7 GO:0044537 regulation of circulating fibrinogen levels(GO:0044537)
0.1 0.7 GO:0009258 10-formyltetrahydrofolate catabolic process(GO:0009258)
0.1 1.9 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 1.9 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.1 0.4 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.1 2.0 GO:0015747 urate transport(GO:0015747)
0.1 1.0 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 0.9 GO:0038161 prolactin signaling pathway(GO:0038161)
0.1 0.3 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.1 2.9 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.1 0.4 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894)
0.1 0.5 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.1 0.8 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.1 0.5 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.1 0.2 GO:0046603 negative regulation of mitotic centrosome separation(GO:0046603)
0.1 0.2 GO:0061727 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 0.2 GO:2000308 iron assimilation(GO:0033212) iron assimilation by chelation and transport(GO:0033214) positive regulation of bone mineralization involved in bone maturation(GO:1900159) negative regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000308)
0.1 0.3 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.1 0.5 GO:0009730 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.1 0.5 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 0.3 GO:1902159 regulation of cyclic nucleotide-gated ion channel activity(GO:1902159)
0.1 0.8 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.1 0.2 GO:2001202 regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904235) positive regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904237) negative regulation of transforming growth factor-beta secretion(GO:2001202)
0.1 0.4 GO:0001712 ectodermal cell fate commitment(GO:0001712)
0.1 0.3 GO:0070253 somatostatin secretion(GO:0070253)
0.1 0.3 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
0.1 0.2 GO:1903964 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1 0.4 GO:0060335 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.1 2.7 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 0.1 GO:0035621 ER to Golgi ceramide transport(GO:0035621)
0.0 0.4 GO:0001951 intestinal D-glucose absorption(GO:0001951)
0.0 6.9 GO:0006970 response to osmotic stress(GO:0006970)
0.0 0.2 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 0.2 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.0 0.4 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 0.6 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 1.0 GO:1900452 regulation of long term synaptic depression(GO:1900452)
0.0 0.5 GO:0042373 vitamin K metabolic process(GO:0042373)
0.0 1.0 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.5 GO:0007167 enzyme linked receptor protein signaling pathway(GO:0007167)
0.0 3.0 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.1 GO:0038193 thromboxane A2 signaling pathway(GO:0038193)
0.0 0.3 GO:0016078 tRNA catabolic process(GO:0016078)
0.0 0.3 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.0 0.3 GO:0071672 regulation of muscle hyperplasia(GO:0014738) negative regulation of smooth muscle cell chemotaxis(GO:0071672)
0.0 0.4 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.0 0.1 GO:1900138 negative regulation of phospholipase A2 activity(GO:1900138)
0.0 0.1 GO:0032900 viral protein processing(GO:0019082) negative regulation of neurotrophin production(GO:0032900) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472)
0.0 0.5 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 0.1 GO:0021938 ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938) notochord regression(GO:0060032)
0.0 0.4 GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential(GO:0098915)
0.0 0.1 GO:0019417 sulfur oxidation(GO:0019417)
0.0 0.3 GO:0018317 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 0.5 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.4 GO:0007320 insemination(GO:0007320)
0.0 0.6 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.0 0.1 GO:0006286 base-excision repair, base-free sugar-phosphate removal(GO:0006286)
0.0 0.1 GO:0036509 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.0 0.2 GO:1905232 cellular response to L-glutamate(GO:1905232)
0.0 0.6 GO:0070129 regulation of mitochondrial translation(GO:0070129)
0.0 0.5 GO:0060746 maternal behavior(GO:0042711) parental behavior(GO:0060746)
0.0 1.9 GO:1902475 L-alpha-amino acid transmembrane transport(GO:1902475)
0.0 1.7 GO:0010107 potassium ion import(GO:0010107)
0.0 0.4 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 0.2 GO:1900244 positive regulation of synaptic vesicle endocytosis(GO:1900244) positive regulation of synaptic vesicle recycling(GO:1903423)
0.0 0.2 GO:0000050 urea cycle(GO:0000050)
0.0 0.4 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.1 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.0 0.2 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.0 0.6 GO:0048714 positive regulation of oligodendrocyte differentiation(GO:0048714)
0.0 2.2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.3 GO:0048007 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 0.7 GO:0048240 sperm capacitation(GO:0048240)
0.0 1.2 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 2.2 GO:0042246 tissue regeneration(GO:0042246)
0.0 0.4 GO:0045023 G0 to G1 transition(GO:0045023)
0.0 0.1 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.0 0.2 GO:2001023 regulation of response to drug(GO:2001023)
0.0 0.2 GO:0070269 pyroptosis(GO:0070269)
0.0 0.3 GO:0015889 cobalt ion transport(GO:0006824) cobalamin transport(GO:0015889)
0.0 0.9 GO:0050427 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0 0.1 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0 0.2 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.0 0.3 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.0 0.5 GO:0044126 regulation of growth of symbiont in host(GO:0044126) negative regulation of growth of symbiont in host(GO:0044130)
0.0 1.2 GO:0007140 male meiosis(GO:0007140)
0.0 1.8 GO:0032945 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.0 0.5 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.5 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.1 GO:1905224 clathrin-coated pit assembly(GO:1905224)
0.0 0.8 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.2 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.3 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0 0.1 GO:0042231 interleukin-13 biosynthetic process(GO:0042231)
0.0 0.3 GO:0010226 response to lithium ion(GO:0010226)
0.0 1.2 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.2 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0 0.5 GO:0050974 detection of mechanical stimulus involved in sensory perception(GO:0050974)
0.0 0.1 GO:0039019 pronephric nephron development(GO:0039019)
0.0 0.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.1 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.0 0.3 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.3 GO:0002347 response to tumor cell(GO:0002347)
0.0 0.1 GO:0071461 cellular response to redox state(GO:0071461)
0.0 0.1 GO:0097105 presynaptic membrane assembly(GO:0097105)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0005960 glycine cleavage complex(GO:0005960)
0.3 1.1 GO:0097182 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.1 2.1 GO:0005577 fibrinogen complex(GO:0005577)
0.1 2.9 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 3.0 GO:0034385 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1 1.9 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 0.7 GO:0098839 postsynaptic density membrane(GO:0098839)
0.1 0.4 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.0 1.5 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.2 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.0 0.2 GO:0016939 kinesin II complex(GO:0016939)
0.0 2.9 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.2 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.6 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.5 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.1 GO:0097451 glial limiting end-foot(GO:0097451)
0.0 0.5 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.2 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.0 0.1 GO:0005602 complement component C1 complex(GO:0005602)
0.0 7.5 GO:0005875 microtubule associated complex(GO:0005875)
0.0 0.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.2 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.5 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.2 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 3.2 GO:0044217 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0 6.6 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.8 GO:0002080 acrosomal membrane(GO:0002080)
0.0 2.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.5 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.3 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.9 GO:0031904 endosome lumen(GO:0031904)
0.0 7.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 4.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.5 GO:0030057 desmosome(GO:0030057)
0.0 0.4 GO:1902711 GABA-A receptor complex(GO:1902711)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.6 GO:0004088 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.8 6.7 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.7 3.4 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.5 2.1 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.3 13.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.3 1.5 GO:0015254 glycerol channel activity(GO:0015254)
0.3 4.2 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.3 1.0 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.2 0.4 GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.2 1.7 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.2 0.7 GO:0061714 folic acid receptor activity(GO:0061714)
0.2 0.5 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.2 1.2 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.1 1.3 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.1 0.9 GO:0004925 prolactin receptor activity(GO:0004925)
0.1 0.7 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.1 2.1 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 2.4 GO:0016594 glycine binding(GO:0016594)
0.1 2.0 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 1.0 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1 2.0 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 3.5 GO:0043495 protein anchor(GO:0043495)
0.1 1.1 GO:0032190 acrosin binding(GO:0032190)
0.1 0.5 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.1 0.5 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.1 3.9 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 0.3 GO:0032090 Pyrin domain binding(GO:0032090)
0.1 0.2 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 0.6 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.1 1.2 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 0.6 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 0.3 GO:0030305 beta-glucuronidase activity(GO:0004566) heparanase activity(GO:0030305)
0.1 0.5 GO:0008865 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.4 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.4 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.6 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.0 0.9 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 0.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0004961 thromboxane receptor activity(GO:0004960) thromboxane A2 receptor activity(GO:0004961)
0.0 0.1 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.0 1.7 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.1 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.0 0.2 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.6 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.6 GO:0043295 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 0.1 GO:0017089 glycolipid transporter activity(GO:0017089)
0.0 0.5 GO:0046870 cadmium ion binding(GO:0046870)
0.0 0.5 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.4 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 1.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 4.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.7 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.4 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 1.6 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.5 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.3 GO:0030882 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.0 0.4 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 4.5 GO:0005262 calcium channel activity(GO:0005262)
0.0 0.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.7 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.7 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.8 GO:0031489 myosin V binding(GO:0031489)
0.0 0.1 GO:0008112 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.3 GO:0031419 cobalamin binding(GO:0031419)
0.0 2.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.7 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.5 GO:0008035 high-density lipoprotein particle binding(GO:0008035)
0.0 0.2 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0 0.3 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.2 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 0.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.7 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.7 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.5 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 1.8 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 0.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 1.8 GO:0051087 chaperone binding(GO:0051087)
0.0 0.2 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.2 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.3 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.8 PID CD40 PATHWAY CD40/CD40L signaling
0.0 2.2 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 3.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 1.7 PID ARF6 PATHWAY Arf6 signaling events
0.0 7.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.4 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.3 PID PTP1B PATHWAY Signaling events mediated by PTP1B

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.3 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.2 4.2 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.2 3.1 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 4.5 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 1.9 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 1.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 1.6 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 9.5 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.1 2.0 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 2.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.7 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.7 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 1.0 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.7 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.9 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.6 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.7 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 1.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 6.5 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.4 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.2 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.4 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.1 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators