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Illumina Body Map 2
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Results for SP1
Z-value: 2.99
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Transcription factors associated with SP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP1 | hg19_v2_chr12_+_53774423_53774658 | -0.13 | 4.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 58.0 | GO:0042119 | neutrophil activation(GO:0042119) |
| 0.4 | 39.8 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
| 0.2 | 34.6 | GO:0072599 | establishment of protein localization to endoplasmic reticulum(GO:0072599) |
| 0.2 | 33.7 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 0.3 | 31.8 | GO:0005977 | glycogen metabolic process(GO:0005977) |
| 0.3 | 30.0 | GO:0070126 | mitochondrial translational termination(GO:0070126) |
| 0.2 | 24.4 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.8 | 23.9 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
| 0.2 | 23.0 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
| 0.5 | 22.3 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 200.1 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.3 | 159.4 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 122.5 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 107.5 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.2 | 81.4 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.1 | 69.0 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.2 | 51.2 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.3 | 49.7 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.2 | 45.3 | GO:0030016 | myofibril(GO:0030016) |
| 0.4 | 42.1 | GO:0005776 | autophagosome(GO:0005776) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 82.3 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.2 | 53.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 44.1 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.1 | 39.9 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.5 | 29.6 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.4 | 27.9 | GO:0001221 | transcription cofactor binding(GO:0001221) |
| 0.5 | 26.1 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.1 | 24.2 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.9 | 23.1 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.3 | 22.0 | GO:0003743 | translation initiation factor activity(GO:0003743) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 45.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.9 | 42.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.6 | 41.4 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.5 | 38.3 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.3 | 34.7 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.6 | 33.2 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.5 | 31.8 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.3 | 28.7 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.5 | 27.7 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.5 | 25.8 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 44.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 40.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.4 | 37.7 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.8 | 32.1 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.4 | 31.7 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.7 | 31.0 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.4 | 30.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.4 | 30.1 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.5 | 29.3 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.2 | 29.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |