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Illumina Body Map 2
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Results for SOX17
Z-value: 1.48
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Transcription factors associated with SOX17
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX17 | hg19_v2_chr8_+_55370487_55370503 | -0.03 | 8.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrY_+_2709906 Show fit | 5.30 |
ENST00000430575.1
|
ribosomal protein S4, Y-linked 1 |
|
| chr22_+_22516550 Show fit | 4.07 |
ENST00000390284.2
|
immunoglobulin lambda variable 4-60 |
|
| chr2_-_89399845 Show fit | 3.81 |
ENST00000479981.1
|
immunoglobulin kappa variable 1-16 |
|
| chr2_+_90139056 Show fit | 3.68 |
ENST00000492446.1
|
immunoglobulin kappa variable 1D-16 |
|
| chr22_+_22723969 Show fit | 3.54 |
ENST00000390295.2
|
immunoglobulin lambda variable 7-46 (gene/pseudogene) |
|
| chr14_-_107013465 Show fit | 3.38 |
ENST00000390625.2
|
immunoglobulin heavy variable 3-49 |
|
| chr2_-_89278535 Show fit | 3.34 |
ENST00000390247.2
|
immunoglobulin kappa variable 3-7 (non-functional) |
|
| chr2_-_89417335 Show fit | 3.29 |
ENST00000490686.1
|
immunoglobulin kappa variable 1-17 |
|
| chr15_-_20193370 Show fit | 3.01 |
ENST00000558565.2
|
immunoglobulin heavy variable 3/OR15-7 (pseudogene) |
|
| chr16_+_2867228 Show fit | 2.93 |
ENST00000005995.3
ENST00000574813.1 |
protease, serine, 21 (testisin) |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX17
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 34.0 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 16.6 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.0 | 5.8 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 5.0 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.0 | 3.6 | GO:0006968 | cellular defense response(GO:0006968) |
| 1.2 | 3.5 | GO:0002728 | negative regulation of natural killer cell cytokine production(GO:0002728) |
| 1.0 | 3.0 | GO:0045957 | regulation of complement activation, alternative pathway(GO:0030451) negative regulation of complement activation, alternative pathway(GO:0045957) |
| 1.0 | 2.9 | GO:0050904 | diapedesis(GO:0050904) |
| 0.5 | 2.7 | GO:0030573 | bile acid catabolic process(GO:0030573) |
| 0.1 | 2.2 | GO:0034587 | piRNA metabolic process(GO:0034587) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 13.9 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 10.4 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 5.9 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 5.8 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 3.6 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 3.0 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.6 | 2.9 | GO:0034669 | integrin alpha4-beta7 complex(GO:0034669) |
| 0.0 | 2.9 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 2.0 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 1.9 | GO:0005577 | fibrinogen complex(GO:0005577) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 30.2 | GO:0003823 | antigen binding(GO:0003823) |
| 0.2 | 13.9 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 8.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 4.9 | GO:0019843 | rRNA binding(GO:0019843) |
| 1.0 | 3.0 | GO:0001861 | complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877) |
| 0.3 | 2.9 | GO:0019960 | C-X3-C chemokine binding(GO:0019960) protein antigen binding(GO:1990405) |
| 0.5 | 2.7 | GO:0047787 | delta4-3-oxosteroid 5beta-reductase activity(GO:0047787) |
| 0.0 | 2.4 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.2 | 2.1 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
| 0.1 | 1.9 | GO:0032052 | bile acid binding(GO:0032052) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.0 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.1 | 2.9 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.9 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 1.7 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 1.4 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 1.2 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 1.1 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 0.8 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 0.8 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.5 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 4.9 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 3.3 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 3.2 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.2 | 2.7 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.1 | 2.1 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 1.9 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.3 | 1.8 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |
| 0.0 | 1.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 1.7 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |