ISMARA results: SP3

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Illumina Body Map 2

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Results for SP3

Z-value: 2.25

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Transcription factors associated with SP3

Gene Symbol	Gene ID	Gene Info
SP3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000172845.9	Sp3 transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SP3	hg19_v2_chr2_-_174830430_174830563	0.18	3.3e-01	Click!

Activity profile of SP3 motif

Sorted Z-values of SP3 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_+_2466218 Show fit	8.66	ENST00000155840.5	KCNQ1 Ensembl NCBI GeneCards UniProt NextProt Show fit	potassium voltage-gated channel, KQT-like subfamily, member 1
chr12_+_6419877 Show fit	6.66	ENST00000536531.1	PLEKHG6 Ensembl NCBI GeneCards UniProt NextProt Show fit	pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr22_-_50746027 Show fit	6.65	ENST00000425954.1 ENST00000449103.1	PLXNB2 Ensembl NCBI GeneCards UniProt NextProt Show fit	plexin B2
chr18_+_11981427 Show fit	6.53	ENST00000269159.3	IMPA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	inositol(myo)-1(or 4)-monophosphatase 2
chr16_+_1203194 Show fit	6.36	ENST00000348261.5 ENST00000358590.4	CACNA1H Ensembl NCBI GeneCards UniProt NextProt Show fit	calcium channel, voltage-dependent, T type, alpha 1H subunit
chr22_-_50746001 Show fit	6.03	ENST00000359337.4	PLXNB2 Ensembl NCBI GeneCards UniProt NextProt Show fit	plexin B2
chr18_+_11981547 Show fit	6.02	ENST00000588927.1	IMPA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	inositol(myo)-1(or 4)-monophosphatase 2
chr14_+_104552016 Show fit	5.54	ENST00000551177.1 ENST00000546892.2 ENST00000455920.2	ASPG Ensembl NCBI GeneCards UniProt NextProt Show fit	asparaginase homolog (S. cerevisiae)
chr18_+_11981014 Show fit	5.53	ENST00000589238.1	IMPA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	inositol(myo)-1(or 4)-monophosphatase 2
chr21_+_35445827 Show fit	5.44	ENST00000608209.1 ENST00000381151.3	SLC5A3 Ensembl NCBI GeneCards UniProt NextProt Show fit SLC5A3 Ensembl NCBI GeneCards UniProt NextProt Show fit	sodium/myo-inositol cotransporter solute carrier family 5 (sodium/myo-inositol cotransporter), member 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of SP3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	42.4	GO:0002283	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
1.1	29.4	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.2	28.2	GO:0006613	cotranslational protein targeting to membrane(GO:0006613)
0.7	27.7	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.3	26.0	GO:0045454	cell redox homeostasis(GO:0045454)
0.5	23.0	GO:0071526	semaphorin-plexin signaling pathway(GO:0071526)
1.1	18.9	GO:0002934	desmosome organization(GO:0002934)
0.2	18.9	GO:0070268	cornification(GO:0070268)
2.1	18.8	GO:0006021	inositol biosynthetic process(GO:0006021)
0.1	16.9	GO:0070125	mitochondrial translational elongation(GO:0070125)

Showing 1 to 10 of 1,861 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	870.4	GO:0070062	extracellular exosome(GO:0070062)
0.1	155.6	GO:0005654	nucleoplasm(GO:0005654)
0.3	69.3	GO:1904813	ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.1	62.1	GO:0005759	mitochondrial matrix(GO:0005759)
0.2	57.6	GO:0005765	lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1	52.4	GO:0005925	focal adhesion(GO:0005925)
1.0	41.0	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.4	40.1	GO:0031526	brush border membrane(GO:0031526)
0.1	40.0	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.4	39.4	GO:0035580	specific granule lumen(GO:0035580)

Showing 1 to 10 of 482 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	109.7	GO:0003700	transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.1	64.0	GO:0045296	cadherin binding(GO:0045296)
0.3	47.8	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	35.5	GO:0003677	DNA binding(GO:0003677)
0.1	34.7	GO:0003735	structural constituent of ribosome(GO:0003735)
0.3	28.6	GO:0033558	protein deacetylase activity(GO:0033558)
0.2	27.5	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.2	26.0	GO:0001158	enhancer sequence-specific DNA binding(GO:0001158)
0.1	25.5	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1	25.3	GO:0003714	transcription corepressor activity(GO:0003714)

Showing 1 to 10 of 1,066 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	50.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4	44.5	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.6	43.6	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.1	37.5	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	36.5	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.4	34.2	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.4	32.6	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.5	31.9	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.5	29.3	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.5	28.9	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway

Showing 1 to 10 of 144 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	38.7	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.6	37.2	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.3	34.9	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.9	34.0	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.7	33.2	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.3	32.2	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.2	30.5	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.3	29.9	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.4	29.0	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
0.4	27.8	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules

Showing 1 to 10 of 235 entries

Results for SP3

Z-value: 2.25

Motif logo

Transcription factors associated with SP3

Activity-expression correlation:

Activity profile of SP3 motif

Sorted Z-values of SP3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of SP3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: